79 results about "Organic acid formation" patented technology

Disclosed herein are methods for the recovery of an organic acid, such as a heat stable lactic acid, from a feed stream which contains at least one of an organic acid amide, an organic acid ammonium salt, or an alkylamine-organic acid complex. The feed stream is mixed with at least one azeotroping agent. The azeotroping agent is a hydrocarbon capable of forming at least one azeotrope with the organic acid that is produced by the thermal decomposition of the amide, ammonium salt, or complex in the feed stream. Preferably the azeotrope is a heteroazeotrope. The mixture of the feed stream and the azeotroping agent is heated to produce a vapor stream. The azeotrope is a component of the vapor stream. The vapor stream can be condensed to a liquid stream, and the organic acid is recovered in the liquid stream that is produced. When the azeotrope is a heteroazeotrope, the vapor stream can be condensed into a liquid stream, which can be separated into a first phase and a second phase. The first phase contains the highest concentration of organic acid and the second phase contains azeotroping agent. The organic acid can be further purified and / or concentrated from the separated first phase or from the liquid stream.

The invention relates to a thick-film high-antiseptic cathode electrophoretic coating which comprises an emulsion, the solid content of the emulsion is 30-35%, the PH value is 5.0-7.0, and the conductivity is 1000-2000 microseconds / cm; the solid content comprises the following components by mass percent for the total solid content: 30-70% of matrix resin, 20-40% of a curing agent, 0.1-10% of a filming auxiliary agent, 0.5-1.5% of a cosolvent, 20-50% of an antiseptic inhibitor, and the balance of an organic acid and deionized water; the matrix resin is an aminated modified epoxy resin capable of forming an ionic salt group with the organic acid; the filming auxiliary agent is a polyether at least containing three ether bonds on each molecule and does not contain any hydroxy after alkylation modification. After being coated with a film, the coating has a thickness within 35-40 micrometers, and has the advantages of large filming thickness and high edge coverage; the cation microgel with a high crosslinking density can greatly improve the phenomenon that edge shrinkage occurs in the coating curing process, thereby increasing the coating coverage of work piece edges, and especially improving the antiseptic performance of sharp edge parts of sharp workpieces.

The invention relates to donepezil salts formed with organic acids and a process for the preparation thereof. Said salts can be used for the preparation of pharmaceutical compositions. The invention also relates to a process for the preparation of said salts, pharmaceutical compositions containing them and the use of said compounds for the treatment of diseases.

To provide a water / oil resistant composition which can impart a sufficient water / oil resistance to a base material even though a fluorinated copolymer having an Rf group with at most 6 carbon atoms is used, said water / oil resistance being not substantially influenced by an adjuvant or the pH of dilution water, and which has little odor; an article treated therewith; and processes for their production. A water / oil resistant composition having a fluorinated copolymer dispersed or dissolved in a medium, wherein the fluorinated copolymer is one having one, some or all of amino groups in a fluorinated copolymer comprising structural units based on a monomer (a) having a C1-6 Rf group and structural units based on a monomer (b) having an amino group, converted to form a salt with an organic acid comprising an organic acid having a pKa of from 2.0 to 4.0.

In order to rapidly remove an organic acid dissolved in contaminated water, a coagulant capable of forming a floc with the organic acid in the contaminated water is configured to include an iron oxide bearing an inorganic acid on surface thereof, and an aqueous solution of an acidic-group-containing polymer. Upon removal of the organic acid as a floc from the contaminated water using the coagulant, the iron oxide bearing an inorganic acid on surface is initially added to the contaminated water, and then the aqueous solution of the acidic-group-containing polymer is added to precipitate a floc, and the floc is magnetically separated. A water treatment apparatus enabling removal of an organic substance from contaminated water is provided with a mechanism for stirring the contaminated water, a mechanism for adding an iron oxide bearing an inorganic salt on surface to the contaminated water, a mechanism for adding an aqueous solution of an acidic-group-containing polymer to form a floc, and a mechanism for magnetically separating the formed floc.

The invention relates to a measurement method for non-fat organic acids in tobacco and a tobacco product and belongs to the technical field of analysis of acidic components in the tobacco and the tobacco product. The measurement method provided by the invention comprises the steps of extracting a to-be-measured sample, and taking extract liquid for derivative reaction to obtain to-be-measured liquid; taking the to-be-liquid, and carrying out gas chromatography-tandem mass spectrometry, wherein a gas chromatography condition comprises the following heating program of keeping 40-60 degrees centigrade for 1-3 min, heating to 140-160 degrees according to 3-10 degrees centigrade / min, heating to 190-210 degrees centigrade according to 5-10 degrees centigrade / min, heating to 270-290 degrees centigrade according to 20-30 degrees centigrade / min, and keeping warm for 15-25 min. According to the measurement method provided by the invention, various non-fat organic acids can be effectively separated, sensitivity is high, and the measurement method can be used for measuring content of the organic acids such as 3-hydroxypropionic acid, m-toluic acid, 4-oxononanoic acid, 2-hydroxybenzoic acid andcinnamic acid.

