Traditional Chinese medicine composition for treating idiopathic pulmonary arterial hypertension and preparing method and application thereof

Abstract

The invention discloses a traditional Chinese medicine composition for treating idiopathic pulmonary arterial hypertension. The traditional Chinese medicine composition comprises, by weight, 2-3 parts of white muscardine silkworms, 5-10 parts of herba cistanche, 5-10 parts of radix angelicae pubescentis, 1-3 parts of lotus seed cores, 1-3 parts of dogbane leaves, 5-10 parts of lemon, 0.01-0.05 part of mint, 0.01-0.05 part of pig lung extract and 0.01-0.05 part of Chinese littleleaf box extract. All the raw materials are prepared, smashed, decocted and extracted, then ethyl alcohol is added to serve as a dissolution assistant, and a finished product is obtained. By means of the traditional Chinese medicine composition, pulmonary arterial hypertension can be reduced, pulmonary artery smooth muscle cell proliferation is reduced, blood-vessel-periphery inflammatory cells are obviously reduced, the lesion lung tissue structure and right ventricular hypertrophy can be improved, alveolar-space edema, bleeding and intrapulmonary arteriolar wall and smooth muscle hypertrophy can be relieved, pulmonary vascular resistance can be improved, idiopathic pulmonary arterial hypertension can be effectively treated, and the curative effect is remarkable.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a traditional Chinese medicine composition for treating idiopathic pulmonary hypertension and its preparation method and application. Background technique [0002] Idiopathic pulmonary arterial hypertension (IPAH) refers to the unexplained increase in pulmonary vascular resistance, causing persistent pulmonary arterial high pressure, resulting in the evaluation of pulmonary artery pressure ≥ 25mmHg in a resting state, excluding all secondary factors that cause pulmonary arterial hypertension, The etiology of the disease is unknown, and it may be related to drug factors, viral infection and genetic factors. The early symptoms of idiopathic pulmonary hypertension are not obvious, mainly the manifestations of pulmonary hypertension and right heart failure. The specific manifestations depend on the severity of the disease. Common Initial symptoms include: dyspnea, fatigue, chest pain, dizzine...

AI Technical Summary

Problems solved by technology

[0002] Idiopathic pulmonary arterial hypertension (IPAH) refers to the unexplained increase in pulmonary vascular resistance, causing persistent pulmonary arterial high pressure, resulting in the evaluation of pulmonary artery pressure ≥ 25mmHg in a resting state, excluding all secondary factors that cause pulmonary arterial hypertension, The etiology of the disease is unknown, and it may be related to drug factors, viral infection and genetic factors. The early symptoms of idiopathic pulmonary hypertension are not obvious, mainly the manifestations of pulmonary hypertension and right heart failure. The specific manifestations depend on the severity of the disease. Common Initial symptoms include: dyspnea, fatigue, chest pain, dizziness, edema, syncope, and palpitations; clinical manifestations include dyspnea, chest pain, syncope, fatigue, hemoptysis, and lower extremity edema; idiopathic pulmonary hypertension may present with right heart failure and lung infection , pulmonary embolism, sudden death, syncope and other complications, which is a progressive disease, the treatment is mainly aimed at vasoconstriction, intimal injury, thrombosis and heart failure, aiming at reducing pulmonary vascular resistance and pressure, and improving heart function , increase cardiac output, improve symptoms and prognosis; most of the current treatment options use western medicine such as oral blockers or injection antagonists, which have the problems of large side effects, high cost, and poor slow-release effect of the disease, and surgical treatment However, it will cost a lot, which is not conducive to the weak patients in the later stage of the disease, and the 5-year survival rate after surgery is only 40%-50%; China has a vast territory, traditional Chinese medicine has a long history, and the side effects of traditional Chinese medicine treatment are small. Ben Peiyuan, if a traditional Chinese medicine preparation can be developed to treat idiopathic pulmonary hypertension, it will greatly reduce the economic burden of the patient, reduce the side effects of the drug, and increase the cure rate

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