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Test paper for fast detecting carcinoma of urinary bladder

A technology for detecting test strips and bladder cancer, which is applied in the field of test strips for rapid diagnosis of bladder cancer. It can solve the problems of many factors affected by urine exfoliation cytology examination, it is not easy for patients to accept and persist, and the positive rate is low, so as to overcome the lack of sensitivity, Inexpensive, highly sensitive and specific effects

Inactive Publication Date: 2016-08-24
刘晓强 +4
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Problems solved by technology

[0002] At present, the diagnosis of bladder cancer, especially the monitoring of postoperative recurrence, is mainly based on urine exfoliated cytology and cystoscopic biopsy, but urine exfoliated cytology is affected by many factors, and the positive rate is low; although cystoscopy is the most reliable Diagnostic method, but it is an invasive operation, has certain trauma and complications, and is not easy to be accepted and adhered to by patients

Method used

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  • Test paper for fast detecting carcinoma of urinary bladder
  • Test paper for fast detecting carcinoma of urinary bladder
  • Test paper for fast detecting carcinoma of urinary bladder

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Experimental program
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Embodiment Construction

[0031] 1. Preparation of test strips for rapid detection of bladder cancer

[0032] attached figure 2 It is a schematic diagram of the vertical section structure of the test paper for rapid detection of bladder cancer. The test paper consists of a three-channel bottom plate 1, and a sample pad 2, a gold standard pad 5, a nitrocellulose membrane 6, and an absorbent paper 7 covered sequentially on the three-channel bottom plate. The three-channel bottom plate 1 is a PVC bottom plate containing three micropipes, the material of the sample pad 2 is made of water-absorbing glass fiber, and the gold standard pad 5 is sprayed with three kinds of gold standard antibody complex solutions on the glass fiber membrane Composition, its width is 1-2cm, spraying amount is 3ul / cm. On the nitrocellulose membrane 6, at a distance of 1cm from the gold standard pad, the three tumor marker systems were sprayed with anti-NMP22, anti-CEACAM1, and anti-BTA polyron antibodies to form the detection a...

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Abstract

The invention relates to test paper for fast detecting carcinoma of urinary bladder. The test paper is combined test paper capable of detecting three kinds of carcinoma of urinary bladder markers, namely, nuclear matrix protein 22 (NMP22), bladder tumor antigens (BTA stat) and carcino-embryonic antigen relevant cell adhesion molecules (CEACAM1) at the same time. The test paper comprises a three-channel bottom plate, a sample adding pad, a gold standard pad, a nitrocellulose membrane and an absorbent paper layer. The three-channel bottom plate is sequentially coated with the sampling pad, the gold standard pad, the nitrocellulose membrane and the absorbent paper layer, and NMP22, BTA, CEACAM1 resisting protein monoclonal gold-labeled antibodies are contained in the gold-labeled pad. The three-channel bottom plate achieves specimen flow division through three fine tubes, and detection of the three kinds of markers is independent from one another. The test paper is fast in detecting, high in sensitivity, high in specificity, good in stability, easy and convenient to operate, visual and reliable in result judgment and easy to master. The test paper can be used for screening of high-risk groups, can also be used for follow-up visiting of carcinoma of urinary bladder postoperative patients, and is very wide in application range.

Description

technical field [0001] The invention is a test paper, specifically a test paper that can quickly diagnose bladder cancer. The test paper is a method for simultaneously detecting nuclear matrix protein 22 (NMP22), carcinoembryonic antigen-related cell adhesion molecule (CEACAM1) and bladder tumor antigen ( BTA stat) combined test strip of three bladder cancer markers. Background technique [0002] At present, the diagnosis of bladder cancer, especially the monitoring of postoperative recurrence, is mainly based on urine exfoliated cytology and cystoscopic biopsy, but urine exfoliated cytology is affected by many factors, and the positive rate is low; although cystoscopy is the most reliable Diagnostic method, but it is an invasive operation, has certain trauma and complications, and is not easy to be accepted and adhered to by patients. [0003] Studies have shown that NMP22 belongs to one of the nuclear matrix protein family, also known as mitotic phase protein. It plays a...

Claims

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Application Information

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IPC IPC(8): G01N33/68G01N33/574
Inventor 刘晓强刘莉陈业刚王尚任杨永姣
Owner 刘晓强
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