159 results about "Homeostatic mechanism" patented technology

Thiazolidinedione (TZD) and its pharmacologically active derivatives can be used, in combination with agonists of glucagon-like peptide-1 (GLP-1), to treat non-insulin dependent diabetes mellitus, optionally with other therapies, by improving glycemic control while minimizing side effects, such as heart hypertrophy and elevated fed-state plasma glucose, which are associate with both TZD and GLP-1 monotherapies. Thus, the co-administration of TZD and GLP-1 helps regulate glucose homeostasis in Type II diabetic patients.

Disclosed are pharmaceutical compositions that comprise gallium complexes of 3-hydroxy-4-pyrones. These compositions provide enhanced gallium bioavailability particularly when orally administered as compared to the gallium bioavailability achieved by use of pharmaceutical compositions containing gallium salts. Compositions included in this invention are useful in providing gallium to humans and other mammals for a wide variety of medical and veterinary applications, including the treatment, prevention, or diagnosis of hypercalcemia, certain cancers, certain disorders of calcium homeostasis, and certain bone diseases including osteoporosis, osteopenia, and Paget's disease.

The invention specifies a method and system for leading a person suffering from “sympathetic predominance”, a specific symptom of which is “hypertension”, to breathe according to a certain pattern for the express purpose of positively altering the condition of sympathetic predominance (over activation), having the effect of bringing the autonomic nervous system into the state of balance, with consequent reductions in “tenseness”, blood pressure, muscular tightness, and emotional strain, as well as the alleviation of the myriad of subtle neuro-physiological consequences resulting from sympathetic predominance potentially including headaches, anxiety, sleep disorders, allergies, and other maladies that have yet to be attributed to this condition, thus leading to a general improvement in health, well being, and homeostasis. It accomplishes this by systematically reducing the breathing frequency with consequent increases in breathing depth, the ultimate goal being the realization and ongoing maintenance of 1 complete breathing cycle in 11.76 seconds or 5 complete breathing cycles in 58.8 seconds, the result being improved health, well being, and homeostasis.

Methods and compositions are provided for the protection of normal cells from cytoreductive therapy that target proliferating cells, by administering an inhibitor of Wnt signaling pathways. Wnt signaling is critically important for homeostasis of the epithelial lining of the adult intestine and other proliferating normal adult tissues.

An NMDA antagonist (such as ketamine) is administered with a safener (such as clonidine) in patients suffering from neurologic disorders other than pain. The ketamine is adminsitered at a dosage that causes slurred speech, for a span of several days. This treatment enables a patient's nervous system to return to a healthy “set point”, also called an improved stable neural homeostasis, in a manner similar to a broken bone healing itself if protected from jostling and reinjury by a cast. In at least some patients, this treatment can ease problems such as addictions to illegal or pain-killing drugs, nicotine, or alcohol, compulsive or criminal behavioral problems, severe depression, obsessive-compulsive disorders, phobias, etc. It may also provide some relief in some patients for problems such as chronic fatigue, chemical sensitivities, allergies, autoimmune disorders, and diabetes.

Compositions, kits and methods are provided for restoring skin barrier function to skin exposed to environmental elements and / or in a pathological condition. In general, divalent cations such as calcium ions and / or magnesium ions are included in a physiologically acceptable medium. In some embodiments, divalent cations are balanced with monovalent cations such as sodium and potassium ions at appropriate ratios in order to maintain the homeostasis of skin barrier. The compositions, kits and methods can be used as cosmetics, cosmeceuticals or pharmaceuticals for improving skin condition, and preventing or treating dermatological diseases and skin disorders.

The subjects of this invention are pharmaceutical compositions that comprise gallium complexes of 3-hydroxy-4-pyrones. The compositions have been developed to provide pharmaceutically acceptable gallium bioavailability together with low toxicity, particularly for oral administration. Compositions included in this invention should be useful in providing gallium to humans and other animals for a wide variety of medical and veterinary applications, including the treatment, prevention, or diagnosis of certain bone diseases, certain cancers, and certain disorders of calcium homeostasis.

