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Active substance for treating diabetes, preparation method thereof and medicine

An active substance, diabetes technology, applied in type 2 diabetes. , the active substance for treating diabetes and its preparation field, which can solve problems such as useless discovery of diabetes

Inactive Publication Date: 2016-03-02
HUANGGANG NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The medicinal effect of PM is considered to be regulated by its powerful antioxidant activity, but there are no reports of its use in diabetes, especially type 2 diabetes.

Method used

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  • Active substance for treating diabetes, preparation method thereof and medicine
  • Active substance for treating diabetes, preparation method thereof and medicine
  • Active substance for treating diabetes, preparation method thereof and medicine

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Embodiment Construction

[0055] specific implementation

[0056] The present invention will be further described in detail below in combination with specific embodiments, so as to help those skilled in the art understand the present invention.

[0057]1. Antidiabetic effect and mechanism of PM extract

[0058] 1.1 Materials and methods

[0059] 1.1.1 Extraction of PM

[0060] The dry root powder of PM was purchased from Hebei Anguo Vanilla Co., Ltd., and the extraction process was slightly modified according to Lu Lishuang's method. Briefly, the dry roots of PM were pulverized and extracted with 60% ethanol at room temperature for 2 days with a solid-to-liquid ratio of 1:10. After the plant material was filtered off, the ethanol extracts were combined and concentrated under reduced pressure on a rotary evaporator. The resulting dry extract was then separated by open column chromatography (CC) packed with porous resin. The column was eluted stepwise with 9 different concentrations of ethanol (10...

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Abstract

The invention belongs to the technical field of medicine and particularly relates to an active substance for treating diabetes, particularly type-2 diabetes, a preparation method thereof and medicine. The active substance is PM extract stilbeneglycoside and more preferably a mixture of cis diphenylethylene glycosides and trans diphenylethylene glycosides. In a type-2 diabetes mouse model induced by high fat, PM extract containing cis-SG and trans-SG represents remarkable blood sugar lowering capacity.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to an active substance for treating diabetes, a preparation method and medicine thereof, especially type 2 diabetes. Background technique [0002] Diabetes is one of the leading causes of death, and the number of people with diabetes in the United States has increased dramatically and is projected to reach 366 million worldwide. Type 2 diabetes, which affects more than 90% of diabetics, is thought to be related to oxidative stress and is characterized by insulin resistance. Due to the side effects of antidiabetic drugs, there has been a strong need for safe and effective hypoglycemic drugs. [0003] The chemical structure of 2,3,5,4'-stilbene 2-O-B-glucopyranoside (stilbene glycoside, referred to as SG) is C 20 h 22 o 9 , molecular weight 406.39, white amorphous powder, soluble in water, methanol and ethanol. It is stable in aqueous solutions, but high temperature...

Claims

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Application Information

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IPC IPC(8): A61K31/7034A61P3/10C07H15/203C07H1/08A23L33/00
Inventor 李士明
Owner HUANGGANG NORMAL UNIV
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