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254results about How to "Achieve targeted" patented technology

Preparation and anti-tumor application of natural active drug-polysaccharide targeted compound

The invention relates to a natural active drug-polysaccharide targeted compound with antitumor activity and targeting property. A natural active drug is introduced onto a polysaccharide framework by chemical grafting, and physically mixed with a ligand distearoylphosphatidyl ethanolamine-polyethyleneglycol-anisoyl amine with targeted transmission capacity to form a natural active drug-polysaccharide targeted compound, and the natural active drug-polysaccharide targeted compound can be self-assembled in water to form a nano micelle. The method is characterized in that the natural active drug-polysaccharide targeted compound has targeted transmission capacity, enhances the tumor transfer efficiency of the preparation, reduces the untoward reaction and enhances the tolerance of the patient; the hydrophobic inner core formed by the hydrophobic group can physically wrap the antineoplastic drug, thereby obviously improving the water solubility of the antineoplastic drug; and the antineoplastic drug which is physically wrapped by the chemically coupled ursolic acid can implement combined treatment of tumors and lower the toxic or side effect. The preparation method is simple and easy to operate, has the advantage of higher yield, and can easily implement industrialization.
Owner:南京科宁检测科技有限公司

Directional induced polarization real-time advance water detecting device and method while drilling for tunnel construction

The invention discloses a directional induced polarization real-time advance water detecting device while drilling for tunnel construction. The device comprises a drill bit, a high-strength insulated sleeve while drilling, and a directional induced polarization detection system, wherein the drill bit is connected with the high-strength insulated sleeve while drilling through a connecting bearing, and the directional induced polarization detection system is distributed at the periphery of the high-strength insulated sleeve while drilling. The invention also provides a corresponding directional induced polarization real-time advance water detecting method while drilling for tunnel construction. According to the device and the method disclosed by the invention, the interference of the construction environment is avoided, the detection effect is better, the utilization efficiency of an advance borehole is improved, current orientation is realized, the low resistance at the borehole wall is broken through, the detection range is enlarged, an electrode is protected, and a better coupling contact between the electrode and a rock-soil body is guaranteed.
Owner:山东百廿慧通工程科技有限公司

Search method, server and client

The invention discloses a search method, a server and a client, and belongs to the field of information technologies. The method comprises the following steps: receiving a primary search keyword and a user mark sent by a social application client; searching relative information of the primary search keyword to obtain search result comprising at least one piece of information; acquiring social relation information corresponding to the user mark; conducting ordering on the information in the search result according to the social relation information to obtain a search result ordering list; sending the search result ordering list to the social application client. According to the invention, the search result ordering list is obtained by conducting ordering on the information in the search result according to the social relation information; search according to the social relation information of the user is realized; the search result ordering list is provided with pertinence, and relatively high in flexibility; the optimized search result ordering list is obtained; meanwhile, the efficiency of acquisition of related information of the user can be improved; the search efficiency is improved.
Owner:TENCENT TECH (SHENZHEN) CO LTD

Classroom management method and system

The invention provides a classroom management method and system and relates to the field of education. The system comprises a teacher terminal, a server, multiple voice collectors, multiple cameras and multiple student terminals. The method comprises the following steps: each voice collector collects a voice signal corresponding to a seat and sends the voice signal to a corresponding student terminal, and each camera collects an image of a student corresponding to a seat and sends the image to the corresponding student terminal; the student terminals, send the voice signals and the images to the server; the server, according to a current lesson mode and the voice signal and the image which are sent by each student terminal, judges whether the student corresponding to each student terminal listens normally; and the server, when determining that the student corresponding to a certain student terminal does not listen normally, sends prompt information to the teacher terminal, wherein the prompt information includes the position and / or student identity information of the student terminal corresponding to the student who does not listen normally so that targeted classroom management of each student is realized.
Owner:安徽智星交通科技股份有限公司

Low latency rate control system and method

An encoder within a video transmission system controls the bit allocation at a sub-frame level. A frame is divided into smaller blocks, known as rate control blocks. Rate control blocks are used as the basic unit for bit allocation. This bit allocation achieves the target bit rate desired by the system as well as meet latency constraints. The encoder uses the slice partitioning capabilities to generate the rate control blocks using one or more slices of the image frame. This feature allows the decoder to decode the rate control blocks independently and ensures that the encoded data size for each rate control block is allocated. The encoder also detects the overflow condition for the buffer and performing an operation to avoid the overflow condition based on whether the image frame is an inter-frame or a intra-frame.
Owner:MARVELL ASIA PTE LTD

