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126 results about "Nitroxyl" patented technology

Nitroxyl (common name) or azanone (IUPAC name) is the chemical compound HNO. It is well known in the gas phase. NO⁻ It is the reduced form of nitric oxide (NO) and is isoelectronic with dioxygen. Nitroxyl can be formed as a reaction intermediate.

Blends of quinone alkide and nitroxyl compounds and polymerization inhibitors

Disclosed herein is a method for inhibiting the premature polymerization of ethylenically unsaturated monomers comprising adding to said monomers an effective amount of: A) at least one nitroxyl compound, and B) at least one quinone alkide compound having an electron-withdrawing group at the 7-position. Additionally, a composition is disclosed that comprises: A) at least one nitroxyl compound, and B) at least one quinone alkide compound having an electron-withdrawing group at the 7-position.
Owner:DEUT BANK AG NEW YORK BRANCH +1

Flame retardant compositions

InactiveUS20040198875A1HydroxylaminePolyolefin
Organic polymeric substrates, for example polyolefins such as polypropylene, can be made flame retardant by the incorporation of a synergistic mixture of (i.) a sterically hindered amine of the nitroxyl, hydroxylamine, alkoxyamine or hydroxyalkoxyamine class, and (ii.) a fluorinated polyolefin. Advantageously, a further flame retardant may be added, without the need of adding an antimony synergist. The compositions of the invention combine good flame retardant properties with light stability and good mechanical properties.
Owner:CIBA SPECIALTY CHEM CORP

N-hydroxylsulfonamide derivatives as new physiologically useful nitroxyl donors

ActiveUS20090163487A1Increase ischemia/reperfusion injuryIncreased myocardial ischemia/reperfusion injuryBiocideOrganic chemistryDiseaseReperfusion injury
The invention relates to N-hydroxylsulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and / or preventing the onset and / or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia / reperfusion injury. Novel N-hydroxylsulfonamide derivatives release NHO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N-hydroxylsulfonamide derivatives.
Owner:THE JOHN HOPKINS UNIV SCHOOL OF MEDICINE

Hypochlorite free method for preparation of stable carboxylated carbohydrate products

A method of making a carboxylated carbohydrate is disclosed, cellulose being a preferred carbohydrate material. Carboxylated cellulose fibers can be produced whose fiber strength and degree of polymerization is not significantly sacrificed. The method involves the use of a catalytic amount of a hindered cyclic oxammonium compounds as a primary oxidant and chlorine dioxide as a secondary oxidant in an aqueous environment. The oxammonium compounds may be formed in situ from their corresponding amine, hydroxylamine, or nitroxyl compounds. The oxidized cellulose may be stabilized against D.P. loss and color reversion by further treatment with an oxidant such as sodium chlorite or a chlorine dioxide / hydrogen peroxide mixture. Alternatively it may be treated with a reducing agent such as sodium borohydride. In the case of cellulose the method results in a high percentage of carboxyl groups located at the fiber surface. The product is especially useful as a papermaking fiber where it contributes strength and has a higher attraction for cationic additives. The product is also useful as an additive to recycled fiber to increase strength. The method can be used to improve properties of either virgin or recycled fiber. It does not require high α-cellulose fiber but is suitable for regular market pulps.
Owner:INT PAPER CANADA PULP HLDG ULC

Nitrosated and nitrosylated phosphodiestrase inhibitor compounds, compositions and their uses

Disclosed are nitrosated and / or nitrosylated phosphodiesterase inhibitors having the formula NOn-PDE inhibitor where n is 1 or 2. The invention also provides compositions comprising such compounds in a pharmaceutically acceptable carrier. The invention also provides a composition comprising a therapeutically effective amount of an phosphodiesterase inhibitor (PDE inhibitor), which can optionally be substituted with at least one NO or NO2 moiety, and one to ten fold molar excess of a compound that donates, transfers or releases nitrogen monoxide as a charged species, i.e., nitrosonium (NO+) or nitroxyl (NO-), or as the neutral species, nitric oxide (NO.) or which stimulates endogenous EDRF production. The invention also provides compositions comprising such compounds in a pharmaceutically acceptable carrier. The invention also provides methods for treating sexual dysfunctions in males and females.
Owner:NITROMED

