Method for detecting nitrofuran veterinary drug residues in gelatin

Abstract

The invention discloses a method for detecting nitrofuran veterinary drug residues in gelatin. Through the method of adding enzymes, sample pretreatment is improved, and the method is suitable for the detection of nitrofuran residues in gelatin and intermediate samples in the production process of gelatin. According to the method for detecting the nitrofuran veterinary drug residues in gelatin, through the method of adding the enzymes, sample pretreatment is improved, the derivatization is more adequate and uniform, the measurement recovery rate and the accuracy are improved, the operation process is simpler and quicker, the sensitivity of the detection method can be significantly improved, the practicality is high, and support is provided for the prevention and control of the nitrofuran veterinary drug residues in gelatin and the production process of gelatin.

Description

technical field [0001] The invention relates to a method for detecting nitrofuran veterinary drug residues in gelatin. Background technique [0002] Gelatin is widely used in various industries such as medicine, food and health products, and is often used in the preparation of hard capsules and soft capsules; it is also widely used in various food processing industries because it is rich in various amino acids and collagen. The production of gelatin often uses animal skins and bones, undergoes complex physical and chemical treatments, and then undergoes hydrolysis to obtain fat-free and high-protein gelatin products. As broad-spectrum antibiotics, nitrofurans have been widely used in cattle, pigs and other livestock and poultry and aquaculture industries. Since raw materials for gelatin preparation mainly come from animals, the detection of nitrofuran drug residues in gelatin has become an unavoidable problem for manufacturers. Studies have shown that nitrofuran drugs have...

AI Technical Summary

Problems solved by technology

The parent drug of nitrofurans is difficult to detect due to instability; the small molecules produced by the metabolism of the parent drug are also difficult to detect due to low activity; the European Union requires that metabolites be used as target analytes for the detection of nitrofuran drug residues, and the sensitivity of the method must be high. reached 1 μg / kg, and China, the United States, and Japan have successively banned the use of furan drugs as growth agents and fungicides in food animals, and the detection limit of the method is required to reach 0.5 μg / kg

At present, the detection of nitrofuran drugs in gelatin is prone to gelation during sample processing, resulting in poor reproducibility and low accuracy of the determination results.

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