211 results about "Nonane" patented technology

The invention discloses a method for reducing 8-benzyl-2,8-diazabicyclo[4,3,0]nonane and a chiral isomer thereof. The method comprises the steps of: taking 8-benzyl-7,9-dioxo2,8-diazabicyclo[4,3,0]nonane or (1S,6R)-8-benzyl-7,9-dioxo2,8-diazabicyclo[4,3,0]nonane as a raw material, and adopting a metal borohydride/BF3 reduction system for reduction to obtain a corresponding product, namely the 8-benzyl-2,8-diazabicyclo[4,3,0]nonane or (S,S)-8-benzyl-2,8-diazabicyclo[4,3,0]nonane. The method adopts the metal borohydride/BF3 reduction system for reduction, avoids the use of an expensive and dangerous reagent, namely lithium aluminum hydride, reduces production cost, improves the safety of the operation, and provides a safe and economical production method for industrial mass production of a moxifloxacin intermediate, namely the (S,S)-8-benzyl-2,8-diazabicyclo[4,3,0]nonane.

The present invention provides a benzoate salt of Formula I:

Formula I is also known as 4-(5-methyloxazolo[4,5-b]pyridine-2-yl)-1,4-diazabicyclo[3.2.2]nonane. The benzoate salt of the invention is useful in the treatment of schizophrenia and Alzheimer's Disease. It is particularly of use in the treatment of cognitive deficits associated with schizophrenia, cognitive and attention deficit symptoms of Alzheimer's Disease, and neurodegeneration associated with Alzheimer's Disease.

The invention discloses a preparation method of moxifloxacin hydrochloride, comprising the steps of: reacting the 1-cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-1,4-dihydro-3-quinoline carboxylic acid and the S,S-2,8-diazabicyclo[4.3.0]nonane to prepare the moxifloxacin in the presence of organic base in organic solvent under the reaction temperature of 60 to 85 DEG C; separating the moxifloxacin, processing the moxifloxacin by concentrated hydrochloric acid in organic solvent under the reaction temperature of 60 to 85 DEG C to obtain the moxifloxacin hydrochloride.

An alcohol oxidation catalyst which is an organic oxidation catalyst to oxidize an alcohol, which contains azabicyclo [3.3.1]nonane N-oxyl represented by the following formula (1) having an N-oxyl group incorporated in a bicycle[3.3.1]nonane skeleton:

wherein X is H₂, O or NOH.

The invention discloses an environmental-friendly drier, a preparation method thereof and applications thereof. The drier is characterized in that: a reaction product of a ligand 3,7-diazabicyclo[3.3.1] nonane and a metal chloride is in a mixed crystal type or a solid-state solution type; and beneficial effects of the drier are that: the drier is free from metal cobalt having risks of "three cause", and has little bad influence on the environment and health; the drier is used for oxidation polymerization drying-type printing ink; and the ink film surface is free from skinning and wrinkling even when the printing ink layer is thick. According to the drier and the preparation method, the ratio of iron to manganese in a complex and the constitution of the ligand can be adjusted according to the drying condition of the printing ink so as to achieve an effect of adjusting the drying time of the printing ink. The ligand 3,7-diazabicyclo[3.3.1] nonane has a general chemical formula shown as follows.

The invention discloses a method for preparing racemic cis-8-benzyl-7, 9-dioxo-2, 8-diazabicyclo[4.3.0]nonane, which relates to a racemization method for (1R,6S)-cis-8-benzyl-7,9-dioxo-2,8-diazabicyclo[4.3.0]nonane. Firstly, the (1R,6S)-cis-8-benzyl-7,9-dioxo-2,8-diazabicyclo[4.3.0]nonane is refluxed for 3 to 10h in the presence of a manganese dioxide catalyst and a dehydrogenation solvent at a temperature of between 60 and 110 DEG C for an oxydehydrogenation reaction, and then obtained 6-benzyl-5,7-dioxo-1,2,3,4-tetrahydro-pyrido[3,4-b]pyridine reacts for 5 to 10 h in the presence of a Pd/C or PtO2 catalyst and a hydrogenation solvent at a temperature of between 70 and 100 DEG C at the pressure of between 5 and 9MPa and is reduced into the racemic cis-8-benzyl-7, 9-dioxo-2, 8-diazabicyclo[4.3.0]nonane. The method has the advantages of simple process, quick reaction, more than 90 percent of two-step overall yield, mild conditions, simple treatment after the reaction, no secondary reactions, and reutilized catalyst, and meets the requirement of environmental protection. The obtained product is the racemic cis-8-benzyl-7, 9-dioxo-2, 8-diazabicyclo[4.3.0]nonane, fully avoids the generation of trans-products, can be directly used for optical resolution, and remarkably improves the utilization rate of raw materials.