Cyclooxygenase inhibition with nitroxyl

Nitroxyl is used to inhibit COX-2 activity and particularly to selectively inhibit COX-2 activity. Nitroxyl also is used to treat conditions that respond favorably to inhibition of COX-2 activity in subjects having such conditions. In some cases nitroxyl is used to treat conditions that respond favorably to inhibition of COX-2 activity in subjects having such conditions and who also have at least one other condition for which inhibition of COX-1 activity is disadvantageous. Nitroxyl can be provided directly, but typically is provided with the use of a nitroxyl donor. Nitroxyl donors include any agent or compound (or combination thereof) that donates HNO or NO−. Diazeniumdiolates are used in some cases as nitroxyl donors. In particular instances, diazeniumdiolates having a primary amine group are used as nitroxyl donors. Nitroxyl-donating compounds also are screened for selective COX-2 inhibition for identification as therapeutic agents.
Owner:SEC OF THE DEPT OF HEALTH & HUMAN SERVICES THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE

Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders

Disclosed are (i) compounds of a steroid, a β-agonist, an anticholinergic, a mast cell stabilizer and a phosphodiesterase (PDE) inhibitor directly or indirectly linked to a NO or NO2 group or a group which stimulates endogenous production of NO or EDRF in vivo; (ii) compositions of steroids, β-agonists, anticholinergics, mast cell stabilizers and PDE inhibitors, which can optionally be substituted with at least one NO or NO2 moiety or a group which stimulates endogenous production of NO or EDRF in vivo, and a compound that donates, transfers or releases nitric oxide as a charged species, i.e., nitrosonium (NO+) or nitroxyl (NO−), or as the neutral species, nitric oxide (NO.) or that stimulates endogenous production of NO or EDRF in vivo; and (iii) uses for them in preventing and / or treating respiratory disorders.
Owner:ARBOR PHARMA LLC

Electric conduction polymer and synthesis method thereof and electroactive electrode with surface covered with electric conduction polymer

The invention relates to electric conduction polymer and a synthesis method thereof and an electroactive electrode with a surface covered with the electric conduction polymer. In the synthesis method for the electric conduction polymer, polybasic acid is used as a doping agent and a cross-linking agent, so that a monomer is polymerized to obtain electric conduction polymer hydrogel, wherein the monomer is at least one of pyrrole or a derivative of the pyrrole, thiophene or a derivative of the thiophene, phenylamine or a derivative of the phenylamine; and the acid group of the polybasic acid comprises a phosphate group or polybasic acid of which each molecule comprises more than two acid groups selected from at least one of a sulfonic acid group, nitroxyl or a carboxylic acid group and which has the molecular weight of less than or equal to 800. The molar ratio of the mole number of the acid group contained in the polybasic acid to the mole number of an electric conduction polymer monomer is preferably 1:12-12:1. The electric conduction polymer obtained by the synthesis method is covered by the surface of the electroactive electrode. The electric conduction polymer has a simple preparation method, and other impurities are not required to be led into the electric conduction polymer. The prepared electric conduction polymer hydrogel has high ionic conductivity, super hydrophilicity and high biological compatibility.
Owner:NANJING UNIV

Charge Transfer Mediator Based Systems for Electrocatalytic Oxygen Reduction

Disclosed are systems for the electrocatalytic reduction of oxygen, having redox mediator / redox catalyst pairs and an electrolyte solution in contact with an electrode. The redox mediator is included in the electrolyte solution, and the redox catalyst may be included in the electrolyte solution, or alternatively, may be in contact with the electrolyte solution. In one form a cobalt redox catalyst is used with a quinone redox mediator. In another form a nitrogen oxide redox catalyst is used with a nitroxyl type redox mediator. The systems can be used in electrochemical cells wherein neither the anode nor the cathode comprise an expensive metal such as platinum.
Owner:WISCONSIN ALUMNI RES FOUND

