Method of manufacture of garlic extract for use as a preventive and therapeutic agent for human prostate and bladder cancers

Abstract

This invention is concerned with clinical investigation of therapeutic effects of garlic extracts containing allicin, diallyl disulfide, and diallyl trisulfide. Because the intake of garlic or therapeutically active substance such as allicin from garlic, induces immunostimulation and possess strong antitumor effects concomitant with apoptosis of tumors that can in turn induces a programmed cell death of human prostatic and bladder tumor cells. This invention claims that garlic and / or garlic extracts possess very effective therapeutic substances not only to treat human prostate and bladder cancers to extend life span of patients, but also to suppress or prevent bladder and prostate gland cancers.

Description

BACKGROUND OF THE NVENTION[0001] 1. Field of the Invention[0002] This invention is related to new therapeutic application of garlic extracts containing allicin, diallyl disulfide, trisulfide, etc. more specifically against human prostate gland and bladder tumors. This therapeutic application relates to strong immunostimulation mediated anticancer effects elicited by allicin, diallyl disulfide, and diallyl trisulfide in garlic extracts, and subsequently induces programmed prostate and bladder cancer cell death.[0003] 2. Description of the Prior Art[0004] Prostate cancer death in the U.S and Europe is the most prevalent and the second highest cancer death among male population. As of aged-male populations increases and importation of advanced diagnostic techinique for prostate cancer in Korea, together with increased consumption of dairy products, and a dramatic changes in dietary habits are associated closely with increase in male prostate cancer patients and increase in male mortali...

AI Technical Summary

Problems solved by technology

Unfortunately, when many of the patients are diagnosed as a prostate cancers, prostate tumors are already metastasized to bone marrow, and lymph nodes and such cases, only treatment mode left is hormonal therapy (either radical orchiectomy of both testes and / or continued injection of LHRH analogues) to which, most of the patients respond well to primary treatment, however, more than half of the patients develop resistance to hormonal treatment and unfortunately, these patients die within one year to a year and a half.

The repeated resection lead to a higher incidence of complication such as urethra stricture, bladder perforation, and a severe inflammation.

Nonetheless, extreme bloody urine, and inflammation of urethra ensu further complicates and cannot stop the continued progression of bladder cancers.

Furthermore, in case of invasive bladder cancers, a radical resection of bladder is required and the use of an artificial bladder is required and cause not only severe inconvenience of daily livelihood of patients, but also often leads to postsurgical complications.

When patients are diagnosed as metastasized bladder cancers, only treatment course left is to treat the patients with aggressive chemotherapy, but leads to severe complications.

Despite the aggressive chemotherapy, the prognosis of patients are not so good.

Furthermore, direct administration of garlic extracts containing allicin directly into tumor vessels can directly regulate a local cellular immunologic response along with activation of humoral immune response, which in turn immediately leads to programmed endothelial cell deaths in both prostatic and bladder tumor masses and thereby, block tumor growth.

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