The invention discloses a preparation method of seven-ingredient heart nourishing and
spleen tonifying granules. The preparation method comprises the following steps: mixing and
grinding fruit of Chinese magnoliavine, mint, cinnamon and platycladi seeds to obtain coarse
powder; implementing
supercritical carbon dioxide extraction on the coarse
powder to obtain a total oil extract, and reserving dregs for later use; mixing the total oil extract with beta-
cyclodextrin, and stirring and including to obtain a
clathrate compound; mixing the dregs with liquorice,
astragalus membranaceus and poria cocos to obtain a mixture, adding water to the mixture, ultrasonically extracting for 2-3 times at normal temperature, mixing extracting solutions, decompressing and concentrating, and
drying in a vacuum environment to obtain a dry extract; mixing the dry extract with
starch and
dextrin, preparing a soft material by taking an
ethanol solution as a
wetting agent, uniformly mixing the soft material and the
clathrate compound, pelleting, straightening and
drying to obtain the seven-ingredient heart nourishing and
spleen tonifying granules. Pharmacological researches show that the seven-ingredient heart nourishing and
spleen tonifying granules have
sedative and
hypnotic effects, and can enhance mice hypoxia tolerance ability and prolong mice survival time and swinging time.