The invention discloses a method for preparing racemic cis-8-benzyl-7, 9-dioxo-2, 8-diazabicyclo[4.3.0]
nonane, which relates to a
racemization method for (1R,6S)-cis-8-benzyl-7,9-dioxo-2,8-diazabicyclo[4.3.0]
nonane. Firstly, the (1R,6S)-cis-8-benzyl-7,9-dioxo-2,8-diazabicyclo[4.3.0]
nonane is refluxed for 3 to 10h in the presence of a
manganese dioxide catalyst and a
dehydrogenation solvent at a temperature of between 60 and 110 DEG C for an oxydehydrogenation reaction, and then obtained 6-benzyl-5,7-dioxo-1,2,3,4-tetrahydro-pyrido[3,4-b]
pyridine reacts for 5 to 10 h in the presence of a Pd / C or PtO2 catalyst and a hydrogenation
solvent at a temperature of between 70 and 100 DEG C at the pressure of between 5 and 9MPa and is reduced into the racemic cis-8-benzyl-7, 9-dioxo-2, 8-diazabicyclo[4.3.0]nonane. The method has the advantages of simple process, quick reaction, more than 90 percent of two-step overall yield, mild conditions, simple treatment after the reaction, no secondary reactions, and reutilized catalyst, and meets the requirement of
environmental protection. The obtained product is the racemic cis-8-benzyl-7, 9-dioxo-2, 8-diazabicyclo[4.3.0]nonane, fully avoids the generation of trans-products, can be directly used for
optical resolution, and remarkably improves the
utilization rate of raw materials.