66 results about "Skeletal tissue" patented technology

The invention discloses a knee prosthesis implantation method, an osteotomy module for usage and a using device, the knee prosthesis implantation method comprises the following steps of measuring the data of knee joint bone tissues, extracting the data of articular cartilage and the skeleton profile, establishing a three-dimensional model in an image processor, designing the osteotomy module, determining the size and the type of the used knee prosthesis and determining an osteotomy module model and the implantation of the knee prosthesis. The knee prosthesis implantation method of the invention can reduce the trauma of a patient, lower the cost, shorten the implantation time, reduce the risk of complications of a user of the knee prosthesis and have comparatively small error and higher precision.

A device and system for stabilizing movement between two or more vertebral bodies and methods for implanting. Specifically, embodiments of the present disclosure may provide medical professionals the ability to selectively position and orient anchors in bony tissue and then attach a plate to the pre-positioned anchors. The plate assembly, once positioned on the anchors, prevents the anchors from backing out of the bony tissue.

A bore is cut into bone tissue to receive an inserted pin or post (7, 23). A pilot bore (2, 22) is formed with a reamer; the post is fixed in the bore, and an enlarged region (16, 29, 30, 31, 32) is formed at the top end of the bore using a tubular cutter (10, 17, 26) which is guided on the post. The enlarged region can be accurately cut even with a hand drill due to the guidance provided by the post. The cutter may have holes (15) or channels for circulation of cooling / lubricating liquid, and a swarf-removing slot (13) may be provided. When the technique is used in dentistry for replacement of a tooth crown, a tubular support element (29a) is fixed around the post in the bore enlargement.

A polymer material capable of gradient degradation. The polymer material is formed by at least two types of aliphatic polyesters having different degradation velocities, the aliphatic polyesters being arranged in an ascending order or descending order of the degradation velocities and fused together. The polymer material may be manufactured as thread materials, barrier materials, tube materials, and controlled drug release carriers, which specifically comprise sutures, medical dressings, adhesion prevention material, hemostasis material, guided tissue regeneration barriers, tissue repair materials, enhancement surgical meshes, drug carriers, cartilage tissue culture scaffolds, scaffolds, and especially urethral scaffolds.

Materials derived from Nelumbo are administered orally to humans or animals for the purpose of enhancing creatine transport into skeletal tissue and for purposes of enhancing lean body mass. Enhancing creatine transport through improved insulin signaling is a new method of depositing creatine and enhancing lean body mass. Such administration is also used for enhancing athletic performance and controlling bodyweight and body fat levels. More specifically, such administration is used for the purpose of enhancing creatine transport into excitable tissues such as skeletal muscle. The material is administered as extracts of Nelumbo and administered in a variety of ways including capsules, tablets, powdered beverages, bars, gels or drinks.

A manual driver for a dental implant drill or other dental implant tools and the method of use for preparing for dental implantation are provided. The manual driver includes a handle, an extension shank and a chuck having an axial channel configured to receive and interlock an implant drill, and a fastening screw transverse to the axial channel. The method of manual preparation for dental implantation using the manual driver has a high precision, and reduces the risk of bone cracking caused by vibration of motor-driven drilling. The manual drilling method provides better tactile sensation and drilling control to the dentist. Further, the method avoids drilling irrigation, allows collection of virgin bone tissue from the drills, and reintroduces the collected bone tissue in the receiving bore to promote bone regeneration after the implantation.

The invention provides novel compositions of hydroxyapatite and block co-polymers, methods of their preparation, and uses thereof, wherein the co-polymers have degradable hydrophobic blocks and hydrophilic blocks for stable interfacing with hydroxyapatite, resulting in stable polymer-hydroxyapatite suspensions. The super-hydrophilicity, strengthened mechanical integrity, and retained structural integrity of the HA-PELA composite in aqueous environment represent major advantages over the HA-PLA composites for skeletal tissue engineering applications.

The present invention is directed to sustained release formulations of biologic agents which permit persistent bioavailability. Preferred biologic agents include bone morphogenetic proteins. Diseases susceptible to amelioration and / or treatment with the formulations of the present invention include skeletal tissue diseases such as, but not limited to, osteoarthritis and other osteochondral diseases. The sustained release formulations of the present invention are especially suitable for treatment of minimally-vascularized or non-vascularized tissue sites such as, but not limited to, intra joint, interarticular, or intraminiscal sites.

