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41 results about "Vicinal" patented technology

In chemistry the descriptor vicinal (from Latin vicinus = neighbor), abbreviated vic, describes any two functional groups bonded to two adjacent carbon atoms (i.e., in a 1,2-relationship). For example, the molecule 2,3-dibromobutane carries two vicinal bromine atoms and 1,3-dibromobutane does not. Mostly, the use of the term vicinal is restricted to two identical functional groups.

Modulators of peroxisome proliferator activated receptors

Disclosed is a compound represented by Structural Formula (I): Ar is a substituted or unsubstituted aromatic group. Q is a covalent bond, —CH2— or —CH2CH2—; W is a substituted or unsubstituted alkylene or a substituted or unsubstituted heteroalkylene linking group from two to ten atoms in length, preferably from two to seven atoms in length. Phenyl Ring A is optionally substituted with up to four substituents in addition to R1 and W, R1 is (CH2)n—CH(OR2)—(CH2)mE1, —(CH)═C(OR2)—(CH2)mE, —(CH2)n—CH(Y)—(CH2)mE or (CH)═C(Y)—(CH2)mE; wherein E is COOR3, C1–C3 alkylnitrile, carboxamide, sulfonamide, acylsulfonamide or tetrazole and wherein sulfonamide, acylsulfonamide and tetrazole are optionally substituted with one or more substituents independently selected from: C1–C6 alkyl, haloalkyl and aryl-C0-4-alkyl; R2 is H, an aliphatic group, a substituted aliphatic group, haloalkyl, an aromatic group, a substituted aromatic group, —COR4, —COOR4, —CONR5R6, —C(S)R4, —C(S)OR4 or C(S)NR5R6, R3 is H, an aliphatic group, a substituted aliphatic group, an aromatic group or a substituted aromatic group. Y is O—, CH2—, —CH2CH2— or CH═CH— and is bonded to a carbon atom in Phenyl Ring A that is ortho to R1. R4–R6 are independently H, an aliphatic group, a substituted aliphatic group, an aromatic group or a substituted aromatic group. n and m are independently 0, 1 or 2
Owner:ELI LILLY & CO +1

Modulators of peroxisome proliferator activated receptors

Disclosed is a compound represented by Structural Formula (I): Ar is a substituted or unsubstituted aromatic group. Q is a covalent bond, —CH2— or —CH2CH2—; W is a substituted or unsubstituted alkylene or a substituted or unsubstituted heteroalkylene linking group from two to ten atoms in length, preferably from two to seven atoms in length. Phenyl Ring A is optionally substituted with up to four substituents in addition to R1 and W, R2 is (CH2)n—CH(OR2)—(CH2)nE, —(CH)═C(OR2)—(CH2)nE, —(CH2)n—CH(Y)—(CH2)mE or (CH)═C(Y)(CH2)mE; wherein E is COOR3, C1-C3 alkylnitrile, carboxamide, sulfonamide, acylsulfonamide or tetrazole and wherein sulfonamide, acylsulfonamide and tetrazole are optionally substituted with one or more substituents independently selected from: C1-C6 alkyl, haloalkyl and aryl-Co-4-alkyl; R2 is H, an aliphatic group, a substituted aliphatic group, haloalkyl, an aromatic group, a substituted aromatic group, —COR4, —COOR4, —CONR5R6, —C(S)R4, —C(S)OR4 or C(S)NR5R6, R3 is H, an aliphatic group, a substituted aliphatic group, an aromatic group or a substituted aromatic group. Y is O—, CH2—, CH2CH2— or CH═CH— and is bonded to a carbon atom in Phenyl Ring A that is ortho to R1. R4-R6 are independently H, an aliphatic group, a substituted aliphatic group, an aromatic group or a substituted aromatic group. n and m are independently 0, 1 or 2.
Owner:ELI LILLY & CO +1

Ketone compound and synthesis method thereof

The invention discloses a method for generation of a ketone compound from a vicinal diol compound. The method includes: dissolving the vicinal diol compound in a solvent, and then under the action of the oxidizing agent 1-chloromethyl-4-fluoro-1, 4-diazabicyclo[2.2.2]octane bis(tetrafluoroborate), enabling carbon-carbon bond breakage of the vicinal diol compound to generate the ketone compound. The method provided by the invention has the advantages of no need for adding of a metal chelating agent, low reaction temperature, no by-product formation, high conversion rate, and a product yield of 56%-90%, thus being an environment-friendly method.
Owner:GUANGDONG UNIV OF TECH

