96 results about "Nitrofuran" patented technology

The invention discloses a pretreatment method for detecting nitrofuran metabolites in an aquatic product. The method comprises the following steps of: weighing a sample to be detected, dissolving, derivating, extracting, and performing chromatographic separation. A constant temperature oscillator, a reduced pressure rotary evaporator, a silica gel chromatographic column and a high speed refrigerated centrifuge are used in the method. A sample solution prepared by the method can be directly detected by liquid chromatography-tandem mass spectrometry. Compared with the conventional national standard method, the pretreatment method has the advantages of low cost, high repeatability and the like, is simply and effectively operated, is high in operability, is expected to be popularized and applied to environmental protection industry, commodity inspection, entry-exit inspection and quarantine and the like on a large scale, and is obvious in economic and social benefits.

The invention is directed to the synthesis and use of nitrofuran compounds, especially Nifurtimox, as medicaments to treat cancer, especially neuroblastoma, and to inhibit angiogenesis. The invention also provides compositions, unit dosage forms, and kits comprising the compounds.

The invention relates to a preparation method of a colloid gold chromatography test strip for rapidly detecting furacilin metabolites, belonging to the detection technology field. The strip comprises a liner and a sample pad, a gold labeled binding pad, a packed capsule and a water absorbing pad which are connected successively on the liner. The gold labeled binding pad is made from glass fiber cotton for absorbing SEM derivative gold labeled antibodies of the furacilin metabolites. A detecting line (T) which is printed by the solution of SEM derivative coupling vector protein and a control line (C) which is printed by goat anti-rabbit IgG solution are arranged on the packed capsule. The two lines are parallel arranged. The colloid gold chromatography test strip is prepared based on polyclonal antibodies with high affinity which are labeled by colloid gold. The test strip has the advantages of strong specificity, high sensitivity, convenience, rapid speed, strong timeliness and onsiteoperation. The lowest detected amount can reach to 5ppb. After the test strip is added in a sample solution to be detected, the detecting result can be judged within 15 minutes. The preparation method of the colloid gold chromatography test strip for rapidly detecting the furacilin metabolites has the advantages of visual, directviewing and accurate result display, cost saving performance, wide application range and convenient popularization.

The invention discloses a method for determining residues of metabolites of four nitrofurans drugs in an animal glue traditional Chinese medicine. The method comprises the following steps: preparing to-be-tested sample solution; preparing standard solution; injecting a standard series of working solution into a liquid chromatograph / mass spectrometer, determining appearance positions of the metabolites of the four nitrofurans drugs and qualitative and quantitative determination ion pairs thereof, and making a standard curve equation by taking the abundance of the quantitative ion pairs as a vertical coordinate and taking the concentration as a horizontal ordinate; substituting data obtained by corresponding detection for the to-be-tested sample solution into the standard curve equation forcalculation, so as to obtain the contents of the metabolites of all the nitrofurans drugs in the to-be-tested sample. The metabolites of the four nitrofurans drugs are: a furanzolidon metabolite (AOZ), a furaltadone metabolite (AOMZ), a furacilin metabolite (SEM) and a furadantin metabolite (AHD).

The present invention includes novel compounds of the formula (I) wherein X is absent or trans or cis CHCH, R1 is (C1-C10) alkyl unsubstituted or substituted by one to three hydroxy, (C1-C10) alkenyl unsubstituted or substituted by one to three hydroxy, (C1-C10) alkynyl unsubstituted or substituted by one to three hydroxy, or aryl unsubstituted or substituted by one to three hydroxy; R2 is hydrogen, alkyl or aryl; R3 and R4 are, independently of each other, H, halogen, or a solubilizing group, with the provisio that at least one of R3 and R4 is halogen; and pharmaceutically acceptable salts thereof. The invention also includes pharmaceutically acceptable formulations of said compounds which exhibit antibiotic activity against a wide spectrum of microorganisms including organisms which are resistant to multiple antibiotic families and are useful as antibacterial agents for treatment or prophylaxis of bacterial infections, or their use as antiseptics, agents for sterilization or disinfection.

The invention provides a combination comprising zidovudine or a pharmaceutically acceptable derivative thereof and an antimicrobial compound selected from nitrofurantoin, mecillinam, fosfomycin, cephalexin and faropenem, or a pharmaceutically acceptable derivative or prodrug thereof. These combinations are particularly useful for the treatment of microbial infections.