A method for fusing spinal bone is provided. The method comprises placing a sac between two or more adjacent sections of the spine to be fused, inserting a cage into the sac, and filling the sac with bone tissue. The surfaces of the sac abutting the sections of the spine comprise porous material for allowing bone to grow between the spine and the sac. Surfaces of the sac not abutting the sections of the spine are nonporous to bodily fluids and thereby prevent premature deterioration of the bone tissue inside the sac. The cage maintains the sac in an expanded state upon filling. A kit comprising the sac and cage is also provided. In other embodiments of the invention, the method comprises placing an inner sac inside the inventive sac and filling the sacs with bone tissue for fusion of spinal bone.

The invention discloses a tissue engineering cartilage stent and a method for preparing the same. The method includes a step A, extracting II-type collagen; a step B, preparing a primary CII-HA-CS-HAP three-dimensional cartilage stent by the aid of the II-type collagen, hyaluronic acid, chondroitin sulfate and hydroxyapatite; a step C, crosslinking the primary CII-HA-CS-HAP three-dimensional cartilage stent by the aid of an EDC / NHS system and freezing and drying the CII-HA-HAP three-dimensional cartilage stent to obtain the CII-HA-CS-HAP three-dimensional tissue engineering cartilage stent. The tissue engineering cartilage stent and the method have the advantages that the tissue engineering cartilage stent is excellent in biocompatibility, low in toxicity and easy to degrade, and degradation products are nontoxic; the tissue engineering cartilage stent is compact in appearance, and various performance parameters are adaptive to repairing cartilage tissues of human bodies; the constructed tissue engineering cartilage stent is made of wide material sources and easy to shape, and can be used for repairing wide-area wound, and the like.

The invention provides a directionally degradable and absorbable magnesium bone screw and a preparation method thereof. The magnesium bone screw comprises a bone screw, wherein the bone screw is made of pure magnesium or a magnesium alloy and has a thread, and the bone screw has different microstructure advantage orientations in the cross section and the longitudinal section respectively, so that the cross section is degraded faster than the longitudinal section during degradation and absorption of the bone screw. The microstructure advantage orientations of the bone screw made of the pure magnesium and the magnesium alloy are changed, so that certain crystal faces have advantage orientations in certain directions and have different microstructures in different directions, different degradation behaviors of different crystal faces of the magnesium and the magnesium alloy are fully utilized, and the degradation rate of the bone screw and growth of bone tissue are regulated to be well matched. The bone screw has different degradation rates in axial and radial directions, so that the bone screw has the characteristic of directional degradation, the intactness of the thread structure can be guaranteed at the early stage of implantation, and the early-stage pre-tightening force of the bone screw can be kept.

The present invention provides nonsteroidal tetrahydroquinoline derivatives of general formula (I) or salts thereof: (R1, R2, X, Y, Z and m are as defined in claim 1) which show no excessive action on the prostate but show a particularly potent androgen receptor agonistic action on skeletal muscle tissue and bone tissue, as well as pharmaceuticals comprising such derivatives or their salts as active ingredients.

The invention discloses a bacterial cellulose / collagen / hydroxyapatite composite material and a preparation method thereof. In the method, the capillary force of internal pores and an ultrasonic-assisted collagen molecule diffusion method are adopted, a bacterial cellulose dry film, collagen, procyanidine, CaCl2 and simulated body fluid are taken as raw materials, and the mass ratio of the bacterial cellulose dry film to the collagen to the procyanidine to CaCl2 is (10-200):(1-50):(4-6):(6-10); the collagen is uniformly distributed in the network structure of the bacterial cellulose in an irregular shape, and the obtained compound is prepared into the bacterial cellulose / collagen / hydroxyapatite composite material by adopting a biomimetic mineralization method. The composite material disclosed by the invention has superior mechanical property and a unique three-dimensional nano-network structure, is more similar to human skeletal tissues on the aspects of structure and component, and is expected to meet the application requirement of a skeletal tissue engineering stent material.

The invention discloses a method for correcting CT ray beam hardening artifact. The method compensates an original image based on X-ray energy spectrum analysis to eliminate hardening artifacts of X-ray beams; that is, according to the known scanning conditions, the energy spectrum distribution of X-rays is obtained and the equivalent energy is calculated. Then, scanning is carried out, the original image is reconstructed according to the image building conditions, the original image is divided into soft tissue, bone tissue and air parts, and energy spectrum projection and equivalent energy projection are carried out on different parts respectively; the difference between the equivalent energy projection and the energy spectrum projection is calculated; the projection difference is backprojected to obtain a compensation image, and the compensation image and the original image are added to obtain a target image corrected by beam hardening artifacts.

