54 results about "Anxiety neurosis" patented technology

Compositions based on hydrogenated pyrido[4,3-b]indoles (variants) of formula (1) or formula (2): are provided, as are methods and kits using those compositions for the treatment of anxiety or mood disorders characterized by stresses, anxiety, neuroses, obsessive fears and their consequences.

The invention relates to an oxadiazole derivative, a preparation method therefor and use of the oxadiazole derivative in medicines. Particularly, the invention relates to an oxadiazole derivative represented by a general formula (I) shown in the description, a preparation method therefor, a pharmaceutical composition containing the derivative and use of the pharmaceutical composition in preparation of drugs for preventing and / or treating diseases with IDO mediated pathological features of a tryptophan metabolism pathway, wherein the diseases comprise cancer, Alzheimer's disease, autoimmune disease, melancholia, anxiety neurosis, cataract, psychological barrier and acquired immunodeficiency syndrome. Each substituent of the general formula (I) is the same as defined in the specification.

The invention relates to a preparation method of tryptanthrin compound and a new application of tryptanthrin compound in preparing indoleamine-2,3-dioxygenase (IDO) inhibitor, in particular to an application of tryptanthrin compound in preparing IDO inhibitor and in preparing medicine for preventing and / or treating diseases having pathological characteristics of tryptophan metabolic disturbance mediated by IDO. The structure of the tryptanthrin compound is shown in formula A in the description, wherein R1 and R2 are respectively and independently selected from hydrogen, nitryl, C1 to C5 alkyl, halogen or piperazinyl. The tryptanthrin compound can be used as an IDO inhibitor with high activity and is used for treating diseases having pathological characteristics of tryptophan metabolic disturbance mediated by IDO such as tumor, cancer, Alzheimer disease, autoimmune disease, cataract, mental block, tristimania, anxiety neurosis, acquired immure deficiency syndrome (AIDS) and other serious diseases, and as a medicinal resource which is very difficult to get, the tryptanthrin compound has good potential on researching and developing new medicine.

The invention discloses application of eucommia ulmoides extracts in the preparation of compositions for tranquilizing and inducing sleep and application of the eucommia ulmoides extracts in the preparation of compositions for treating insomnia, anxiety neurosis or convulsion. The eucommia ulmoides extracts are continuously extracted from eucommia bark, eucommia leaves, eucommia male flowers and\or eucommia whole plants by petroleum ether, ethyl acetate, normal butanol, ethanol and water. The eucommia ulmoides extracts are obtained by extracting from eucommia plants. And results of researcheson the application of the eucommia ulmoides extracts in the field of tranquilization and sleep induction show that the eucommia ulmoides extracts have remarkable effects of tranquilizing and inducingsleep and resisting convulsion, wherein the ethyl acetate extract of eucommia and the normal butanol extract of the eucommia have more obvious effects. The eucommia ulmoides extracts are natural active materials for researching and developing novel health-care foods and new drugs for tranquilizing and inducing sleep, and can be applied to the treatment of nervous system diseases such as insomnia,anxiety neurosis and convulsion without side effects and psychic dependence.

Mice in which OCT3 expression is suppressed were successfully constructed by administering antisense against OCT3 gene into the brain. Mice in which OCT3 expression is suppressed display phenotypes related to mental disorders such as anti-depression and anti-anxiety, and therefore the mice can be applied to the screening of therapeutic agents for mental disorders. In addition, substances suppressing the OCT3 expression or function were shown to be in fact effective as therapeutic agents for depression and anxiety neuroses.

The present invention is one kind of Chinese medicine composition, named Xinyue, with obvious treating effect on depression and anxiety neurosis. The Chinese medicine composition is the mixture of ginseng, tuckahoe, grassleaved sweetflag rhizome and polygala root in certain proportion or the mixture of their active components extracted, and may be prepared into various preparation forms. It is suitable for depression and anxiety neurosis caused by different reasons, and has the action mechanism of raising the content of NE, 5-HT and metabolism product 5-HIAA in body, activating the 5-HT neuron in brain and lowering the content of corticosteroid in depression blood plasma.

