Hydroxypropyl-beta-cyclodextrin inclusion liposome of zedoary turmeric oil and preparation method thereof
A technology of hydroxypropyl and cyclodextrin inclusion compound of zedoary oil, which is applied in the field of cyclodextrin inclusion compound lipid of zedoary oil and its preparation, which can solve the problems of difficult to meet the requirements of clinical medication, low concentration, limited drug loading effect, etc. problems, to achieve the effects of high inclusion rate, high safety performance, and high drug loading capacity
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Embodiment 1
[0030] The preparation of embodiment 1 turmeric oil hydroxypropyl-beta-cyclodextrin inclusion compound liposome
[0031] (1) First weigh 1g of zedoary oil, dissolve it in 2ml of absolute ethanol, and set aside, weigh 6g of hydroxypropyl-β-cyclodextrin, dissolve it in 12ml of distilled water, and stir the zedoary oil under constant temperature magnetic stirring at 40°C. Add the absolute ethanol solution dropwise to the aqueous solution of hydroxypropyl-β-cyclodextrin for inclusion. After the dropwise addition, continue to stir for 1 hour to make the inclusion fully, evaporate the ethanol, and filter through a 0.45 micron microporous membrane to remove the unencapsulated Combined free zedoary oil medicine, freeze-drying, obtains white powdery turmeric oil hydroxypropyl-beta-cyclodextrin inclusion compound, color method (by the 2005 edition Chinese Pharmacopoeia two recorded zedoary oil content assay methods, below The same) to determine the content of zedoary oil is 90mg / g. Dis...
Embodiment 2
[0034] The preparation of embodiment 2 zedoary oil hydroxypropyl-beta-cyclodextrin inclusion compound liposome
[0035] (1) First weigh 1g of zedoary oil, dissolve it in 2ml of absolute ethanol, and set aside, weigh 4g of hydroxypropyl-β-cyclodextrin, dissolve it in 6ml of distilled water, and stir the zedoary oil under constant temperature magnetic stirring at 40℃. Add the absolute ethanol solution dropwise to the aqueous solution of hydroxypropyl-β-cyclodextrin for inclusion, continue to stir for 1.5 hours after the dropwise addition to fully include, evaporate the ethanol, and filter through a 0.45 micron microporous membrane to remove the unencapsulated The combined free zedoary oil drug was freeze-dried to obtain a white powdery hydroxypropyl-β-cyclodextrin inclusion complex of zedoary oil, and the content of zedoary oil was 150 mg / g as determined by colorimetric method. Dissolving the prepared zedoary oil hydroxypropyl-β-cyclodextrin inclusion compound in distilled water...
Embodiment 3
[0038] The preparation of embodiment 3 zedoary oil hydroxypropyl-beta-cyclodextrin inclusion compound liposome
[0039] (1) First weigh 0.5g of turmeric oil and dissolve it in 1ml of absolute ethanol, and set aside; then weigh 10g of hydroxypropyl-β-cyclodextrin, add 5ml of water and grind it into a paste, then add turmeric oil dropwise under grinding Add the absolute ethanol solution until all the addition is complete, continue to grind for 1 hour, and dry in vacuum to obtain a white powder, then wash away the unincluded free zedoary oil drug with petroleum ether, dry at low temperature, and obtain the hydroxypropyl- β-cyclodextrin inclusion complex. The content of zedoary oil was determined to be 38 mg / g by colorimetric method. Dissolving the prepared zedoary oil hydroxypropyl-β-cyclodextrin inclusion compound in distilled water to prepare a solution with a concentration of zedoary oil of 10 mg / ml.
[0040] (2) Take by weighing 0.5g turmeric oil, 20g soybean lecithin and 2...
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