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Detection method of anti-anxiety pharmaceutical composition

A composition and anti-anxiety technology, which is applied in the direction of drug combination, pharmaceutical formula, medical preparations containing active ingredients, etc., can solve problems such as memory loss, curative effect reduction, gastrointestinal tract reactions, etc., and achieve good quality and accurate detection methods Effect

Active Publication Date: 2012-10-10
BEIJING UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Long-term use is prone to addiction and tolerance, and there are adverse reactions such as memory loss, gastrointestinal reactions, and curative effect reduction

Method used

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  • Detection method of anti-anxiety pharmaceutical composition
  • Detection method of anti-anxiety pharmaceutical composition
  • Detection method of anti-anxiety pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0308] Embodiment 1: the detection method of capsule

[0309] Spider incense 12g Albizia juniper skin 9g

[0310] 9g wild jujube kernels 1g rushes

[0311] Take the spider incense and grind it into a coarse powder, use 35% ethanol equivalent to 10 times by weight of the spider incense medicinal material, and reflux extract it for 3 times, each time for 1 hour; grind the jujube seed and the bark of Albizia Julibrissin into a coarse powder, add 10 times by weight of water, Reflux extraction 3 times, 2 hours each time; crush the rushes into coarse powder, use 50 times by weight of 95% ethanol, reflux extraction 3 times, 1 hour each time; recover the solvent from the above extracts respectively, concentrate them into dry paste, and The components of the dry paste are mixed according to the prescription ratio, add dextrin 0.5 times the amount of dry paste by weight, mix well, 90% ethanol is used as a wetting agent, and granulate, pass through a 20-mesh sieve, and the granules shou...

Embodiment 2

[0317] Embodiment 2: the detection method of capsule

[0318] Spider Incense 8g Albizia Peel 12g

[0319] Stir-fried jujube kernels 14g rush grass 0.8g

[0320] Take the spider incense and grind it into a coarse powder, use 35% ethanol equivalent to 6 weight times of the spider incense medicinal material, and reflux extract it for 4 times, each time for 1.2 hours; grind the jujube seed and the bark of Albizia Julibrissin into a coarse powder, add 8 weight times of water, Reflux extraction 2 times, 2.5 hours each time; crush the rush into a coarse powder, use 56 times by weight of 95% ethanol, reflux extraction 2 times, each 0.8 hour; recover the solvent from the above extracts respectively, concentrate into a dry paste, each The components of the dry paste are mixed according to the prescription ratio, add dextrin 0.6 times the weight of the dry paste, mix well, 95% ethanol is used as a wetting agent, and granulate, pass through a 20-mesh sieve, and the granules should be kep...

Embodiment 3

[0326] Embodiment 3: the detection method of capsule

[0327] Spider Incense 10g Albizia Peel 14g

[0328] Stir-fried Suanzaoren 12g Rush 0.6g

[0329] Take the above-mentioned raw materials, add conventional auxiliary materials, and make capsules according to conventional processes.

[0330]Chromatography and detection conditions: Agilent C18 chromatographic column (4.6mm×250mm, 5μm); 26:72 acetonitrile-0.3% phosphoric acid solution as mobile phase; column temperature 35°C; flow rate 1mL / min, detection wavelength 280nm.

[0331] Preparation of the reference solution: Accurately weigh 9.8mg of hesperidin, dissolve it in methanol and dilute to a 25mL volumetric flask, shake well, and obtain.

[0332] Preparation of the sample solution: remove the capsule preparation of the pharmaceutical composition of the present invention, weigh 5g of the granule, put it in a Soxhlet extractor, add an appropriate amount of methanol, put it on a water bath and extract it under reflux until t...

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Abstract

The invention discloses a detection method of an anti-anxiety pharmaceutical composition and a detection method of capsules of the anti-anxiety pharmaceutical composition. The method is characterized by using high performance liquid chromatography (HPLC) to detect and carrying out linear relation test, precision test, repeatability test, stability test and recovery test and a series of tests. The detection method of the invention is accurate and effective, and can well control the product quality.

Description

technical field [0001] The invention relates to a detection method of a pharmaceutical composition, in particular to a detection method of a pharmaceutical composition with anxiolytic effect. Background technique [0002] Anxiety disorder is a neurosis characterized by recurrent episodes of acute anxiety, including generalized anxiety and panic disorder, often accompanied by dizziness, chest tightness, palpitations, dyspnea, dry mouth, frequent urination, urgency, sweating, and tremors And motor restlessness, and sleep disorders, etc., accompanied by autonomic dysfunction. With the development of modern society, people's pace of life is generally accelerated, and the pressure from society, life and work is increasing, so the number of patients with anxiety disorders is increasing day by day. [0003] Anxiolytic drugs commonly used in clinical practice are divided into benzodiazepines and non-benzodiazepines. Benzodiazepines such as chlordiazepoxide (chlordiazepoxide), diaz...

Claims

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Application Information

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IPC IPC(8): A61K36/88A61K9/48G01N30/36A61P25/22
Inventor 石晋丽刘勇郑虎占郭建友赵保胜王延丽彭敏翟玉静
Owner BEIJING UNIV OF CHINESE MEDICINE
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