90 results about "Anti-Anxiety Effect" patented technology

Compositions based on hydrogenated pyrido[4,3-b]indoles (variants) of formula (1) or formula (2): are provided, as are methods and kits using those compositions for the treatment of anxiety or mood disorders characterized by stresses, anxiety, neuroses, obsessive fears and their consequences.

An anxiolytic drug of the invention comprises an orexin receptor antagonist, a pharmacologically acceptable salt thereof, or a solvate thereof as an active ingredient. A method for screening a compound having an anxiolytic action of the invention comprises a step of using orexin-A.

The invention discloses a Chinese medicinal composition with the effects of antidepressant and anti-anxiety, and belongs to the field of Chinese traditional medicines. The Chinese medicinal composition comprises (by weight parts) radix bupleuri 6-15, cape jasmine fruit 5-15 or paeonia suffruticosa bark 5-20, and angelica sinensis 3-15 or ligusticum chuanxiong 3-15; and can be prepared into any conventional oral preparations. Different ministerial drugs and adjuvant drugs are added according to different subjects to better exert therapeutic effect. The inventive composition has the effects of antidepressant and anti-anxiety; and can be used for relieving depression and anxiety with the advantages of definite therapeutic effect and rapid drug effect. The inventive composition can also be used for relieving headache, palpitation, insomnia and melancholia.

The present invention provides novel compositions in the form of a powder, capsule, liquid or lozenge, and methods for administering said novel compositions to assist the body in its ability to maintain a reasonable homeostatic mechanism for compensating for chronic internal acidity. The composition may contain several active ingredients, such as potassium bicarbonate, citric acid, calcium citrate, magnesium citrate, glycine, and licorice. The composition may also contain other inactive excipients, such as hypoallergenic rice, flour, glycerine, tangerine oil and gelatin. Following oral administration, the composition is rapidly broken down and absorbed into the systemic circulation. Upon absorption, the individual components are able to assist the physiological acid-alkaline buffer systems, promote anti-anxiety effects, and decrease inflammation in the digestive system.

The present invention provides the extraction of wild jujube seed oil, the preparation of soft capsule and the function on central nervous system. The extraction of wild jujube seed oil includes squeezing wild jujube seed in squeezer to obtain dregs and coarse oil; mixing the dregs and petroleum ether to obtain refined oil after recovering petroleum ether; dissolving the coarse oil and petroleum ether to obtain refined oil after recovering petroleum ether; merging refined oil, heating in evaporating pot to eliminate residual solvent and water and to obtain wild jujube seed oil. The preparation of soft wild jujube seed oil capsule includes soaking gelatin, heating in water bath, adding glycerin and Nipagin A, and filtering to obtain gelatin liquid; preparing gelatin plate with the gelatin liquid; sandwiching wild jujube seed oil with two gelatin plates and pressing with steel mold. Research shows that wild jujube seed oil has tranquilizing, hypnotic, memory-promoting and anxiety resisting effects, and may be used in treating neurosis and insomnia.

The invention provides to an anti-anxiety medicine by using a rheum officinate root extract as an active ingredient. The anti-anxiety medicine uses the rheum officinate root extract as the active ingredient and can be made into various oral administration formulations such as tablet, granules, capsule, oral liquor, etc.; other components and supplementary materials can be added to form a compound preparation; and the anti-anxiety medicine has evident anti-anxiety effect and can be used for health and treatment of anxiety disorder. Moreover, the invention further provides health food prepared from the rheum officinate root extract and food additives, and preparation methods of the medicine and the food.

The invention discloses an anti-anxiety pharmaceutical composition which is prepared from the following raw medicines: jatamans valeriana rhizome, cortex albiziae, spina date seed and juncus communis. By using the pharmaceutical composition disclosed by the invention for carrying out a mouse elevated plus-maze test, a light and dark box test, an independent activity test, a nikethamide-induced mouse convulsion test, a rat elevated plus-maze test, a rat Vogel test, a rat independent drinking test and a pain threshold test, the test results show that the pharmaceutical composition and capsules disclosed by the invention have obvious anti-anxiety effects and have no calming effects or side effects.

The invention discloses a traditional Chinese medicine composition for treating mental anxiety. Generalized anxiety is a clinical common type, characterized by chronic anxiety and easy to recur and difficult to cure. Anxiety disorder has the main symptoms of fear and tension lacking definite objects and concrete contents, and is accompanied with vegetative nerve symptoms, muscular tension and motion disturbance of patients. On treatment, medicaments with anti-anxiety effects, such as benzodiazepines, tricyclic compounds, SSRIS (selective serotonin reuptake inhibitors) and the like are adopted generally, but the side reactions are relatively large. Anxiety disorder can be classified according to the aetiological agents into types of stagnation of the liver-qi, deficiency of both heart and spleen, deficiency of heart blood, moist heat in both liver and gall and deficiency of both qi and blood by differentiation of symptoms and signs in traditional Chinese medicine. The traditional Chinese medicine composition for treating mental anxiety is capable of soothing the liver and relieving depression, arresting convulsion and soothing nerves, and is used for treating mental depression, panic insomnia, chest distress and other symptoms. The traditional Chinese medicine composition is prepared from bupleurum, angelica, chuanxiong rhizome, tuckahoe, uncaria, multiflower knoweed stem, fried bighead atractylodes rhizome and licorice. In the prescription, the bupleurum is bitter in taste and cool in nature, has good efficacies on treating alternate attacks of chills and fever, fullness sensation in chest, hypochondriac pain, bitter taste, deafness, headache, dizziness and the like. The traditional Chinese medicine composition can alleviate patients from the suffering of mental anxiety and reduce the economic burden on patients. The traditional Chinese medicine composition is a pure traditional Chinese medicine oral preparation, and can be safely taken for a long term.

