43 results about "Prostate excision" patented technology

Methods and systems are provided that use clinical information, molecular information and computer-generated morphometric information in a predictive model for predicting the occurrence (e.g., recurrence) of a medical condition, for example, cancer. In an embodiment, a model that predicts prostate cancer recurrence is provided, where the model is based on features including seminal vesicle involvement, surgical margin involvement, lymph node status, androgen receptor (AR) staining index of tumor, a morphometric measurement of epithelial nuclei, and at least one morphometric measurement of stroma. In another embodiment, a model that predicts clinical failure post prostatectomy is provided, wherein the model is based on features including biopsy Gleason score, lymph node involvement, prostatectomy Gleason score, a morphometric measurement of epithelial cytoplasm, a morphometric measurement of epithelial nuclei, a morphometric measurement of stroma, and intensity of androgen receptor (AR) in racemase (AMACR)-positive epithelial cells.

The method disclosed may be used following a prostatectomy may comprise inserting an instrument having an end effector into the bladder lumen via the urethra; using the end effector to urge the bladder wall to the pelvic floor and drive an anchor through the bladder wall into the pelvic floor, thereby connecting a balloon harness within the bladder to the pelvic floor; withdrawing the end effector; inserting and inflating a balloon catheter within the balloon harness, thereby pressing the bladder wall surrounding the bladder opening against the pelvic floor; maintaining the balloon catheter in place and draining the bladder during the time required for the tissues to effectively knit; and then deflating and withdrawing the balloon catheter and disconnecting and withdrawing the balloon harness. The instrument may comprise one or more tubes that support an end effector comprising a positioner and an anchor driver.

Methods and systems are provided that use clinical information, molecular information and computer-generated morphometric information in a predictive model for predicting the occurrence (e.g., recurrence) of a medical condition, for example, cancer. In an embodiment, a model that predicts prostate cancer recurrence is provided, where the model is based on features including one or more (e.g., all) of biopsy Gleason score, seminal vesicle invasion, extracapsular extension, preoperative PSA, dominant prostatectomy Gleason grade, the relative area of AR+ epithelial nuclei, a morphometric measurement of epithelial nuclei, and a morphometric measurement of epithelial cytoplasm. In another embodiment, a model that predicts clinical failure post-prostatectomy is provided, wherein the model is based on features including one or more (e.g., all) of dominant prostatectomy Gleason grade, lymph node invasion status, one or more morphometric measurements of lumen, a morphometric measurement of cytoplasm, and average intensity of AR in AR+ / AMACR− epithelial nuclei.

The present invention relates to the identification of four cytokine biomarkers in prostatic tissue that exhibit differential expression following prostatectomy that, in combination at least one other factor, are able to reliably predict the development of biochemical recurrence following surgery. This marker combination improves the risk stratification of patients after primary local treatment for localized prostate cancer.

Embodiments for an anchor for use in effecting the anastomosis of a patient's bladder and urethra following a prostatectomy are disclosed. The anchor may comprise a shaft with a lodging structure. Alternative embodiments may include a penetration limiting structure, a driver interface proximate to a rearward end, a forward end with a penetration facilitating shape that may comprise a point defined by three flat intersecting faces, a bioabsorbable portion of one or more bioabsorbable materials, and a metal portion of one alloy, or a plurality of alloys which may have differing expansion properties.

Methods and systems are provided that use clinical information, molecular information and computer-generated morphometric information in a predictive model for predicting the occurrence (e.g., recurrence) of a medical condition, for example, cancer. In an embodiment, a model that predicts prostate cancer recurrence is provided, where the model is based on features including one or more (e.g., all)of biopsy Gleason score, seminal vesicle invasion, extracapsular extension, preoperative PSA, dominant prostatectomy Gleason grade, the relative area of AR+ epithelial nuclei, a morphometric measurement of epithelial nuclei, and a morphometric measurement of epithelial cytoplasm. In another embodiment, a model that predicts clinical failure post-prostatectomy is provided, wherein the model is based on features including one or more (e.g., all) of dominant prostatectomy Gleason grade, lymph node invasion status, one or more morphometric measurements of lumen, a morphometric measurement of cytoplasm, and average intensity of AR in AR+ / AMACR- epithelial nuclei.