The present invention relates to a body volume substitute comprising cartilage for grafting by injection, and a dual needle-type syringe for injecting same. The volume substitute of the present invention is characterized by comprising one or more types selected from ground cartilage, physiological saline, and body fluid. According to the present invention, it is possible to graft a volume substitute not only for repairing skin tissue damage caused by an external injury and augmenting skin from a cosmetic point of view, but also for repairing skeletal tissue loss and augmenting skeletal tissue volume, by a simple method of injection. In addition, using the syringe of the present invention, it is possible to finely adjust the amount of injection solution being injected when injecting the body volume substitute into a human body, thereby precluding the danger to a patient caused by an overdose of the injection solution.

An interactive segmentation framework for 3-D teeth CT volumetric data enables a user to segment an entire dental region or individual teeth depending upon the types of user input. Graph cuts-based interactive segmentation utilizes a user's scribbles which are collected on several 2-D representative CT slices and are expanded on those slices. Then, a 3-D distance transform is applied to the entire CT volume based on the expanded scribbles. Bony tissue enhancement is added before feeding 3-D CT raw image data into the graph cuts pipeline. The segmented teeth area is able to be directly utilized to reconstruct a 3-D virtual teeth model.

The invention discloses a cartilage tissue cutting and cell separating and extracting integrated device. The device comprises a device shell, a crushing assembly and a separating and extracting assembly are sequentially arranged on the device shell from top to bottom, the crushing assembly comprises a crushing barrel, a crushing assembly body is arranged in the crushing barrel, and a plurality ofbutt-joint sinking grooves are formed in the lower bottom surface of the crushing barrel in the circumferential direction; and the separating and extracting assembly comprises centrifugal barrels anda lifting ring, the lifting ring is connected with the inner wall of the lower part of the device shell through a plurality of groups of lifting motors, the number of the centrifugal barrels is the same as that of the butt-joint sinking grooves, the two sides of each centrifugal barrel are connected with the fracture of the lifting ring through a rotating motor, and butt-joint clamping covers forbutt joint with the butt-joint sinking grooves are arranged at the upper end and the lower end of each centrifugal barrel correspondingly. The cartilage tissue cutting and cell separating and extracting integrated device can carry out integrated automatic cartilage tissue cutting and centrifugal separation treatment, and improves the working efficiency of cartilage tissue cutting and cell separation and extraction.

The invention relates to a magnesium / hydroxyapatite composite material and a preparation method thereof. The magnesium / hydroxyapatite composite material is prepared by mixing magnesium and hydroxyapatite serving as raw materials in a mass ratio of 80.5-99.9 percent: 0.1-19.5 percent for molding and sintering the mixture in a vacuum microwave sintering furnace. The composite material provided by the invention has proper mechanical property and can meet the requirements on human body bone tissue materials. A microwave sintering method is adopted, so the method has the advantages of high temperature rise speed, short sintering time, short preparation period, low energy consumption and no pollution.

The invention discloses a combined-type soft tissue horizontal dental implant which comprises a base of the dental implant, an implant root and a fixing screw which connects the base with the implant root. An outer thread is arranged at the implant root, and the surfaces of dental sides of one or more sides of the outer thread are rough surfaces. By means of the combined-type soft tissue horizontal dental implant, 'synostosis' between the dental implant root and the surrounding bone tissue is more facilitated, and meanwhile the phenomenon of spin of the implant under the action of external force can be hindered.

The invention relates to the field of medical titanium alloys, in particular to a medical titanium alloy special for a narrow-diameter high-strength implant capable of being immediately implanted anda preparation method of the medical titanium alloy. The medical titanium alloy is prepared from, by weight percent, 14%-17% of Zr, 3.0%-10% of Cu and the balance Ti. The preparation method of the medical titanium alloy comprises the steps that after cogging and forging and before rolling, heat preservation is carried out for 0.5-6 hours at the temperature of 900 DEG C to 1200 DEG C, and water cooling is carried out to reach the room temperature; and rolling is carried out at the temperature of 720 DEG C to 850 DEG C, the strain rate is larger than 0.1 s<1>, and a bar obtained after rolling iscarried out is used for subsequent implant processing. According to the medical titanium alloy special for the narrow-diameter high-strength implant capable of being immediately implanted, immediate planting can be achieved without any surface treatment, and firm combination of the implant and bone tissue is achieved. According to the preparation method of the medical titanium alloy, the implant narrow in diameter (3.0-3.5 mm) can be prepared and is high in strength, and the aim of firm implanting on the narrow edentulous gum is achieved.

The present invention provides novel acyl, sulfur, carbamate, thiocarbamate, and related compounds that inhibit cytokine-mediated inflammatory responses in cultured cells and improve bone tissue in animal models of arthritis disrupts, and lowers blood glucose levels in animal models of type 2 diabetes. The present invention discloses that the compound can be used in various treatments, including the treatment of diabetes, insulin resistance, inflammation, inflammatory diseases, immune diseases, and cancer.