The invention provides a synthesis method of high-purity moxifloxacin hydrochloride, which comprises the following steps: protecting carbonyl of ethyl 1-cyclopropyl-6,7-difluoro-8-methoxy-1,4-dihydro-4-oxoquinolyl-3-carboxylate by using ethyl borate; performing condensation with (S,S)-2,8-diazabicyclo[4.3.0]nonane; deprotecting with hydrochloric acid to obtain a moxifloxacin hydrochloride crude product; dissolving the obtained moxifloxacin hydrochloride crude product with an alkali water solution, extracting with organic solvent, removing the organic phase, and adding hydrochloric acid into the water phase to regulate the pH value to acidity; crystallizing, filtering to obtain a filter cake, and recrystallizing the obtained filter cake with water-containing organic solvent; and finally, filtering, and drying to obtain the high-purity moxifloxacin hydrochloride. The product prepared by the method has the advantages of high purity, high yield and favorable reproducibility, and has very high industrial operation feasibility.

The invention relates to the field of a medical technology, and discloses a racemization method of (1R, 6S)-8-benzyl-7, 9-dioxo-2, 8- diazabicyclo (4, 3, 0) nonane. The method comprises the steps of (1) in ether solvent or polar aprotic solvent, carrying out oxidative dehydrogenation on the (1R, 6S)-8-benzyl-7, 9-dioxo-2, 8-diazabicyclo (4, 3, 0) nonane by taking elemental iodine and oxygen as co-oxidant to prepare 6-benzyl-5, 7-dioxo-1, 2, 3, 4-tetrahydron-pyrrolo (3, 4-b) pyrrole; (2) in ester solvent or alcohol solvent, carrying out catalytic hydrogenation on oxidative product by taking Pd/ Al2O3 as a catalyst to obtain the racemic cis-8-benzyl-7, 9-dioxo-2, 8-diazabicyclo (4, 3, 0) nonane. The method is simple in technology, convenient to operate, mild in reaction conditions, etc.

The present invention provides fully renewable turbine and diesel fuels derived completely from biomass sources. In one embodiment the fully renewable turbine fuel is comprised of mesitylene and at least one alkane. Preferably, the turbine fuel comprises from about 50 to 99 wt % mesitylene and from about 1 to 50 wt % of at least one alkane. In another embodiment the diesel fuel comprises mesitylene, octadecane, and optionally octane or nonane. Preferably, the diesel fuel comprises from about 50 to 99 wt % mesitylene, and from about 1 to 50 wt % octadecane. These biomass derived fuels may be formulated to have a wide range of cetane values and differing freezing and boiling points.

The invention relates to a preparation method for liquid polyborosilazane and belongs to the field of inorganic nonmetallic materials. The preparation method comprises the following steps: liquid polyborosilazane and 9-borabicyclo [3,3,1]-nonane are added in a solvent in inert atmosphere to obtain mixed solution, then the obtained mixed solution is hydroborated under the stirring condition, and then the solvent is removed after completion of hydroboration to obtain the liquid polyborosilazane. The preparation method solves the problems in the traditional polymer route that excessive cross-linking is easily caused in the hydroboration addition reaction, and solid polyborosilazane has poorer fluidity. The prepared liquid polyborosilazane has good fluidity and high ceramic yield and can be directly used for the high polymer infiltration and pyrolysis method for preparing SiBCN ceramic matrix composites.

The invention provides a method for chiral synthesis of (S,S)-2-8-diazabicyclo[4.3.0]nonane. A target product with a desired structure is prepared by using pyridine 2,3-diformate as a raw material and carrying out a four-step reaction comprising hydrogenation, resolution, aminolysis and reduction. According to the method, a synthetic route is simple and short, the step of resolution is carried out at an early stage, and reaction raw materials and reagents are saved; thus, production cost is reduced, and production efficiency is improved.

The invention discloses a one-dimensional organic semiconductor nano material and a preparation method and an application thereof. The material employs a unsymmetrical perylene bisimide derivative monomer as a construction monomer, hydrophilic branched-chain alkyl (5-nonane) and pentafluorophenyl substituent are respectively introduced at two sides of perylene bisimide, and the one-dimensional organic semiconductor nano material can be obtained by self assembly preparation through Pi-Pi interacting of construction monomers. The one-dimensional organic semiconductor nano-material has the advantages of high fluorescence quantum yield, porous performance, large surface area, and good stability, greatly reduces the detection lowest limitation, has good anti-interference capability for an aggregate such as triphosgene and other common gases and organic solvent steam, and realizes specific and high-sensitivity detection on phosgene.

