The invention discloses a blocky
calcium bisphosphonate complex and a preparation method thereof. The
chemical formula is Ca(2Zol)(2H2O), wherein Ca represents
calcium, Zol represents 1-hydroxy-2- (
imidazole-1-yl)-ethylidene-1, 1-diphosphoric acid, H2O represents water, the
crystal system is a triclinic
system, the
space group is P-1, the lattice constants are alpha=105.648, beta=109.149 degrees, gamma=97.8570 degrees, and z=1. The preparation method comprises the following steps: taking
calcium salt and 1-hydroxy-2-(
imidazole-1-yl)-ethylidene-1, 1-diphosphoric acid as raw materials and deionized water as a
solvent, adjusting the pH value to 2.5-3.5 by using a
sodium hydroxide solution, standing at 20-30 DEG C for 20-60 days, and performing filtering, washing and
drying to obtain a blocky transparent
crystal, namely, the blocky calcium
bisphosphonate complex. The preparation method disclosed by the invention is extremely simple, moderate in
crystal growth speed, small in stress, good in uniformity and very complete in appearance, and has important potential application prospects in the fields of
drug sustained release, targeted delivery,
bone tissue repair and the like.