The present invention is a device for delivering a low frequency magnetic field pulse (Cnp) to affect the physiological and/or neurological conditions of an animal or human. In particular, distinct Cnps are designed to have anti-depression, analgesic, or anti-anxiety effects. These Cnps may be applied in combination in a sequence.

The invention discloses a series of lignan compounds. The series of lignan compounds are compounds as shown in a formula I, a formula II, a formula III, a formula IV, a formula V, a formula VI, a formula VII and a formula VIII. The invention also discloses a pharmaceutical composition which comprises the compounds; and a pharmaceutically acceptable carrier or diluent. The invention also discloses a preparation method of the compounds. The invention also discloses application of the series of lignan compounds in preparation of drugs with sedative, hypnotic, anti-depression and/or anti-anxiety effects or preparation of kits with sedative, hypnotic, anti-depression and/or anti-anxiety effects or in scientific research. The series of lignan compounds found by the invention are clear in function, good in effect and free of toxic and side effects, and can be used as potential sedative-hypnotic, anti-depression and anti-anxiety drugs.

The invention discloses a detection method of an anti-anxiety pharmaceutical composition and a detection method of capsules of the anti-anxiety pharmaceutical composition. The method is characterized by using high performance liquid chromatography (HPLC) to detect and carrying out linear relation test, precision test, repeatability test, stability test and recovery test and a series of tests. The detection method of the invention is accurate and effective, and can well control the product quality.

The invention relates to application of coptis and alkaloid thereof in preparation of an anti-anxiety medicament. The problem that the coptis or the alkaloid is applied in preparation of the anti-anxiety medicament can be effectively solved. The invention adopts the technical scheme that: the coptis is decocted into coptis decoction by adding water, or the coptis is extracted by using ethanol, then coptis alkaloid is prepared by using water bath, and the coptis water bath fluid or the coptis alkaloid is subjected to mouse cross maze or light and dark box passing experiments; and the experiment results show that the coptis and the alkaloid thereof have anti-anxiety effect. The application can expand the medicinal value of the coptis, and is an innovation on the anti-anxiety medicament.

The invention provides a use of ferulic acid in preparation of a drug for resisting mammal anxiety and provides a novel antianxiety drug having good effects and small side effects. Ferulic acid is an effective component of the antianxiety drug. Results of mouse elevated plus-maze test, hole-board test and spontaneous activity test on ferulic acid shows that ferulic acid has substantial antianxiety effects and no calmness effect and thus adverse reactions such as fatigue and somnolence caused by calmness effects of the existing antianxiety drug are avoided.

The invention discloses a use of a Qing'e prescription extract in preparation of an antidepressant and anxiolytic composition. With oral administration of the Qing'e prescription extract, the experimental animal mine field movement total distance can be increased, the tail suspension immobility time is reduced, the elevated plus maze open-arm time is increased, the forced swimming immobility time is reduced, and relatively good antidepressant and anxiolytic effects are shown. The Qing'e prescription extract can increase the contents of hippocampal area 5-hydroxytryptamine (5-HT), norepinephrine (NE) and gamma-aminobutyric acid (gamma-GABA), and reduces the content of glutamate (Glu). On one hand, the gamma-GABA increasing role and the Glu reduction role of the Qing'e prescription extract indicate that the Qing'e prescription extract has a role in adjusting metabolism of central nervous system neurotransmitters Glu and gamma-GABA, reduces the Glu/gamma-GABA ratio, reduces transmission of GABAergic neurotransmitters, regulates the reactivity of a catecholamine acceptor, thereby playing antidepressant and anxiolytic roles. On the other hand, the Qing'e prescription extract increases the central nervous system 5-HT level and plays the antidepressant and anxiolytic roles by inhibiting the activity of monoamine oxidase.

The present invention provides peptides for use in a medicament which is administered nasally, wherein the peptide is an agonist of neuropeptide S receptor (NPSR), of the receptor TGR23 and/or of vasopressin receptor-related receptor 1 (VRR1) or for use in the treatment of a patient by causing, promoting or increasing relieve or healing of phobic anxiety, avoidance anxiety, dissociative anxiety such as flashbacks, depersonalization, derealization, intrusions, vegetative symptoms related to anxiety symptoms, especially in panic attacks, in posttraumatic stress disorder, in generalised anxiety disorder and in anxiety accompanying depressive, or psychotic episodes, arousal, awakening, alertness, activity, spontaneous movement, an anxiolytic effect or a combination thereof in the patient, wherein the peptide is administered nasally or for use in the prophylaxis and/or treatment of an anxiety or sleep disorder, especially in any type of hypersomnia like idiopathic hypersomnia, wherein the peptide is administered nasally. Further provided are pharmaceutical compositions for nasal administration comprising at least one of said peptides, uses of said peptide or said pharmaceutical composition. The invention also provides a method for identifying target neurons of a peptide in an animal, wherein the peptide is administered nasally.