Neo-gambogic acid SLN (solid lipid nanoparticle) and preparation method thereof

The invention relates to a neo-gambogic acid SLN (solid lipid nanoparticle) and a preparation method thereof. The neo-gambogic acid SLN comprises a therapeutically effective amount of neo-gambogic acid, medicinal phosphatide, a surfactant and a lipid material. In the invention, the neo-gambogic acid is prepared into SLNs (solid lipid nanoparticles), thereby improving the solubility of the neo-gambogic acid, reducing the irritability, improving the bioavailability, and prolonging the action time of medicaments in a human body, in addition, the neo-gambogic acid SLNs can be gathered partially in the human body so as to play the targeted action of the SLNs and exert the anti-cancer therapeutic action of the SLNs better.
Owner:彭代银 +4

System and method for ventilating stacks and collecting exhaust gases and percolate of compost

The invention discloses a system and a method for ventilating stacks and collecting exhaust gases and percolate of compost. At least one air tube is laid in a base at the bottom of each stack along a length direction of the stack; grooves are reserved on the bases above vents of the air tubes; ventilation protecting layers are laid in the grooves above the vents; one end of each air tube is connected with a main air tube connected with a blower, while the other end is sealed with a pipe closer; a percolate outlet is downwards reserved at the closed end of each air tube; cleaning grooves are reserved on the peripheries of the pipe closers and the percolate outlets; percolate buffering and discharging devices connected with the percolate outlets are arranged in the cleaning grooves; an exhaust pipeline is arranged above each stack along the length direction; exhaust openings are distributed at the bottom of the exhaust pipeline; and each exhaust pipeline is connected with a main exhausttube. The system and the method have the advantages of greatly reducing the quantity of civil engineering at the same time of ensuring relatively better oxygenation state in the whole composting body, and simultaneously realizing the directed and highly-efficient collection of the exhaust gases produced in a composting process; and the system has a simpler structure and is convenient to operate.
Owner:ENVIROSYST BEIJING ENVIRONMENTAL ENG & TECH CO LTD

Brain delivery method for nano-medicament carrier

The invention provides a brain delivery method for a nano-medicament carrier. Brain delivery of the nano-medicament carrier carrying a diagnosis and treatment medicament is mediated by using ultrasonic waves and micro-vesicles together; the nano-medicament carrier and the micro-vesicles are administrated separately or administrated simultaneously after being mixed easily or administrated simultaneously through non-covalent and covalent connection; and in the brain delivery of the nano-medicament carrier carrying the diagnosis and treatment medicament under the mediation of ultrasonic waves and micro-vesicles, ultrasonic treatment is performed immediately or a certain time interval after micro-vesicles are applied to a mechanism. Compared with the conventional brain delivery of a medicament under the mediation of ultrasonic waves and micro-vesicles, the method has the advantages that: poor in-vivo properties (poor stability, easiness in clearing by the organism and the like) of the medicament can be eliminated, the diagnosis molecular signal strength is enhanced, the detection sensitivity is enhanced, and focus targeting can be realized; and compared with the conventional brain delivery technology for the nano-medicament carrier, the method has the advantage that: external ultrasonic waves are applied in a technology, so that more efficient and more specific brain medicament delivery can be realized.
Owner:SHANGHAI JIAOTONG UNIV SCHOOL OF MEDICINE

Mesoporous silica drug-loaded nanoparticle and preparation method and application thereof

The invention discloses a mesoporous silica drug-loaded nanoparticle. Mesoporous silica is used as a drug carrier, and is wrapped with a polydopamine layer; through a Schiff base addition reaction, the raw material is connected to tumor-directed osmotic peptide iRGD and poly (2-ethyl-2-oxazoline) so as to obtain the mesoporous silica drug-loaded nanoparticle MSN (at) PDA-PEOz-iRGD. The invention also discloses a preparation method of the above drug-loaded nanoparticle. By loading the prepared drug-loaded nanoparticle on an anti-cancer drug, the drug has obvious pH-responsive release, obvious tumor cell targeting ability and good photothermal treatment effect and good antitumor effect in vivo and in vitro, and provides theoretical basis for the research of novel targeted drug delivery system.
Owner:XIAN MEDICAL UNIV