Vicinal diol functionalized macroporous through-hole material as well as preparation method and boric acid adsorption application thereof

The invention discloses a vicinal diol functionalized macroporous through-hole material as well as a preparation method and boric acid adsorption application thereof. The preparation method comprisesthe following steps: (1) adding an anionic surfactant into a polyethyleneimine aqueous solution; (2) adding microcrystalline cellulose into the system as a supporting material, and oscillating at a high speed for several minutes to form an air-in-water emulsion; (3) adding a cross-linking agent into the air-in-water emulsion, and oscillating at a high speed for several minutes to partially cross-link polyethyleneimine to cure the emulsion to form a block material; (4) forming a through-hole material through vacuum dehydration, wherein the microcrystalline cellulose can prevent the porous material from overall great shrinkage in the dehydration process, but local microscopic shrinkage still occurs, so that a porous through-hole structure is formed, and the anionic surfactant adsorbed on thesurface of holes is removed through alkaline washing; and (5) converting amino hydrogen on the surface of the porous material into vicinal diol functional groups through glycidyl ether treatment. Thevicinal diol functionalized macroporous through-hole material has the characteristics of simplicity and convenience in preparation, large adsorption capacity, mild regeneration conditions, repeated regeneration and no powder falling.
Owner:TONGJI UNIV

Leoligin derivatives as smooth muscle cell proliferation inhibitors

InactiveUS20170157301A1Increase stereoselectivityEfficiently prevent restenosisOrganic active ingredientsOrganic chemistryLeiomyocyte2-Methyl-2-butene
A compound of formula (II), and a method of preparation thereof, for use as a smooth muscle cell (SMC) proliferation-inhibiting drug:wherein: R1 to R6 are —H, —F, —CH3, —CF3, —CF2CH3, —OCH3, —COCH3, —C4H9, —COOC2H5, or —C6H5, or two vicinal residues from R1 to R6 form a saturated or unsaturated carbocyclic ring together with the two carbon atoms to which they are attached; R7 is OH, allyloxy, propargyl-oxy, 2,2-dimethylpropanoyloxy (pivaloyloxy), butanoyloxy, 3-methylbutanoyloxy, 2-buten-oyloxy, 2-methyl-2-butenoyloxy, 3-methyl-2-butenoyloxy, isopentanoyloxy, 2-ethylbutanoyl-oxy, 3,3-dimethylbutanoyloxy, cyclopropylcarbonyloxy, cyclobutylcarbonyloxy, cyclo-pentylcarbonyloxy, cyclopentenylcarbonyloxy, cyclohexylcarbonyloxy, cyclo-hexenylcarbonyloxy, adamantylethanoyloxy, 3-phenylpropenoyloxy (cinnamyloyloxy), 2-methylbenzoyloxy, or naphthoyloxy; wherein, in ring A and / or B, one or more carbon ring atoms are optionally replaced by heteroatoms; wherein the compounds of formula (II) are obtained by combining the residues R1 to R7 and which inhibit SMC proliferation at least 50% more effectively than EC proliferation.
Owner:VIENNA UNIVERSITY OF TECHNOLOGY

Composite preservative containing amino acid derivatives and preparation method for composite preservative and cosmetic

PendingCN111135108AGrowth inhibitionIncrease antiseptic and antibacterial effectCosmetic preparationsToilet preparationsBiotechnologyMicroorganism
The invention discloses a composite preservative containing amino acid derivatives. The composite preservative contains the amino acid derivatives, 1,2-vicinal diol and a solvent; the amino acid derivatives are octanoyl amino acid derivatives and/or lauroyl amino acid derivatives. The composite preservative can disturb and inhibit a physiological environment of a cell membrane, namely that the composite preservative is selectively gathered on an oil-water interface in an oil-in-water emulsion system, so that a food source for microorganisms in a region where the composite preservative is gathered is changed to result in being not in favor of growth of the microorganisms, and thereby, the growth of the microorganisms is inhibited; while after the 1,2-vicinal diol is compounded with the octanoyl amino acid derivatives and lauroyl amino acid derivatives dissolved in the solvent, a synergistic effect is generated, so that antisepsis and bacteriostasis effects of octyl chains in the octanoyl amino acid derivatives and lauryl chains in the lauroyl amino acid derivatives can be enhanced to make the composite preservative have a good antisepsis and bacteriostasis effect, and the compositepreservative is very safe and mild to use. The invention further provides a preparation method for the composite preservative and a cosmetic containing the composite preservative.
Owner:广东迪美生物技术有限公司 +1

