50results about How to "Mild reaction system" patented technology

The invention relates to the field of a biomedical material, and particularly discloses a crosslinked alginate-bacterial cellulose sponge and a preparation method thereof. The crosslinked alginate-bacterial cellulose sponge takes an alginate biomaterial and bacterial cellulose as raw materials. The crosslinked alginate-bacterial cellulose sponge is characterized in that a sponge product is prepared from the alginate biomaterial and the bacterial cellulose in manners of crosslinking and freeze-drying after being compounded, wherein the alginate biomaterial accounts for 80-95% of the sponge product in mass fraction; the bacterial cellulose accounts for 5-20% of the sponge product in mass fraction. The crosslinked alginate-bacterial cellulose sponge is abundant in used material sources, low in cost, controllable to process, and simple in production technology; the prepared crosslinked alginate-bacterial cellulose sponge has good mechanical property, liquid absorption property, water retention capacity and air permeability, and is applicable to bleeding healing of large seepage or a bleeding wound.

The invention belongs to the field of biomedical materials, and particularly discloses an alginic acid-chitosan composite fiber for tranma repairing and a preparation method thereof. The alginic acid-chitosan composite fiber for the tranma repairing is characterized by comprising an alginic acid component of which the mass fraction is 50-95%, and a chitosan component of which the mass fraction is 5-50%. The processing technique disclosed by the invention is not involved with an organic reagent or an organic chemical reaction, so that the preparation method is mild in reaction system and controllable in condition; the residue problems of a toxic crosslinking agent or an assistant and the like do not exist; used materials, reagents and the like have good biosecurity; the security risk of clinical applications is greatly reduced. In addition, the technology disclosed by the invention is simple and controllable, and has the good product transformation feasibility; the difficulty of risk management in the preparation process is greatly reduced.

The method provides a Method for preparation of vitaminA derivant's important intermediate- 1-chloro-2-methyl-4-hydrocarbon acyloxy-2-butylene, this invention adopting isoprene as material to carry through chlorohydrination reaction; the getted product has high content, high produce rate, convenierce operate, little waste and easy to commercial manufacture.

The invention relates to a cerium oxide / iron oxide / mesoporous silica nano composite material. The surfaces of amino-modified mesoporous silica nanoparticles are respectively modified by ligand-converted cerium oxide nanocrystals and ligand-converted iron oxide nanocrystals. The invention also relates to a preparation method and application of the cerium oxide / iron oxide / mesoporous silica nano composite material. Not only can the composite material carry a drug for treating Alzheimer apostrophe s disease (AD), but also can remove reactive oxide species (ROS) in AD-similar cells, and can be used for diagnosis of the AD as a nuclear magnetic resonance imaging contrast agent, thus realizing integration of diagnosis and treatment of the AD.

The invention discloses a preparing method of cellulose composite sponge. The preparing method of the cellulose composite sponge comprises the following steps of 1, preparing an aqueous solution of HPMC and an aqueous solution of CMC separately, and conducting even stirring to make the aqueous solution of HPMC and the aqueous solution of CMC fully dissolved; 2, proportionally mixing the aqueous solution of HPMC and the aqueous solution of CMC which are prepared in the step 1, and conducting even mixing; 3, freezing and drying the evenly mixed liquid obtained in the step 2; 4, cross-liking the frozen and dried mixture obtained in the step 3 in a cross-linking agent; 5, using a refrigerator to freeze and dry the cross-linking product cross-linked in the cross-linking agent obtained in the step 4 to obtain a spongy product; 6, packaging and sterilizing the spongy product obtained in the step 5 to obtain the cellulose composite sponge used for hemostasis nursing. According to the preparing method of the cellulose composite sponge, the water absorption and the water binding capacity of the composite material are improved, and the wet strength and flexibility are remarkably improved.

The invention discloses a 5-deoxy-D-ribofuranose 1-[2-(1-styryl) benzoate] derivative as shown in a general formula (I) and a preparation method of the derivative, wherein the structure of the generalformula (I) is as follows, and the invention discloses a method for preparing a uracil nucleoside derivative and an antitumor drug doxifluridine by taking the derivative as shown in the general formula (I) as a raw material. The 5-deoxy-D-ribofuranose 1-[2-(1-styryl) benzoate] derivative used as a reaction raw material can be activated as a glycosyl donor under the condition of a catalytic amountof lewis acid trimethylsilyl trifluoromethanesulfonate and N-iodosuccinimide. The method avoids traditional use of equivalent or excessive lewis acid, has a mild reaction system, has no other side reaction, has efficient reaction, and has a yield up to 98%.

