47 results about "Lower mortality" patented technology

The invention discloses a method for propagating market hogs. According to the different growth and physiological stages of the market hogs, the growth of the market hog comprises the stages of lactation and luring, weaning and stress, pigling breeding, growing development and beef gain, fodder with good nutrition, smell, and luring performance is provided in the stage of lactation and luring; fodder with diarrhea resistance and high nutrition concentration and capable of keeping the healthy of intestinal tract is provided in the stage of weaning and stress; fodder capable of strengthening immunity, promoting growth and exercising the intestinal tract is provided in the pigling breeding; fodder for increasing nutrition and protein synthesis is provided in the stage of growing development;the fodder with high energy and high amino acid is provided in the beef gain. According to the method, the fodder is schemed according to the physiology and development stage and the stress conditions; the method has the advantages of low mortality, quick growth speed, short propagation period, low feed conversion ratio, high weight and the like; in addition, the propagation cost of the market hog is lowered, and the economic benefits of propagating market hog are improved.

The invention discloses a formula feed of broilers and a preparation method thereof. The formula is as follows: 50-65% of corn, 0-2% of fishmeal, 20-25% of soya bean meal, 0-3% of corn protein powder, 0-1% of whole hen egg, 0-5% of wheat middling, 0-5% of rice pericarps, 0-5% of rice bran, 0-3% of cottonseed meal, 0.5-1.5% of bean oil, 0.1-0.3% of acidulant, 0.05-0.1% of sodium butyrate, 0.03-0.05% of compound enzyme preparation and 1.5-2% of compound premix. The feed is prepared by the steps of removing impurities from raw materials, grinding raw materials, weighing raw materials, mixing raw materials, palletizing and packing finished products, etc. in sequence. The invention selects the additives which promote the broilers to grow and develop and the feed materials which improve the immunocompetence, etc. The feed product has moderate metabolic energy value, high nutrition level and good palatability, is easy to digest and absorb and is easy to satisfy the nutritional requirements of 1-7 days of growth, therefore, the broilers grow fast and have high disease resistance, low mortality and low feed coefficient, and the coefficient of the formula feed is 0.8-0.9.

The invention discloses a fine feed for rhizomys in a rearing period. The fine feed comprises the following raw materials in percentage by weight: 20%-42% of corn, 12%-18% of soybean meal, 30%-50% of rice bran, 10%-23% of bran, 1%-3% of fish meal, 2% of calcium hydrophosphate, 0.5% of stone dust, 1% of common salt and 1% of premix. One kilogram of premix provides 88 million IU (international units) of VA (vitamin A), 60,000 IU of VE (vitamin E), 325 million IU of VD (vitamin D), 310g of VK (vitamin K), 110g of VB (vitamin B), 220g of VB, 65g of VB, 1220g of VB, 50g of pantothenic acid, 10g of nicotinic acid, 800mg of folic acid, 10g of biotin, 30g of Lys (lysine), 60g of Met (methionine), 30g of potassium, sodium, zinc and the like, and 30g of VC (vitamin C); and the main nutritional levels of the obtained fine feed are that the digestible energy is 2.85-3.01 Mcal / kg, and crude protein is 15.52%-18.07%. The fine feed disclosed by the invention can meet the nutritional requirements of the rhizomys sinensis in the rearing period, has a reasonable formula, and can ensure the rapid growth, robust physique, low disease incidence and low mortality rate of the rhizomys.

The invention relates to the usage of pirfenidone for treating hepatic injury and necrosis and acute lung injury, more specifically the invention relates to the application of pirfenidone in abatement of symptoms for patients with hepatic injury, necrosis and acute lung injury, and in lowering mortality rate. The invention also provides the medicinal composition for treating hepatic injury, necrosis and acute lung injury.

The invention discloses a modeling method of a non-alcoholic fatty liver mouse model, and the method is characterized by consisting of the following steps that (1) a healthy mouse is caught and first adaptively raised for 3 to 7 days in an animal house, a backing material and clean water in a mouse cage are changed every day, and basic fodder is fed during that period of time; (2) after adaptive raising, composite high-fat fodder is fed every day; (3) 5 percent CC14 liquid is injected into the abdominal cavity of the mouse two weeks later, the liquid carbon tetrachloride is diluted to 5 percent emulsion with deionized water, and the liquid which is injected into the abdominal cavity shall be newly prepared; the abdominal cavity injection state continues for the 28th day, and meanwhile the composite high-fat fodder is fed; and the model is obtained. The modeling method has the advantages of short time, high modeling success rate, extremely low mortality rate and low cost.