Physiologically active agents containing vicinal dithioglycols and use thereof in various branches of economy

The invention relates to the food and medical industries, medical cosmetics, dermatology, agriculture and the mixed feed industry. According to the invention vicinal dithioglycole (common formula RCH(SH)CH(SH)R−1 (I)) is used as a food additive, a food product, physiologically-active substances and active ingredients of forage additives and of forage, in cosmetic and / or dermatological and skin-therapeutic remedies. The invention comprises methods for producing such additives, products and remedies. The substance of formula (I) stimulates physiological processes, increases human and animal immunity, inhibits undesirable process in organisms and food products, produces curative and preventive action of skin, hair and nails and after vicinal dithioglycole is administered the intoxication effect of alcohol consumption known as hang-over is completely remored.
Owner:ZENOVICH SERGEI MIKHAILOVICH +1

Novel mycobacterial inhibitors

The present invention relates to novel substituted quinoline derivatives according to the general formula (Ia) or the general formula (Ib) salts, quaternary amines, stereochemically isomeric forms, tautomeric forms and N-oxide forms thereof, wherein R1 is hydrogen, halo, haloalkyl, cyano, hydroxy, Ar, Het, alkyl, alkyloxy, alkylthio, alkyloxyalkyl, alkylthioalkyl, Ar-alkyl or di(Ar)alkyl; p is 1, 2, 3 or 4; R2 is hydrogen, hydroxy, thio, alkyloxy, alkyloxyalkyloxy, alkylthio, mono or di(alkyl)amino or a radical of formula R3 is alkyl, Ar, Ar-alkyl, Het or Het-alkyl; R4 is hydrogen, alkyl or benzyl; R5 is hydrogen, halo, haloalkyl, hydroxy, Ar, alkyl, alkyloxy, alkylthio, alkyloxyalkyl, alkylthioalkyl, Ar-alkyl or di(Ar)alkyl; or two vicinal R5 radicals may be taken together to form together with the phenyl ring to which they are attached a naphthyl; r is 1, 2, 3, 4 or 5; R6 is hydrogen, alkyl, Ar or Het; R7 is hydrogen or alkyl; R8 is oxo; or R7 and R8 taken together form the radical CH═CH—N═; Z is CH2 or C(═O). The claimed compounds are useful for the treatment of mycobacterial diseases, particularly those diseases caused by pathogenic mycobacteria such as M. tuberculosis, M. bovis, M. avium, M. smegmatis and M. marinum. Also claimed is a pharmaceutical composition containing a compound of the present invention, the use of the claimed compounds or compositions for the manufacture of a medicament for the treatment of mycobacterial diseases and a process for preparing the claimed compounds.
Owner:JANSSEN PHARMA NV

Gene Encoding Protein With Vicinal Diketone or Diacetyl-Reducing Activity and Use Thereof

The present invention relates to a gene encoding a protein having a vicinal diketone or diacetyl-reducing activity and use thereof, in particular, a brewery yeast for producing alcoholic beverages with superior flavor, alcoholic beverages produced with said yeast, and a method for producing said beverages. More particularly, the present invention relates to a yeast, whose capability of producing vicinal diketones, especially diacetyl, that are responsible for off-flavors in products, is reduced by amplifying expression level of MMF1 gene encoding a protein (Mmflp) having a vicinal diketone or diacetyl-reducing activity, especially the non-ScMMF1 gene or ScMMF1 gene specific to a lager brewing yeast, and to a method for producing alcoholic beverages with said yeast.
Owner:SUNTORY HLDG LTD
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