The invention relates to an injectable type alginic acid radical biological material for heart failure adjuvant therapy and a preparation method thereof. The preparation method comprises steps of: preparing two systems of a sodium alginate system and a cross-linking agent system, mixing the two components uniformly by utilizing a three-way syringe and preparing the injectable type alginic acid radical biological material for heart failure / myocardial infarction adjuvant therapy after a proper time of balancing. The materials and processing technologies which are adopted by the invention do not involve organic reagents or organic chemical reactions, the reaction systems are moderate, the conditions are controllable, and the problem of residues of toxic cross-linking agents or auxiliaries cannot be caused; a hydrogel which is prepared according to the technical scheme is injected into the spherical expanding myocardium after heart failure by using the syringe No.271 / 2, so that cardiac ventricles can be helped to reshape, the sizes of the cardiac ventricles can be effectively reduced, and the tension of ventricle walls is decreased; and the biological material can be used for heart failure adjuvant therapy, has good mechanical properties and biological properties as well as good cytocompatibility and is convenient and reliable to operate.

The invention discloses a 2-methoxy-4-methylphenol preparation method based on vanillin selective hydrodeoxygenation, which comprises the following steps: adding a reactant vanillin into a reaction kettle containing a certain amount of solvent, and carrying out hydrodeoxygenation reaction in the presence of a catalyst to obtain 2-methoxy-4-methylphenol, the catalyst is a porous carbon nanosphere loaded with a metal active component, the expression of the catalyst is M (at) CNS, M is any one of metal ruthenium, platinum, palladium, iridium, rhodium and gold, and CNS is a porous carbon nanosphere carrier. The porous carbon nanosphere not only has the characteristics of large specific surface area, abundant shell pore channels and easy regulation and control of pore diameter, but also has high dispersity and uniform size of loaded metal nanoparticles. The catalyst can realize high-efficiency and high-selectivity hydrodeoxygenation of vanillin under mild conditions to prepare 2-methoxy-4-methylphenol.

The invention provides an alginic acid-hyaluronic acid in situ tissue engineering cell scaffold and its preparation method. The preparation method comprises the following steps: alginic acid or its derivative and hyaluronic acid or its derivative are respectively made into solutions by the use of normal saline or physiological buffer; any one of the above solutions is mixed with cells which need to be loaded and then is mixed with the other remaining solution; and balancing lasts for a period of time at room temperature so as to obtain the alginic acid-hyaluronic acid in situ tissue engineering cell scaffold. The prepared alginic acid-hyaluronic acid in situ tissue engineering cell scaffold effectively prolongs degradation time of alginic acid and hyaluronic acid in vivo. By appropriate intramolecular crosslinking, mechanical properties and tissue filling / supporting performance of the scaffold are raised greatly. The scaffold has good security and validity. The preparation method of the alginic acid-hyaluronic acid in situ tissue engineering cell scaffold does not involve any organic reagent; the reaction system is simple and mild; and clinic application security is good.

The invention discloses a preparation method for 4-alkoxy-1-chlorobutane used as a synthetic resin raw material and a pharmaceutical intermediate compound. The prior method adopting basic catalyst has shortcomings that: the basic catalyst is difficult to be separated from the reaction system when the reaction is completed, and is difficult to be cleaned even if a large amount of water is used, thereby which brings difficulties to the fine purification for the product. The invention adopts 4-alkoxy-1-chlorobutane as the raw material, which is reacted with thionyl chloride under the existence of quaternary ammonium salt catalyst so as to get the product 4-alkoxy-1-chlorobutane, and then the product is implemented with water scrubbing and stratification for removing the catalyst and destroying the superfluous thionyl chloride, and then the product is washed with lye and water, and the pure product is obtained after distilled in atmospheric pressure and pressure reduction finally. The invention has the advantages of less secondary reaction, convenient post treatment since the product is implemented with water scrubbing and stratification for removing the catalyst and destroying the superfluous thionyl chloride, good catalytic result of the catalyst, less use amount of thionyl chloride, and high content and yield of the product.

The invention relates to a method for preparing vicinal diol by catalytic oxidation of alkene in a hydrogen peroxide / cationic resin system and belongs to the field of organic synthesis. The method is carried out by the following steps: adding alkene and cation exchange resin into a single-ported round-bottom flask; stirring and heating with a constant temperature oil bath pan at the temperature of 0-90 DEG C; measuring a hydrogen dioxide solution with a constant voltage dropping funnel according to the dosage of the added alkene; slowly adding a reaction solution after reaching a set temperature and reacting for 0.1-10h; adding a few amount of Na2S2O3 to quench the reaction after the end of the reaction; filtering out the cation exchange resin, cleaning with methanol and recovering; and extracting a reaction solution with ethyl acetate and water, putting a water phase into a refrigerator, and precipitating white crystals, namely a vicinal diol compound. The method requires no solvent; a catalyst can be recycled; a reaction system is mild; environmental pollutants are few; the method has a wide application range; and production cost is low. By optimizing reaction conditions, product purity is higher than 92%, and yield can reach 89%. The method has a strong industrial application prospect.

