Traditional Chinese medicine foot bath preparation prepared by utilizing microbial fermentation and preparation method thereof

Abstract

The invention discloses a traditional Chinese medicine foot bath preparation prepared by utilizing microbial fermentation and a preparation method thereof and belongs to the field of parenteral administration preparations. The preparation method includes: placing brewer's yeast, candida utilis and lactobacillus reuteri in a water solution of ginkgo leaf extract, algae powder, menthol, baking soda, edible salt and glucose at 37-40 DEG C for anaerobic cultivation to obtain microbial fermentation foot bath preparation engineering bacterium liquid. The bacterium liquid is adopted for fermenting compound traditional Chinese medicine. The ginkgo leaf extract has promoting effect on expanding pores and blood vessels and increasing administration speed, menthol has transdermal efficacy and can improve permeability of drug in a plantar dermis layer and a cuticle layer, density of foot bath liquid prepared by baking soda, edible salt and glucose is greater than that of body fluid, so that osmotic pressure of the foot bath liquid is increased. Toxic and harmful substances in the compound traditional Chinese medicine are degraded after fermentation, and absorbing effect of traditional Chinese medicine activity agent is improved by utilizing synergistic effect of beneficial bacteria and active ingredients of the traditional Chinese medicine. The traditional Chinese medicine foot bath preparation is effective in disease dispelling, healthcare and scientific administration.

Description

Technical field [0001] The invention relates to the field of traditional Chinese medicine foot bath preparations, in particular to a traditional Chinese medicine foot bath preparation prepared by microbial fermentation and a preparation method thereof. Background technique [0002] There are many health care methods of traditional Chinese medicine administration, all of which can effectively play a role in health care and disease healing. [0003] According to the dosage form: [0004] (1) Traditional preparations: decoction, pill, powder, ointment, pill, alcohol, syrup, extract, granule and granule, oil extract, lozenge, lotion, gel, tea, Nail, stick, suppository, koji, paste, cake, lotion, oil, thread, strip, iron, moxibustion, smoke, medicinal incense, etc.; [0005] (2) Modern dosage forms: tablets, granules, sachets, oral liquids, capsules, drops, mixtures, tinctures, aerosols, enemas, films, ophthalmic preparations, nasal preparations, sponges , Injections, etc. [0006] Accord...

AI Technical Summary

Problems solved by technology

At present, foot bath administration has attracted much attention, but the absorption effect of foot bath administration in the prior art is poor

Reasons why the traditional foot bath method affects drug absorption: 1. Because the density of foot bath water is lower than that of human body fluid, the absorption and utilization rate of drugs is low; 2. The physical method of increasing water temperature is used to expand pores and blood vessels, increase the flow rate and flow of body fluids and blood, The temperature is difficult to control, and the purpose of rapid and stable absorption of drug active ingredients cannot be achieved; 3. Passively adding auxiliary materials to promote transdermal effects is unscientific, and it increases the difficulty of preparing materials for foot baths

Example: add borneol to the foot bath, borneol has a transdermal effect, but is insoluble in water; eucalyptus oil has a good penetrating cutin and transdermal effect, but it has a different density from the foot bath, so it is difficult to combine with drugs