Block-chain-based advertisement pushing method, device and computing device

The invention discloses an advertisement pushing method based on block chain, a device and a computing device, wherein, the method comprises the following steps: obtaining an advertisement pushing instruction generated by a media platform end according to the requirement information of a user terminal, and storing the advertisement pushing instruction in the block chain mode; storing the advertisement pushing instruction in the block chain mode. The advertisement pushing instruction includes identification information of the user terminal. The advertisement pushing instruction is provided to the advertiser terminal for the advertiser terminal to push the advertisement data to the user according to the advertisement pushing instruction. The advertisement pushing instruction of the inventionaccords with the reading demand of the current user terminal, and the advertiser terminal pushes the advertisement data according to the advertisement pushing instruction, so that the accurate advertisement can be pushed for the current user terminal; and the advertiser terminal pushes the advertisement data according to the advertisement pushing instruction. At the same time, the invention utilizes the block chain to optimize the mutual relationship among the advertiser end, the user terminal and the media platform end, and the advertiser end carries out point-to-point interaction with the user terminal according to the advertisement pushing instruction of the media platform, so as to realize the maximum optimization of the advertisement effect.
Owner:苏州朗润创新知识产权运营有限公司

Multi-data center based natural resource geospatial data organization method and system

The invention provides a multi-data center based natural resource geospatial data organization method and system. The method comprises a data type identification step, a feature class model establishment step, a relation class data model establishment step and an auxiliary information acquisition step. Firstly, the type of natural resource geospatial data is identified and data centers, a database, a data set and an auxiliary information set are established; secondly, according to the identified data type, establishing a feature class data integration organization model and establishing a relation class data model; and finally, according to the identified data type and a relation class data calculation result, acquiring auxiliary information and storing the auxiliary information in the auxiliary information set. According to the organization method provided by the invention, unification of different data types in a conception layer based on a plurality of data centers and integration organization management of different data types are realized; orderly data management and data tracking and backtracking are realized; and the application convenience and flexibility of the natural resource geospatial data are satisfied.
Owner:国家信息中心

Docetaxel long-circulation formulation

The invention provides a long-circulating preparation which is an invisible nano particle, a stealth lipidosome, or an invisible micelle containing docetaxle, carrier materials and additive. The long-circulating preparation is prepared by wrapping the docetaxle with the carrier materials that are modified by polyethylene glycol, a hydrotropic substance. The long-circulating preparation of the docetaxel can avoid being captured or swallowed by the hepatolienal reticular endothelial system in the body, thus prolonging circulation time in blood. Compared with the common injection of the docetaxel or the non-stealth lipidosome of the docetaxel, the long-circulating preparation of the docetaxel provided by the invention has stronger inhibit function on a tumor.
Owner:SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI

Programmed multi-target tree-shaped macromolecular assembled body medicine conveying system as well as preparation method and application thereof

The invention discloses a programmed multi-target tree-shaped macromolecular assembled body medicine conveying system as well as a preparation method and application thereof and belongs to the field of biomedical materials. The medicine conveying system taking an amphipathic tree-shaped macromolecular assembled body as a carrier is used for realizing programmed multi-target through responding a tumor micro-environment, so that main biological obstacles met in a process of transferring the medicine carrier in a body are overcome, and finally, medicines are conveyed to the destination. The obtained self-assembled body has a multi-target effect through the functionalization effect of a plurality of types of terminal groups. On one hand, tree-shaped molecules are used as the medicine carrier and have the advantages of good stability, high mechanical strength, multivalent terminal groups, hyper-branched structures, and intracellular conveying of echoviruses; on the other hand, a multi-element cooperated self-assembling policy is integrated with the advantages of all functional groups on a tree-shaped macromolecular self-assembled unit, so that the assembled body can be conveyed by the multifunctional and efficient medicine system. The system is particularly suitable for conveying anti-tumor medicines.
Owner:SICHUAN UNIV

Small interfering ribonucleic acid (siRNA) lipid nanometer vesicles with targeted hepatic stellate cells, and application of siRNA lipid nanometer vesicles

The invention relates to the technical field of gene therapy drugs, and in particular discloses small interfering ribonucleic acid (siRNA) lipid nanometer vesicles with targeted hepatic stellate cells, and the application of the siRNA lipid nanometer vesicles. The nanometer vesicles respectively comprise a treatment component and a delivery component, wherein the treatment component is siRNA having a targeted gene inhibition effect, and the delivery component is a lipid carrier. The nanometer vesicles formed by encapsulating the treatment component by the delivery component are prepared by an ethanol dilution method; a gene delivery system existing in a form of nanometer vesicles is capable of effectively overcoming the obstacles preventing the delivery of the gene therapy drugs in the body.
Owner:EAST CHINA NORMAL UNIV