A method for treating a disease by returning the body to a natural condition. The method adjusts a parameter of a thermotherapy for treating or preventing the disease, disability, or condition of a patient and comprises (A) a step of measuring the redox potential (or pH value) of the patient and (B) a step of determining the parameter of thermotherapy suited to the patient according to the redox potential. Considering returning the biopotential to a range called homeostatic potential, a therapeutic potential of −75 mV to −90 mV (the potential in the cell is −75 mV) the absolute value of which is higher than that of the cell is given. It has been found that this therapy effects a cure.

The present invention relates to a composition for suppressing or ameliorating a symptom accompanying diminished homeostasis, comprising theanine; and a mineral composition comprising theanine and a mineral. According to the present invention, there can be provided a composition for suppressing or ameliorating the above symptoms; and a mineral composition having a reduced peculiar metal taste, of which administration is made easily.

Disclosed are embryoid bodies having a uniform size of approximately 415 nm and comprising genetically modified embryonic stem cells, and methods of making same. The genetically uniform embryoid bodies can be multiplexed as one embryoid body per well in a multiwell format, and used as a high to medium throughput screen for test agents that affect the development and homeostasis of animals, including humans. The genetic modification of the embryonic stem cells is a promoter-report-selection construct that enables the selection and detection of cells of a particular lineage in the EB, to determine the effects of a test agent.

The present invention is directed to novel compositions of bio-active compounds comprising 4-hydroxyisoleucine and one or more compounds selected from the group of amino acids, alkaloids, glycosides, volatile oils, saponins, sapogenins, mannans, flavonoids, fatty acids, vitamins and provitamins, minerals, and carbohydrates. Preferably, the novel compositions of bio-active compounds include 4-hydroxyisoleucine and one or more amino acids selected from the group consisting of arginine, aspartate, threonine, serine, glutamate, proline, glycine, alanine, cysteine, valine, methionine, isoleucine, leucine, tryptophan, phenylalanine, ornithine, proline, lysine, histidine, and gamma-aminobutyrate. The composition of bio-active compounds preferably include between about ten percent and about seventy percent of 4-hydroxyisoleucine and between about twenty percent and about forty percent of other amino acids. The bio-active compounds of the novel composition of the present invention may be derived, isolated, and / or extracted from Fenugreek seeds. A preferred method for extracting the bio-active compounds from Fenugreek seeds includes the steps of: (1) providing a plurality of Fenugreek seeds; (2) preparing the Fenugreek seeds; and (3) extracting a novel composition of bio-active compounds from the Fenugreek seeds, which include a preliminary extraction step and a secondary extraction step. The compositions of bio-active compounds have been found to be helpful in restoring healthy energy balance in humans and animals, aiding in weight management efforts, and for balancing blood sugar levels by way of assisting the body to make more efficient use of existing (i.e., endogenous) insulin.

A pharmaceutical delivery system comprising a slow-release formulation of vitamin C (ascorbic acid) and a plain-release formulation of vitamin E (tocopherol) has been found to raise and maintain the concentrations of these vitamins in the blood plasma to a ratio of approximately 2.2:1. The steady-state concentration and ratio of these antioxidants has been found to be critical in the prevention and treatment of oxidative stress related disorders such as arteriosclerosis and diabetes and neural degenerative disorders such as Alzheimer's Disease.

A homeostatic flying hovercraft preferably utilizes at least two pairs of counter-rotating ducted fans to generate lift like a hovercraft and utilizes a homeostatic hover control system to create a flying craft that is easily controlled. The homeostatic hover control system provides true homeostasis of the craft with a true fly-by-wire flight control and control-by-wire system control.

Compositions, kits and methods are provided for restoring skin barrier function to skin exposed to environmental elements and / or in a pathological condition. In general, divalent cations such as calcium ions and / or magnesium ions are included in a physiologically acceptable medium. In some embodiments, divalent cations are balanced with monovalent cations such as sodium and potassium ions at appropriate ratios in order to maintain the homeostasis of skin barrier. The compositions, kits and methods can be used as cosmetics, cosmeceuticals or pharmaceuticals for improving skin condition, and preventing or treating dermatological diseases and skin disorders.

