The invention relates to a calcium-iron-zinc-selenium multivitamin chewable tablet and a preparation method thereof. The calcium-iron-zinc-selenium multivitamin chewable tablet takes vitamin A, acetic ester, vitamin B1, vitamin B2, vitamin B6, vitamin C, vitamin D3, folic acid, calcium carbonate, ferrous lactate, zinc lactate and selenium-enriched yeast as main raw materials, and lemon yellow, glucose, maltodextrin and magnesium stearate as auxiliary materials. The calcium-iron-zinc-selenium multivitamin chewable tablet has the advantages of multiple nutritional components, stable property, easiness in storage, convenience in carrying and taking, and safety.