31results about How to "No participation" patented technology

provided by the invention N 2 -Alkenyl benzotriazole derivatives are compounds such as formula I:, with chloroform as solvent, M(OTf) n As a catalyst, react benzotriazole, N-iodosuccinimide and olefin at room temperature for 0.5-5h, then concentrate, use methanol as solvent and potassium carbonate as base, react at 50-70°C for 8-15h, The target compound can be obtained. A notable feature of this method is that the reaction conditions are simple and mild, no transition metals are involved, and the yield and N 2 ‑ Higher selectivity. Currently, the one-pot method directly builds N 2 The method of ‑alkenylbenzotriazole has not yet been reported, and the synthetic method is very simple and cheap, and is easy to operate and has reached more than 84%. N 2 ‑Selectivity, strong universality of response.

The invention provides a preparation method of (R)-2-(α-deuterium-α-alkyl-α-aryl) azaaryl compound. During preparation, 2-(α-chloro-α-alkyl ‑α‑aryl) azaarene, photosensitizer DPZ, chiral catalyst CPA, Hans ester HEH, deuterium source and sodium bicarbonate dispersed in an organic solvent, after degassing treatment at no higher than ‑78 °C, Put it at 20~30℃, irradiate with 3~10W blue light, and react for 20~40 minutes. After the reaction, separate and purify to obtain (R)‑2‑(α‑deuterium‑α‑alkyl -α-aryl) azaaryl compounds. The enantiomeric excess of the target product obtained in the present invention is about 90%, the deuterium substitution rate is as high as over 99%, the yield is high, and the reaction conditions are mild and pollution-free.

The present invention provides a kind of preparation method of 2-(α-deuterium-α-hydroxy-α-aryl / alkyl) azaaromatic compound, 2-aryl / alkanoyl azaaryl, photosensitizer DPZ, Han Stilbene ester HEH, chiral catalyst CPA, deuterium source and sodium chloride are dispersed in an organic solvent. Lamp irradiation, reaction 3~14 hours, after reaction finishes, separates and purifies and promptly obtains 2-(α-deuterium-α-hydroxyl-α-aryl / alkyl) azaaromatic compound; the enantiomer of the product obtained in the present invention The excess is about 90%, the deuterium substitution rate is over 90%, and the yield of some target products is as high as 99%, and the reaction conditions are mild, environmentally friendly, metal-free, less photocatalyst consumption, and short reaction time. It has laid a good foundation for chemical production.

The invention discloses a method for preparing nano-gold with a size less than 5nm by using banana pulp extract. The method uses the banana pulp extract as a reducing agent and a stabilizer to reduce gold tetrachlorate, and controls the amount of additive sodium hydroxide in the reaction process. The timing and amount of addition are used to control the reaction process of gold tetrachlorate and reducing agent in a boiling water bath, and then achieve the purpose of controlling the particle size of nano-gold particles, and obtain good dispersion, uniform particle size, and a particle size of 1.5 to 4.9 nm spherical gold nanoparticles solution. The method of the invention has mild conditions, short reaction time, simple operation, low cost, non-toxic and pollution-free reducing agent and additives, and the synthesized nano gold particles have good stability at room temperature and in salt solution, and belong The green synthesis method is suitable for related applications in the fields of medicine and pharmacy.

The invention discloses a sulfonylated indolo[1,2-a]quinoline compound and a preparation method thereof. The invention uses o-aryl alkynyl phenyl indole and aryl sulfonyl hydrazide as raw materials, Synthesis of sulfonylated indolo[1,2‑a]quinoline compounds under the action of ammonium iodide and tert-butyl hydroperoxide. The raw materials are cheap and easy to obtain, the reaction conditions are mild, the operation is simple, and the synthesis yield is high, which is beneficial to industrial production. Such derivatives have potential applications in the fields of chemical industry, medicine, etc., and the present invention provides a method for the synthesis of sulfonylated indolo[1,2-a]quinoline compounds for the first time.

The invention discloses an N-difluoromethyl hydrazone compound and a synthesis method thereof and belongs to the technical field of chemical synthesis of medicines. The synthesis method comprises thefollowing steps: putting a hydrazone compound, bromine difluoromethyl trimethyl silane, a phase transfer catalyst, an alkali and an organic solvent, heating to 25-110 DEG C, stirring to carry out reactions, and after the reactions are completed, cooling to the room temperature, and separating and purifying products, thereby obtaining the N-difluoromethyl hydrazone compound. The synthesis method disclosed by the invention is easy in raw material obtaining, low in cost, simple and safe to operate, free of metal, good in environment protection, high in functional group adaptability, high in substrate adaptability and good in industrial application prospect.