Multifunctional nano material in metal organic framework mesoporous structure and preparation method thereof

The invention provides a multifunctional nano material in a metal organic framework mesoporous structure and a preparation method thereof. The MOFs mesoporous nano material with high stability, good dispersibility and excellent hydrophilicity is prepared through a high-temperature pyrolysis method and an electrostatic adsorption method, a large surface area is provided for introduction of a large quantity of functional molecular groups, and a large aperture is provided for absorbing and packaging biological molecules. Fe3O4 serves as a photo-thermal reagent and a target reagent, and through responses to external magnetic fields and infrared light sources, targeting and photo-thermal treatment of cancer cells are achieved. By means of Au25 serving as a photosensitizer, Au25 can be directly photosensitized through infrared light, a large amount of singlet oxygen is generated, and accordingly the anti-cancer function is achieved. By changing the mass of reactants, the multifunctional nano composite materials in different sizes and in a MOFs structure can be synthesized.
Owner:HARBIN ENG UNIV

Management context-based human resource assessment system and method thereof

The invention discloses a management context-based human resource assessment system and a method thereof. The management context-based human resource assessment system includes a basic data management module, a question bank management module, an assessment information module, an assessment generation module and an analysis module, wherein the basic data management module, the assessment information module and the question bank management module are respectively connected with the analysis module through the assessment generation module. With the management context-based human resource assessment system and the method thereof of the invention adopted, the pertinence and accuracy of human resource assessment organization and effectiveness of organizational decision making can be improved, and launch of work such as human resource selection, training and development, and human resource check can be facilitated for enterprises.
Owner:申向阳

Multifunctional cationic polymer gene vector, and preparation method and application thereof

InactiveCN103396557AHas a targeted effectEnhanced proton buffering capacityGenetic material ingredientsPharmaceutical non-active ingredientsCytotoxicityPlasmid dna
The invention relates to a multifunctional cationic polymer gene vector and a preparation method and application thereof. A multifunctional cationic polymer is synthesized by oxidizing low molecular weight chitosan used as a framework material with potassium periodate and subjecting the oxidized low molecular weight chitosan and polyethyleneimine coupled with a sartan-class drug to reduction and ammonification. To overcome technical problems, the invention provides the novel cationic polymer with targeting performance of the acceptor of the tumor cell AT1, multiple proton buffering capability and adjuvant therapy effects on tumors and provides a preparation method with the advantages of mild conditions, low cost, applicability and reliability for the cationic polymer. A compound formed by the cationic polymer provided by the invention and plasmid DNA has the advantages of low cytotoxicity, good targeting performance, high transfection efficiency, substantial in-vitro antineoplastic effects, etc.; the polymer can be used for preparation of a non-virus gene transfer system capable of simultaneously transferring a gene drug and a chemical drug for cooperated treatment of a tumor.
Owner:CHINA PHARM UNIV

Hexaminoacid ester phenoxyl cyclotriphosphazene, its fluorescent nano-microsphere and preparation method thereof

Relating to cyclotriphosphazene and its fluorescent nano-microsphere as well as a preparation method, the invention provides hexaminoacid ester phenoxyl cyclotriphosphazene, its fluorescent nano-microsphere and a preparation method thereof. Hexaminoacid ester phenoxyl cyclotriphosphazene has a general structural formula as shown in the picture, wherein, M is amino acid x ester. And hexaminoacid ester phenoxyl cyclotriphosphazene is prepared by first reacting 6 pairs of carboxyphenoxyl cyclotriphosphazene with thionyl chloride, and then adding amino-acid ester hydrochloride and an acid binding agent for reaction. Composed of hexaminoacid ester phenoxyl cyclotriphosphazene, the fluorescent nano-microsphere is prepared by the steps of: dissolving hexaminoacid ester phenoxyl cyclotriphosphazene in an organic solvent, then adding distilled water dropwisely, and pouring water, then conducting dialysis and freeze-drying, thus obtaining the fluorescent nano-microsphere. Hexaminoacid ester phenoxyl cyclotriphosphazene has stable structure, good biocompatibility, easy degradation, degradation product free of toxicity and inflammatory response, and its preparation method has a yield up to over 80%, mild reaction conditions, and a simple process, thus boasting very good industrial application prospects. Under ultraviolet excitation, the fluorescent nano-microsphere can generate a fluorescence phenomenon, and can serve as a carrier of targeting drug delivery.
Owner:NORTHEAST FORESTRY UNIVERSITY

