103 results about "Treatment side effects" patented technology

Methods, systems, and apparatus for assessing a state of an epilepsy disease or a comorbidity thereof are provided. The methods comprise receiving at least one autonomic index, neurologic index, stress marker index, psychiatric index, endocrine index, adverse effect of therapy index, physical fitness index, or quality of life index of a patient; comparing the at least one index to at least one reference value; and assessing a state of an epilepsy disease or a body system of the patient based on the comparison. A computer readable program storage device encoded with instructions that, when executed by a computer, perform the method described above is also provided. A medical device system capable of implementing the method described above is also provided.

Methods, systems, and apparatus for assessing a state of a comorbidity associated with a primary disease are provided. The methods comprise receiving at least one autonomic index, neurologic index, stress marker index, psychiatric index, endocrine index, adverse effect of therapy index, physical fitness index, or quality of life index of a patient; comparing the at least one index to at least one reference value; and assessing a state of a body system of the patient that is a site of the comorbidity, based on the comparison. A computer readable program storage device encoded with instructions that, when executed by a computer, perform the method described above is also provided. A medical device system capable of implementing the method described above is also provided.

Removing malware from a computer system. An inspection module obtains an inspection log representing operational history of the operating system and the application programs of the computer system. The inspection log is analyzed to detect a presence of any malware on the computer system. A treatment scenario is generated that defines a plurality of actions to be executed for removing any malware present on the computer system, as detected in the analyzing. The treatment scenario is generated based on the information contained in the inspection log and on a knowledge base of malware removal rules. The generated treatment scenario is evaluated to assess the actions defined in the generated treatment scenario that are associated with a risk of damaging the operating system or the application programs of the computer system. A modified treatment scenario can be created to reduce the risk in response to an assessment of the risk.

Thiazolidinedione (TZD) and its pharmacologically active derivatives can be used, in combination with agonists of glucagon-like peptide-1 (GLP-1), to treat non-insulin dependent diabetes mellitus, optionally with other therapies, by improving glycemic control while minimizing side effects, such as heart hypertrophy and elevated fed-state plasma glucose, which are associate with both TZD and GLP-1 monotherapies. Thus, the co-administration of TZD and GLP-1 helps regulate glucose homeostasis in Type II diabetic patients.

The present invention relates to methods of protecting patients and sensitizing cancer cells in combination with chemotherapy and / or radiation therapy. More specifically, the invention provides nutritional methods and formulations that are capable of reducing cancer growth without causing chronic weight loss in patients, protecting normal cells, tissues and organs from chemotherapy and / radiation therapy, and sensitizing cancer cells against low, normal and high-dose chemotherapy. Some of the methods also impede cancer growth even without chemotherapy.

Removing malware from a computer system. An inspection module obtains an inspection log representing operational history of the operating system and the application programs of the computer system. The inspection log is analyzed to detect a presence of any malware on the computer system. A treatment scenario is generated that defines a plurality of actions to be executed for removing any malware present on the computer system, as detected in the analyzing. The treatment scenario is generated based on the information contained in the inspection log and on a knowledge base of malware removal rules. The generated treatment scenario is evaluated to assess the actions defined in the generated treatment scenario that are associated with a risk of damaging the operating system or the application programs of the computer system. A modified treatment scenario can be created to reduce the risk in response to an assessment of the risk.

The present invention provides a compound of formula I: wherein R1, R2, R2′ and X′ are as defined and described herein, methods of manufacture thereof and compositions thereof, useful for example as peripheral mu opioid receptor antagonists in treatment of side effects of opioid administration.

A Chinese medicine for treating gout is prepared from Chinese fevervine herb through extracting.

The invention relates to a chimeric antigen receptor and an expression gene thereof, a double-antigen regulated type T cell modified by the chimeric antigen receptor, and application thereof. The expression gene of the chimeric antigen receptor comprises a first fusion protein expression gene and a second fusion protein expression gene, wherein the first fusion protein expression gene comprises a mucoprotein-1 antibody expression gene, a notch receptor expression gene and a Gal4-VP64 transcription activating protein expression gene which are sequentially connected; the second fusion protein expression gene comprises a Gal4-UAS promoter expression gene and an anti-mesothelin expression gene which are sequentially connected. By adopting the innovative design, the chimeric antigen receptor has the advantages that the chimeric antigen receptor can be successfully imported into the T cell to form the T cell modified by the chimeric antigen receptor; the immune reaction cannot be produced until the mucoprotein-1 and the anti-mesothelin signals simultaneously exist, so as to reach the controllable immune reaction of the chimeric antigen receptor, fewer side effects in treatment, and high specificity.