The invention relates to an oral traditional Chinese medicine preparation for treating melancholia and anxiety neurosis, which is prepared by adopting the following raw materials of traditional Chinese medicines in parts by weight: 15+ / -3 of roasted astragalus root, 10+ / -2 of American ginseng, 10+ / -2 of white atractylodes rhizome, 10+ / -2 of tall gastrodia tuber, 10+ / -2 of medlar, 10+ / -2 of prepared rehmannia root, 10+ / -2 of white peony root, 10+ / -2 of radix salviae miltiorrhizae, 10+ / -2 of angelica, 10+ / -2 of rhizoma ligustici wallichii, 10+ / -2 of herba epimedii, 15+ / -3 of spine date seed, 10+ / -2 of tuckahoe, 10+ / -2 of rhizoma anemarrhenae, 10+ / -2 of rhizoma cyperi, 10+ / -2 of radix bupleuri, 10+ / -2 of TurmericRoot-tuber and 6+ / -1.2 of roasted licorice. The observation of clinical curative effect proves that the total effective rate of the invention for treating the anxiety neurosis is 92.2%; the total effective rate of the invention for treating the melancholia is 91.0%. The curative effect of the oral traditional Chinese medicine preparation is similar to the curative effect of the western medicines of buspirone for treating the anxiety neurosis and fluoxetine for treating the melancholia. Moreover, the traditional Chinese medicine preparation has no obvious toxic or side effect and can be taken for a long time. The preparation has small dose, easy release of the effective components of the medicine, quick absorption, full exertion of the medicine effect, convenient carrying and easy taking and is beneficial to large-scale production.

The present invention relates to the interconnected medicine precursor of gabapentin and pregabalin and its non-toxic pharmaceutically acceptable salt and their use in preparing medicines for treating epilepsy, neurogenic pain and / or anxiety neurosis.

The present invention relates to a Chinese medicine composition for curing depression and anxiety neurosis with obvious therapeutic effect. It is made up by using Chinese medicinal materials of forsythia fruit, curcuma tuber, acorus root, ginseng, polygala root and silk tree flower as main raw material and adding beta-cyclodextrin as auxiliary material through a certain preparation process. It can be made into capsule preparation.

The invention relates to a medicine compound from Chinese traditional medicines and its manufacturing method, the utilization of the medicine and its ingredients. The medicine is applied to cure spirit and nerve system diseases, such as anxiety neurosis and depressions.

The invention relates to a traditional Chinese medicine composition for resisting depression, which is characterized by being prepared from the following raw medicines in percentage by weight: 40-70% of hemerocallis fulva, 15-40% of radix curcumae and 15-40% of raw white peony root. The invention also provides a preparation method as well as application of the traditional Chinese medicine composition for resisting depression. The invention has the advantages that the traditional Chinese medicine composition provided by the invention is prepared by screening layer by layer and simplifying gradually on the basis of taking traditional Chinese medicine theories and clinical researches as guidance, pure natural traditional Chinese medicine raw materials are selected, and all raw materials are proportioned to accord with the 'monarch, minister, assistant and guide' principle in the traditional Chinese medicine. The pharmacological experiment proves that the traditional Chinese medicine composition has obvious functions of calming the liver, relieving depression, tranquilizing mind and soothing the nerves, has the advantages of obvious treatment effect, small side effect, easy avalaibility of resources, few medicines and low price, is simple and convenient to prepare, is suitable for being taken for a long time, is a safe and effective medicament for treating depression and anxiety neurosis, and has wide application prospects.

The invention relates to a preparation method of Chinese herbal medicine preparation for treating depression and anxiety disorder, having the materials of roasted milkvetch root, Largehead Atractylodes Rhizome, Rhizoma Gastrodiae, medlar, Prepared Rehmannia Root, root of herbaceous peony, danshen root, angelica sinensis, Szechwan Lovage Rhizome, Epimedium Herb, semen zizyphi spinosae, polygalae, pachyma cocos, medicinal glue, American ginseng and Hairy Antler. The water volume of water decoction, extraction time and extraction times of the roasted milkvetch root, Largehead Atractylodes Rhizome, Rhizoma Gastrodiae, medlar, Prepared Rehmannia Root, root of herbaceous peony, danshen root, angelica sinensis, Szechwan Lovage Rhizome, Epimedium Herb, semen zizyphi spinosae, polygalae, pachyma cocos are preferred by adopting orthogonal test in the invention, which remain every component of medicinal materials having effect on the indications to the utmost extent; simultaneously the extraction of ineffective ingredient is reduced; the concentration is processed, and the active ingredient is not lost; the cost is lowered; the medicinal glue, American ginseng and Hairy Antler are ground, and the raw powder is used as medicines. The capsules prepared by the preparation method of Chinese herbal medicine preparation has the advantages of convenient administration, small administration dosage, easy discharge of the drug active ingredient, rapid absorption, increased bioavailability and fully exerted drug efficacy.