Methods and systems are provided that use clinical information, molecular information and computer-generated morphometric information in a predictive model for predicting the occurrence (e.g., recurrence) of a medical condition, for example, cancer. In an embodiment, a model that predicts prostate cancer recurrence is provided, where the model is based on features including seminal vesicle involvement, surgical margin involvement, lymph node status, androgen receptor (AR) staining index of tumor, a morphometric measurement of epithelial nuclei, and at least one morphometric measurement of stroma. In another embodiment, a model that predicts clinical failure post prostatectomy is provided, wherein the model is based on features including biopsy Gleason score, lymph node involvement, prostatectomy Gleason score, a morphometric measurement of epithelial cytoplasm, a morphometric measurement of epithelial nuclei, a morphometric measurement of stroma, and intensity of androgen receptor (AR) in racemase (AMACR)-positive epithelial cells.

A method and system method and system automated digital image analysis of prostrate neoplasms using morphologic patterns. The method and system provide automated screening of prostate needle biopsy specimens in a digital image and automated diagnosis of prostatectomy specimens.

The instrument disclosed may comprise a tube assembly supporting an end effector that may be adapted for insertion into and through the urethra, and adapted for use in effecting the anastomosis of a patient's bladder and urethra following a prostatectomy. In one embodiment the end effector may comprise a positioner having an extendable and retractable petal operably connected to a tube, and an anchor driver. In another embodiment the end effector may comprise a positioner and an anchor driver having a driver pin operably connected to a tube.

The instrument disclosed may comprise a tube assembly supporting an end effector that may be adapted for insertion into and through the urethra, and adapted for use in effecting the anastomosis of a patient's bladder and urethra following a prostatectomy. In one embodiment the end effector may comprise a positioner having a positioner arm that is extendable and retractable by rotation of a tube, and an anchor driver. In another embodiment the end effector may comprise a positioner and an anchor driver having a driver arm that is extendable and retractable by rotation of a tube.

The instrument disclosed may comprise a tube assembly further comprising substantially coaxially situated and relatively longitudinally movable tubes, supporting and operating an end effector that may be adapted for insertion into and through the urethra, and adapted for use in effecting the anastomosis of a patient's bladder and urethra following a prostatectomy. In alternative embodiments the tube assembly may comprise a rod and two tubes, three tubes, a rod and three tubes, or four tubes. The method disclosed may comprise inserting an instrument having an end effector into the bladder lumen, and using the end effector to urge the bladder wall to the pelvic floor and drive an anchor through the bladder wall and into the pelvic floor.

The method disclosed may be used following a prostatectomy may comprise inserting an instrument having an end effector into the bladder lumen via the urethra; using the end effector to urge the bladder wall to the pelvic floor and drive an anchor through the bladder wall into the pelvic floor, thereby connecting a balloon harness within the bladder to the pelvic floor; withdrawing the end effector; inserting and inflating a balloon catheter within the balloon harness, thereby pressing the bladder wall surrounding the bladder opening against the pelvic floor; maintaining the balloon catheter in place and draining the bladder during the time required for the tissues to effectively knit; and then deflating and withdrawing the balloon catheter and disconnecting and withdrawing the balloon harness. The instrument may comprise one or more tubes that support an end effector comprising a positioner and an anchor driver.

