92 results about "Bladder tumor" patented technology

The invention provides a bladder tumor detection method based on MaskRcnn, At least that method comprise: a few pictures of medical bladder are collected as training samples, An image processing method is used to solve the problem of over-fitting caused by inadequate medical bladder training pictures which generate unbalanced sample data. The picture has a specific rectangular recognition frame which contains bladder position marker or tumor position marker or has both bladder and tumor position marker. A medical picture is characterized by utilizing a brand-new paramete ResNet debugged according to that invention, and a predicted ROI region is generate; The predicted ROI region represents the possible location of the bladder and tumor; The training speed and testing speed are effectivelyimproved by weighting ResNet operation. The coordinate translation and scale scaling of the region of interest are carried out by using the edge of the border. A target rectangular frame is obtained by using a non-maximum resistance. The invention uses artificial intelligence method, namely deep learning, which greatly reduces the repetitive manual operation of the traditional method and improvesthe speed and efficiency. An instanteous function is achieved.

The invention discloses an endoscope used for prostate operations, which comprises an endoscope body, wherein a light source port and an observation mirror are installed on the endoscope body. The endoscope is characterized in that the endoscope body is perpendicular to the observation mirror; a closer and an anti-reflux sealing cap are sequentially connected at the rear part of the endoscope body; a cavity on which changeable surgical instruments are put is arranged in the endoscope body; a treatment channel for the surgical instruments to pass through is connected at the front part of the endoscope body; and two carbon dioxide inlet valves are arranged at the front part of the endoscope body. The closer is provided with more than three pore canals for the surgical instruments to pass through for operation. The endoscope can be used in prostatectomy, resection of bladder tumors, vesical diverticulectomy, ureterocystostom and the like, and has the good effects that the endoscope can provide the doctor with a clear picture of the affected part before the operation, and with the endoscope, the doctor can operate with both hands to finish the highly difficult operations of resection, suture and the like, thus providing convenience for the doctor to conduct medical operations.

The present invention relates to a bladder tumor-targeting peptide and use thereof. More particularly, the present invention relates to a bladder tumor-targeting peptide having an amino acid sequence represented by SEQ ID NO: 7 and use thereof. The peptide according to the present invention is capable of specific binding to bladder tumor cells in vivo and in vitro. The peptide according to the present invention or an antibody thereof is useful for a marker for the diagnosis of bladder tumors, and for a drug carrier targeting bladder tumor.

The present invention relates to aluminum sulfate for injection and aluminum sulfate injection for treating bladder tumor. The aluminum sulfate injection for treating bladder tumor includes aluminum sulfate for injection, local anesthetic, colorizing agent and water for injection. The aluminum sulfate for injection has heavy metal content not more than 0.0005 wt%, iron salt content not more than 0.004 wt% and arsenic salt content not more than 0.0001 wt%. The present invention also relates to the preparation process of the aluminum sulfate for injection.

The present invention relates to a 3 dimensional mimetic tissue structure—“Assembloid” based on patient-derived multiple cell types to develop next generation organoid technology serving as a novel platform for new drug development and a disease model and a method of manufacturing the same, and more particularly, to a stem cell- or tumor cell-based 3D multicellular mimetic tissue structure manufactured by reconstituting epithelial or tumor cells with various cellular components of a microenvironment such as stromal cells, vascular cells, immune cells or muscle cells based on three-dimensional (3D) bioprinting, and a method of manufacturing the same. As the stem cell- or tumor cell-based 3D multicellular mimetic tissue structure containing the major factors of a tissue microenvironment, such as stromal cells, vascular cells, immune cells and muscle cells, designed according to the present invention is confirmed to mimic physiological and pathological characteristics of tissue in the body better than conventional organoids, normal and tumor assembloids may be used as a new platform for new drug development and a disease model. More specifically, together with 3D bioprinting technology, it is expected that in vitro bladder tissue and bladder tumor tissue are effectively used as a platform to develop precise and personalized therapeutic options for bladder related diseases including bladder cancer.

