The invention discloses a novel polyhalogenated
isoquinoline class derivate and a synthetic method thereof. The structure of the polyhalogenated
isoquinoline class derivate is as a formula I, wherein Z=NH, NR', O, S; n=1,2,3; the R' is
alkyl and
aryl; R is the
alkyl, the
aryl, heteroaryl, condensed
aryl, alkoxyl and alkylthio group; R1 is a
halogen atom, a
hydrogen atom, the
alkyl, the aryl, alkylamino radical, arylamine, alkylthio group and arylthio; R2 is cyano-group,
nitryl, ester group, the
halogen atom, the
hydrogen atom, the alkyl, the aryl, the alkylamino radical, the arylamine, the alkylthio group and the arylthio; X1 is the
halogen atom; and the X2 is also the halogen atom. The synthetic method of the polyhalogenated
isoquinoline class derivate including the steps of porphyrizing and heating polyhalogenated cyanobenzene and heterocyclic
ketene aminals derivates in a
mortar. When raw materials are basically completely disappeared, and the polyhalogenated cyanobenzene and the heterocyclic
ketene aminals derivates are all transferred to a
round bottom flask by menstruum and then reacted to synthesize the polyhalogenated isoquinoline class derivate with potential
medicine activity in the formula I after a catalyst is added into the
round bottom flask. The invention has simple synthesis technology, high productive rate, stable products, simple routes, rapidness, and the like, realizes a parallel high-efficiency
heterocyclic compound library and really realizes the molecular diversity.