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Application of coptis and alkaloid thereof in preparation of anti-anxiety medicament

A Coptis alkaloid and anti-anxiety technology, applied in the field of medicine, can solve the problems of no clear understanding, no public reports, etc., and achieve the effect of expanding the medicinal value

Inactive Publication Date: 2011-05-18
HENAN UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, whether Coptidis Rhizoma and its extracts (alkaloids) are active against anxiety disorders is not well understood
There is no public report

Method used

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  • Application of coptis and alkaloid thereof in preparation of anti-anxiety medicament
  • Application of coptis and alkaloid thereof in preparation of anti-anxiety medicament
  • Application of coptis and alkaloid thereof in preparation of anti-anxiety medicament

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] 1. Anti-anxiety effect of coptis decoction

[0012] 1.1 Experimental method Take 50g of Coptis chinensis, put it in a round-bottomed flask, extract it twice in a water bath, and control the temperature at 93-95°C. Add 300ml of water for the first time to extract for 1.5 hours, and store the filtrate; add 200ml of water for the second time to extract for 1 hour, combine the filtrates to a total of 410ml, and concentrate to a concentration of 0.12g (crude drug) / ml.

[0013] 60 male Kunming mice, 18-20g, were randomly divided into 5 groups, model group, positive control group, Coptis decoction high dose group 1.8g / kg, Coptidis decoction medium dose group 0.9g / kg, Coptidis water Decoction low dose group 0.45g / kg, 12 in each group. Food and water were not restricted and raised for three days, the room temperature was kept at about 20°C, and the animals were kept quiet. On the 4th day, gavage was started, and the volume of gavage was 0.1ml / 10g. The model group was given CM...

Embodiment 2

[0026] 2. Anti-anxiety effects of coptis alkaloids

[0027] Coptidis rhizome dried product, reflux extraction with 80% ethanol 6 times, 5 times, 4 times in sequence for 2h, 1.5h, 1.5h, filter, combine the filtrate, concentrate under reduced pressure to a small amount, transfer to an evaporating dish, and concentrate in a water bath to Thick paste, then vacuum-dried (60°C) to obtain Coptidis rhizome alkaloids (85.21%), weighed, and stored for future use (dry, low temperature). When needed, add 0.5% CMC-Na to form a solution.

[0028] Preliminary experiments have found that it is difficult to achieve ideal results at the same time with the results of the plus maze and light and dark box experiments at the same dose. Therefore, it is considered to do light-dark box experiment and cross maze experiment with different doses.

[0029] 2.1 Experimental results (experimental method is the same as above) with the middle dose of 0.0395g / kg, the behavioral experiment of plus maze was c...

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Abstract

The invention relates to application of coptis and alkaloid thereof in preparation of an anti-anxiety medicament. The problem that the coptis or the alkaloid is applied in preparation of the anti-anxiety medicament can be effectively solved. The invention adopts the technical scheme that: the coptis is decocted into coptis decoction by adding water, or the coptis is extracted by using ethanol, then coptis alkaloid is prepared by using water bath, and the coptis water bath fluid or the coptis alkaloid is subjected to mouse cross maze or light and dark box passing experiments; and the experiment results show that the coptis and the alkaloid thereof have anti-anxiety effect. The application can expand the medicinal value of the coptis, and is an innovation on the anti-anxiety medicament.

Description

1. Technical field [0001] The invention relates to medicine, in particular to the application of Coptis rhizome and its alkaloids in the preparation of anti-anxiety drugs. 2. Background technology [0002] Coptis chinensis Franch., Coptis chinensis Franch., C.deltoidea C.Y.Chenget Hsiao or C.teetaWall. are the dry rhizomes of Coptis chinensis Franch., C.teetaWall. There is a saying of "Huang Lian Xiexin". Coptis chinensis is also often used as the main drug in compound prescriptions, and it is used to clear away heart-fire and relieve fire. Such as Cinnabar Anshen Pills, Angong Niuhuang Pills, Niuhuang Qingxin Pills and other prescriptions, the meaning of Coptis chinensis is also intended to clear the heart and relieve fire, so as to eliminate annoyance and calm the nerves. However, whether Coptidis Rhizoma and its extracts (alkaloids) are active against anxiety disorders is not well understood. There have been no public reports. 3. Contents of the invention [0003] I...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/718A61P25/22A61K125/00
Inventor 崔瑛郭花玲纪彬李阳阳
Owner HENAN UNIV OF CHINESE MEDICINE
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