The intelligent in-situ implanted artificial bladder consists of urine conveying and storing system and automatic intelligent system, the former includes artificial ureter, artificial bladder body and artificial urethra; and the latter incldues pressure sensing alarm, automatic flow returning mechanisms, urine pump and controller. The present invention is used mainly for patient needling bladder reconstruction and urethra reformation owing to bladder tumor, necrotic and interstitial cystitis, traumatic bladder damage, etc. After the body's bladder is ablated, the artificial bladder is in-situimplanted into the pelvic cavityk, the artificial ureter is anastomosed with the ureter stump, the artificial urethra is anastomosed with the urethra strump, and the urine conveying and storing system is reconstructed. The present invention makes it possible for the patient to control urination time autonomously.

The present invention relates to a novel application of a compound. The compound 4-hydroxy-2,3-dimethoxy-6-methyl-5-(3,7,11-trimethyl-dodeca-2,6,10-trienyl)-cyclohex-2-enone of the invention is isolated and purified from the extracts of Antrodia camphorata, which can be applied for inhibiting the survival of bladder cancer cells and be used as a pharmaceutical composition to inhibit the bladder tumor growth.

Analysis of nucleophosmin / B23 mRNA expression provides sensitive, quantitative, rapid and specific analysis to detect cancer cells in tissues for predicting and monitoring recurrence and high stage bladder carcinoma. Over-expression of nucleophosmin / B23 mRNA is a useful prognostic marker for disease recurrence and high stages in bladder carcinoma. The use of such prognostic marker for the prediction of bladder tumor recurrence and high stages facilitates more effective management of the cancer.

This invention is concerned with clinical investigation of therapeutic effects of garlic extracts containing allicin, diallyl disulfide, and diallyl trisulfide. Because the intake of garlic or therapeutically active substance such as allicin from garlic, induces immunostimulation and possess strong antitumor effects concomitant with apoptosis of tumors that can in turn induces a programmed cell death of human prostatic and bladder tumor cells. This invention claims that garlic and / or garlic extracts possess very effective therapeutic substances not only to treat human prostate and bladder cancers to extend life span of patients, but also to suppress or prevent bladder and prostate gland cancers.

The invention provides an Ag85B / IL-2 fusion protein through gene engineering recombination, wherein the fusion protein is fused from M. tuberculosis Ag85B antigen or Ag85B antigen in other mycobacterium with human IL-2. The invention also provides the genes for encoding the recombination fusion protein, which possesses the functions of activating immunocyte and improving body antineoplastic immunological reaction, thus can be used in preparing medicament for immunization therapy of tumor, especially suitable for preparing medicament or protein vaccine for treating bladder tumor and preventing its recurrence.

The invention provides construction of TRAIL (Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand) recombinant bacille calmette guerin (rBCG), and relates to a shuttle expression vector comprising a signal peptide fragment of a major secretory antigen Ag85B of BCG and a gene fragment of a TRAIL and a construction method thereof. The obtained shuttle expression vector pMV261-Ag85B-TRAIL is used for constructing rBCGTRAIL, and can be applied to preparation of TRAIL rBCG for treating superficial bladder tumors, preventing postoperative recurrence thereof and preventing tuberculosis. The rBCG has dual functions of TRAIL and BCG, so that cooperative and synergistic actions of the TRAIL and BCG can be better brought into play; rBCG-TRAIL can secrete TRAIL, and the using amount of the rBCG-TRAIL can be lower than that of the BCG under the condition that the same or better immune effect is achieved, so that the toxic or side effect is reduced; and the rBCG-TRAIL can directly secrete TRAIL efficiently on a certain part, so that tumor cells can be killed in cooperation with the rBCG-TRAIL, and high cost caused by the use of a foreign cell factor is avoided.