Content recommendation method and device, and electronic equipment

The invention discloses a content recommendation method and device, and electronic equipment. One specific embodiment of the content recommendation method comprises the following steps of: obtaining attribute information of at least one candidate terminal; filtering the candidate terminal based on the attribute information so as to determine a target terminal; and recommending a content according to stored interest point information corresponding to the target terminal. By means of the embodiment, the content recommendation accuracy is improved; and targeted content recommendation is realized.
Owner:SAMSUNG ELECTRONICS CHINA R&D CENT +1

Attention evaluation and training method, device and equipment and readable storage medium

PendingCN111223566AAttention adjustmentThe assessment results are objective and accurateHealth-index calculationMental therapiesPhysical medicine and rehabilitationEeg data
The invention discloses an attention evaluation and training method, device and equipment and a readable storage medium, and the method comprises the steps: obtaining the answer data of a test objectwhen the test object plays a preset attention game, and obtaining the EEG data of the corresponding test object when the answer data is obtained through an intelligent head ring; according to the answer data and the EEG data, calculating through a detailed algorithm an attention score value of the test object; if the attention score value is smaller than a first preset value, switching to a training mode; obtaining electroencephalogram characteristics of the test object during training, and outputting and displaying a corresponding Me5 model animation based on the electroencephalogram characteristics so as to perform neural feedback training and targeted matched course training on the test object. Therefore, accurate measurement of the attention level of the test object is realized, targeted training is performed according to the measurement result, and the attention level and the comprehensive quality of the test object are effectively improved.
Owner:ZHEJIANG BRAIN ENHANCE TECH CO LTD

Albumin nanoparticle preparation for anthracycline antitumor antibiotic oleic acid compound

ActiveCN102552154AProlong the action timeTo achieve the purpose of targeted deliveryPowder deliveryAntinoxious agentsTumor targetingBiology
The invention provides a method for preparing an anthracycline antitumor antibiotic oleic acid compound and an oil-water double phase for preparing the compound and albumin, and the anthracycline antitumor antibiotic oleic acid compound is prepared into an albumin nanoparticle preparation. The albumin nanoparticle preparation prepared by the method is little in using amount of auxiliary materials, high in medicine-carrying dose and high in stability, and a preparation process is simple and is suitable for large-scale industrial production; and the albumin nanoparticle preparation has the tumor targeting and good clinical application value.
Owner:SICHUAN BAILI PHARM CO LTD

Nano granules of solid lipid of tanshinone and its preparation method

A solid lipoid nanoparticle of tanshinone is prepared from tanshinone, medicinal phosphatide, emulsifier, lipoid material and additive. Its advantages are high dissolving speed and biological utilization rate, high target property to myocardial tissue, high curative effect, low dosage and low toxic by-effect.
Owner:CHINA PHARM UNIV

Method for synthesizing dextran-magnetic LDH-fluorouracil magnetic targeting sustained and controlled release tripolymer

ActiveCN101607091ASolve the problems of preparation and antioxidant protectionGood biocompatibilityOrganic active ingredientsInorganic non-active ingredientsSolventChemistry
The invention relates to a method for synthesizing dextran-magnetic LDH-fluorouracil magnetic targeting sustained and controlled release tripolymer, comprising the following steps of: finishing the synthesis of magnetic layered composite hydroxide and the intercalation assembly of fluorouracil to the magnetic layered composite hydroxide under the condition of nitrogen protection; performing the in-situ composite process of magnetic LDH-fluorouracil under the condition of nitrogen protection with the dextran as the wrapping material; and finally separating the product through the solvent conversion technology. The invention realizes the merging and unification of the targeting and the sustained release of a magnetic targeting drug, thereby solving the problems of the preparation of magnetic LDH-Drugs and protection against oxidation, and synthesizing a magnetic targeting sustained and controlled release drug delivery system which has good biocompatibility and high storage stability and fits for transport in vivo; and the invention is suitable for the chemical synthesis of various magnetic targeting sustained and controlled release drugs, and has the advantages of simple and rapid preparation technology, high product purity, energy consumption saving, no environment pollution, wide application range and the like.
Owner:NINGXIA MEDICAL UNIV

