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Method for preparing piper laetispicum extract, extract and its use

A technology for the preparation of betelwort extracts and extracts, which can solve the problems of large damage to active ingredients, high difficulty in experimental operations, and poor pharmacological activity of extracts, and achieve improved The content of amide alkaloids and the effect of improving the biological activity of the extract

Active Publication Date: 2007-12-26
SUZHOU YI HUA BIOMEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Previously, the inventor had applied for two Chinese invention patents related to betels, the first of which (application number: 00119452.6) disclosed the application of betel and its extracts in the preparation of pharmaceutical compositions; the second (application number: 00119452.6) Application No.: 03115911.7) discloses a method for preparing the extract of the effective part of betelwort. The extract prepared by this method can be used for the treatment and prevention of depression or other affective disorders, etc., but the extraction process Using the reflux method, due to the relatively high temperature of the reflux method, the damage to the active ingredients is relatively large, so the pharmacological activity of the extract is not good
In addition, the experimental operation is more difficult

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Example 1 , the preparation of betel leaf extract

[0014] As shown in Table 1, the roots, rhizomes, canes, leaves, fruits or whole plants of the betelwort were taken respectively to prepare the betelew extract, as follows:

[0015] Sample 1: Cut the roots and rhizomes of the betelwort into sections, add about 80% ethanol and soak at room temperature for about 24 hours, then add ethanol with the same concentration to 15 times the amount of medicinal materials, and percolate to obtain a crude extract. Slowly add about the same amount of warm water at 60°C and mix well, then put the diluted percolation liquid on the D101 macroporous adsorption resin column, and elute with 50% and 85% ethanol respectively after flowing through, and collect 85% ethanol to elute The liquid was concentrated and dried at ≤70°C to obtain a refined extract.

[0016] Sample 2: Cut the roots and rhizomes of Betelwort into segments, add about 45% ethanol and soak at room temperature for about 48 ...

Embodiment 2

[0029] Embodiment 2, the extract of betel is used for preparing medicine

[0030] The No. 1-12 extracts obtained in Example 1 are used as pharmaceutical raw materials, and prepared into capsules, tablets, granules, powders, dropping pills, micropills, injections, powder injections, and oral liquid preparations according to conventional production methods in the pharmaceutical field , sustained-release and controlled-release preparations, targeted preparations and other dosage forms. In view of the fact that these methods all belong to the routine operations in the prior art, only sample No. 1 obtained in Example 1 is used as an example to prepare capsules, granules and tablets.

[0031] 2-1. Capsules

[0032] prescription:

[0033] Extract 20g;

[0034] Corn starch 170g:

[0035] Magnesium stearate 10g

[0036] Preparation method:

[0037] The extract is mixed with starch and magnesium stearate, sieved, evenly filled into 1000 prefabricated empty capsules and sealed. Eac...

Embodiment 3

[0055] Embodiment 3, antidepressant effect-forced swimming test

[0056] Get the mice into random groups, and give the test drug as shown in Table 2 respectively, wherein the numbering of the drug corresponds to the sample number of embodiment 1 (the same below), and with normal saline as a control, the positive control group is venlafaxine. Give the test drug for 14 consecutive days, once a day, 60 minutes after the administration on the 14th day, put the animals in a glass cylinder with a diameter of about 10 cm, a height of about 20 cm, and a water depth of 8-10 cm, and the water temperature is 22-24 °C . Starting from the 2nd minute, record the accumulated time without moving for 4 minutes. The results are shown in Table 2.

[0057] Table 2

[0058] drug *

Dose (mg / kg / d)

n

Cumulative immobility time (s) X±SE

CK-

-

10

83.94±6.89

CK+

20

10

21.87±4.56 **

1

10

...

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PUM

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Abstract

The present invention discloses a method of extracting and refining extract from medicinal plant Piper laetispicum, the extract thus obtained, and the application of the extract in medicine and food additive for preventing and treating depression, anxiety neurosis and other psychogenic diseases and other fields.

Description

technical field [0001] The present invention relates to the medicinal plant Piper laetispicum C.DC, in particular to the method for preparing the extract of Piper laetispicum C.DC, the extract prepared by the method, and the extract Applications. Background technique [0002] Depression and (or) anxiety have become one of the most important diseases that hinder human health. According to WHO data, the total disease burden caused by depression and (or) anxiety has been second only to coronary heart disease in developed countries. In my country, it ranks second only after chronic obstructive pulmonary disease. Neuropsychiatric diseases rank first in the total burden of diseases in my country, accounting for about 1 / 5 of the total burden of diseases. At the same time, numerous community and medical studies have revealed that both depression and anxiety disorders have relatively high incidence rates. For example, the National Syndrome Survey found that 17.3% of the general popu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/67A61K9/00A61P25/24A61P25/22
CPCA61K36/67A61P25/00A61P25/06A61P25/08A61P25/16A61P25/18A61P25/20A61P25/22A61P25/24A61P25/28
Inventor 王厄舟蒋毅
Owner SUZHOU YI HUA BIOMEDICAL TECH CO LTD
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