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Reeombinnt human granulocyte colony stimulating factor microemulsion

A technology of colony-stimulating factor and granulocytes, which is applied in the field of medicine, can solve problems such as the inability to effectively solve the administration method of recombinant human granulocyte-colony-stimulating factor, difficulties in the industrialization of the pharmaceutical industry, and complicated preparation processes, so as to avoid the first-pass effect, Extensive social and economic benefits, effects of avoiding inconvenience and pain

Inactive Publication Date: 2007-10-31
QINGDAO UNIV
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Problems solved by technology

Due to the limitations of drug stability and physical and chemical properties, there is no suitable preparation form for recombinant human granulocyte colony-stimulating factor for clinical use, and it is still unable to effectively solve the problem of the administration of recombinant human granulocyte colony-stimulating factor
[0006] Microemulsion preparations can improve the bioavailability of many drugs to a large extent, but this preparation form has high requirements on the physical and chemical properties and stability of drugs, and the preparation process is also quite complicated. many difficulties

Method used

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  • Reeombinnt human granulocyte colony stimulating factor microemulsion

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Embodiment

[0022] Seven kinds of specific prescriptions are as follows: (determine the auxiliary material type and quantity of microemulsion preparation)

[0023] Prescription A:

[0024] Recombinant Human Granulocyte Colony Stimulating Factor 1.0g

[0025] Absolute ethanol 1.0g

[0026] Propylene glycol 0.5g

[0027] Polyoxyethylene hydrogenated castor oil 4.0g

[0028] Glyceryl Linoleate 2.5g

[0029] water 1000ml

[0030] Make 1000ml microemulsion

[0031] Preparation process: Weigh 1.0g of rhG-CSF, add it to 2.5g of linoleic acid glyceride, stir to dissolve, then add 4.0g of polyoxyethylene hydrogenated castor oil, 1.0g of absolute ethanol, 0.5g of propylene glycol, and stir well , After dispersing in 1000ml water, the microemulsion is obtained.

[0032] Prescription B:

[0033] Recombinant Human Granulocyte Colony Stimulating Factor 1.0g

[0034] Absolute ethanol 1.0g

[0035] Macrogol 200 0.5g

[0036] Sorbitan Fatty Acid Ester 2.0g

[0037] ...

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Abstract

The invention discloses a retooling human granulocyte colony stimulating factor microemulsion to medicinal technique, which comprises the following steps: allocating mass ratio of retooling human granulocyte colony stimulating factor, surface activator, cosurfactant, oil phase and water phase at 1 : (1-5) : (0. 5-3) : (1-3) : (500-2000); adding the retooling human granulocyte colony stimulating factor into oil phase; stirring evenly; dispersing in water phase; getting the product. This product is fit for treat neutrophilic granulocytopenia, which can keep bioavailability with the same effect in injection give medicine.

Description

Technical field: [0001] The invention belongs to medical technology, in particular to a recombinant human granulocyte colony-stimulating factor microemulsion. Background technique: [0002] Recombinant human granulocyte colony-stimulating factor (rhG-CSF) is human granulocyte colony-stimulating factor (rhG-CSF) produced by recombinant DNA technology. It has the same amino acid sequence and sugar chain as natural granulocyte colony-stimulating factor. The N-terminus of the colony-stimulating factor chain contains methionine. This product can work by binding to the target cell membrane receptor. Granulocyte colony-stimulating factor is one of the main cytokines regulating granulocyte hematopoiesis in bone marrow. It mainly stimulates granulocyte hematopoiesis, and can also make pluripotent hematopoietic stem cells enter the cell cycle; promote the proliferation, differentiation and maturation of myeloid hematopoietic progenitor cells, Regulate the proliferation, differentiat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/19A61K9/107A61K47/34A61K47/44A61P7/00A61P35/00A61K47/10A61K47/14A61K47/26
Inventor 孙勇徐丽洒徐平沈若武刘占涛
Owner QINGDAO UNIV
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