A compound with general formula (I), accepted additional salt formed of inorganic and organic acids, its production, medicinal composition and usage are disclosed. It belongs to azithromycin pentadecenic macrolide derivative, R1 represents hydrogen or acetyl or methane; R2 represents fatty hydrocarbon, substituted aromatic fatty hydrocarbon or substituted aromatic heterocyclic fatty hydrocarbon. It can be used to prepare medicines in treatment of bacterial infections.

The invention provides compounds with a general formula (I) or (II), and acceptable salts or esters prepared from the compounds and inorganic acid or organic acid. In the general formula (I) or (II), Ar refers to aromatic heterocyclic hydrocarbyl or substituted aromatic heterocyclic hydrocarbyl; and X refers to hydrogen or fluorine. The compounds have a novel structure; 9-oxime hydroxyl of ketolide is connected with an aromatic heterocyclic hydrocarbon through a propargyl side chain; and the compounds are easy and convenient to synthesize and are suitable for industrial production. Moreover, the compounds have outstanding antibacterial activity on clinically common sensitive bacteria and drugfast bacteria, such as staphylococcus aureus, streptococcus pneumonia, streptococcus pyogenes, staphylococcus epidermidis and the like, can be independently used or serve as one of active ingredients to be mixed with other medicines to treat bacterial infection and the like in various formulations or medication ways. Correspondingly, the invention also provides a preparation method for the compounds, use of the compounds as anti-infective agents and corresponding medicinal compositions.

The invention discloses a processing method of dendrobe health care black tea. A processing technique comprises sorting, cleaning, withering, rolling, incipient drying and re-firing drying. In the technical scheme, room temperature heavy-withering, medium-temperature incipient drying and high temperature re-firing technologies are adopted, overmuch organic acid forming ways caused by fermentation and a high temperature incipient drying process in the traditional technique are avoided, the high temperature re-firing technique is adopted to basically remove herbal flavour of dendrobe leaves and achieve representative high-fired fragrance and sweetness, and thus the dendrobe tea processed in this way is tight in twig, reddish brown and glossy in color, mellow in taste, and good, fragrant and sweet in aftertaste, has effects of nourishing yin and boosting essence, beautifying and detoxifying, nourishing the stomach and intestine, and improving eyesight, and has perfect improvement effects in improving immunity, and relieving insomnia, cardiovascular disease and diabetes.

The invention relates to a novel fifteen-member macrolide derivative which has a general formula (I) and comes from azithromycin, wherein R1 represents hydrogen, acetyl or benzoyl, and R2 and R3 represent an aliphatic group, a substituted aroma aliphatic group or a substituted aroma heterocycle aliphatic group respectively. The invention also relates to an intermediate product and a preparation method thereof, acceptable addition salts formed by the fifteen-member macrolide derivative together with inorganic acid or organic acid, and a preparation method for a medicine compound and the application of the medicine compound to the treatment of bacterial infection.

The invention provides a novel stilbene derivative. The novel stilbene derivative is a compound with a general formula I or general formula II shown as the specification, or is an acceptable salt formed by the compound with the general formula I or general formula II and an inorganic acid or organic acid. Specifically, in the general formula I or general formula II, the atom represented by X is hydrogen atom or halogen atom, the substituent group represented by R is C1-C6 alkyl, 1-6 membered heteroalkyl, C2-C4 alkenyl, C2-C4 alkynyl, C3-C6 cycloalkyl, substituent C3-C6 cycloalkyl, 3-6 membered heterocycloalkyl, substituent 3-6 membered heterocycloalkyl, 5-18 membered aryl, substituent 5-18 membered aryl, 5-18 membered heteroaryl, and substituent 5-18 membered heteroaryl. The novel stilbene derivative has neurogenesis activity and low nerve cell toxicity.