The method disclosed may be used following a prostatectomy, and may comprise inserting an instrument into the bladder lumen through incisions in the abdomen and bladder wall; using an end effector thereon to urge the bladder wall to the pelvic floor and align the openings of the bladder and urethra, and drive an anchor through the bladder wall into the pelvic floor, thereby connecting a balloon harness to the pelvic floor; inflating a balloon within the harness, which holds the bladder wall surrounding the bladder opening against the pelvic floor; maintaining the balloon in place and draining the bladder via a catheter during the time required for the tissues to effectively knit; and then deflating the balloon, disconnecting the harness, and withdrawing the instrument. The instrument may comprise one or more tubes that support an end effector comprising a positioner, an anchor driver, a harness, a balloon and a catheter.

A catheter system suitable for use in suprapubic prostatectomy is provided. The catheter system includes a multi-lumen tube having a plurality of lumens, the multi-lumen tube further comprising a plurality of outlet openings positioned on a first lumen, which are used to facilitate passage of fluid out of the urinary bladder, at least an inlet opening positioned on a second lumen, which is used to facilitate passage of fluid in to the urinary bladder, and an expandable balloon connected to the distal end of the multilumen tube. The catheter system is fixed inside the prostatic lodge, wherein the distal end of the catheter system is positioned in the urethra and is blocked to prevent leakage of fluid through the urethra. The expandable balloon, positioned inside the prostatic lodge, applies pressure on the walls of the prostatic capsule and thus helps in controlling bleeding.

We present, in exemplary embodiments of the present invention, a system combining optical imaging technologies with anatomical imaging technologies (e.g., MR, ultrasound). The system can be used for a variety of applications, including, but not limited to, (1) cancer diagnosis and staging; (2) image guidance; and (3) radiation therapy planning. Image guidance may include guiding a biopsy. For example, a prostatectomy potentially has severe side effects, such as impotence and incontinence. Thus, a histologically-confirmed diagnosis, such as one provided from a biopsy, may prevent unnecessary prostatectomy. Image guidance may also include guiding minimal invasive therapy, such as brachytherapy focused ultrasound. The present invention may be used to plan radiation therapy, for example, by detecting, and thus sparing, healthy tissue from radiation exposure.

The invention discloses an endoscope used for prostate operations, which comprises an endoscope body, wherein a light source port and an observation mirror are installed on the endoscope body. The endoscope is characterized in that the endoscope body is perpendicular to the observation mirror; a closer and an anti-reflux sealing cap are sequentially connected at the rear part of the endoscope body; a cavity on which changeable surgical instruments are put is arranged in the endoscope body; a treatment channel for the surgical instruments to pass through is connected at the front part of the endoscope body; and two carbon dioxide inlet valves are arranged at the front part of the endoscope body. The closer is provided with more than three pore canals for the surgical instruments to pass through for operation. The endoscope can be used in prostatectomy, resection of bladder tumors, vesical diverticulectomy, ureterocystostom and the like, and has the good effects that the endoscope can provide the doctor with a clear picture of the affected part before the operation, and with the endoscope, the doctor can operate with both hands to finish the highly difficult operations of resection, suture and the like, thus providing convenience for the doctor to conduct medical operations.

We present, in exemplary embodiments of the present invention, a system combining anatomical imaging technologies (e.g., MR) with molecular imaging technologies (e.g., ultrasound). The system can be used for a variety of applications, including, but not limited to, (1) cancer diagnosis and staging; (2) image guidance; and (3) radiation therapy planning. Image guidance may include guiding a biopsy. For example, a prostatectomy potentially has severe side effects, such as impotence and incontinence. Thus, a histologically-confirmed diagnosis, such as one provided from a biopsy, may prevent unnecessary prostatectomy. Image guidance may also include guiding minimal invasive therapy, such as brachytherapy focused ultrasound. The present invention may be used to plan radiation therapy, for example, by detecting, and thus sparing, healthy tissue from radiation exposure.