Alcohol Oxidation Catalyst and Method of Synthesizing the Same

An organic oxidation catalyst for alcohols which is environmentally less harmful and with which efficient oxidation can be conducted. The oxidation catalyst for alcohols is a 1-alkyl-2-azadamantan-N-oxyl which has a nitroxyl group incorporated in the adamantane skeleton and was synthesized from as a base material a bicyclic compound obtained by the Grob-type ring-opening reaction of 1,3-adamantanediol. Due to the nitroxyl group on the adamantane skeleton, the α-position hydrogen is stabilized based on Bredt's rule and the stability of the oxoammonium group generated by the oxidation thereof is ensured. Compared to TEMPO, which is a conventional oxidation catalyst, this catalyst is reduced in steric hindrance and is usable in a wide range of reaction fields. Because of this, not only a primary alcohol but a secondary alcohol having a sterically complicated structure, which has been difficult to oxidize with TEMPO, can be oxidized at a high efficiency.
Owner:NISSAN CHEM IND LTD

A kind of selective amination method of bacterial cellulose

The invention relates to a selective amination method of bacterial cellulose and in particular relates to a bacterial cellulose selective amination method, which is to oxidize primary hydroxyl on C6 of anhydroglucose ring of the bacterial cellulose into carboxylic acid under an acidic condition by adopting a nitroxyl / enzyme co-oxidant system, and performing amination. The method comprises the following steps: (1) placing the lyophilized bacterial cellulose into the nitroxyl / enzyme system solution, regulating the pH to be acidic, slowly adding an oxidant, regulating the pH to be neutral, and cleaning to obtain selectively oxidized bacterial cellulose; and (2) placing the selectively oxidized bacterial cellulose into a diamine substance solution, heating to react for 2 to 4 hours, and washing to obtain the selectively aminated bacterial cellulose. According to the selective amination method of bacterial cellulose, the primary hydroxyl on C6 of the anhydroglucose ring of the bacterial cellulose can be selectively converted into amidogen completely and effectively, and can provide a chelation group to bacterial cellulose supported functional particles.
Owner:DONGHUA UNIV

Method for preparation of stabilized carboxylated cellulose

The invention is directed to a method of making a heat and light stable carboxylated cellulose fiber whose fiber strength and degree of polymerization is not significantly sacrificed. The method involves the use of a catalytic amount of a hindered cyclic oxammonium salt as a primary oxidant and a peracid and halide salt as a secondary oxidant in an aqueous environment. The oxammonium compounds may be formed in situ from their corresponding amine, hydroxylamine, and nitroxyl compounds. The oxidized cellulose is then stabilized against D.P. loss and color reversion by further treatment with an oxidant such as sodium chlorite, a chlorine dioxide / hydrogen peroxide mixture, or a peracid under acidic conditions. Alternatively it may be treated with a reducing agent such as sodium borohydride. The method results in a high percentage of carboxyl groups located at the fiber surface. The product is especially useful as a papermaking fiber where it contributes strength and has a higher attraction for cationic additives. The product is also useful as an additive to recycled fiber to increase strength. The method can be used to improve properties of either virgin or recycled fiber. It does not require high alpha-cellulose fiber but is suitable for regular market pulps.
Owner:WEYERHAEUSER CO

Inhibiting polymerization of vinyl aromatic monomers

When a nitroxyl compound is heated in an oxygen-free atmosphere with a vinyl aromatic monomer at 50-140 DEG C. for up to 60 days, it forms an activated inhibitor mixture which is superior to the nitroxyl compound itself in preventing the premature polymerization of a vinyl aromatic monomer during its processing and purification.
Owner:ECOLAB USA INC