The invention provides a Chinese traditional medicine combination which is applied to preparing anxiety neurosis medicines. Proved in the clinical experiments, the medicine combination has functions of supplementing qi and nourishing yin, promoting coronary arteries circulation to remove obstruction in the heart-vessels, tranquillizing and regulating main nerves through three ways of nourishing, preserving and restraining, so as to effectively relieve worrying mood of the anxiety neurosis patients and improve regulation and control ability for various functions of organism and have no obvious side effects; thus being good for clinical promotion and application.

The invention discloses a pharmaceutical composition or health food for treating anxiety neurosis made from the raw materials containing ginsenoside (Rg1+Rb1), glycyrrhetic acid and chinese date cAMP, especially a pharmaceutical composition or health food for treating anxiety neurosis with definite functions, evident effects, low side effect and high safety for long term taking. The experiments verify that: comparing with mainstream medicines for treating anxiety neurosis in current technology, such as Diazepam, the medicine in the invention achieves more remarkable anti-dysphoria effect.

The present invention discloses a kind of buspirone hydrochloride slow / control released micropills and capsule and their preparation method. The invented buspirone hydrochloride slow / control released micropill includes buspirone hydrochloride medicine pill core and isolating layer (slow-released coating layer) which can be used for covering exterior of said medicine pill core. Said buspirone hydrochloride slow / control released micropills and capsule can be used for curing anxiety neurosis.

The invention relates to a traditional Chinese medicine preparation for treating anxiety neurosis, which has the advantages of favorable curative effect and small side effect. The traditional Chinese medicine preparation for treating anxiety neurosis is prepared from the following raw materials in parts by weight: 35-70 parts of arisaema cum bile, 30-80 parts of tuber pinellia, 25-60 parts of immature bitter orange, 30-80 parts of radix curcumae, 70-110 parts of fritillaria cirrhosa, 15-50 parts of artificial ox gallstone, 10-50 parts of bamboo shavings, 20-60 parts of tuckahoe, 30-75 parts of polygala root, 2-70 parts of albizia bark, 20-75 parts of self-heal, 20-75 parts of coptis, 5-35 parts of Cordyceps and 30-85 parts of licorice. The raw materials are mixed, extracted and purified into powder, thereby obtaining the traditional Chinese medicine preparation for treating anxiety neurosis. The invention provides a prescription obtained through many years of clinical experience in our hospital, and is very popular among patients due to obvious curative effect.

A composite medicine in the form particle or oral disintegrating tablet for enxiety is prepared from tandopsirone or its derivative and the pharmacologically acceptable additive. Its oral disintegrating form is also disclosed.

The invention discloses a traditional Chinese medical health protection product for alleviating anxiety neurosis and a preparation method thereof. The traditional Chinese medical health protection product comprises the following raw materials by weight: 10g of radix bupleuri, 6g of coptis chinensis, 10g of plumula nelumbinis, 20g of poria cocos, 10g of polygata tenuifolia, 10g of radix rehmanniae, 10g of cortex moutan radicis, 10g of radix paeoniae rubra, 10g of fried fructus aurantii, 30g of forged magnet, 30g of caulis polygoni multiflori, and 10g of radix paeoniae alba. The health protection product has the effects of clearing heat, relieving restlessness, and alleviating fluster and irritation, and is mainly applied for remedying anxiety neurosis. The traditional Chinese medical composition has the advantages of high biological availability, a fast speed of reaching effective blood concentration, non-dependency, accurate quantification, stable quality and the like, and the production can be finished via ordinary equipment.

The present invention relates to oligose ester extracted from Chinese medicinal material and possessing obvious treating effect on depression and anxiety neurosis. The oligose ester is extracted from polygala, and may be prepared into different preparation forms. It is suitable for treating various types of depression caused by chronic and acute stress and diseases, owing to its functions of increasing contents of NE, 5-HT and their metabolite 5-HIAA in body, activating 5-HT neuron in brain, lowering the content of corticosteroid in plasma, increasing the p-CREB expression of hippocampal areas, raising the expression of cerebral neurotrophic factor and its induced gene transcription and promoting the recovery of damaged cerebral neuron.