The invention discloses a navel dressing and nursing agent used for treatment after prostatectomy, aiming to solve the problem of treatment after prostatectomy. The navel dressing and nursing agent used for treatment after prostatectomy is characterized by being prepared from a variety of Chinese medicinal herbs (raw materials) in parts by weight: 6-10 parts of timothy grass, 8-15 parts of holy basil, 8-15 parts of asarum pulchellum, 6-10 parts of Viola arcuata, 6-10 parts of betula luminifera bark, 8-15 parts of jasminum grandiflorum, 6-10 parts of allium caelureum, 8-15 parts of fructus liquidambaris and 3-6 parts of gorgon euryale seed. The clinical experiments prove that the navel dressing and nursing agent used for treatment after prostatectomy has the characteristics of good curative effect and high safety and is worthy of clinical application and popularization.

The invention provides a device for urethral anastomosis, for example, following prostatectomy. The device has a flexible slender shaft including a flexible outer sleeve and a flexible inner sleeve inside a lumen of the outer sleeve. A bladder anchoring system anchors the distal end of the inner sleeve inside a urinary bladder, and a urethral anchoring system anchors the outer sleeve in a urethral stump. A ratchet mechanism allows proximal movement of the inner sleeve inside the outer sleeve while preventing distal movement of the inner sleeve inside the outer sleeve. The device is used to urge the urinary bladder towards the internal termination of the urethra to allow anastomosis of the bladder neck to the urethral stump.

Provided is a device for urethral anastomosis, for example, following prostatectomy. The device has a flexible slender shaft including a flexible outer sleeve and a flexible inner sleeve inside a lumen of the outer sleeve. A bladder anchoring system anchors the distal end of the inner sleeve inside a urinary bladder, and a urethral anchoring system anchors the outer sleeve in a urethral stump. A ratchet mechanism allows proximal movement of the inner sleeve inside the outer sleeve while preventing distal movement of the inner sleeve inside the outer sleeve. The device is used to urge the urinary bladder towards the internal termination of the urethra to allow anastomosis of the bladder neck to the urethral stump.

An assisted anastomosis apparatus and a method thereby for reconnecting the urethral stump to the neck of the bladder after removal of the prostate during a prostatectomy, comprising two suture units, namely a urethral stump suturing unit (1a) and a bladder suturing unit (1b), at least a section of said urethral stump suturing unit (1a) has suitable dimensions to be introduced into a bladder neck and at least a section of said bladder suturing unit (1b) has suitable dimensions to be introduced into a urethral stump; such that each needle pulls the suture leading from its equivalent position on the urethral stump through the wall of the bladder neck.

The invention discloses an induction urinary catheterization traction tube device which has no impact on urination and has effects of intelligently compressing wound surface traumatic cavity after electro-prostatectomy and laser electrotomy and stopping surgical wound bleeding. A balloon on a tube body automatically squeezes a surgical wound of a patient to prevent continuous bleeding of the surgical wound; an intelligent induction device is linked with a traction box and automatically adjusts the electric traction box according to the number of red blood cells in urine and tightens a tractionpull rope to enable an airbag to compress the wound surface to stop bleeding, so that urethra of the patient is supported effectively, the surgical wound is compressed, the urine is drained and discharged, bleeding is stopped effectively, all defects of conventional rubber strip traction including that pressure cannot be quantified and intelligently adjusted and can only be adjusted according toexperience of nurses and doctors and compression bleeding stopping and rubber strip elasticity coefficient cannot by quantified due to inconvenience in movement and tension loss after movement causedby the fact that one ends of rubber strips are tied on feet of patients are avoided, and rehabilitation and health of the patients are benefitted better.

We present, in exemplary embodiments of the present invention, a system combining anatomical imaging technologies (e.g., MR) with optical technologies. The system can be used for a variety of applications, including, but not limited to, (1) cancer diagnosis and staging; (2) image guidance; and (3) radiation therapy planning. Image guidance may include guiding a biopsy. For example, a prostatectomy potentially has severe side effects, such as impotence and incontinence. Thus, a histologically-confirmed diagnosis, such as one provided from a biopsy, may prevent unnecessary prostatectomy. Image guidance may also include guiding minimal invasive therapy, such as brachytherapy focused ultrasound. The present invention may be used to plan radiation therapy, for example, by detecting, and thus sparing, healthy tissue from radiation exposure.

