44results about How to "Less side effects of treatment" patented technology

An arthritis fumigation-therapy instrument comprises a steam kettle, a steam tube and a fumigation-therapy cover. When the arthritis fumigation-therapy instrument is used, traditional Chinese medicine, other pharmaceuticals and water are placed into the steam kettle of the arthritis fumigation-therapy instrument, automatic control program performs after the arthritis fumigation-therapy instrument is started, pharmaceutical steam enters the fumigation-therapy cover through a one-way flow adjusting valve and the steam tube, the arthritis of a human body is treated by utilizing the pharmaceutical steam, and the fumigation-therapy instrument is closed automatically when fumigation time is up. The steam flow, the temperature and the time in the physical therapy process of the arthritis fumigation-therapy instrument are controlled automatically or intelligently, the side effect in treatment is small, and physical health of people is facilitated.

The invention relates to a chimeric antigen receptor with a safety switch, an expression gene of the chimeric antigen receptor, an NK cell modified by the chimeric antigen receptor and an applicationof the chimeric antigen receptor. The chimeric antigen receptor comprises first signal peptide, c-Met single-chain antibody, CD8 structural domain, 41BB intracellular domain, DAP12-ITAM structural domain, T2A, second signal peptide and modified EGFRt. Experimental results show that the chimeric antigen receptor modified NK cells has features that the chimeric antigen receptor is controllable in immune response, the safety performance is good, the treatment side effect is less and the specificity is high.

The invention relates to a targeted superparamagnetic monodisperse nano-flower probe, the preparation and the application thereof. A nano-flower probe is composed of three parts, namely a magnetic gold-bearing particle nano-flower, a hyperbranched macromolecular HPG and a target molecule, wherein one end of the hyperbranched macromolecular HPG is provided with a mercapto group and a branched terminal. The nano-flower probe is prepared through the hot solvent method. That is, firstly, a Fe3O4 carrier is prepared. Secondly, a golden seed is loaded on the carrier, and then the magnetic gold-bearing particle nano-flower is obtained. Finally, the magnetic gold-bearing particle nano-flower is connected sequentially with the HPG and the target molecule. The above nano-probe is applied to the oncotherapy for animal in-vivo double-targeted imaging under the alternating magnetic field. Compared with the prior art, the targeted superparamagnetic monodisperse nano-flower probe is simple to prepare, low in cost, high in targeting efficiency, and small in oncotherapy side effect. Compared with the prior art, the targeted superparamagnetic monodisperse nano-flower probe has the advantages of simple preparation, low cost, high targeting efficiency, small oncotherapy side effect and the like.

The invention discloses a double-targeting chimeric antigen receptor, which comprises a double-antigen binding region, a first hinge region, a chimeric antigen receptor T cell activation domain and a protein co-expression self-cleavage domain which are sequentially connected in series, and the double-antigen binding region comprises a heavy chain VH and a light chain VL of an MSLN and MUC1 single-chain antibody which are connected in series, and a second hinge region connected with the MSLN and the MUC1 single-chain antibody. The double-targeting CAR-T cell can kill tumor cells expressing double antigens, killing is more accurate and efficient, meanwhile, the off-target effect is reduced or avoided, the side effect of non-specific killing is reduced, and the anti-tumor effect is enhanced.

The invention provides a cryotherapy catheter and a cryotherapy system. The cryotherapy catheter comprises a delivery pipe, wherein a blood leading-out channel, a blood leading-in channel and a balloon pressure control channel are formed in the delivery pipe; the delivery pipe is provided with a balloon for blocking blood circulation, the balloon is arranged close to the delivery tail end of the delivery pipe; the delivery pipe is provided with an autologous blood leading-out cavity opening, the autologous blood leading-out cavity opening is positioned at one side, far from the delivery tail end, of the balloon, and the autologous blood leading-out cavity opening communicates with the blood leading-out channel; the blood leading-in channel communicates with the delivery tail end of the delivery pipe from the delivery starting end of the delivery pipe; and the balloon pressure control channel communicates with a balloon inner cavity. The cryotherapy catheter is provided with the blood leading-out channel and the blood leading-in channel at the same time, so that the catheter can perform conveying and pump drainage synchronously, only an intervention wound needs to be opened on a human body, and the pain of a patient and the operation difficulty of medical staff are greatly reduced.

The invention relates to a targeted superparamagnetic monodisperse nano-flower probe, the preparation and the application thereof. A nano-flower probe is composed of three parts, namely a magnetic gold-bearing particle nano-flower, a hyperbranched macromolecular HPG and a target molecule, wherein one end of the hyperbranched macromolecular HPG is provided with a mercapto group and a branched terminal. The nano-flower probe is prepared through the hot solvent method. That is, firstly, a Fe3O4 carrier is prepared. Secondly, a golden seed is loaded on the carrier, and then the magnetic gold-bearing particle nano-flower is obtained. Finally, the magnetic gold-bearing particle nano-flower is connected sequentially with the HPG and the target molecule. The above nano-probe is applied to the oncotherapy for animal in-vivo double-targeted imaging under the alternating magnetic field. Compared with the prior art, the targeted superparamagnetic monodisperse nano-flower probe is simple to prepare, low in cost, high in targeting efficiency, and small in oncotherapy side effect. Compared with the prior art, the targeted superparamagnetic monodisperse nano-flower probe has the advantages of simple preparation, low cost, high targeting efficiency, small oncotherapy side effect and the like.

The invention discloses a minimally invasive collective integral acupotomy scope, which comprises a light microscope assembly of a scope-acupotomy integral body, a tube core assembly of the scope-acupotomy integral body and a hard sleeve assembly of the scope-acupotomy integral body. The light microscope assembly of the scope-acupotomy integral body comprises a lens, a lens base and a light guide tube. The tube core assembly of the scope-acupotomy integral body comprises a knife tube core. The hard sleeve assembly of the scope-acupotomy integral body comprises a knife tube. The light guide tube is inserted in the knife tube core. The knife tube core is inserted in the knife tube. An operation method of the minimally invasive collective integral acupotomy scope disclosed by the invention comprises the following steps of: (1) holding the acupotomy scope, and inserting the acupotomy scope into a knee joint through front external approach; (2) opening a water inlet channel to full a joint cavity; and (3) sequentially searching suprapatellar bursa, patellofemoral joint, internal tibia clearance, fossa intercondyloidea, external tibia clearance, knee lateralis sulci, rear internal clearance and rear external clearance, wherein the scope surface angle of the whole acupotomy scope is correspondingly adjusted according to searched specific parts in the searching process.

The invention provides a fusion protein combined with CD40L and application of the fusion protein, and belongs to the field of biological medicine. The fusion protein combined with CD40L provided by the invention does not contain a human antibody Fc structural domain, and research finds that the fusion protein does not cause activation of any blood platelets while being combined with CD40L, so that the safety of the fusion protein is greatly improved and the treatment side effects are reduced while the biological activity of the fusion protein is ensured; and a new thought and a new method are provided for treatment of immune system diseases. In addition, the fusion protein shows extremely high expression quantity in the construction and screening process of a stably transfected cell line, and is beneficial to large-scale development and production.