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Aluminium sulfate for injection and aluminium sulfate injection for treating bladder tumor

A technology for aluminum sulfate and injection, which is used in antitumor drugs, active ingredients of aluminum/calcium/magnesium, drug delivery, etc., and can solve the problems of inability to use injections, inaccurate amount of aluminum sulfate, and unstable aluminum sulfate content.

Active Publication Date: 2005-10-19
GENERAL HOSPITAL OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The currently used aluminum sulfate is aluminum sulfate with certain water molecules. Its heavy metal and iron salt content is high, and it is unstable in aqueous solution, so the content of aluminum sulfate is unstable. When it is used in injections, the amount of aluminum sulfate is inaccurate. And due to the side effects caused by heavy metals and iron salts, it cannot be used for injections

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Preparation of aluminum sulfate for injection

[0024] Weigh 800g (1.20mol) of aluminum sulfate as a water purifier, dissolve it in 1090ml of distilled water, filter, and add 380ml of concentrated sulfuric acid (containing H 2 SO 4 6.62mol), the solution was heated to 72°C, stirred and cooled in a water bath at 50°C to crystallize, and stirred at this temperature for 1 hour. Then, the temperature was lowered to room temperature at a rate of 3-5°C / hour, and stirring was continued for 1 hour. Suction filtration, washing with 95% ethanol for 3 times, and drying at room temperature to obtain 653 g of flake crystals with a yield of 81.6%. Weigh 600g (0.90mol) of the above crystalline aluminum sulfate, dissolve it in 1000ml distilled water, filter, add 367ml concentrated sulfuric acid (containing H 2 SO 4 6.62mol), the same method as above for crystallization. It was filtered with suction, washed with 95% ethanol, and dried at room temperature to obtain 496 g of flake crystals wi...

Embodiment 2

[0025] Example 2 Injection of 7.2% aluminum sulfate

[0026] Accurately weigh 3.6 g of aluminum sulfate obtained in Example 1, 0.75 g of lidocaine hydrochloride, 1 mg of methylene blue, add water for injection to 50 ml, filter, fill in a 10 ml ampoule, seal, and sterilize with steam at 100°C for 30 minutes to obtain An injection with an aluminum sulfate content of 7.2%.

Embodiment 3

[0027] Example 3 10.8% aluminum sulfate injection

[0028] Precisely weigh 5.4 g of aluminum sulfate obtained in Example 1, 0.75 g of lidocaine hydrochloride, 1 mg of methylene blue, add water for injection to 50 ml, filter, fill in a 10 ml ampoule, seal, and sterilize with steam at 100°C for 30 minutes to obtain An injection with an aluminum sulfate content of 10.8%.

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PUM

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Abstract

The present invention relates to aluminum sulfate for injection and aluminum sulfate injection for treating bladder tumor. The aluminum sulfate injection for treating bladder tumor includes aluminum sulfate for injection, local anesthetic, colorizing agent and water for injection. The aluminum sulfate for injection has heavy metal content not more than 0.0005 wt%, iron salt content not more than 0.004 wt% and arsenic salt content not more than 0.0001 wt%. The present invention also relates to the preparation process of the aluminum sulfate for injection.

Description

Technical field [0001] The invention relates to aluminum sulfate for injection, and aluminum sulfate injection for treating tumors. The aluminum sulfate injection includes aluminum sulfate for injection, local anesthetics, colorants and water for injection. The content of heavy metals in the injected aluminum sulfate is 0.0005%≤, and the content of iron salt is 0.004%. ≤, arsenic salt content 0.0001%≤. The invention also relates to a preparation method of aluminum sulfate for injection. Background technique [0002] At present, the treatment of bladder tumors is mainly local treatment, and the effect of systemic treatment is not good. There are four main treatment methods: surgery, radiotherapy, chemotherapy and immunotherapy. Li Luxia, Zhu Xiaoling, Liu Xiaorong, et al. in "Journal of Practical Nursing" 1997; 13(9):468-469. "The nursing and curative effect observation of 318 cases of bladder cancer postoperative bladder perfusion." He Zuo Yanan. "Journal of Suzhou Medical Colleg...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K33/06A61P35/00
Inventor 徐风华郭德嵩王晓雄
Owner GENERAL HOSPITAL OF PLA
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