The invention discloses a new type of diselenide oxalate compound and its synthesis method and application. The preparation method uses oxalyl chloride as an oxalylating reagent, dialkyl diselenide as a selenyl source, and N-methylimidazolium salt As an additive, acetonitrile is used as a solvent, and diselenide oxalate is synthesized under heating conditions. The preparation method has the advantages of simple operation, short steps, mild conditions, easy post-processing and no metal participation. The synthesized diselenide oxalate is a new class of selenide compounds, which can realize the selenoalkylation of indole compounds under photocatalysis.

The invention relates to the field of a medical technology, and discloses a racemization method of (1R, 6S)-8-benzyl-7, 9-dioxo-2, 8- diazabicyclo (4, 3, 0) nonane. The method comprises the steps of (1) in ether solvent or polar aprotic solvent, carrying out oxidative dehydrogenation on the (1R, 6S)-8-benzyl-7, 9-dioxo-2, 8-diazabicyclo (4, 3, 0) nonane by taking elemental iodine and oxygen as co-oxidant to prepare 6-benzyl-5, 7-dioxo-1, 2, 3, 4-tetrahydron-pyrrolo (3, 4-b) pyrrole; (2) in ester solvent or alcohol solvent, carrying out catalytic hydrogenation on oxidative product by taking Pd / Al2O3 as a catalyst to obtain the racemic cis-8-benzyl-7, 9-dioxo-2, 8-diazabicyclo (4, 3, 0) nonane. The method is simple in technology, convenient to operate, mild in reaction conditions, etc.

The invention provides a silver nanocluster preparation method with hydrogen serving as a reducing agent. The silver nanocluster preparation method is characterized in that polyelectrolyte and silver salt react at a room temperature in a hydrogen atmosphere by taking the polyelectrolyte as a template and the hydrogen as the reducing agent so as to obtain a near-infrared emission silver nanocluster. The silver nanocluster preparation method has the advantages of low cost, simplicity, mild reacting conditions, no participation of highly-toxic substance and more economy and environmental protection, and the prepared silver nanocluster is excellent in fluorescence characteristic and stability.

The invention belongs to the technical field of organic compound synthesis, provides a method for synthesizing a 1,4-butene diketone compound and aims to solve the problems that metal participates, materials are complex and the conditions are harsh in the method for synthesizing the 1,4-butene diketone compound at present. The synthesizing method comprises the step of reacting for 12-48h at 25-80 DEG C by using substituted aryne and phenol as initial materials, using 1-chloromethyl-4-fluoro-1,4-diazabicyclo[2.2.2] octane bi(tetrafluoroboric acid) salt (selectfluor) as an oxidant and using CH3CN as a solvent to prepare the 1,4-butene diketone compound. The invention provides a method for synthesizing the 1,4-butene diketone compound, which has the advantages that materials can be easily obtained, no metal participates and the reaction condition is moderate. The reaction formula is shown in the specification.

The invention relates to a synthetic method of benzo oxepin compounds. The synthetic method comprises the following steps of: with an o-fluorobenzene acetylene compound and ketone as raw materials, alkali as an accelerant and an organic solvent as a solvent, increasing temperature to 80-150 DEG C under the protection of inert gas, and stirring to react for 6-24 hours; after the reaction is finished, cooling to room temperature, carrying out reduced pressure distillation and concentration to obtain a crude product, and then purifying through column chromatography to obtain the benzo oxepin compounds. The synthetic method of the benzo oxepin compounds, which is disclosed by the invention, has the advantages of safety and easiness in operation, good adaptability to a functional group, wide adaptability to substrates and environmental friendliness and is favorable for industrial production and widely applied to medicines and organic synthesis, and the raw materials are easily available and low in price.

The invention discloses a 1, 2, 3, 4-tetradroquinoline derivative and a method for preparing the same. The method for preparing the1, 2, 3, 4-tetradroquinoline derivative which can be a chemical compound shown by a formula I includes a step of enabling a chemical compound shown in a formula II and hydrogen to carry out reduction reaction under the catalysis effects of HB(C<6>F<5>)<2> and styrene to obtain the chemical compound shown in the formula I. Alternately, the method for preparing the 1, 2, 3, 4-tetradroquinoline derivative which can be an optically active chemical compound shown in a formula I includes a step of enabling the chemical compound shown in the formula II and hydrogen to carry out reduction reaction under the catalysis effects of the HB(C<6>F<5>)<2> and a chemical compound shown in a formula III to obtain the optically active chemical compound shown in the formula I. The 1, 2, 3, 4-tetradroquinoline derivative and the method have the advantages that the HB(C<6>F<5>)<2> and the styrene are used as catalysts, quinoline derivatives with different structures are used as substrates, accordingly, the high-yield all-cis 1, 2, 3, 4-tetradroquinoline derivative can be synthesized, and the stereoselectivity of products can be controlled; alternately, the HB(C<6>F<5>)<2> and chiral diene are used as catalysts, the quinoline derivatives with the different structures are used as the substrates, accordingly, the high-yield optically active 1, 2, 3, 4-tetradroquinoline derivative can be synthesized, and the enantioselectivity of products can be controlled.