Composition and method for inhibiting polymerization and polymer growth

InactiveUS20050113626A1Prevent polymer growthUtility and effectivenessThermal non-catalytic crackingHydrocarbon purification/separationHydrogenElectron acceptor
A method for inhibiting the premature polymerization and the polymer growth of ethylenically unsaturated monomers is disclosed wherein the method comprises adding to said monomers an effective amount of at least one hydrogen donor or electron acceptor. In a preferred embodiment, the hydrogen donor or electron acceptor is used in combination with a stable nitroxyl free radical.
Owner:UNIROYAL CHEM CO INC

Method for preparing beta-cyclodextrin-gold nano-particles and method for detecting cholesterol

The invention discloses a method for preparing beta-cyclodextrin-gold nano-particles and a method for detecting cholesterol. The method for preparing the beta-cyclodextrin-gold nano-particles includes enabling water, gold source solution and beta-cyclodextrin solution to carry out contact reaction in the presence of buffer solution to obtain the beta-cyclodextrin-gold nano-particles. The gold source solution can be one or a plurality of types of chloroauric acid trihydrate solution, chloroaurate solution, tetra-nitroxyl alloy acid solution and tetra-nitroxyl alloy salt solution. The methods have the advantages that the beta-cyclodextrin-gold nano-particles can be prepared at one step, raw materials of the beta-cyclodextrin-gold nano-particles are easily available, and post-treatment is simple; the cholesterol can be sensitively and quantitatively detected by the aid of the beta-cyclodextrin-gold nano-particles, and the beta-cyclodextrin-gold nano-particles are excellent in anti-interference capacity.
Owner:ANHUI NORMAL UNIV

Anti-heparin interference leucine aminopeptidase measuring reagent

InactiveCN102864206AGood anti-heparin interference performanceImprove stabilityMicrobiological testing/measurementHydrogenPreservative
The invention discloses an anti-heparin interference leucine aminopeptidase measuring reagent, which consists of a reagent 1 and a reagent 2, wherein the reagent 1 and the reagent 2 comprises the following components in the concentration ranges: the reagent 1 comprises 50-500 mmol / L of buffer solution (pH (Potential of Hydrogen) of 3.0-6.0), 1-100 ml / L of anti-interference agent and 0.1-100 g / L of preservative; and the reagent 2 comprises 50-500 mmol / L of buffer solution (pH (Potential of Hydrogen) of 3.0-6.0), 1-100 ml / L of L-leucine-p-nitroxyl aniline, 1-100 g / L of stabilizer and 0.1-100 g / L of preservative. The anti-heparin interference leucine aminopeptidase measuring reagent has the advantages of good anti-heparin interference capacity, good stability and capability of completely meeting requirements of clinical inspection.
Owner:NINGBO MEDICAL SYSTEM BIOTECHNOLOGY CO LTD

Composition and method for inhibiting polymerization and polymer growth

A method for inhibiting the premature polymerization and the polymer growth of ethylenically unsaturated monomers is disclosed wherein the method comprises adding to said monomers an effective amount of at least one hydrogen donor or electron acceptor. In a preferred embodiment, the hydrogen donor or electron acceptor is used in combination with a stable nitroxyl free radical.
Owner:ADDIVANT USA

Rare earth metal ionic liquid, preparation method and application thereof

The invention relates to a novel ionic liquid of nitryl rare earth metal acid salt anion, a preparation method and an application thereof, and belongs to the fields of rare earth functional materials, preparations and applications thereof. According to the method, a rare earth metal nitrate solution is added into a corresponding imidazole or pyridine nitrate ionic liquid solution in a mole ratio of 1:3, a solvent is removed after a reaction, and the rare earth metal ionic liquid is obtained. The prepared ionic liquid of the nitryl rare earth metal acid salt anion has good stability, is provided with characteristics of the ionic liquid as well as advantages of the rare earth metal simultaneously, and can be provided with characteristics of luminescence and magnetism; and the required cost is low, the preparation is simple and convenient, the product purity is high, the ionic liquid is suitable for large-scale production and application, and liquid luminescent materials / liquid magnetic materials with high-concentration rare earth can be prepared through the provided process which is simple, efficient and environment-friendly.
Owner:SICHUAN UNIV