The invention discloses transurethral double-operation-channel bladder tumor laser monoblock excision equipment, which comprises an outer sheath, an operation sheath, a cystoscope endoscope, a laser optical fiber, traction pliers and pushing pliers, wherein the outer sheath comprises an outer sheath body, a water feeding connector and a water discharging connector; the inner end side wall of the outer sheath body is provided with a plurality of perfusion holes; the operation sheath comprises a bladder endoscope operation pipe, a laser operation pipe and an auxiliary pliers operation pipe, wherein the bladder endoscope operation pipe, the laser operation pipe and the auxiliary pliers operation pipe are arranged in parallel, and the operation sheath can be put in the outer sheath body; the bladder endoscope comprises an eyepiece, an endoscope body, an objective lens and a light guiding barrel, wherein the endoscope body of the bladder endoscope can be put in the bladder endoscope operation pipe; the laser optical fiber can be put in the laser operation pipe; the traction pliers and the pushing pliers independently comprise a handle, a pliers rod and a pliers head and can be put in the auxiliary pliers operation pipe; the pliers clamping surface of the pliers head of the traction pliers has a fine grained structure, and the outer end of the pliers head of the traction pliers has a mouse tooth structure; the handle has a buckling and locking structure; and the pliers clamping surface of the pliers head of the pushing pliers has a sawtooth structure. The transurethral double-operation-channel bladder tumor laser monoblock excision equipment has the advantages that a surgeon can conveniently operate the transurethral double-operation-channel bladder tumor laser monoblock excision equipment, operation is more accurate, an applicable range is wide and the like.

The invention discloses an internal type bladder irrigation chemotherapy pump, which comprises a chemotherapy pump elastic medicine storage bag, wherein an administration soft hose, which communicates with the chemotherapy pump elastic medicine storage bag, is arranged at one end of the chemotherapy pump elastic medicine storage bag; the end, away from the chemotherapy pump elastic medicine storage bag, of the administration soft hose is provided with an administration hard pipe which communicates with the administration soft hose; a clamp is arranged on the administration hard pipe; an administration pipe, which communicates with the chemotherapy pump elastic medicine storage bag, is arranged at the other end of the chemotherapy pump elastic medicine storage bag; and a valve is arranged on the administration pipe. According to the chemotherapy pump provided by the invention, medicines can be continuously applied to mucosa of a pathologically changed bladder wall through drop irrigation; the chemotherapy pump is fixed to the bladder mucosa by virtue of the clamp, and the medicines, which is applied through drop irrigation in a pipeline, can be siphoned and spread to surrounding bladder walls at the first time through the bladder mucosa, and finally the medicines can be siphoned and spread to the entire bladder wall; then, the medicines are mixed with urine, so that dilution of the medicines, before getting into contact with the bladder wall, is greatly relieved; an administration position is relatively precise; and the medicines, which are continuously discharged through drop irrigation, has a sufficient time to get into contact with the bladder wall, so that a recurrence rate of normuscle invasive bladder cancer which accepts transurethral resection of bladder tumor is reduced.

The invention discloses a chip organ model for screening bladder tumor chemotherapy drugs. The chip organ model comprises a surface modified plastic or glass base and a PDMS film, wherein the PDMS film is arranged on the top of the surface modified plastic or glass base; and one end of the PDMS film is provided with a liquid exchange tank outlet, and the other end of the PDMS film is provided witha liquid exchange tank outlet. The invention also discloses a manufacturing method of the chip organ model for screening bladder tumor chemotherapy drugs. The invention has the beneficial effects asfollows: the design of a microfluidic chip is further optimized by applying the PDMS film polymer breathable hydrophobic film, a special tissue culture chip is applied to high-throughput culture of invitro tumor tissues of individualized patients, and chemotherapy drugs are quickly and accurately screened through their reactions to different chemotherapy drugs in clinical practice, so as to improve the effective rate of drug therapy and reduce the treatment period of patients. According to the invention, the microfluidic chip technology is applied to the individualized treatment of bladder cancer, and the focus is on the screening of individualized chemotherapy drugs, which is helpful to improve the guidance of current clinical medication.