Substrate of traditional Chinese medicine biochip as well as preparation method and use thereof

The invention provides a substrate of a traditional Chinese medicine biochip formed by a silanizated slide and an organic active group connected through -O-. The substrate of the traditional Chinese medicine biochip is characterized in that the organic active group is -(CH2)2SO2CHCH2, an active ethenyl is at the end of the group and can be in cross-linking reaction with micromolecular organic matters such as carbonyls, glycosides and alkaloids and the like so that the organic micromolecule can be fixed on the substrate to prepare the traditional Chinese medicine biochip using the micromolecular organic matters as a probe, for example, a high throughput biochip which screens active ingredients of Chinese medicinal herb.
Owner:SOUTHERN MEDICAL UNIVERSITY

Preparation method, product and application of molecularly imprinted polymer

The invention provides a preparation method, a product and an application of a molecularly imprinted polymer. The preparation method of the molecularly imprinted polymer mainly includes the steps: performing interaction on yfqsmdk-C10 short peptides serving as template molecules with methacrylic acid, N-isopropylacrylamide, N, N-dimethyl bisacrylamide and N-n-tert-butyl acrylamide by non-covalentbonds (such as hydrogen bonds and Van der Waals force); adding an appropriate quantity of initiators to perform polymerization reaction, and imprinting the surface of the polymer with short peptide molecules; eluting the short peptide molecules imprinted on the surface by proper solvents (namely, extraction agents) after polymerization reaction to reserve a cavity capable of specifically recognizing the short peptide molecules. As the short peptide molecules are highly expressed on the surface of a tumor, after the short peptides are eluted, the formed cavity can specifically recognize the short peptide molecules highly expressed on the surface of the tumor, and selectivity and targeting ability of the molecularly imprinted polymer for tumor cells are finally realized.
Owner:刘飞

Antharcycline antitumor antibiotics loaded nano-micelle preparation and preparation method thereof

The invention discloses an antharcycline antitumor antibiotics loaded nano-micelle preparation, which comprises antharcycline antitumor antibiotics, A-B-C type triblock polymer and assisting agents, wherein the antharcycline antitumor antibiotics is one or more of adriamycin, daunorubicin, pharmorubicin, perarubicin or lacinomycin; and the A-B-C type triblock polymer is polyethylene glycol-polyethylene glycol containing carboxyl on side chain-polyester. According to the preparation, drugs are coated in the nano-micelle by virtue of the coaction of self-assembly of segmented copolymer and electrostatic adsorption, the nano-micelle has uniform and stable grain diameter, the encapsulation efficiency reaches 99 percent, and the prepared nano-micelle preparation is of a spherical structure with grain diameter between 20 and 300nm; and the shell of the micelle is made from polyethylene glycol molecules, so that drugs are prevented from being contacted with enzyme and other protein molecules in blood or identified and swallowed by a reticuloendothelial system in the body, so that the circulating period of micelle in the body can be prolonged.
Owner:CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI +1

NIR-II conjugated nano particles, and preparation method and application thereof

The invention relates to NIR-II conjugated nano particles and a preparation method and application thereof. The NIR-II conjugated nano particles comprise NIR-II conjugated small molecules and amphiphilic polymers; a structural formula of the NIR-II conjugated small molecules is as follows; and the amphiphilic polymers are self-assembled and encapsulated on the NIR-II conjugated small molecules. The nanoparticles have good biocompatibility, high NIR-II photothermal conversion efficiency, good photoacoustic imaging effect and NIR-II tumor photothermal therapy effect.
Owner:ZHEJIANG UNIV

Block copolymer and synthesis method thereof, and preparation method of nano particles

The present invention relates to the technical field of biology, and in particular to a block copolymer and a synthesis method thereof, and a preparation method of nano particles. The block copolymer provided by invention comprises a first block, a second block and a third block, which are connected successively. The first block and the third block are hydrophilic blocks, and the second block is a hydrophobic block. Compared with prior art, the block copolymer provided by the invention can effectively shield surface charges of cationic particles like polycation gene complex particles, exclude in vivo circulation barriers of cationic particles, and improve in vivo circulation efficiency, and also can be grafted to a target group to realize pathological cell targeting in vivo, and effectively improve the targeting effect.
Owner:SHANGHAI JIAO TONG UNIV
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