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Bonding polymer, medical adhesive and preparation method of medical adhesive

A polymer and adhesive technology, applied in surgical adhesives, applications, medical science, etc., can solve the problem of weakening the bonding strength of the adhesive interface such as van der Waals force, weakening the chemical bond of the adhesive, and insufficient bonding strength, etc. problems, to achieve the effect of short reaction time, simplified follow-up processing, and simple preparation process

Active Publication Date: 2020-07-24
SHENZHEN LANDO BIOMATERIALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, both have advantages and disadvantages: fibrin glue has good biocompatibility and degradability, but has disadvantages such as high preparation cost, insufficient bonding strength, risk of embolism, allergic rejection, etc., which limit its use. application
However, due to the presence of water and body fluids inside the tissue, the interfacial bonding strength of adhesives such as van der Waals force will be weakened, and even the chemical bonds inside the adhesive will be weakened.

Method used

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  • Bonding polymer, medical adhesive and preparation method of medical adhesive
  • Bonding polymer, medical adhesive and preparation method of medical adhesive
  • Bonding polymer, medical adhesive and preparation method of medical adhesive

Examples

Experimental program
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preparation example Construction

[0029] see figure 1 , the preparation method of the binding polymer of the present embodiment, comprises the steps:

[0030] Step S110: mixing polyhydric alcohol, polycarboxylic acid compound and polyphenol compound, heating and melting under the protection of an inert gas, and then adding a catalyst for polymerization reaction to obtain a crude product.

[0031] Wherein, the polyol includes at least one of alcohol compounds containing multiple hydroxyl groups and polymers containing multiple hydroxyl groups.

[0032] For example, the alcohol compound includes at least one of glycerin, xylitol and sorbitol. It can be understood that, in this embodiment, the alcohol compound also includes at least one of glycerol derivatives, xylitol derivatives and sorbitol derivatives.

[0033] The polymer is a linear or bulk alcohol polymer containing multiple hydroxyl groups. For example, the polymer includes at least one of polyethylene glycol, multi-armed polyethylene glycol, polyglyce...

Embodiment 1

[0075] The preparation process of the medical adhesive of the present embodiment is specifically as follows:

[0076] (1) Melt polymerization: add 3.72g citric acid, 6.69g polyethylene glycol (average molecular weight 400), 1.76g four-armed polyethylene glycol (average molecular weight 2000) and 1.00g dopamine hydrochloride simultaneously in the three-necked flask, nitrogen gas 15min. Place the above-mentioned three-neck flask in an oil bath that has been heated to 160°C, start stirring, and melt for 2 hours while stirring. After the reactant is completely melted, add an acidic catalyst, continue to stir the reaction until the end of the reaction, turn off the stirring and heating, stop nitrogen filling, and obtain the crude product.

[0077] (2) Dissolving: Pour 30 g of purified water into the three-necked flask after the reaction in step (1), and start stirring for 24 hours to dissolve the crude product.

[0078] (3) Dialysis: the dissolved crude product obtained in step (...

Embodiment 2

[0083] The preparation process of the medical adhesive of the present embodiment is specifically as follows:

[0084] (1) Melt polymerization: add 3.72g citric acid, 6.34g polyethylene glycol (average molecular weight 400), 3.52g four-armed polyethylene glycol (average molecular weight 2000) and 1.00g dopamine hydrochloride simultaneously in the there-necked flask, nitrogen gas After 15 minutes, put the above-mentioned three-neck flask in an oil bath that has been heated to 160°C, start stirring, and melt while stirring for 2 hours. After the reactant is completely melted, add an acidic catalyst, continue to stir the reaction until the end of the reaction, turn off the stirring and heating , stop filling nitrogen, and obtain crude product.

[0085] (2) Dissolving: Pour 30 g of purified water into the three-necked flask after the reaction in step (1), and start stirring for 24 hours to dissolve the crude product.

[0086] (3) Dialysis: the dissolved crude product obtained in s...

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Abstract

The invention relates to a bonding polymer, a medical adhesive and a preparation method of the medical adhesive. The preparation method of the bonding polymer comprises the following steps of: mixingpolyhydric alcohols, a polycarboxylic acid compound and a polyphenol compound, heating and melting under the protection of inert gas, and then adding a catalyst for polymerization reaction to obtain acrude product, wherein the polyhydric alcohols comprise at least one of an alcohol compound containing multiple hydroxyl groups and an alcohol polymer containing multiple hydroxyl groups; mixing andstirring the crude product with water to dissolve the crude product; and separating and freeze-drying the dissolved crude product to obtain the colloidal bonding polymer. The preparation process of the bonding polymer is simple, and the prepared bonding polymer is good in biocompatibility and high in bonding strength, so that the bonding polymer can be used for preparing the medical adhesive.

Description

technical field [0001] The invention relates to the field of medical adhesives, in particular to an adhesive polymer, a medical adhesive and a preparation method thereof. Background technique [0002] Both suturing and bonding are the primary techniques for clinical soft tissue closure. Compared with suturing, bonding has many advantages, such as: it can effectively stop bleeding, isolate air, avoid damage to human tissue caused by needle sticks, shorten operation time, and do not need to be removed. Currently common medical adhesives are mainly divided into two categories: biological adhesives and synthetic adhesives. Among them, bioadhesives that have been marketed and applied clinically are mainly fibrin adhesives prepared by extraction, and cyanoacrylate adhesives among synthetic adhesives are the earliest and most widely used medical adhesives. However, both have advantages and disadvantages: fibrin glue has good biocompatibility and degradability, but has disadvantag...

Claims

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Application Information

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IPC IPC(8): A61L24/04A61L24/00C08G63/664C08G63/78
CPCA61L24/046A61L24/001C08G63/664C08G63/78
Inventor 敖鹏王明波谭荣伟佘振定
Owner SHENZHEN LANDO BIOMATERIALS
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