The invention relates to a preparation method of moxifloxacin hydrochloride, which comprises the steps of: (a) in an organic solvent, carrying out condensation on 1-cyclopropyl-6, 7-difluoro-8-methoxy-4-oxo-1, 4-dihydro-3-quinoline carboxylic acid and (S, S)-2, 8-diazabicyclo (4. 3. 0) nonane under the catalysis of tertiary amine to produce 1-cyclopropyl-6-fluoro-1, 4- dihydro-8-methoxy-7-((4aS, 7aS) octahydro-6H-pyrrole (3, 4-b) pyridine-6-group)-4-oxo-3- quinoline carboxylic acid; (b) in an organic solvent, reacting1-cyclopropyl-6-fluoro-1, 4- dihydro-8-methoxy-7-((4aS, 7aS) octahydro-6H-pyrrole (3, 4-b) pyridine-6-group)-4-oxo-3-quinoline carboxylic acid with pure chiral organic acid to produce easily purified complex salt; and (c) reacting the complex salt with hydrochloric acid or hydrogen chloride gas in water solution of a water-soluble organic solvent to produce moxifloxacin hydrochloride of a certain crystal form. The method has the advantages that reaction route is simple, raw materials are cheap and easy to obtain, reaction conditions are mild and easy to control; therefore, the method is suitable for industrial production.

The invention discloses a 4''-benzimidazole-5-formacyl-ester carbazate clarithomycin derivative shown in the formula (I) and a pharmaceutically-acceptable salt. R1 is hydrogen, acetyl or benzoyl; R2 is hydrogen, fatty alkyl, halogenated hydrocarbon or substituted aromatic radical; and R3 is hydrogen, fatty alkyl, halogen, halogenated hydrocarbon, benzyl or substituted benzyl. The invention also relates to a prepared intermediate product and a preparation method thereof, a pharmaceutically-acceptable salt formed with inorganic or organic acid, a medicine composition and application to treating bacterial infection. The derivative represents relatively strong in-vitro antibacterial activity to sensitive staphylococcus aureus, sensitive streptococcus pneumoniae and sensitive streptococcus pyogenes and represents obviously enhanced antibacterial activity to drug-resistant streptococcus pneumoniae derivated by different drug-resistant genes.

The invention relates to preparation of novel fluoro thiazole hydrazone compounds I to IV, combination of the compounds and application thereof to anti-tumor and / or anti-cancer medicine. The invention also relates to a preparation method of the compound. The general chemical formula of the compound is shown as the accompanying drawing, wherein R1, R2 and R3 in the general chemical formula are respectively one kind of materials from H, Br, F and CF3; R1 in the first compound I is Br, and the R2 and the R3 are H; the R1 in the compound II is H, and the R2 and the R3 are F; the R2 in the compound III is CF3; the R1 and the R3 are H; the R2 in the compound IV is H, and the R1 and the R3 are CF3. The invention also relates to a salt containing at least one compound and a physically acceptable inorganic acid or organic acid; if proper, a pharmaceutically acceptable excipient and / or a diluting agent or an excipient can be used. The invention also relates to a formula-shown compound medication preparation containing at least one kind of the compound shown by the structure formula and the salt thereof. The preparation type is tablets, capsules, infusion solutions, suppositories, patches, powder, supensoid agents.

The invention relates to bromophenol amino thiourea compounds (I-IV), and compositions and applications thereof, and also relates to a preparation method of the compounds. The chemical structure formula of the compounds is represented in the description. In the chemical structural formula, R1, R2, R3, R4, R5 and R6 are one or two of H, Br, OH, and OCH3. For the compound (I), R1 and R2 are Br; R3 and R4 are OCH3; and R5 and R6 are H. For the compound (II), R1 R2, and R5 are Br; R3 and R4 are OCH3; and R6 is H. For the compound (III), R1 and R2 are Br; R3 and R4 are OH; R5 is H; and R6 is phenyl. For the compound (IV), R1 and R2 are Br; R3 and R4 are OH; and R5 and R5 are H. The invention also relates to a composition containing at least one compound mentioned above or salts formed by a physiologically acceptable inorganic acid / organic acid and the compounds. The invention further relates to a dosage form of the composition, and the dosage form can be tablet, capsule, injection solution, suppository, patch, powder, suspension, and the like.

The invention relates to an absorbent of harmful gas generated during material fermentation in the organic fertilizer production process, and the absorbent is a composite aqueous solution formed by sulfates of trace element copper, iron, manganese and zinc, and inorganic acid or organic acidity. The solution can absorb a lot of harmful gas ammonia, hydrogen sulfide, sulfur dioxide and organic harmful gas released in the material fermentation process, and after the harmful gas absorbing solution is detected to be qualified, the solution can be directly used for producing liquid type macro and medium trace element water-soluble fertilizer, and raw materials of water-soluble fertilizer after drying, thereby effectively using macroelement N and medium element S, and avoiding losses of macroelement and medium element in the traditional deodorizing technology and environment pollution.