The invention provides a method for preparing a moxifloxacin intermediate and moxifloxacin hydrochloride, which comprises the following steps: carrying out condensation reaction on main ring chelate disclosed as Formula (I) and (S,S)-2,8-diazabicyclo-[4.3.0]nonane in the presence of an acid acceptor in a solvent, acidifying for salification, crystallizing, filtering, washing and drying to obtain the moxifloxacin hydrochloride. The method is characterized in that the solvent in the condensation reaction is alcohol. The condensation reaction is carried out in the alcohol solvent at the controlled temperature of 30-80 DEG C (preferably lower temperature), so the method has the advantage of mild reaction conditions, greatly reduces the generation of impurities, saves the energy; the alcohol solvent can be directly acidified after sufficient reaction, thereby saving the complex step of removing acetonitrile by evaporation and greatly simplifying the steps; and the method is suitable for industrial production.

The invention discloses a method for industrial production of moxifloxacin side chain. The method comprises the steps of A, dissolving 3-aldehyde pyridine-2-carboxylic acid and benzylamine in a mixed solvent of distilled water and an organic solvent, putting the above solution into an autoclave to carry out catalytic hydrogenation, and thus 6-benzyl-hexahydro-pyrrolo[3,4-b] pyridine-7-one is obtained; B. dissolving 6-benzyl-hexahydro-pyrrolo[3,4-b] pyridine-7-one in an organic solvent, adding a reducing agent in the solution to carry out a reduction reaction, and thus 6-benzyl-octahydro pyrrolo[3,4-b]pyridine is obtained; C. dissolving 6-benzyl-octahydro pyrrolo[3,4-b]pyridine in an organic solvent, adding D-(-)-tartaric acid to carry out resolution, and thus (s, s)-6-benzyl-octahydro-pyrrolo[3,4-b]pyridine is obtained; and D. dissolving (s, s)-6-benzyl-octahydro-pyrrolo[3,4-b]pyridine in an organic solvent, putting the solution in the autoclave to carry out catalytic hydrogenation for debenzylation, and thus (S,S)-2,8-diazabicyclo[4.3.0]nonane is obtained. The technical solution provided by the invention is simple and practical, low in cost and high in production efficiency, and is suitable for industrialized production.

The invention discloses a method for preparing an imine compound from alcohol and amine through catalytic oxidation. According to the method, an alcohol compound and an amine compound are used as reaction substrates, and a feeding mol ratio of the alcohol compound to the amine compound is 100: 100-60; 9-azabicyclo[3.3.1]nonane N-oxyl free radical is used as a catalyst, potassium hydroxide is used as an auxiliary agent, and a feeding mol ratio of the amine compound to the 9-azabicyclo[3.3.1]nonane N-oxyl free radical to potassium hydroxide is 100: 1-6: 10-50; air is used as an oxidizing agent, the reaction substrates are added into an organic solvent, and the mass of the used organic solvent is 2.5 to 5 times of the reaction substrate the amine compound; and a reaction is carried out at normal pressure at a temperature of 70 to 110 DEG C for 2 to 12 h, and aftertreatment is carried out after completion of the reaction so as to obtain the imine compound. The method provided by the invention is simple and safe to operate, reduces environmental cost due to usage of clean oxygen as the oxidizing agent and prevents the problem of transition-metal pollution by discarding usage of any transition-metal catalyst.

The invention provides a cold accumulation material, which is prepared from at least one of a first group of substances, a second group of substances, a third group of substances, a fourth group of substances and a fifth group of substances, wherein the first group of substances comprise n-nonane, n-octane and hexamethyl disiloxane; the second group of substances comprise p-cymol and decamethyl tetrasiloxane; the third group of substances comprise o-cymol, vinyltoluene, ammonia and R1233ze(E); the fourth group of substances comprise 1,1,2,2,3-pentafluoropropane, 2H,3H-perfluoropentane, butylbenzene and octamethyl trisiloxane; the fifth group of substances comprise tetrafluoromonochlorethane, 1,1,1,3,3,3-hexafluoropropane, propanone, perfluoroethane and pentafluoroethane. Through the cold accumulation material, according to a different required temperature zone, the cold accumulation material which is prepared from a different monomer or a plurality of substances can be selected, can be used for meeting the demand of the temperature of subzero 60 to subzero 100 DEG C, and adapts to a plurality of scenes. In addition, the invention also provides a cold accumulator and a cold accumulation type refrigeration device.