The invention relates to test paper for fast detecting carcinoma of urinary bladder. The test paper is combined test paper capable of detecting three kinds of carcinoma of urinary bladder markers, namely, nuclear matrix protein 22 (NMP22), bladder tumor antigens (BTA stat) and carcino-embryonic antigen relevant cell adhesion molecules (CEACAM1) at the same time. The test paper comprises a three-channel bottom plate, a sample adding pad, a gold standard pad, a nitrocellulose membrane and an absorbent paper layer. The three-channel bottom plate is sequentially coated with the sampling pad, the gold standard pad, the nitrocellulose membrane and the absorbent paper layer, and NMP22, BTA, CEACAM1 resisting protein monoclonal gold-labeled antibodies are contained in the gold-labeled pad. The three-channel bottom plate achieves specimen flow division through three fine tubes, and detection of the three kinds of markers is independent from one another. The test paper is fast in detecting, high in sensitivity, high in specificity, good in stability, easy and convenient to operate, visual and reliable in result judgment and easy to master. The test paper can be used for screening of high-risk groups, can also be used for follow-up visiting of carcinoma of urinary bladder postoperative patients, and is very wide in application range.

The present invention provides a microarray useful as a tool in the diagnosis and / or prognosis of certain types of cancers, particularly urogenital cancers. The microarray can include a plurality of genomic regions represented thereon, the genomic regions corresponding to regions wherein alterations, such as copy number aberrations, at such locations correlate to specific, identifiable cancers, particularly prostate, renal, or bladder tumors. The invention further provides methods of diagnosing certain types of cancers, particularly urogenital cancers, more particularly renal cortical cancers. The methods can comprise analyzing genetic material from a human individual to determine the presence or presence of certain aberrations and using a decision tree to classify the subtype of renal cortical neoplasm present in the sample.

The invention discloses a loop ligature device for a bladder tumor, which comprises a loop ligature device body and a loop ligature metal coil, wherein the loop ligature device body takes the shape of a hollow cavity, one end of the loop ligature device body is connected with a handle, on end of the handle is connected with a binding post, the binding post is located in the hollow cavity in the loop ligature device body, a flexible insulation sleeve is connected onto the binding post, the loop ligature metal coil is led in from an on-point of the binding post and led out from an off-point of the binding post and is simultaneously sleeved in the flexible insulation sleeve and a lower flexible insulation sleeve, the on-point and the off-point of the binding post are respectively connected with electrodes, and the electrodes are connected with an external power source. The loop ligature device for the bladder tumor is simple in structure and convenient in operation, the field is clear in the operation process, and the directivity and the controllability of the operation can help to completely remove the tumor better and shorten the operation time.

The invention discloses application of proguanil to preparation of an anti-tumor drug and application of proguanil to preparation of a drug for inhibiting primary tumor growth and / or metastatic tumorgrowth; a tumor is a malignant tumor or a benign tumor, wherein the malignant tumor comprises one or more of a bladder tumor, melanoma, mastadenoma, non-Hodgkin's lymphoma, a colorectal cancer, a pancreatic cancer, an endometrial cancer, a prostate cancer, renal carcinoma, renal cell carcinoma, a non-melanoma skin cancer, leukemia, a thyroid cancer, a lung cancer, a cervical cancer, an ovarian cancer, a testicular cancer and a central nervous system tumor; the drug is a proguanil single component or a pharmaceutical composition containing an effective dose of proguanil, a drug mixture or a molecular structure modifier. Study results show that the proguanil realizes a strong anti-cancer effect by key protein AMPK in targeting tumor cell energy metabolism, and the effect of the proguanil ontumor treatment is stronger than that of N-(4-fluorophenyl) biguanidine, metformin and other biguanidine drugs.