The invention discloses a traditional Chinese medicine preparation for treating anxiety neurosis, prepared from the following medicinal raw materials in weight: 12g of bupleurum, 9g of scullcap, 12g of cassia twig, 30g of dragon bone, 30g of oyster, 1g of pearl, 15g of tuckahoe and 6g of rhubarb. The prescription takes the bupleurum as a monarch medicine for relieving shao yang; the scullcap is bitter in flavor and cold in property and can clear pathogenic heat to internally eliminate pathogenic heat from shao yang gallbladder, the cassia twig is pungent in flavor and warm in property and can activate obstructed yang, and the scullcap and the cassia twig are both ministerial medicines to play the efficacies of activating yang and expelling heat, and the monarch medicine and the ministerial medicines are matched for externally activating yang and internally expelling heat. The dragon bone, the oyster and the pearl powder are adjuvant medicines mainly effecting on the heart meridian and the liver meridian to play the efficacy of tranquilizing with heavy material; the tuckahoe has the efficacy of relieving mental stress and is good at clearing damp and promoting diuresis; and the rhubarb has the efficacies of expelling heat and harmonizing the stomach. All the medicines are combined to play the efficacies of tranquilizing mind, calming the liver to stop the wind, expelling fire in the gallbladder and stomach, activating qi of sanjiao, and benefiting urination and defecation to eliminate exopathogen by urination and defecation. The monarch medicine, the ministerial medicines and the adjuvant medicines supplement and complement each other by cold and warm treatment to play the efficacies of relieving depression of the liver and benefiting the gallbladder, harmonizing the exterior and interior, tranquilizing mind, and relieving complex pathogenic factors from the exterior and interior.

The invention relates to a kit used for accurately detecting whether valine at the 66th position of BDNF in a specimen is variated into methionine by a fluorescence PCR detection technique. The invention provides effective guide for clinically and individually treating mental sickness, such as anxiety neurosis, melancholia, post-traumatic stress syndrome, and the like correlative to BDNF gene variation.

The invention discloses a plant essential oil composition and an anxiolytic effect thereof. The plant essential oil composition consists of the following components in parts by volume: 20-80 parts of cassia twig oil, 20-80 parts of cupressin, 20-80 parts of juniper wood oil and 5-20 parts of a component B essential oil; the component B essential oil consists of the following supercritical extracts in parts by weight: 10 parts of fennel seed, 10 parts of schisandra chinensis, 10 parts of costus root, 5 parts of rhizoma atractylodis, 10 parts of curcuma aromatica, 10 parts of wild chrysanthemum flower, 20 parts of pogostemon cablin, 5 parts of sandalwood, 10 parts of rhizoma ligustici wallichii, 10 parts of red sage root, 20 parts of cassia seed, 5 parts of frankincense, 5 parts of myrrh, 5 parts of agilawood and 20 parts of rhizoma cyperi. According to the plant essential oil composition, the cassia twig oil, the cupressin, the uniper wood oil and the component B essential oil are screened out from a plurality of plant essential oils and are mixed together in proportion to prepare the plant essential oil composition which can be used as an external medicament for preventing and treating anxiety neurosis. The plant essential oil composition is derived from pure natural plants, is nontoxic and harmless, and is simple in preparation process.

The invention relates to a medical oral preparation of coptis chinensis donkey hide gelatin soup, which is prepared with five traditional herbs such as the coptis chinensis mainly for treating the insomnia of yin deficiency and fire excess and heart-kidney imbalance, and a preparation method thereof; according to conventional processes, the preparation is prepared with the extracts mixture of coptis chinensis, scutellaria, herbaceous peony, egg yolk and donkey hide gelation as raw materials, and pharmaceutically acceptable carriers or excipients as substrates; the invention has the effects of yin-enriching and fire-downbearing and fidget-relieving and nerve-calming, mainly cures the yin deficiency and fire excess and the insomnia of heart-kidney imbalance; the long clinical application of the prescription shows that the invention has good effects for neurasthenia and anxiety neurosis.

The invention belongs to the field of Chinese herbal medicines, in particular relates to a Chinese herbal medicine pill capable of invigorating the brain and nourishing the heart. The effective components of the Chinese herbal medicine pill are prepared from the following raw materials in proportions: fleece-flower root, radix rehmanniae, medlar, rhizoma anemarrhenae, lily, seed of wild jujube, shiandra powder, lotus seed, dogwood, radix curcumae, rhizoma cyperi, rhizoma curculiginis, herba epimedii, anemone powder, rhizoma gastrodiae powder, dens draconis and amber. The Chinese herbal medicine pill has the functions of nourishing the liver and kidney, invigorating the brain and nourishing the heart, improves the effective rate of treating the anxiety neurosis, has good medicine dependence and high withdrawal success rate, has higher safety after being taken for a short time, does not have side effects after being taken for a long time, has the functions of tranquilizing and allaying excitement, is prepared normatively and scientifically, and is safe and effective clinically.