An arthritis fumigation-therapy instrument comprises a steam kettle, a steam tube and a fumigation-therapy cover. When the arthritis fumigation-therapy instrument is used, traditional Chinese medicine, other pharmaceuticals and water are placed into the steam kettle of the arthritis fumigation-therapy instrument, automatic control program performs after the arthritis fumigation-therapy instrument is started, pharmaceutical steam enters the fumigation-therapy cover through a one-way flow adjusting valve and the steam tube, the arthritis of a human body is treated by utilizing the pharmaceutical steam, and the fumigation-therapy instrument is closed automatically when fumigation time is up. The steam flow, the temperature and the time in the physical therapy process of the arthritis fumigation-therapy instrument are controlled automatically or intelligently, the side effect in treatment is small, and physical health of people is facilitated.

The invention relates to the use of fevervine iridoid total glycoside or the composition of the effective component thereof in preparing medicines for treating pains and inflammation, and belongs to the field of the medical use of the effective component of Chinese medicine. The invention uses the fevervine iridoid total glycoside to prepare analgesics, overcomes disadvantages of strong side effects of the prior Western medicine therapy, etc., and provides the effective component extracted from a single medicine with little side effects as the ideal analgesics. The sources of the raw materials of the fevervine are rich, the invention develops the medicinal prospect for the fevervine iridoid total glycoside, and relative new medicine development can be performed on the basis of the invention.

There are provided a DNA oligomer, a genetic marker, and a DNA oligomer set (PCR primer set) and a DNA oligomer (extension primer) for predicting a possibility of onset of a side-effect from radiation therapy for cancer by determining whether a specific base in a DNA sequence is a risk allele or a non-risk allele, and a method for predicting onset of a side-effect from radiation therapy. The DNA oligomer for a prediction of onset of a side-effect from radiation therapy has a DNA sequence of at least 10-241 contiguous bases with a 121st base from a sequence of any one of SEQ ID NOs: 1-173 in the Sequence Listing.

The present invention provides a personalized medical decision supporting system based on collaborative filtering and recommendation. The system is characterized by comprising a medical record original database, a definition target retrieval module, and a recommendation and retrieval filtering system. The medical record original database comprises a treatment history file, a personal electronic medical record file and other related files of a patient. The definition target retrieval module is used for generating a patient feature matrix based on data in the medical record original database and converting the patient feature matrix to a retrieval feature matrix. The recommendation and retrieval filtering system is used for treating a specific disease according to selection and design, and referring to other patients for therapeutic side effects studies and / or other purposes. The system provided by the present invention is designed to support cancer specialists in selecting the optimal treatment regimen at each decision node.

The invention provides a pharmaceutical composition. The pharmaceutical composition comprises ginseng extract, and an anti-tumor pharmaceutical component 5-fluorouracil, wherein preferably the mass ratio of the ginseng extract to the 5-fluorouracil is 1:1, and the ginseng extract comprises ginsenoside Rb1, ginsenoside Re, ginsenoside Rd, ginsenoside Rb3, ginsenoside Rg3, ginsenoside Rh2, ginsenoside Rg1. The pharmaceutical composition is used to enhance the curative effect of antitumor components and reduce the treatment side-effect caused by the antitumor components. The pharmaceutical composition is especially designed for treating stomach cancer diseases.

This invention provides methods to predict the likelihood of occurrence of the side effect of edema in patients treated with a drug including, but not limited to, a TKI, such as Imatinib or GLEEVEC™ / GLIVEC®. The methods employed use gene expression profile comparisons and the determination of specific SNPs and in the IL-1β gene. Methods of treatment of edema and kits for the performance of the above assays are also provided.