The invention discloses an ecological health care type carp complete expanded compound feed, which is prepared from the following components in parts by weight: 12%-15% of fish meal, 17%-20% of flour, 11%-14% of green bran, 0-3% of DDGS (dried distiller grains with soluble), 10%-13% of soybean meal, 28%-31% of rapeseed meal, 12.6%-15.6% of cottonseed meal, 2.2%-4% of soybean oil, 0.8%-1% of lecithin oil, 0.2% of common salt, 2.0%-2.4% of calcium dihydrogen phosphate, 0.15% of choline, 0.03%-2.5% of zeolite powder, 1% of premix, 0.01% of bacillus licheniformis and 0.01% of liquid phytase. Compared with an original product, the ecological health care type carp complete expanded compound feed disclosed by the invention has the characteristics of fastness in carp growth, low feed coefficient, few plant diseases, low mortality rate, a small quantity of used medicament, low incidence of fish hypoxia, low eutrophication of water quality and the like, and can realize a green and ecological development way for sustainable development of healthy cultivation and ecological cultivation of aquiculture.

The invention discloses a method and a special device for live crab transportation. A water vapour generating device is adopted to supply water vapour made of the cooling water of semiconductor refrigeration blocks to an insulation casing with an insulating door, and the insulation casing keeps temperature to be between 3 DEG C to 5 DEG C and the concentration of oxygen to be larger than 70 percent in a transportation process. The invention has the advantages of small consumption of water for transportation, low mortality rate of live crabs and long live time of the live crabs in transportation, simple and convenient operation, low cost, and the like, thereby suiting large-scale popularization.

A method for preparation of a feed additive containing surfactin, which uses a high-yield mutant strain, Bacillus subtilis T, and soybeans as the substrate in semi-solid state fermentation and after drying and grinding of the fermented soybeans into soybean powder to give a feed additive containing surfactin. Each kilogram of the fermented soybean powder contains about 6-7 g of surfactin. Feeding grouper with the feed additive containing surfactin can promote growth rate, increase expression of immune genes (e.g. AMP, Mx and IFN-induced protein), and lower mortality rate of virus-infected fish, indicating the feed containing surfactin has the effects of growth promotion, immunity enhancement and provides resistance to pathogen infection.

The present invention provides a non-human animal model of myocardial infarction, which can be created by a less invasive method, shows an extremely low mortality during and after surgical induction of myocardial infarction, ensures the blood reflow after necrosis of cardiac muscles caused by blocking blood flow, and therefore, is usable in topical therapy for myocardial infarction and studies on regenerative medicine. The present invention also provides a method for creating the non-human animal model comprising administering a temporary embolic agent to a branch blood vessel of a heart coronary artery to block blood flow in the branch blood vessel; and after a definite period of time after said vascular branch blockage, administering a temporary embolic agent to the target coronary artery which is intended to induce myocardial infarction to block blood flow in the target coronary artery.

The invention discloses a near-shore cultivating and breeding method and device suitable for dendroidal Hermatypic coral. The method comprises the steps of: fixing a dendroidal Hermatypic coral attaching device onto flat reef bottom or gravel bottom at the seabed of a shallow and near-shore sea area with water depth of 2-10 m at the time of low tide, wherein the dendroidal Hermatypic coral attaching device comprises an attaching frame and a supporting rack thereof, multiple attaching strips are arranged in the attaching frame, and multiple attaching branches are fixed on the attaching strips; and binding the dendroidal Hermatypic coral to the attaching branches in a ramification manner, so that the dendroidal Hermatypic coral grows in the ramification manner 15-20 cm away from the seabed. As compared with dendroidal Hermatypic coral subjected to traditional cement block transplanting, the dendroidal Hermatypic coral cultivated by the near-shore cultivating and breeding method suitable for dendroidal Hermatypic coral has the advantages of low mortality, high survival rate, higher growth rate and more healthy coral condition.

