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Chinese medicinal composition, preparation method and application thereof

A composition and technology of traditional Chinese medicine, applied in the direction of drug combination, medical formula, plant raw materials, etc., can solve problems such as few, unoptimistic mental health problems, lack of significant curative effect and other adverse reactions, and achieve antagonism of drooping eyelids and hypothermia, shortening Effects of Tail Suspension and Forced Swimming Immobility Time, Good Antidepressant Efficacy

Inactive Publication Date: 2014-10-15
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

A survey in 2012 showed that in China, the public’s mental health problems are not optimistic. More than 26 million people suffer from different degrees of depression, but 90% of patients are not aware of the disease
[0006] Since ancient times, my country’s traditional Chinese medicine has accumulated rich experience in the prevention and treatment of depression. Traditional Chinese medicine compound prescriptions for depression have the advantages of long-term use without causing various adverse reactions caused by synthetic drugs, and good treatment compliance of patients. However, the current market There are not many antidepressant Chinese patent medicines on the Internet, and there is still a lack of Chinese patent medicines with significant curative effect and small adverse reactions for the treatment of depression

Method used

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  • Chinese medicinal composition, preparation method and application thereof
  • Chinese medicinal composition, preparation method and application thereof
  • Chinese medicinal composition, preparation method and application thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] The preparation of embodiment 1 granule

[0032] Weigh each raw material according to the following weight: Poria 200g, Pinellia 200g, Bupleurum 200g, Citrus aurantium 200g, Radix Paeoniae Alba 200g, Magnolia officinalis 200g, Licorice 120g, Gardenia 200g, Perilla leaf 200g;

[0033] After mixing the above medicines, soak in 8 times the weight of water for 2 hours, then decoct with a slow fire for 0.5 hours, filter, add 8 times the weight of water for the second time, cook with a slow fire for 0.5 hours, filter, combine the filtrates, and concentrate the filtrate to 60 When the relative density is 1.10-1.12 when measured at ℃, a concentrated solution is obtained; the prepared concentrated solution is dried under reduced pressure at a pressure of 0.06-0.08Mpa and a temperature of 80°C to obtain a dry extract; the dry extract is crushed and passed through 80°C Mesh sieve, add appropriate amount of dextrin, mix thoroughly, make granules, and dry to obtain.

Embodiment 2

[0034] The preparation of embodiment 2 tablet

[0035] Weigh each raw material according to the following weight: Poria 200g, Pinellia 200g, Bupleurum 200g, Citrus aurantium 200g, Radix Paeoniae Alba 200g, Magnolia officinalis 200g, Licorice 120g, Gardenia 200g, Perilla leaf 200g;

[0036] After mixing the above medicines, soak in 8 times the weight of water for 2 hours, then decoct with a slow fire for 0.5 hours, filter, add 8 times the weight of water for the second time, cook with a slow fire for 0.5 hours, filter, combine the filtrates, and concentrate the filtrate to 60 When the relative density is 1.10-1.12 when measured at ℃, a concentrated solution is obtained; the prepared concentrated solution is dried under reduced pressure at a pressure of 0.06-0.08Mpa and a temperature of 80°C to obtain a dry extract; the dry extract is crushed and passed through 80°C Mesh sieve, add appropriate amount of dextrin, granulate, dry, granulate, compress into tablets to make tablets. ...

Embodiment 3

[0037] The preparation of embodiment 3 capsules

[0038] Weigh each raw material according to the following weight: Poria 200g, Pinellia 200g, Bupleurum 200g, Citrus aurantium 200g, Radix Paeoniae Alba 200g, Magnolia officinalis 200g, Licorice 120g, Gardenia 200g, Perilla leaf 200g;

[0039] After mixing the above medicines, soak in 8 times the weight of water for 2 hours, then decoct with a slow fire for 0.5 hours, filter, add 8 times the weight of water for the second time, cook with a slow fire for 0.5 hours, filter, combine the filtrates, and concentrate the filtrate to 60 When the relative density is 1.10-1.12 when measured at ℃, a concentrated solution is obtained; the prepared concentrated solution is dried under reduced pressure at a pressure of 0.06-0.08Mpa and a temperature of 80°C to obtain a dry extract; the dry extract is crushed and passed through 80°C Mesh sieve, add appropriate amount of dextrin, granulate, dry, granulate, pack into capsules to make capsules. ...

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Abstract

Belonging to the technical field of traditional Chinese medicines and natural drugs, the invention specifically relates to a Chinese medicinal composition, a preparation method and application thereof. The Chinese medicinal composition is characterized by being prepared from the following Chinese herbal medicines by weight: 10-40 parts of poria, 10-40 parts of pinellia ternata, 10-40 parts of radix bupleuri, 10-40 parts of Fructus aurantii Immaturus, 10-40 parts of Radix Paeoniae Alba, 10-40 parts of Magnolia officinalis, 6-24 parts of licorice, 10-40 parts of gardenia, and 10-40 parts of perilla leaf. The Chinese medicinal composition provided by the invention can be prepared into clinically suitable oral preparations according to traditional Chinese medicine conventional preparation methods. The Chinese medicinal composition significantly shortens the immobility time of mouse tail suspension and forced swimming, significantly increases the hand shaking time of mice given 5-hydroxytryptophan, has a significant antagonistic effect on mouse blepharoptosis and hypothermia caused by reserpine, and significantly antagonizes mouse body temperature decline caused by high dose apomorphine. According to the invention, research results show that the Chinese medicinal composition has a significant anti-mouse experimental depression effect.

Description

technical field [0001] The invention relates to a pharmaceutical composition, in particular to a traditional Chinese medicine composition and its preparation method and application, and belongs to the field of traditional Chinese medicine. Background technique [0002] Depression is a common mental illness, characterized by high prevalence, high relapse rate, high disability rate and high fatality rate, and is called "the first psychological killer". The specific manifestations are: long-lasting depressed mood, and this mood obviously exceeds the necessary limit, lack of self-confidence, feeling a significant decrease in physical energy, and not being able to experience joy in any interesting activities. Such disorders can also cause physical dysfunction in patients, such as sleep disturbance, localized body pain, or loss of appetite. In western countries, depression is the most common mental illness, and the lifetime incidence of depression is between 6% and 8%. With the g...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8888A61P25/24
Inventor 马世平傅强马占强杨文马春华
Owner CHINA PHARM UNIV
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