The invention relates to a medicament for treating an anxiety neurosis, which is prepared from the following raw medicine in parts by weight: 3-10 parts of shizandra berry, 10-20 parts of polygala tenuifolia, 10-30 parts of Astragalus root, 10-30 parts of spina date seed, 5-15 parts of cassia twig, 5-10 parts of honeysuckle, 5-15 parts of bighead atractylodes rhizome, 10-20 parts of acanthopanax root, 10-20 parts of Albizia julibrissin and 10-20 parts of glaucousback threewingnut root-bark. The medicament for treating the anxiety neurosis, disclosed by the invention, utilizes natural medicines and has the advantages of rapid effect, obvious therapeutic effect, good tolerance, low cost, and no toxic side effects.

The invention relates to a traditional Chinese medicine for treating anxiety neurosis, belongs to the technical field of medicines, and aims at solving the treatment problem of the anxiety neurosis. By means of analysis through traditional Chinese medical science views, the anxiety neurosis belongs to deficiency of both qi and yin and phlegm-heat disturbing heart, and the traditional Chinese medicines, capable of tonifying heart qi, discharging heat, resolving phlegm and tranquilizing the mind, of 15 parts of radix pseudostellariae, 15 parts of radix curcumae, 10 parts of bulbus lilii, 10 parts of dried tangerine peel, 5 parts of radix aucklandiae, 9 parts of radix et rhizoma rhei, 10 parts of fructus gardeniae, 15 parts of pharbitis seeds, 15 parts of semen persicae, 10 parts of fructus aurantii, 15 parts of pheretima, 12 parts of calcined oyster shells, 6 parts of grassleaf sweelflag rhizomes and 7 parts of licorice roots are combined. The traditional Chinese medicine for treating the anxiety neurosis is correct in medical analysis and significant in treatment effect.

The invention discloses a heart-nourishing and nerve-soothing preparation for a patient with anxiety neurosis. The heart-nourishing and nerve-soothing preparation is prepared from the following raw medicinal materials in parts by mass: 8-13 parts of white hyacinth bean, 6-12 parts of ziziphora bungeana, 9-14 parts of root of foldleaf daylily, 7-12 parts of peppermint, 6-13 parts of leaf of siam cycas, 8-14 parts of stem and leaf of beechey fig, 5-10 parts of platycladi seed, 7-13 parts of common nandina, 6-11 parts of ginseng, 8-12 parts of all-grass of repent pellionia, 9-15 parts of cassia bark, 7-14 parts of root and leaf of affined conehead, 6-10 parts of pine among the Indian bread and 8-15 parts of snakegourd peel. The heart-nourishing and nerve-soothing preparation disclosed by the invention is prepared from traditional Chinese medicine plant materials and is wide in medicine source and low in cost, and the formula completely accords with traditional Chinese medicine principles; and all the medicinal materials work together to achieve the effects of nourishing blood to soothe nerves, reinforcing the spleen to benefit the lung and the like. The heart-nourishing and nerve-soothing preparation disclosed by the invention is significant in clinical curative effect, high in apparent rate and less in adverse reaction, and can be easily accepted by patients.

The invention discloses a traditional Chinese medicine composition for treating anxiety neurosis, belonging to traditional Chinese medicine compositions. The traditional Chinese medicine composition for treating the anxiety neurosis is composed of rhizoma coptidis, cortex phellodendri, radix scutellariae, gardenia, radix rehmanniae, acorus tatarinowii schott, polygala tenuifolia, cortex albiziae, radix bupleuri, radix curcumae, radix gentianae, caulis bambusae, alisma orientalis, caulis akebiae, juncus effuses and wild licorice in a certain weight ratio. The traditional Chinese medicine composition for treating the anxiety neurosis has the functions of cultivating mental and alleviating depression, tranquilizing and sedating the mind, and releasing worry and relieving thirst, and can effectively treat the anxiety neurosis.

The invention discloses an anxiety-removing calming traditional Chinese medicine decoction for treating anxiety neurosis. Aiming at the disease causes of anxiety neurosis, traditional Chinese medicines with the functions of soothing liver and dispelling depression, nourishing spleen and blood and eliminating phlegm and inducing resuscitation, including cyperus tuber, bupleurum root, radix curcumae, salvia miltiorrhiza, Astragalus root, Atractylis ovata, medlar, common dodder, schisandra, polygala, acorus gramineus, citrus aurantium and poria, are selected and decocted with water to obtain the decoction. Through clinical trial, the total effective rate reaches 97.5%, and the adverse effect is significantly lower than that of a control group, thus the traditional Chinese medicine decoction is worthy of clinically popularizing and applying.