The invention provides a composition for production of a sterilizer having a water content of 1 to 25% by weight and comprising (A) an ester of a polyhydric alcohol and an organic acid having a hydrocarbon group which may have a hydroxyl group and (B1) hydrogen peroxide. From the composition, a sterilizer is obtained as an aqueous solution containing an organic peracid.

The invention discloses an azithromycin derivative shown in the formula (I) and a pharmaceutically acceptable salt thereof, wherein R1 represents hydrogen, acetyl or benzoyl, R2 represents hydrogen, aliphatic hydrocarbon, substituted aromatic alkyl, substituted aromatic heterocyclic alkyl, halogen, nitryl, alkoxy or-AR7, R3 represents OR5, R4 represents hydroxyl; or, R3 and R4 can form a ring with a structure that X represents oxygen and nitrogen; R5 represents nitrogen or CONHR6, R6 represents aliphatic hydrocarbon, substituted aromatic alkyl or substituted aromatic heterocyclic alkyl, and R7 represents aliphatic hydrocarbon, substituted aromatic alkyl or substituted aromatic heterocyclic alkyl; n is from 1 to 6, A is one of -O-,-CO-,-CONR8-,-NHCO- and -S-. The invention further relates to a prepared intermediate and a method thereof, an acceptable salt thereof forming with inorganic or organic acid, a drug composite and application thereof in the treatment of bacterial infection.

The present invention relates to nanometer ferromanganese oxidation composite electrode materials for a super capacitor and a preparation method thereof. The materials are made through combination of the manganese oxide and the ferric oxide through a solvothermal method, wherein the mass percent of the manganese oxide is 40-60%. The concrete preparation steps comprise: dissolving the manganese source and the iron source in the deionized water, adding the organic acid to form dispersed and uniform solution, adjusting the pH to be neutral, heating the solution to allow the solution to gradually change to the viscous gel, continuing heating the gel until becoming a block, and after drying, obtaining the nanometer ferromanganese oxidation composite electrode materials through calcination. The nanometer ferromanganese oxidation composite electrode materials are good in cycle stability and high in specific capacity, and are used in a super capacitor device to greatly improve the whole electrochemical performance.

The invention provides a pregnane alkaloid derivative with an effect of resisting breast cancer cell metastasis or a pharmaceutically acceptable salt thereof. The structure of the pregnane alkaloid derivative is shown by a general formula I in the specification, wherein R1 and R2 are independently selected from hydrogen, straight-chain or branched alkyl with the carbon atom number of 1-8, naphthenic base, unsaturated alkyl, benzyl and benzene ring substituted benzyl respectively; or R1R2N is piperidyl or pyrrolyl; R3 and R4 are independently selected from hydrogen and hydroxyl respectively; or R3R4 together represents carbonyl oxygen atoms; R5 and R6 are different substituting groups and are independently selected from hydrogen or methyl respectively; and the pharmaceutically acceptable salt is a salt formed with inorganic acid or organic acid, wherein the inorganic acid or organic acid is selected from hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, methane sulfonic acid, benzene methane sulfonic acid, oxalic acid, tartaric acid, maleic acid, citric acid or ascorbic acid. The invention also provides an application of the pregnane alkaloid derivative in preparation of a medicament for resisting breast cancer metastasis.

The invention discloses an application of anthraquinone or an anthraquinone derivative as a matrix in matrix assisted ultraviolet-visible light laser desorption / ionization mass spectrometry (MALDI). The anthraquinone derivative is any one of the following 1) to 3): 1) a substituted anthraquinone substituted by at least one of the following groups: alkyl, amino, halogen, nitro, carboxyl, aldehyde group, carbonyl, aryl, cyan, and quaternary ammonium group; 2) a salt formed by metal ions and substituted anthraquinone substituted by sulfo group or carboxyl group, wherein the metal ions are sodions, potassium ions, calcium ions, or magnesium ions; 3) a salt formed by inorganic acid or organic acid and substituted anthraquinone substituted by at least one of the following groups: alkyl, amino, halogen, nitro, carboxyl, aldehyde group, carbonyl, aryl, cyan, and quaternary ammonium group. The invention technically overcomes the defect that recently-reported ultraviolet-visible light matrixes are easy to cause severe matrix background interference phenomena in the low molecular weight zone and thus lead to ineffective analysis of micromolecular samples.