The invention discloses a double white shells patinopecten yessoensis cultivation method. The patinopecten yessoensis individual, in which the upper shell whitening region area is more than 30% and the gonad development is plump, is firstly selected as a parent scallop. In the particular conditions such as density, temperature and so on, the accelerated ripening, the induced spawning, the artificial insemination, the hatching, the cultivation, the attachment seedling collection, the ex-storage, the intermediate seedling protection and growth, as well as the mariculture are implemented, so that the patinopecten yessoensis in which the whitening area is increased further is cultivated. Moreover the patinopecten yessoensis obtained is taken as a parent scallop to repeat the above steps. The steps are repeated for several times until a scallop seedling in which the upper and lower shells colours are entire pure white is obtained. The double white shells patinopecten yessoensis not only has the bright colour, at the same time the stress resistance enhancement is in favour of the inhibition of disease occurrence, and the perforation of parasites and other microorganisms can be reduced. With a nice appearance, the scallop is well received among consumers, and with the heat-resisting ability, the scallop can tolerant the high temperature up to 25 DEG C. With a low mortality rate which is less than 10%, the growth rate of the scallop is stronger than the general patinopecten yessoensis. Therefore, the economic benefits of farmers can be effectively increased.

The invention relates to the technical field of pig feed, in particular to feed for weaned piglets. The feed comprises, by weight, 25-35 parts of corn flour, 20-25 parts of wheat, 15-20 parts of plasma protein powder, 8-15 parts of milk powder, 10-15 parts of whey powder, 6-10 parts of coconut oil, 3.5-6 parts of complex enzyme preparation, 2-5 parts of acid preparation, 18-26 parts of traditional Chinese medicine preparation and 5-9 parts of multi-vitamin. The feed has the advantages that the raw materials used by the feed is fresh in quality, wide in source, comprehensive in nutrition, good in palatability, easy to digest, capable of increasing the immunity and disease resistance of the weaned piglets, capable of improving the appetite of the weaned piglets, capable of effectively promoting the growth of the weaned piglets and capable increasing the utilization rate of the feed; by using organic acid, an acidification effect can be achieved, the pH of gastrointestinal tracts can be lowered, and effects of sterilizing, preventing corrosion, regulating flora balance of the gastrointestinal tracts and lowering mortality and elimination rate are achieved.

The invention provides a method for breeding blister pearls by using magnetic attraction to fix pearl nuclei. The method includes the steps of connecting a strong magnetic material to one side of the bottom surface of a traditional blister pearl nucleus; wrapping the pearl nucleus with an anti-corrosive and skid-proof soft glue film on the outer side to form a magnetic pearl nucleus; disposing the magnetic pearl nucleus in a preset nucleus position on the inner side of a shell; fixing another strong magnetic material in the same position on the inner side of the shell so as to fix the magnetic pearl nucleus in the preset nucleus position under the attraction between the two magnetic materials; and breeding the nucleus-transplanted shell in the sea area for a certain period of time to generate a magnetic blister pearl. The method has the advantages of convenient use, good effect of pearl-nucleus fixation, reduced time for nucleus-transplanting operation, reduced nucleus-transplanting efficiency, and lowered mortality rate for shells after operation, thus overcoming the deficiency in prior method of breeding blister pearls that uses cementing compound to fix pearl nuclei.

The invention discloses a construction method of a diabetic cardiomyopathy animal model. An SD (Sprague Dawley) rat under high-sugar and high-fat feeding is subjected to multiple abdominal injection with STZ (streptozocin); after the diabetics diagnosis standard is reached, subcutaneous injection with isoprenaline is performed; after 2 weeks of continued feeding, left ventricular cannulation and three-lead electrocardiogram test of ventricular hemodynamic parameters and electrocardiogram parameters shows that the rat experiences cardiac dysfunction; heart weight index and left ventricular index show that the rat experiences evident ventricular hypertrophy; biochemical analysis on rat blood shows that the rat has evident myocardial damage; HE (hematoxylin-eosin) pathological staining satisfies pathological changes in diabetic cardiomyopathy; Masson collagen staining satisfies myocardial connective tissue proliferation of diabetic cardiomyopathy. The construction method has the advantages of good operational simplicity, short construction time, low mortality in construction phase, high construction success rate and the like, and the pathological process of myocardial damage due to human type 2 diabetes mellitus can be well simulated.