The invention is of both a composition and method for inhibiting the proliferation of cancerous cells. The composition is, and the method is based on the use of a composition consisting (among active ingredients) substantially of 2-methoxyestradiol and / or one of a number of anaologues thereof. The present inventors have demonstrated beyond serious doubt that these compounds have a pronounced effect in inhibiting the proliferation of cancerous cells and, therefore, provide a desperately needed stepping stone for advancing toward meaningful treatment of cancer.

The present invention presents a biocidic packaging for cosmetics and / or foodstuffs, comprises at least one insoluble proton sink or source (PSS). The packaging is provided useful for killing living target cells (LTCs), or otherwise disrupting vital intracellular processes and / or intercellular interactions of said LTC upon contact. The PSS comprises, inter alia, (i) proton source or sink providing a buffering capacity; and (ii) means providing proton conductivity and / or electrical potential. The PSS is effectively disrupting the pH homeostasis and / or electrical balance within the confined volume of the LTC and / or disrupting vital intercellular interactions of the LTCs while efficiently preserving the pH of said LTCs' environment. The present invention also discloses a method for killing living target cells (LTCs), or otherwise disrupting vital intracellular processes and / or intercellular interactions of said LTC being in a packaging, especially cosmetic or foodstuffs' packaging.

A compound of the formula [I]wherein R1 is optionally substituted aryl group or optionally substituted heteroaryl group; R2 is optionally substituted C1-6 alkyl group, C3-7 cycloalkyl group and the like; R3 is hydrogen atom, C1-6 alkyl group, hydroxyl group and the like; R4 is hydrogen atom, C1-6 alkyl group and the like; R5 and R6 are each C1-6 alkyl group and the like; R7 is optionally substituted aryl group or optionally substituted heteroaryl group; X1, X2 and X3 are each C1-6 alkylene group and the like; and X4 and X5 are each a single bond, methylene group and the like, a salt thereof, a solvate thereof or a prodrug thereof, and a pharmaceutical composition containing the compound, particularly a calcium receptor antagonist and a therapeutic agent for osteoporosis, are provided. The compound of the present invention is useful as a therapeutic drug of diseases accompanied by abnormal calcium homeostasis, or osteoporosis, hypoparathyreosis, osteosarcoma, periodontal disease, bone fracture, steoarthrosis, chronic rheumatoid arthritis, Paget's disease, humoral hypercalcemia, autosomal dominant hypocalcemia and the like.In addition, an intermediate for the compound is provided.

Methods and compositions are provided for the protection of normal cells from cytoreductive therapy that target proliferating cells, by administering an inhibitor of Wnt signaling pathways. Wnt signaling is critically important for homeostasis of the epithelial lining of the adult intestine and other proliferating normal adult tissues.

In a preferred embodiment of the present invention, an osteogenetic-orthodontic appliance, device, system, and method optimizes craniofacial homeostasis by means of a 3-D axial spring that influences the patient's genome and thereby addresses problems existing primarily within the mid-facial region, as well as the other contiguous regions. Growth and development of the craniofacial structures can be influenced by foundational (skeleto-dental) correction in concert with functional (myo-spatial) correction, according to the genome of a particular patient by means of the method and systems of the present invention.

The present invention relates generally to a method of modulating glutathione metabolism in the central nervous system of mammals and to agents for use therein. More particularly, the present invention relates to a method of up-regulating glutathione metabolism in the central nervous system by up-regulating levels of glutathione precursor molecules. The method of the present invention is particularly useful, inter alia, in the treatment and / or prophylaxis of conditions characterised by aberrant, unwanted or otherwise inappropriate central nervous system oxidation homeostasis including, but not limited to, schizophrenia.

The present invention is a biological dressing produced by the extraction liquid of the Chinese medicine with antibacterial and homeostasis properties comprising the soaking gall and the notoginseng, which takes the cotton, gauze or non-woven fabrics as the substrate and the chitosan as the membrane forming material. The present invention can be applied in the wound dressing for the burning wound and the injury. The present invention has characteristics of good biocompatibility, safety property, absorbing the wound exudates, antibacterial property, and homeostasis property and accelerating the healing in the wound. The main material of the present invention is the natural material.

