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Application of P2X2 receptor agonist or opening agent in preparation of anti-depression or anti-anxiety drugs

An agonist and anti-anxiety technology, which is applied in the field of medical biology, can solve the problems of high price, slow onset, and difficulty in identification, and achieve the effects of wide application prospects, small toxic and side effects, and long-lasting effects

Active Publication Date: 2013-08-21
誉神(广州)医学科技有限公司
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  • Abstract
  • Description
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AI Technical Summary

Problems solved by technology

The treatment of depression mainly relies on drug therapy; although there are many effective antidepressants clinically, they still cannot meet the needs of treatment
Especially the existing antidepressant ubiquitous serious problems: 1, onset is slow, generally just can improve clinical symptom after taking medicine 3-6 weeks, and will cure and need long-term medicine more; This is the main reason why the clinical effect of depression treatment is poor at present.
2. There are many side effects; 3. It is expensive; 4. At least 35% of patients with depression do not respond to current drug treatment
[0004] Although anxiety and depression are medically divided into two mental illnesses, they often coexist clinically and are sometimes difficult to distinguish. Therefore, many scholars suggest that the two be combined for treatment

Method used

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  • Application of P2X2 receptor agonist or opening agent in preparation of anti-depression or anti-anxiety drugs
  • Application of P2X2 receptor agonist or opening agent in preparation of anti-depression or anti-anxiety drugs
  • Application of P2X2 receptor agonist or opening agent in preparation of anti-depression or anti-anxiety drugs

Examples

Experimental program
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Embodiment 1

[0046] Pharmacological / Pharmacological Experimental Study of P2 Receptor Agonist ATP and Its Derivative ATPγs on Antidepressant and Anxiety

[0047] 1. Forced swimming test (FST): Porsolt et al. proposed the forced swimming model in 1977, and found that different drugs have different changes in the immobility time of forced swimming in the FST test. Antidepressants can effectively reduce the immobility time. Models are one of the most commonly used methods for screening antidepressants. We used a modified FST experiment, the specific steps are: put the mouse into an open transparent glass tank (45cm in height, 19cm in diameter, 23-25℃ in water temperature) to swim freely for 6 minutes, measure and calculate The time of Immobility within 4 minutes is used as an indicator of the antidepressant effect of the drug. The standard for the mice not to swim is that the experimental mice are slightly curled up, in a floating state, and their nostrils are exposed to the water. Potent a...

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Abstract

The invention discloses an application of a P2X2 receptor agonist or a P2X2 receptor opening agent in preparation of anti-depression or anti-anxiety drugs. According to the present invention, experiment research results confirm that: the P2X2 receptor agonist or the P2X2 receptor opening agent has an anti-depression and / or anti-anxiety effect, such that the P2X2 receptor agonist or the P2X2 receptor opening agent can be used for preparing anti-depression or anti-anxiety drugs, and can be adopted to screen prevention and treatment target points of anti-depression and / or anti-anxiety drugs and screen early stage pre-warning and clinical diagnostic reagents of depression and / or anxiety so as to provide broad application prospects.

Description

Technical field: [0001] The present invention belongs to the field of medical biology, and specifically relates to the application of P2X2 receptor agonists or openers in the preparation of antidepressant and / or anti-anxiety drugs and the use of P2X2 receptors in screening, preventing and treating anti-depression and / or anti-anxiety Drug target application. Background technique: [0002] Depression seriously endangers human life and health. Depression refers to a type of mood disorder syndrome characterized by depressed mood, slow thinking, accompanied by psychomotor retardation symptoms such as decreased interest and decreased initiative. The incidence rate is very high, about 15-17%, and it has been increasing year by year in recent years; according to the World Health Organization, by 2020, depression will become the first cause of disability, and it is the main killer of human beings in the 21st century (Murray ,1997). Depression has caused a huge burden on society, f...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A61K38/00A61K31/7076A61K49/00A61P25/22A61P25/24
Inventor 朱心红曹雄
Owner 誉神(广州)医学科技有限公司
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