The invention relates to a Chinese herbal medicine used for curing livestock foot and mouth diseases. The Chinese herbal medicine comprises the following Chinese herbal medicaments by weight part: 90 to 130 parts of rose moss, 90 to 130 parts of houttuynia, 90 to 130 parts of radix isatidis, 90 to 130 parts of andrographis paniculata, 90 to 130 parts of baikal skullcap root, 90 to 130 parts of forsythia, 90 to 130 parts of honeysuckle, 90 to 130 parts of hyacinth bletilla, and 90 to 130 parts of sophora flavescens ait. The Chinese herbal medicine is capable of antibiosis and antivirus, and curing local ulceration and pathological changes, which is both capable of detoxication, reducing fever, and antiinflammation, and capable of eliminating symptoms throughout the bodies caused by foot-and-mouth disease virus. The Chinese herbal medicine has remarkable curative effect on foot and mouth diseases of livestock, and has comprehensive curative effect in relieving the primary and secondary symptoms at the same time. Compared with the prior art, the Chinese herbal medicine can reduce the period of treatment by 2 / 3, and prevent complications with high cure rate of more than 99 percent and low mortality. By applying or spraying the Chinese herbal medicine on livestock which is not infected, or soaking the liverstock which is not infected in the Chinese herbal medicine, the Chinese herbal medicine plays a good role in preventing foot and mouth diseases.

The invention discloses a sterilization method for a squid larva, which comprises the steps of (1) temperature and salinity adaptation, namely, putting the squid larva to be sterilized in a sterilization container, and then heating water in the sterilization container from the temperature of water in a culture pond to 26.5 to 30 DEG C, and adjusting the salinity from 32 to 36 thousandths; (2) violent change by fresh water, namely, adding fresh water in water in the sterilization container to lead the salinity of water around the squid larva to be reduced from the salinity in the step of temperature and salinity adaptation to below 10 thousandths in one minute, and damaging the surface structure of germ due to inadaptation to low-salinity water when the gem absorbs water; and (3) temperature and salinity recovery, namely, immediately transferring the squid larva after violent fresh-water change to an environment with temperature of 26.5 to 30 DEG C and salinity of 32 to 36 thousandths for temporary culture, and then recovering the temperature and salinity of water to the standard of water in the culture pond. The sterilization method for the squid larva is simple and easy, causes little damage to the squid larva, has low mortality rate, and is environment-friendly and safe.

The invention discloses feed for breeding river crabs and a preparation method thereof. The invention aims at providing the feed for breeding river crabs, the river crabs have obvious growth effects after eating the feed, and the feed is free of any side effects. An additive formula mainly provides the river crabs with vitamins, mineral ion elements, various enzymes and other components required by growth of the river crabs for accelerating the growth of the river crabs, and the components are nuisance-free for the growth of the river crabs. The additive formula also contains antibiotics and various bacteria for inhibiting growth of harmful bacteria in the internal and external environments of the river crabs, so the river crabs have obvious growth effects and low mortality after eating the feed containing a basic formula and the additive formula, and the feed is free of any side effects.

The invention relates to three-stage feed for local broiler chickens and a preparation method thereof and belongs to the technical field of feed. The three-stage feed for local broiler chickens comprises first-stage feed, second-stage feed and third-stage feed; and the three-stage feed is mainly prepared from corn, rice bran, bean meal, calcium hydrogen phosphate, stone powder, trace element premix, vitamin premix, salt, a microecological preparation and the like. The three-stage feed for local broiler chickens has good palatability and low feed conversion ratio, is easy to digest and absorb and can meet the nutritional requirements of local broiler chickens, improve the disease resistance of the local broiler chickens and improve the immunity of the chickens. Meanwhile, the three-stage feed for local broiler chickens has moderate metabolic energy value and high nutritional level, the local broiler chickens have fast growth and low mortality after the feed is used, occurrence of respiratory disease in the chickens can be effectively prevented, and the fed broiler chickens maintain the due meat quality and mouthfeel of local chickens and have a delicious meat taste and high popularization value.

This invention is related to the use of immunoglobulins obtained from the egg yolk of hens hyperimmunized with a mixture of oocysts from several Eimerias species, but can be extended to any human or animal parasites. The immunoglobulins are obtained through the aqueous phase extraction of egg yolk through the use of hydroxypropylmethylcellulose phtalate at a final concentration of 0.05% and sodium azide at a final concentration of 0.001% as preservative. This invention is related also to the administration of said immunoglobulins in powder form in the food at a rate of 0.5 kg per ton of finished food. The administration of immunoglobulins both in liquid as well as in powder form lowers mortality, lesions and counts of coccidian oocysts in treated animals. On the other hand, the use of immunoglobulins produces weight gain in the treated animals.