A bioreactor includes a housing and a support mechanism for suspending the housing above the bottom surface of a culture vessel. The housing includes a member having oppositely disposed first and second surfaces and an inner surface defining an opening. The opening extends between the first and second surfaces of the member. The bioreactor includes a gas and liquid permeable membrane having first and second surfaces attached to the second surface of the member. The first surface of the gas and liquid permeable membrane and the member define a culture space for growing or culturing cells.

The invention discloses a modified bamboo fiber enhanced chitosan-based porous material and a preparation method thereof. The porous material is prepared by ultrasonically stirring modified bamboo fibers and a compound of chitosan and inorganic particles in an aqueous solution, then performing uniform mixing, then adding a small amount of glacial acetic acid to obtain a compound gel substance, putting the compound gel substance in a culture dish, pre-cooling the compound gel substance and then performing lyophilization. Because carboxyl with the surface-modified bamboo fibers and cations of chitosan acidic solutions have a strong ionic crosslinking effect, compared with a porous material with non-modified bamboo fibers or without the bamboo fibers, the porous material disclosed by the invention has the advantage that the mechanical performance and the degradation performance are greatly improved. The novel porous material disclosed by the invention has the advantages that the used rawmaterials are rich in sources, and the preparation method is simple; and through content of the components of the porous material, the mechanical performance, the degradation performance, the osteoconductivity and the antibacterial performance of the porous material are regulated and controlled, and the porous material is expected to be used as a bone tissue engineering scaffold material.

A surgical system includes a first implant support that is engageable with a receiver of a first fastener having a shaft fixed with vertebral tissue. At least one adaptor includes a first adaptor extending longitudinally along and being engageable with the first implant support. The first adaptor is oriented to releasably engage a surgical instrument to distract and / or compress the vertebral tissue. An angulation module is connected to at least one of the first adaptor, the first implant support and the surgical instrument. Surgical instruments, constructs, implants and methods are disclosed.

The invention discloses a titanium-based functional material with an aperture gradient structure and a preparation method and application. The method comprises the steps that firstly, a pure titanium or titanium alloy matrix plate is prepared through a selective laser melting technology, then holes are drilled in the plate and filled with pure aluminum powder, then a friction stir method is adopted for machining, the aluminum powder and a friction stir machining area are fully mixed, finally, acid washing or alkali washing treatment is conducted on the aluminum powder to remove aluminum particle clusters and form a porous structure, and accordingly, the titanium-based functional graded material of which the surface and a matrix have aperture gradient is obtained. By means of the friction stir machining technology, alloy grains can be refined, the porosity of the material is reduced, and the comprehensive performance of the material is improved. The material is of a rough porous structure, the aperture of the surface layer is inconsistent with the aperture of the matrix, the growth requirements of different cells can be met, bone tissue can grow towards an implant easily, and the material has very good clinical application value. The preparation process is simple, low in cost and beneficial to market promotion.

The invention discloses a surface modification treatment method for a titanium metal implant material. According to the method, titanium metal is subjected to reduction treatment to obtain the surface characteristic rich in surface oxygen vacancies, so that the osseointegration capacity of the titanium metal and a matrix is promoted. According to the titanium metal surface rich in oxygen vacancies, the proportion of the oxygen vacancies is 5% to 40%. The prepared titanium metal rich in oxygen vacancies on the surface has the excellent capability of accelerating osseointegration of an implant and the matrix. The adopted treatment and preparation method is simple, high in controllability and suitable for industrial preparation and treatment of bone tissue repair titanium metal materials for biomedicine.

The invention relates to the technical field of Mo alloys, in particular to a Mo-Re-T series alloy as well as a preparation method and application thereof. The Mo-Re-T series alloy comprises Re, Mo and inevitable impurities as well as further comprises T, wherein the content of T is less than that of Mo; and T is selected from at least one element of K, Al, Si, Mn, Ga, Ge, Sr, Ru, Rh, Cd, In, Sn, Ag, Ta, W, Au, Cu, Sb, Ba, Ir, Bi or rare earth. The material strength of the Mo-Re-T series alloy is remarkably improved; the mechanical and biological compatibilities between the modulus, the hardness, the abrasion resistance and the fatigue performance of the Mo-Re-T series alloy and bone tissues are better; meanwhile, the Mo-Re-T series alloy has excellent ray impermeability and low magnetic susceptibility; and the accurate tracking during radiography is further facilitated.