A bladder tumor specimen extractor comprises an automatically opened and closed net bag device, wherein the automatically opened and closed net bag device comprises a titanium alloy rod and a memory alloy rod, two ends of the memory alloy rod are connected with two ends of the titanium alloy rod, and the titanium alloy rod and the memory alloy rod form an annular structure. A heating ring is installed on the memory alloy rod. When the memory alloy rod and the titanium alloy rod which are in an oppositely folded state extend into the inner side of the bladder, the heating ring can heat the memory alloy rod, and the folding state is changed into an unfolding state when the memory alloy rod is heated, so that the annular structure formed by the memory alloy rod and the titanium alloy rod is opened to facilitate bladder sleeving by a specimen bag, the heating ring stops heating, then the memory alloy rod is slowly recovered to the folding state, and the annular structure formed by the memory alloy rod and the titanium alloy rod is recovered to the folding state to facilitate bladder taking out.

An enucleator and method of use for resection of tumors, especially tumors of the bladder. The enucleator has a plurality of tentacles that are selective extensible and retractable from an elongate body. In a deployed, extended position, the tentacles may be positioned to surround the tumor and tumor stalk. The ends of the tentacles have a razor tipped edge that are oriented inwardly to surround. Utilizing the energy source at the tip of the razor ends, cut through the tumor stalk will finalize the enucleation en-bloc of the whole tumor in one piece.

The invention discloses a noninvasive bladder tumor thermotherapy system. The noninvasive bladder tumor thermotherapy system comprises a medicine tank containing thermotherapy liquid medicine and a heating device arranged at the bottom of the medicine tank. The medicine tank is connected with a therapy tube comprising a therapy section and a transmission section. A first temperature sensor arranged on the therapy section is connected with a temperature controller, and the transmission section is provided with an air changing tube, a water returning tube connected with the medicine tank, and a water inlet tube. The water inlet tube is provided with a micropump. A second temperature sensor arranged in the medicine tank is connected with the temperature controller, the temperature controller controls work of the heating device and the micropump through signals transmitted by the first temperature sensor and the second temperature sensor, and it is guaranteed that the temperature of liquid medicine conveyed by the therapy section on the therapy tube is in the noninvasive and safe temperature range. According to the noninvasive bladder tumor thermotherapy system, the temperature controller controls the work of the micropump and the heating device according to the precise signals transmitted by the temperature sensors, the temperature of the liquid medicine conveyed by the therapy section on the therapy tube is constant, the temperature of the bladder tumor tissue is detected in a noninvasive and precise mode, and the thermotherapy effect is guaranteed.

The invention discloses an application of epigallocatechin gallate in preparing a drug for preventing or treating the bladder tumor. The invention proves that epigallocatechin gallate has a certain curative effect on the bladder tumor, and therefore the epigallocatechin gallate can be taken as a drug active ingredient for preparing the drug for preventing or treating bladder tumor.

The present invention relates to a bladder tumor-targeting peptide and use thereof. More particularly, the present invention relates to a bladder tumor-targeting peptide having an amino acid sequence represented by SEQ ID NO: 7 and use thereof. The peptide according to the present invention is capable of specific binding to bladder tumor cells in vivo and in vitro. The peptide according to the present invention or an antibody thereof is useful for a marker for the diagnosis of bladder tumors, and for a drug carrier targeting bladder tumor.