It is intended to provide a method of improving dietary life or screening cancer which comprises measuring the content of an element in head hair or body hair, paying attention to the fact that the content of the element remains constant in healthy humans (i.e., homeostasis) and thus evaluating the physical conditions based on changes in the homeostasis. Namely, a method of evaluating the physical conditions whereby the physical conditions can be evaluated by measuring the content of an element in an arbitrary part of head hair or body hair. Although one's physical conditions change everyday, these changes are scarcely self-noticeable. Therefore, it is required to objectively indicate such changes in the physical conditions in numerical terms. Because of being solid, head hair or body hair can be easily handled. Thus, they are most suitable for analyzing the content of an element and enable large-scaled diagnosis at fixed intervals. This method of evaluating the physical conditions using head hair or body hair, whereby the content of an element at present can be measured by analyzing the hair root while its content of the past can be measured by analyzing at an arbitrary part, is highly effective in evaluating the physical conditions.

This invention provides unique technology, systems and methods of treatment of stress induced afflictions in the musculoskeletal system, the vascular system or the nervous tissue. More specifically, the systems comprise diagnosis of a stress-induced consistent tightness on the right side of the cranial, cervical, thoracic, lumbar, sacral spine, referred herein as “The Twist”, and utilize “Stress Relief Methods” to reduce The Twist to resolve any afflictions associated with it. The invention comprises a coordinated series of untwisting dynamic motions, spinal manipulation and / or motion palpations that result in release of nitric oxide and relief from pain. The systems and methods of the invention therefore provide the benefits of increased nitric oxide release to maintain homeostasis in pulmonary vasculature. The invention also provides methods of training others in the correct use of the Stress Relief Methods to prevent and treat afflictions associated with the Twist.

Methods and compositions are directed to a dietary supplement comprising boron that is an a complex with a carbohydrate, wherein administration of the complex increases steroid levels, and particularly 25-hydroxy vitamin D3. Thus, contemplated compositions are useful for treatment of impaired steroid homeostasis, and especially beneficial for prevention and / or treatment of bone density loss. Particularly preferred compositions further include calcium, magnesium, and / or vitamin D in a nutritionally acceptable form.

The present invention provides novel compositions in the form of a powder, capsule, liquid or lozenge, and methods for administering said novel compositions to assist the body in its ability to maintain a reasonable homeostatic mechanism for compensating for chronic internal acidity. The composition may contain several active ingredients, such as potassium bicarbonate, citric acid, calcium citrate, magnesium citrate, glycine, and licorice. The composition may also contain other inactive excipients, such as hypoallergenic rice, flour, glycerine, tangerine oil and gelatin. Following oral administration, the composition is rapidly broken down and absorbed into the systemic circulation. Upon absorption, the individual components are able to assist the physiological acid-alkaline buffer systems, promote anti-anxiety effects, and decrease inflammation in the digestive system.

A device determining a biological state of a driver more accurately, including a hypnagogic symptom phenomenon detecting mechanism, an imminent sleep phenomenon detecting mechanism, a subjective sleepiness / low consciousness traveling state detecting mechanism, and a homeostasis function level determining mechanism, which are configured to function in parallel. Therefore, detection of a hypnagogic symptom phenomenon or an imminent sleep phenomenon, or detection of a period resisting a light sleepiness mild sleepiness or a strong sleepiness which occurs consciously, or the case where a low consciousness traveling state due to a decrease in consciousness level momentarily occurs or the case where it occurs longer continuously, or the like, can be determined / detected, and the driver's biological state can be accurately determined

In a preferred embodiment of the present invention, an osteogenetic-orthodontic appliance, device, system, and method optimizes craniofacial homeostasis by means of a 3-D axial spring that influences the patient's genome and thereby addresses problems existing primarily within the mid-facial region, as well as the other contiguous regions. Growth and development of the craniofacial structures can be influenced by foundational (skeleto-dental) correction in concert with functional (myo-spatial) correction, according to the genome of a particular patient by means of the method and systems of the present invention.