The invention discloses Salmonella pullorum sp9905, which has been preserved. The preservation unit: China Typical Culture Collection Center; address: Wuhan University; preservation date: October 15, 2014; collection number: CCTCC NO.M 2014478 . The invention also provides the application of the Salmonella pullorum pullorum in the preparation of live vaccines. The vaccine prepared by the present invention has the advantages of high number of viable bacteria and low freeze-drying mortality rate, and the product is safe and reliable. The immune protection can produce a strong protective force on the 14th day, and the immune protection rate reaches 100%. It is also resistant to other serotypes of Salmonella (Salmonella enteritidis, Salmonella gallinarum typhi) also has a good protection ability (80%~100%).

The invention discloses a hen feed. The feed consists of the following components in parts by weight: 300-450 parts of corn, 100-250 parts of wheat, 120-150 parts of soybean meal, 50-60 parts of cottonseed meal, 10-30 parts of rapeseed meal, 40-60 parts of a maize gluten feed, 40-60 parts of distillers dried grains with solubles (DDGS), 20-30 parts of chrysanthemum powder, 10-50 parts of rice bran, 85-90 parts of stone powder, 5-8 parts of soybean oil, 6-10 parts of calcium hydrogen phosphate, 2.5-3 parts of salt, 1-2 parts of sodium sulfate, 0.5-1 part of choline, 2 parts of composite trace elements, 0.4-0.5 part of compound vitamins, 1-2 parts of lysine, 1-1.5 parts of methionine and 0.8 part of an additive. Through many years of practice, with the compounding and matching of a pluralityof raw materials and by adding a nutritional additive into the feed, the complete feed for laying hens realizes low cost, long-term egg-laying peak time, low mortality and elimination rate of layinghens and high egg-laying rate.

The invention discloses a feed additive for preventing and treating colibacillosis in minks. The feed additive is prepared from the following raw materials: soaked barley leaves, turtle meat, japonica rice, figs, lemongrass, Patrinia chinensis, knotweed, forsythia, Garlic, hawthorn, cabbage, purslane, psyllium, oyster mushroom, fennel, roasted licorice. The feed additive is made of natural Chinese herbal medicines and ingredients, safe and non-toxic, and can quickly and effectively treat colibacillosis in mink. The product is directly added to the feed to facilitate the mink to eat. Vitamins, minerals and other nutrients needed by the mink body can enhance their physical fitness, improve their immunity, promote the recovery of mink, reduce the impact of the disease on the normal growth and development of mink, reduce mortality, and ensure the use of farmers.

The invention relates to the technical field of medical treatment and especially relates to a method for making a rat unilateral pulmonary fibrosis model. The method comprises animal anesthetization, tracheal intubation, bleomycin perfusion into unilateral lung, and postoperative care, wherein concentrations of bleomycin for perfusion into unilateral lung is 1.5, 3.0 and 5.0mg / kg. The method has the advantages of simple making processes, wide popularization range, high experiment setting ratio, stable result, small pathology variation and low mortality. The rat unilateral pulmonary fibrosis model has a pathological process high similar to a human chronic pulmonary fibrosis pathological process and thus the rat unilateral pulmonary fibrosis model has a high etiology and pathology research value and has an important meaning for evaluation of pulmonary fibrosis-resistant drugs.

The invention discloses a low-mortality breeding method of Myxocyprinus asiaticus. The method particularly comprises the following steps: 1) determining a pond setting environment; 2) determining specifications of the pond; 3) cleaning the pond refuse; 4) digging a groove, which is about 15-20cm deeper than other places, in the bottom of a water discharge port of the pond, and arranging an anti-escape net; 5) arranging an oxygen charging plant on the bottom of the pond; 6) injecting underground water, which is extracted by a water pump, into the pond, and disinfecting the pond water by using an acidic potassium permanganate solution; 7) adding a fertilizer into the fish pond; 8) growing aquatic plants in the fish pond; 9) after the aquatic plants grow for 5 weeks, spreading a phagostimulant, adding feed, and putting fishes into the pond; 10) disinfecting fingerlings; and 11) adding fish fries. The method provided by the invention has the advantages of obvious yield increase effect within a short time and high living rate, and is suitable for industrialized large-scale development.