The invention provides a novel transurethral bladder tumor electrocision electrode with a hook-shaped structure. The electrocision electrode comprises a urethral catheter which is smooth in appearanceand free of sharp protruding structures, a sight glass tube and an electrode catheter are arranged in the urethral catheter, an indwelling device sleeving the outer wall of the electrode catheter isarranged in the urethral catheter, and the electrode catheter is slidably connected to the indwelling device through a sliding way; hollow bearings are symmetrically fixed to the two ends of the interior of the electrode catheter, a cable catheter penetrates through the interior of each of the two sets of bearings, and the end, placed in the bladder, of the cable catheter is connected to an electrocision electrode of a hook-shaped structure; the electrocision electrode is convenient to rotate and adjust in the angle direction, the urethral catheter is stably attached to the urethra in the adjusting process, and damage of the catheter to the urethral wall is reduced; and the electrocision electrode is of a hook-shaped structure, the contact surface between the electrocision electrode and atumor is reduced, burn damage to the inner wall of the bladder is reduced during electrocision, the hook end of the hook-shaped structure can lift and tear the tumor to separate the tumor from the inner wall of the bladder, and the electrocision electrode is convenient to use.

The invention belongs to the technical field of biological medicine, and discloses a bladder targeted drug-loaded exosome and application as well as a drug for treating bladder diseases. The drug for treating bladder diseases is introduced into the exosome with bladder tissue targeting property to obtain the exosome, and the exosome with bladder tissue targeting property is derived from kidney cells; and a bladder tumor treatment drug contains the bladder targeted drug-loaded exosome. Compared with the prior art, the exosome secreted by the kidney cells can be enriched in the bladder tissue without any modification, the exosome derived from the kidney cells is used, the problem of exosome yield is solved, and the application prospect is very good; and the exosome from the kidney cells can be used for loading different drugs or active molecules, through targeted bladder tissue administration, the treatment effect on bladder diseases is improved, and toxic and side effects of the drugs are reduced.

The invention discloses an anchor type bipolar electric cutting ring, and belongs to the field of urological surgical instruments. The ring comprises a Y-shaped power transmission rod and an anchor type cutting electrode, the cutting electrode comprises a T-shaped conductive rod and an arc-shaped electrode fixed to a bottom end of a T-shaped conductive rod, two ends of the arc-shaped electrode aretip ends, and the two ends of the upper portion of the T-shaped conductive rod are respectively connected to the Y-shaped power transmission rod through a connecting pipe. The arc surface of the arc-shaped electrode can perform the cutting of a large area of a bladder tumor, the end of the arc-shaped electrode can be used for achieving the whole piece cutting of the tumor, the anchor-shaped bipolar electric cutting ring has the advantages of a ring electrode and a needle electrode, the two ends can adjust the curvature and angle according to the needs so as to facilitate the cutting of tumorsin various parts of a bladder, frequent replacement of the electric cutting equipment during the operation is avoided, 'no dead angle and blind area' are achieved, and the ring shortens the operationtime, reduces the pain of patients, and provides a guarantee for accurate pathological staging.

The invention provides an externally-applied traditional Chinese medicine for treating carcinoma of urinary bladder. The externally-applied traditional Chinese medicine for treating carcinoma of urinary bladder is composed of main medicine and auxiliary medicine, wherein the main medicine is composed of thirty-eight medicine raw materials such as astragalus membranaceus, hairyvein agrimony, bighead atractylodes rhizome and glossy privet fruit, and the auxiliary medicine is composed of red flowers, liquorice and mature Shanxi vinegar. The externally-applied traditional Chinese medicine can be used for remarkably restraining bladder tumors and has the advantages of being safe, effective, capable of becoming effective rapidly, easy to operate, capable of making patients be free of pain, and economical.

The invention belongs to the technical field of medicine, and particularly relates to polymer composite hydrogel for treating bladder tumor and a preparation method and application. The composite hydrogel comprises freeze-dried polymer material powder, guanidine active substances for treating bladder tumor and normal saline, wherein the polymer material is one or a mixture of chitosan and chitin.The composite hydrogel improves the cell interaction and drug absorption of mucous membrane tissues such as bladder walls, prolongs the drug action time, achieves the slow release effect, and enablesthe effect of treating bladder tumors in a perfusion administration mode to be better.