The invention provides a novel stilbene derivative. The novel stilbene derivative is a compound with a general formula I or II as described in the specification or a salt formed by the compound with the general formula I or II as described in the specification and inorganic acid or organic acid. In the general formula I or II, X represents a hydrogen atom or halogen atom; R represents a substituent selected from a group consisting of C1-5 alkyl groups, C2-4 alkenyl groups, C2-4 alkynyl groups, C3-6 cycloalkyl groups, five-to-twelve-component aryl groups, two-to-five-component heteralkyl groups, three-to-six-component hetercycloalkyl groups, five-to-twelve-component heteraryl groups, substituted three-to-six-component cycloalkanes, substituted five-to-twelve-component aryl groups and substituted five-to-twelve-component heteralkyl groups; or the substituent represented by R is a first substituent formed by a spacer group and any one selected from a group consisting of C3-6 cycloalkanes, three-to-six-component hetercycloalkanes, five-to-twelve-component aryl groups and five-to-twelve-component heteraryl groups, and the spacer group comprises -CH2-, -(CH2)2-, -CH=CH-, -CH2O-, -CH(OCH3)- and -CH2S-.

The present invention relates to preparation process of isocollidine preparation for eye. Through mixing isocollidine and inorganic acid or organic acid to form soluble isocollidine, dissolving in water, adding osmotic pressure regulator to osmotic pressure 280-320 mOsm / kg, adding hydrochloric acid or sodium hydroxide solution to regulate pH value to 3.0-7.0, adding water via stirring and sterilizing, solution for eye is obtained; or, gel as excipient is further added to obtain gel for eye. The isocollidine preparation for eye may be used to replace atropine, which has serious toxic side effect, for mydriasis, may be used also in regulating eyesight, treating pseudomyopia of teenage and eliminate eye fatigue, and is safe, effective and controllable.

A component of a substrate processing apparatus that performs plasma processing on a substrate includes a base mainly formed of an aluminum alloy containing silicon. A film is formed on the surface of the base by an anodic oxidation process which includes connecting the component to an anode of a power supply and immersing the component in a solution mainly formed of an organic acid. The film is impregnated with ethyl silicate.

The invention relates to preparation of novel bromophenol-thiazole compounds I-IV, combination of the novel bromophenol-thiazole compounds, and application of the novel bromophenol-thiazole compounds in anti-tumor and / or anti-cancer pharmaceuticals. The invention also relates to a preparation method of the compounds, wherein chemical structures of the compounds have a general formula as follows: (shown in the figure), R1, R2 and R3 in the general formula are respectively selected from one of H, F, CF3 and Br, wherein R3 in the compound I is H, R1 and R2 are F; R1 in the compound II is H, R2 is CF3 and R3 is H; R3 in the compound III is Br, R1 and R2 are F; R1 and R2 in the compound IV are H, and R3 is Br. The invention further relates to salt formed by at least one of the compounds or physiologically acceptable inorganic acid or organic acid thereof, if appropriate, a pharmaceutically acceptable excipient and / or diluent or excipient; the invention further relates to an administering dosage form containing at least one of the compounds or the salt thereof, wherein the dosage form is tablet, capsule, infusion solution, suppository, patch, powder, suspension and the like.

The invention provides a macrolide and carbostyril heterocomplex. The macrolide and carbostyril heterocomplex is characterized by comprising compounds shown in the formula I and the formula II, or thecompounds shown in the formula I and the formula II and salt formed by inorganic acid or organic acid and accepted by pharmacy, the macrolide and carbostyril heterocomplex can better adapt to industrial production and has good activity of resisting sensitive bacteria and drug-resistance bacteria on clinically common streptococcus pneumoniae, staphylococcus aureus, streptococcus pyogenes, catarrhmoraxella catarrhalis, haemophilus influenza and other pathogenic bacteria which are capable of resisting erythrocin, and clinical bacterial pneumonia or pneumonia caused by other microorganisms (suchas mycoplasma, legionella and the like) and other tissue infections can be effectively treated.

The present invention relates to preparation of a novel water-soluble fertilizer through absorbing harmful gases produced by material fermentation during organic fertilizer production process with an absorption agent, wherein the absorption agent is a composite aqueous solution formed by a sulfate of a trace element such as copper, iron, manganese and zinc and an inorganic acid or an organic acid, a large amount of harmful gases released during a material fermentation process can be absorbed with the solution, and the solution absorbing the harmful gases is directly used for preparing the novel water-soluble fertilizer, wherein the harmful gases comprise ammonia, hydrogen sulfide, sulfur dioxide and the like. With the process, macro element N and medium element S in the harmful gases are effectively utilized, and macro element and medium element loss and environment pollution caused by the traditional deodorizing process are avoided.