The invention specifically discloses novel gossypol derivatives, and a preparation method and application thereof, belonging to the technical field of organic synthesis. According to the method, gossypol and isonitrile are used as raw materials and undergo a stirring reaction in a polar solvent at 70 to 80 DEG C for 24 and 36 h, then simple filtering and separating are carried out, and thus, a series of the gossypol derivative with modified aldehyde groups are prepared through one-step reaction. The preparation method and post-treatment are simple; a reaction system is mild; and the synthesized novel gossypol derivatives retain all the active phenolic hydroxyl groups unique to gossypol to a greatest extent, and it is estimated that all the excellent biological activities of gossypol are retatined and the problem of toxic aldehyde groups carried by gossypol is overcome. Most of the gossypol derivatives prepared in the invention have good anti-prostatic cancer activity and can be applied in the antineoplastic field.

The invention discloses a synthetic method of a cyanobenzofuran compound. The synthetic method comprises the following steps: taking a benzofuran-2-ketone compound as a reaction initiator, taking ethyl alcohol as a solvent, slowly adding a reducing agent NaBH4 under a condition of 0 DEG C, then carrying out stirring for a reaction at room temperature, adding water for quenching, extracting the product by using ethyl acetate, then carrying out washing with saturated salt water, collecting the organic layer, carrying out drying and concentrating, carrying out column chromatography or thin-layerchromatography to obtain an intermediate benzofuran-2-ol, taking the benzofuran-2-ol as a raw material, AlCl3 as an additive, and benzene as a solvent to carrying out stirring for a reaction for 2 hours at 60 DEG C in a nitrogen environment, adding water for quenching, extracting the obtained product by using ethyl acetate, collecting the organic layer, carrying out drying and concentrating, and carrying out column chromatography or thin-layer chromatographic separation purification to obtain the target product. The synthesis reaction is simple to operate, the adopted reagents are cheap and are easily available, the reaction system is mild, the conditions are simple, the yield is good, and the method has relatively good popularization and application values.

The invention relates to a cerium oxide / iron oxide / mesoporous silica nano composite material. The surfaces of amino-modified mesoporous silica nanoparticles are respectively modified by ligand-converted cerium oxide nanocrystals and ligand-converted iron oxide nanocrystals. The invention also relates to a preparation method and application of the cerium oxide / iron oxide / mesoporous silica nano composite material. Not only can the composite material carry a drug for treating Alzheimer apostrophe s disease (AD), but also can remove reactive oxide species (ROS) in AD-similar cells, and can be used for diagnosis of the AD as a nuclear magnetic resonance imaging contrast agent, thus realizing integration of diagnosis and treatment of the AD.

The invention discloses a method for synthesizing indolizine compounds under the catalysis of silver, which comprises the following steps of in an organic solvent system, stirring N-benzoylmethyl pyridinium bromide as shown in a formula (1) and an isocyanide compound as shown in a formula (2) according to a feeding molar ratio of 1: (1.2-2.0) in the presence of a metal silver salt as a catalyst to react in the air under an alkaline condition, and carrying out TLC tracking detection until the reaction is complete, and carrying out post-treatment on the reaction liquid to obtain the indolizine compound as shown in a formula (3). The method is easy to operate, raw materials and reagents are easy to obtain, reaction conditions are mild, a reaction system is environmentally friendly, products are easy to separate and purify, the yield reaches up to 91%, and the method is suitable for efficient and high-yield preparation of indolizine compounds and particularly suitable for synthesis of various 1, 2-substituted indolizine compounds. The method is suitable for large-scale industrial production, and has wide application prospects and important significance in organic synthesis.

The invention relates to a preparation method of a pH-responsive nanosilver assembly. The preparation method comprises the following steps: 1), dissolving silver nitrate in oleylamine and oleic acid,heating for a reduction reaction, and precipitating by using a poor solvent to obtain silver nanoparticles; 2), dissolving an amphiphilic polymer in a good solvent, adding a modifier having a pH-responsive group, stirring at room temperature for a reaction, and dialyzing to obtain a pH-responsive amphiphilic polymer; 3), by a film dispersion method or an emulsion solvent evaporation method, assembling the silver nanoparticles obtained in the step 1) into the pH-responsive amphiphilic polymer obtained in the step 1) to obtain the pH-responsive nanosilver assembly. The invention further relatesto the pH-responsive nanosilver assembly prepared by the preparation method and application thereof. The pH-responsive nanosilver assembly has good antibacterial performance, not only can effectivelyinhibit growth of medicine-resistant bacteria, but also has the effects of inhibiting and destroying a bacterial biofilm.