Use of poly-nitroxyl-functionalized dendrimers as contrast enhancing agent in mri imaging of joints

The image obtained by MR imaging of the joint of an animal, including humans, is enhanced by injecting into the joint prior to the scan of an imaging enhancing amount of a nitroxyl functionalized dendrimer containing at least 6 nitroxyl terminal functional groups, e.g, of Formula (I) wherein each R independently is either a nitroxyl group of Formula (II) wherein X is an oxygen atom or two hydrogen atoms, R' is lower alkyl and R'' is H or lower alkyl, or a group of Formula (III) wherein R''' is lower alkyl, or a group of Formula (IV): wherein each alkylene in Formulae (I), (III) and (IV) is a bridging divalent alkylene group of 2-6 carbon atoms with 2-3 carbon atoms in the chain and R is as defined herein, with the proviso that the total number of R groups in the molecule which are nitroxyl groups of Formula (II) is at least 6.
Owner:NITROSCI PHARMA

Flame retarding compounds

Novel flame retarding compounds that comprise at least one sterically hindered nitroxyl, hydroxylamine or hydrocarbyloxyamine moiety and at least one conventional organohalogen or organophosphorus flame retardant moiety, represented by whereHA is independently of each other a sterically hindered nitroxyl, sterically hindered hydroxylamine or sterically hindered hydrocarbyloxyamine moiety,L is independently of each other a direct bond or chemical linking group,FRM is independently of each other an organohalogen or an organophosphorus flame reatardant moiety, andx, y and z are each independently greater than or equal to 1,are especially effective towards providing flame retardancy to organic polymer substrates.
Owner:CIBA SPECIALTY CHEM CORP

Composition and method for inhibiting polymerization and polymer growth

InactiveUS20050113625A1Prevent polymer growthUtility and effectivenessThermal non-catalytic crackingHydrocarbon purification/separationHydrogenElectron acceptor
A method for inhibiting the premature polymerization and the polymer growth of ethylenically unsaturated monomers is disclosed wherein the method comprises adding to said monomers an effective amount of at least one hydrogen donor or electron acceptor. In a preferred embodiment, the hydrogen donor or electron acceptor is used in combination with a stable nitroxyl free radical.
Owner:UNIROYAL CHEM CO INC

High-temperature compound polymerization inhibitor used in rectification process of aromatic alkene monomer and application thereof

InactiveCN106554244ANot easy to aggregate and adhereInhibit aggregate adhesionHydrocarbon purification/separationHydrocarbonsSolventAlkene
The invention relates to a high-temperature compound polymerization inhibitor used in a rectification process of an aromatic alkene monomer and an application thereof. The compound polymerization inhibitor includes a component A, a component B and a component C, wherein the component A is a piperidine nitroxyl free radical compound, the component B is an alkoxyphenol compound, and the component C is solvent oil. The polymerization inhibitor has polymerization inhibition effect at high temperature and also has anti-scaling effect, thus solving the problems that polymerization inhibition is achieved only if a polymerization retarder is compounded with a real polymerization inhibitor, and the compound is complex in ingredient, has poor polymerization inhibition effect at high temperature and has no anti-scaling effect. The compound polymerization inhibitor has low toxicity, has good polymerization inhibition effect at high temperature and has the anti-scaling effect, thereby increasing rectification yield of aromatic alkene, reducing pollution and eliminating safety risk.
Owner:CHINA PETROLEUM & CHEM CORP

Stabilized electrochromic media

Disclosed are compositions, which are stabilized against degradation and yellowing during exposure to ultraviolet light by the presence of certain nitroxyl, hydroxyl amine and hydroxyl amine salt additives, a method of stabilizing the compositions by the addition of said additives, to the use of such compositions as media in electroactive devices such as electrochromic and electrophoteric devices, and the electroactive devices comprised of these media.
Owner:CIBA SPECIALTY CHEM CORP
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