The invention discloses a quick fattening feed for winter geese. The quick fattening feed is prepared from the following components in parts by weight: 60-80 parts of corn, 20-30 parts of unhulled rice, 15-20 parts of rice bran, 9-11 parts of fish meal and 2-5 parts of a premix. According to the quick fattening feed disclosed by the invention, different nutritional type feeds are prepared according to the constitution characteristics of the winter geese at different growth phases, so that the condition that the winter geese have high growth speed can be guaranteed, besides, the winter geese can have high meat quality and low mortality rate, and the breeding economic benefits can be effectively increased. After the winter geese at the brooding phase and the adult goose phase are reasonably fed, the winter geese have a quick fattening base, and at this time, when the quick fattening feed provided by the invention is fed to the winter geese, the quick fattening effect can be more significant.

The invention discloses a Chinese herbal medicine compound preparation for controlling dove trichomoniasis and a preparing method thereof. The compound preparation comprises at least one of radix dichroa, fructus cnidii, cortex phellodendri, radix stemonae, pericarpium zanthoxyli, herba schizonepetae, cortex dictamni, herba patriniae, radix astragali, radix glycyrrhizae, polygala tenuifolia, radixsophorae flavescentis, notopterygium root, radix sileris, gallnut, rhizoma atractylodis macrocephalae, Artemisia apiacea, Chinese pulsatilla root, Chinese prickly ash, lumbricus, herba artemisiae scopariae and rhizoma polygonati. The preparing method includes: crushing the raw materials; decocting; performing freeze drying; placing freeze-dried powder into purified water to obtain a traditional Chinese medicine suspension. The Chinese herbal medicine compound preparation is natural, green, free of pollution, capable of guaranteeing animal health, capable of killing and controlling trichomonadand increasing animal immunity at the same time, capable of lowering medicine side effects, capable of lowering mortality and capable of increasing animal productivity. The preparing method is simpleand applicable in process flow, capable of saving energy, environmentally friendly, incapable of generating wastewater, waste gas and waste residues and harmless to environments.

The invention discloses a formula feed of broilers and a preparation method thereof. The formula is as follows: 50-65% of corn, 0-2% of fishmeal, 20-25% of soya bean meal, 0-3% of corn protein powder, 0-1% of whole hen egg, 0-5% of wheat middling, 0-5% of rice pericarps, 0-5% of rice bran, 0-3% of cottonseed meal, 0.5-1.5% of bean oil, 0.1-0.3% of acidulant, 0.05-0.1% of sodium butyrate, 0.03-0.05% of compound enzyme preparation and 1.5-2% of compound premix. The feed is prepared by the steps of removing impurities from raw materials, grinding raw materials, weighing raw materials, mixing rawmaterials, palletizing and packing finished products, etc. in sequence. The invention selects the additives which promote the broilers to grow and develop and the feed materials which improve the immunocompetence, etc. The feed product has moderate metabolic energy value, high nutrition level and good palatability, is easy to digest and absorb and is easy to satisfy the nutritional requirements of 1-7 days of growth, therefore, the broilers grow fast and have high disease resistance, low mortality and low feed coefficient, and the coefficient of the formula feed is 0.8-0.9.

The invention discloses a compound premix for weaned piglets. The compound premix is prepared from the following components in parts by weight: 5-10 parts of Chinese herbal medicine additives, 3-7 parts of compound trace elements, 0.5-2 parts of compound vitamins, 3-5 parts of compound amino acids, 0.2-1 part of L-lysine hydrochloride, 0.1-0.5 part of choline chloride, 10-25 parts of calcium dihydrogen phosphate, 0.5-2 parts of lecithin, 1-3 parts of compound bacteria, 15-25 parts of zeolite powder and 0.2-0.5 part of an antioxidant. The premix disclosed by the invention is reasonable in proportioning and uniform in nutrition, enhances the immunity and anti-stress capability of the piglets, and ensures that the piglets have strong physique, high vitality and low mortality.

The invention discloses an aquaculture nontoxic water purifying agent and a preparation method thereof; the aquaculture nontoxic water purifying agent is made from, by weight, 20-40 parts of microorganism flocculating agent, 10-30 parts of an aquatic oxygen supply agent, 5-12 parts of nano titanium dioxide, 4-10 parts of nano silica powder, 3-8 parts of soda mica, 1-4 parts of L-ascorbic acid, 2-6 parts of citrate pentahydrate, 2-8 parts of lignin, 10-20 parts of basic aluminum chloride, and 5-12 parts of a ceramic dispersant. The preparation method herein is simple, the aquaculture nontoxic water purifying agent prepared herein can improve water quality, can absorb and degrade organic matters in water, can effectively kill germs, and can promote the growth of aquatics and lower mortality.