We present, in exemplary embodiments of the present invention, a system combining anatomical imaging technologies (e.g., MR) with optical technologies. The system can be used for a variety of applications, including, but not limited to, (1) cancer diagnosis and staging; (2) image guidance; and (3) radiation therapy planning. Image guidance may include guiding a biopsy. For example, a prostatectomy potentially has severe side effects, such as impotence and incontinence. Thus, a histologically-confirmed diagnosis, such as one provided from a biopsy, may prevent unnecessary prostatectomy. Image guidance may also include guiding minimal invasive therapy, such as brachytherapy focused ultrasound. The present invention may be used to plan radiation therapy, for example, by detecting, and thus sparing, healthy tissue from radiation exposure.

The invention relates to a portable uroclepsia cleaning device for males purposely for male old people, uroclepsia patients and patients after prostatectomy. Water absorbing staple is filled in a triangular impermeable cloth urine bag buckled on the front end of a waistband so that urine drips into the water absorbing staple in the impermeable cloth urine bag after putting into penis. Thus, the urine bag can be kept dry, comfortable and clean. The invention is continent to carry and replace by users at any time in daily life and outdoors, and can be used repeatedly.

An assisted anastomosis apparatus and a method thereby for reconnecting the urethral stump to the neck of the bladder after removal of the prostate during a prostatectomy, comprising two suture units, namely a urethral stump suturing unit (1a) and a bladder suturing unit (1b), at least a section of said urethral stump suturing unit (1a) has suitable dimensions to be introduced into a bladder neck and at least a section of said bladder suturing unit (1b) has suitable dimensions to be introduced into a urethral stump; such that each needle pulls the suture leading from its equivalent position on the urethral stump through the wall of the bladder neck.

An apparatus for perineal retraction during a prostatectomy includes a handle portion with a first end, a second end and a curvilinear segment between the first and second end. The second end faces in a direction toward the first end. The apparatus also includes a head portion including a first surface on one side of the head portion and a second surface on an opposite side of the head portion, the second surface being connected to or engageable with the second end of the handle. Use of the apparatus for perineal retraction during prostatectomy is also described.

The invention belongs to the technical field of intelligent assistance for medical operation, and discloses an FPGA-based intelligent early warning method for BPH (benign postatic hperplasia) bipolarprostatectomy. The method comprises the following steps: constructing a prostate capsule tissue detection module arranged on an FPGA based on a Squeezenet network; acquiring a real-time operation image and transmitting the real-time operation image to the FPGA; detecting prostate capsule tissue on the real-time operation image by a prostate capsule tissue detection module to obtain early warning information. Doctors can be assisted to operate in BPH (benign postatic hperplasia) bipolar prostatectomy, early warning information can be given in time, excessive resection is avoided, and the operation error rate is reduced.

The invention belongs to the technical field of surgery assisting, and discloses an artificial intelligence-based early warning method for BPH (benign prostatic hyperplasia) bipolar prostatectomy. Themethod comprises the following steps: constructing a squeezenet network; acquiring data and establishing a data set; importing the squeezenet network and the data set into the TensorFlow framework, and using the data set to train the squeezenet network to generate an early warning model; inputting a medical image; calibrating the capsule position in the medical image according to the early warning model. Doctors can be assisted to perform judgment more accurately and rapidly, the risk of excessive prostate capsule incision caused by lack of operation experience of the surgery doctors is reduced, and the success rate of surgery is increased.

Composition comprising chitosan for use in the prevention and / or treatment of incontinence and / or impotence in a subject undergoing prostatectomy.