The invention relates to a chimeric antigen receptor with a safety switch, an expression gene of the chimeric antigen receptor, an NK cell modified by the chimeric antigen receptor and an applicationof the chimeric antigen receptor. The chimeric antigen receptor comprises first signal peptide, c-Met single-chain antibody, CD8 structural domain, 41BB intracellular domain, DAP12-ITAM structural domain, T2A, second signal peptide and modified EGFRt. Experimental results show that the chimeric antigen receptor modified NK cells has features that the chimeric antigen receptor is controllable in immune response, the safety performance is good, the treatment side effect is less and the specificity is high.

The invention discloses a group of gene sequence of gastric cancer auxiliary diagnosis and a gene chip and a kit aiming at the group of gene sequence. The invention also discloses the application of the group of gene sequence of gastric cancer auxiliary diagnosis. The gene sequence of gastric cancer auxiliary diagnosis applied in the invention can type gastric cancer from molecular level and helps clinical diagnosis, thus more effectively healing patients and reducing treatment side effect to the utmost extent.

It is intended to provide pergolide-containing transdermal preparations having reducreduced side effects and exerting sufficient therapeutic effects. Namely, a pergolide-containing transdermal preparation which is capable of achieving a plasma AUC ratio of pergolide or the like to at least one pergolide metabolite of 1:0.5 to 1:5; and / or transdermal preparation containing pergolide and / or a pharmaceutically acceptable salt thereof which is capable of achieving a ratio (A / B) of the maximum plasma level (A) of pergolide and / or a pharmaceutically acceptable salt thereof to the plasma level (B) thereof in the next administration of less than 2.

The invention discloses a sleep-promoting medicated pillow formulation and a sleep-promoting medicated pillow for treating insomnia. The sleep-promoting medicated pillow formulation comprises, by weight, 5-25 parts of raw Cacumen Platycladi, 5-25 parts of Flos Chrysanthemi, 5-15 parts of Rhizoma Ligustici Wallichii, 5-15 parts of Flos Albiziae, 5-15 parts of Medulla Junci, 5-55 parts of Spica Prunellae, 5-55 parts of Caulis Polygoni Multiflori, 5-35 parts of Excrementum Bombycis and 5-35 parts of Semen Cassiae. By joint action of various medicinal components, efficacies of heart fire clearing,restlessness relieving, nerve calming and sleep promoting are achieved. According to clinical observation, the sleep-promoting medicated pillow is capable of improving postoperation sleep quality ofpatients to further improve life quality of the patients, capable of assisting in treatment side effect reduction, convenient to use, effective, safe and worthy of popularization.

The invention relates to a novel insomnia treatment special-effect drug, which is characterized by comprising, by weight, 20-30% of ziziphus jujuba mill.var.spinosa, 20-30% of tuber fleeceflower stem, 12-20% of codonopsis pilosula, 10-20% of milkvetch root, 10-30% of radix rehmanniae preparata, 10-30% of raw paeonia lactiflora pall, 10-20% of radix bupleuri, and 10-30% of citrus medica l. var. sarcodactylis swingle. According to the present invention, with the novel insomnia treatment special-effect drug, the problems of high side effect, long taking time, high recurrence rate after drug discontinuance and incapable cure of the modern clinical insomnia treatment drug are solved.

The present invention relates to a compound Chinese Mongolian medicine for effectively curing diabetes and its preparation method. It is made up by using Chinese medicinal materials of Chinese angelica root, typha pollen, leonurus, dianthus, bamboo leaf, black ant, seal's genitals, sea horse and dragon's blood as raw material and adding carboxymethyl cellulose sodium and magnesium stearate as excipient through a certain preparation process.

The invention discloses an intelligent arthritis fumigation cover which comprises a steam generator, a fumigation cover and a controller, wherein the steam generator comprises a water bladder, a steam distribution box electric heating element and a medicine box; the fumigation cover comprises a cover cloth, a sealing pad and a fastener; the sealing pad is fixedly connected with the cover cloth; and the controller comprises a liquid level switch, a first temperature controller, a second temperature controller and a control panel. The intelligent arthritis fumigation cover is used for fumigating and treating arthritis by means of medicine steam and the temperature and time of the treating process are automatically or intelligently controlled, so that the side effects in treating are fewer and benefit is brought to the health of people; and the controller is provided with an inversion-proof switch, so that the intelligent arthritis fumigation cover can be prevented from being inverted for use.

