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NIR-II conjugated nano particles, and preparation method and application thereof

A nanoparticle and near-infrared technology, applied in wave energy or particle radiation treatment materials, pharmaceutical formulations, medical preparations with inactive ingredients, etc., can solve problems such as limiting large-scale preparation and clinical transformation, and achieve good clinical transformation possibilities. The effect of stability, mild reaction system and stable properties

Active Publication Date: 2019-03-29
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the potential long-term in vivo toxicity of inorganic materials and the batch-dependent properties of conjugated polymer nanoparticles limit their large-scale preparation and clinical translation.

Method used

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  • NIR-II conjugated nano particles, and preparation method and application thereof
  • NIR-II conjugated nano particles, and preparation method and application thereof
  • NIR-II conjugated nano particles, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Example 1: Conjugated Small Molecules

[0046] Dibromobenzobisthiadiazole (88.0mg, 0.25mmol), 4-tert-butyl-N-(4-tert-butylphenyl)-N-(4-(5'-trimethyltinyl) -(2,2'-Bithienyl)-5-phenyl)aniline (342.3 mg, 0.50 mmol) and bis(triphenylphosphine)palladium dichloride (8.77 mg, 0.0125 mmol) were dissolved in 30 mL of dry toluene , refluxed for 24 hours under an inert atmosphere, and finally silica gel column chromatography (dichloromethane as the eluent) obtained a conjugated small molecule in the second near-infrared region with a yield of 60%.

[0047] The obtained conjugated small molecules in the second near-infrared region were characterized by proton nuclear magnetic resonance spectroscopy and MALDI-TOF mass spectrometry. The results are shown in the attached figure 1 And attached figure 2 shown.

Embodiment 2

[0048] Example 2: Conjugated Small Molecules

[0049] Dibromobenzobisthiadiazole (88.0mg, 0.25mmol), 4-tert-butyl-N-(4-tert-butylphenyl)-N-(4-(5'-trimethyltinyl) -(2,2'-Bithienyl)-5-phenyl)aniline (342.3 mg, 0.50 mmol) and tetrakis(triphenylphosphine)palladium (14.4 mg, 0.0125 mmol) were dissolved in 30 mL of dry toluene, inert Reflux under the atmosphere for 24 hours, and finally silica gel column chromatography (eluent is dichloromethane) to obtain the conjugated small molecule in the second near-infrared region with a yield of 65%.

Embodiment 3

[0050] Example 3: Conjugated Small Molecules

[0051] Dibromobenzobisthiadiazole (88.0mg, 0.25mmol), 4-tert-butyl-N-(4-tert-butylphenyl)-N-(4-(5'-trimethyltinyl) -(2,2'-Bithienyl)-5-phenyl)aniline (342.3 mg, 0.50 mmol) and bis(dibenzylideneacetone)palladium (7.19 mg, 0.0125 mmol) were dissolved in 30 mL of dry toluene, Reflux for 24 hours under an inert atmosphere, and finally silica gel column chromatography (dichloromethane as the eluent) to obtain a conjugated small molecule in the second near-infrared region with a yield of 61%.

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Abstract

The invention relates to NIR-II conjugated nano particles and a preparation method and application thereof. The NIR-II conjugated nano particles comprise NIR-II conjugated small molecules and amphiphilic polymers; a structural formula of the NIR-II conjugated small molecules is as follows; and the amphiphilic polymers are self-assembled and encapsulated on the NIR-II conjugated small molecules. The nanoparticles have good biocompatibility, high NIR-II photothermal conversion efficiency, good photoacoustic imaging effect and NIR-II tumor photothermal therapy effect.

Description

technical field [0001] The invention relates to the field of preparation of conjugated nanoparticles, in particular to a conjugated nanoparticle in the second near-infrared region and its preparation method and application. Background technique [0002] In today's world, malignant tumor has become the number one killer threatening human health. Although traditional treatment methods such as surgery, chemotherapy and radiotherapy have been widely used in clinic, these treatment methods have the disadvantages of invasiveness, large side effects and non-targeting. [0003] In recent years, laser-based photodynamic therapy and photothermal therapy have gained widespread attention due to their advantages of non-invasiveness, minimal side effects, and remote controllability. [0004] At present, photothermal reagents mainly include: noble metal nanomaterials, metal sulfide nanocrystals, carbon materials, two-dimensional materials, and organic nanoparticles. However, the optical ...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K9/51A61K47/10A61K47/24A61K49/22A61P35/00
CPCA61K9/5146A61K41/0052A61K49/225A61P35/00
Inventor 凌代舜李方园邵伟
Owner ZHEJIANG UNIV
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