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Series of lignan compounds, pharmaceutical composition, preparation method and application

A technology of lignans and compounds, applied in the directions of drug combination, active ingredients of heterocyclic compounds, preparation of ethers, etc., can solve problems such as temporary amnesia, withdrawal syndrome, accompanied by side effects, etc., and achieve good effect and clear function. , the effect of non-toxic side effects

Pending Publication Date: 2021-07-23
GUANGXI XINHAI PHARM TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But sometimes it is accompanied by side effects, which can cause muscle weakness and drowsiness, and may also cause temporary amnesia for a certain period of time. In addition, long-term use of sleeping pills will cause dependence. If it is suddenly discontinued, it may lead to withdrawal syndrome.
Non-drug treatments mainly include psychotherapy, cognitive-behavioral therapy, and music therapy, but the audience of such treatments is relatively limited, and the efficacy is uncertain

Method used

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  • Series of lignan compounds, pharmaceutical composition, preparation method and application
  • Series of lignan compounds, pharmaceutical composition, preparation method and application
  • Series of lignan compounds, pharmaceutical composition, preparation method and application

Examples

Experimental program
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Effect test

preparation example Construction

[0038] The present invention also discloses a preparation method of the series of lignan compounds, comprising the following steps:

[0039] Step 1, take the dry stems and branches of Litsea cubeba of the genus Litsea cubeba in the lauraceae family, add 8 times the volume of 70% ethanol to soak overnight, and first use reflux extraction, extract 3 times, each time for 2 hours, and extract the solution while Filtrate hot, combine three filtrates, and then use a rotary evaporator to concentrate under reduced pressure at 50°C to form a viscous liquid, disperse with water, and then sequentially extract with petroleum ether, dichloromethane, ethyl acetate, and n-butanol to obtain petroleum Ether extraction part, dichloromethane extraction part, ethyl acetate extraction part, n-butanol extraction part and water part, and finally concentrate and dry each part;

[0040] Step 2. First, take the dichloromethane extraction part, dissolve it with dichloromethane:methanol at a volume ratio...

Embodiment 1

[0062] Effects of a series of lignans on sleep induced by subthreshold doses of sodium pentobarbital in mice.

[0063] Experimental animals: Kunming strain male mice, SPF grade, weighing 28-32 g, purchased from Hunan Slake Jingda Experimental Animal Co., Ltd., SCXK (Xiang) 2016-0002. The series of lignan compounds adopts the mixture of the above-mentioned 8 compounds of formula I, formula II, formula III, formula IV, formula V, formula VI, formula VII and formula VIII with the same quality.

[0064] Experimental method: After the mice were adaptively fed for one week, the mice were randomly divided into normal group, low (4.5mg / kg), medium (9mg / kg) and high (18mg / kg) dose groups of series lignans 1. Positive drug group was given diazepam solution 2mg / kg by gavage, 15 in every group. The normal group was given equal volume of distilled water by intragastric administration, and the other groups: the administration volume was 0.1ml / 10 g. After a single administration for 30 minu...

Embodiment 2

[0070] Effects of a series of lignans on sleep latency and sleep time in mice induced by suprathreshold doses of pentobarbital sodium.

[0071] Experimental animals are the same as in Example 1. The series of lignan compounds adopts the mixture of the above-mentioned 8 compounds of formula I, formula II, formula III, formula IV, formula V, formula VI, formula VII and formula VIII with the same quality.

[0072] Experimental method: After the mice were adaptively fed for one week, the mice were randomly divided into normal group, low (4.5mg / kg), medium (9mg / kg), high (18mg / kg) dose groups of lignin compounds, positive The drug group was given diazepam solution 2 mg / kg by gavage, 15 rats in each group. The normal group was given equal volume of distilled water by intragastric administration, and the administration volume was 0.1ml / 10g. After 30 minutes of single administration, each mouse was injected intraperitoneally with pentobarbital sodium (45mg / kg) according to the best s...

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Abstract

The invention discloses a series of lignan compounds. The series of lignan compounds are compounds as shown in a formula I, a formula II, a formula III, a formula IV, a formula V, a formula VI, a formula VII and a formula VIII. The invention also discloses a pharmaceutical composition which comprises the compounds; and a pharmaceutically acceptable carrier or diluent. The invention also discloses a preparation method of the compounds. The invention also discloses application of the series of lignan compounds in preparation of drugs with sedative, hypnotic, anti-depression and / or anti-anxiety effects or preparation of kits with sedative, hypnotic, anti-depression and / or anti-anxiety effects or in scientific research. The series of lignan compounds found by the invention are clear in function, good in effect and free of toxic and side effects, and can be used as potential sedative-hypnotic, anti-depression and anti-anxiety drugs.

Description

technical field [0001] The invention belongs to the field of natural medicines, and specifically relates to a series of lignan compounds, a pharmaceutical composition, and a preparation method of the series of lignan compounds, in particular to a series of lignan compounds in the preparation of Use of drugs with sedative, hypnotic, antidepressant and / or anxiolytic effects. Background technique [0002] Insomnia refers to a disease caused by inability to fall asleep or maintain a sleep state due to environmental factors, individual factors, physical factors, mental factors, emotional factors, etc., resulting in insufficient sleep. Also known as sleep onset and maintenance sleep disorders. The main manifestations of insomnia are too little sleep time, insufficient sleep depth, fatigue after waking up, inability to recover physical strength and energy through sleep, and difficulty falling asleep repeatedly at night. With the modern fast-paced lifestyle and the increase of soc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D307/87C07D307/20C07D407/14C07D317/54C07C41/34C07C43/23C07C41/36C07C41/38A61P25/20A61P25/24A61P25/22A61K31/343A61K31/36A61K31/09
CPCC07D307/87C07D307/20C07D407/14C07D317/54C07C43/23A61P25/20A61P25/24A61P25/22
Inventor 高红伟杨世林
Owner GUANGXI XINHAI PHARM TECH CO LTD
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