The invention discloses a traditional Chinese medicine formula for removing acnes by traditional Chinese medicines. The formula is characterized by comprising the following herbal medicines by weight: 12g of radix scrophulariae, 12g of radix rehmanniae, 12g of radix paeoniae rubra, 15g of rhizoma polygoni cuspidati, 15g of herba violae, 10g of cortex moutan, 10g of radix sophorae flavescentis, 10g of cortex lycii radicis, 10g of raw fructus crataegi and 10g of periostracum cicada. Methods for preparing and taking a formula drug comprise the steps of decocting the herbal medicines with water, and taking a decoction twice per day. According to the formula, the problem of large treatment side effect of an existing drug is solved; and the formula is suitable to remove the acnes.

The invention provides a traditional Chinese medicine formula for treating infantile pneumonia. The traditional Chinese medicine formula for treating infantile pneumonia is characterized by comprising the following components by weight: 8 grams of herba houttuyniae, 6 grams of semen persicae, 6 grams of almond, 6 grams of salviae miltiorrhizae, 6 grams of cortex mori radicis, 6 grams of thunberg fritillary bulb, 3 grams of platycodon grandiflorum, 3 grams of radix glycyrrhizae, 5 grams of radix scutellariae, 5 grams of earthworm and 5 grams of semen plantaginis. According to a preparation and administration method, one dose of the traditional Chinese medicine formula is orally taken every day, and is decocted with water to obtain decoction, the decoction is divided into three parts which are orally taken in three different times in a day, and if a child patient is younger than 2 years old, the dosis is halved. The problem that treatment side effects of existing medicines are large is solved. The traditional Chinese medicine formula is suitable for treating infantile pneumonia.

The invention relates to an application of Weichangan to preparation of drugs for preventing and treating alcohol-induced acute and chronic gastric ulcers. Animal experiments show that a Weichangan extract has obvious inhibiting effects on gastric ulcer in mice caused by 90% of short-term alcohol and 50% of long-term alcohol, so that Weichangan can serve as a drug for preventing and protecting alcoholic gastric ulcer. Weichangan has the obvious advantages that Weichangan has small treatment side effects on diseases, is small in dosage, has good effects and has not only good prevention effects but also better treatment and protection effects on alcoholic gastric ulcer.

A method of treating side effects of antibiotic treatment includes the step of internally administering an antibiotic that is capable of inducing hearing loss in a mammal. The method further includes the step of internally administering a composition to the mammal in conjunction with administration of the antibiotic. The composition includes a biologically effective amount of at least one scavenger of singlet oxygen, vitamin E, vitamin C, and a vasodilator comprising magnesium. The combination of vitamins and the vasodilator comprising magnesium, in the biologically effective amounts, provides an effective treatment for treating side effects of antibiotic treatment.

The invention relates to a medicinal preparation for treating an Alzheimer disease and an application of the medicinal preparation. The medicinal preparation comprises coptis, perilla stems, epimedium, semen cuscutae, black soya beans, holly leaves, obcordateleaf raspberry fruits, burdock, wild rice shoots, orchis, liquorice, rhizoma acori graminei, polygala tenuifolia, rhodiola rosea, root of kudzu vine, eupatorium, piper cubeba, sophora flowers, Chuanxiong rhizome and borneol. The traditional Chinese medicine formula treats the Alzheimer disease by a qi regulating and blood circulation activating method. The medicinal preparation in the traditional Chinese medicine formula is low in therapeutic side effect and prepared from traditional Chinese medicines serving as raw materials through the scientific formula and repeated verification and preparation of clinical tests, conforms to the theory of traditional Chinese medicine, improves body immunity, has multiple action targets, is high in effective rate and suitable for clinical popularization and application, and has high development values.

The invention discloses substitute tea for treating a distending pain of superior belly. The substitute tea comprises the following raw materials in parts by mass: 2 parts of orange peel, 3 parts of haws, 0.5 part of medicinal evodia fruits, 2 parts of longans, 1 part of honey, 3 parts of large white paeony roots, 2 parts of Chinese wolfberry fruits, 1 part of sepium, 3 parts of malt and 4 parts of endothelium corneum gigeriae galli. The invention further discloses a preparation method and drinking method of the substitute tea. The substitute tea disclosed by the invention has the advantages of being small in treatment side effects, high in security coefficient and small in dependence.