Relating to cyclotriphosphazene and its fluorescent nano-
microsphere as well as a preparation method, the invention provides hexaminoacid ester phenoxyl cyclotriphosphazene, its fluorescent nano-
microsphere and a preparation method thereof. Hexaminoacid ester phenoxyl cyclotriphosphazene has a general
structural formula as shown in the picture, wherein, M is
amino acid x ester. And hexaminoacid ester phenoxyl cyclotriphosphazene is prepared by first reacting 6 pairs of carboxyphenoxyl cyclotriphosphazene with
thionyl chloride, and then adding amino-acid
ester hydrochloride and an acid binding agent for reaction. Composed of hexaminoacid ester phenoxyl cyclotriphosphazene, the fluorescent nano-
microsphere is prepared by the steps of: dissolving hexaminoacid ester phenoxyl cyclotriphosphazene in an
organic solvent, then adding
distilled water dropwisely, and pouring water, then conducting
dialysis and freeze-
drying, thus obtaining the fluorescent nano-microsphere. Hexaminoacid ester phenoxyl cyclotriphosphazene has stable structure, good
biocompatibility, easy degradation, degradation product free of
toxicity and
inflammatory response, and its preparation method has a yield up to over 80%, mild
reaction conditions, and a simple process, thus boasting very good industrial application prospects. Under
ultraviolet excitation, the fluorescent nano-microsphere can generate a
fluorescence phenomenon, and can serve as a carrier of targeting
drug delivery.