33 results about "Sulfanyl" patented technology

Matrix metalloproteinases (MMPs) are a group of enzymes that have been implicated in the pathological destruction of connective tissue and basement membranes. These zinc containing endopeptidases consist of several subsets of enzymes including collagenases, stromelysins and gelatinases. TNF-alpha converting enzyme (TACE), a pro-inflammatory cytokine, catalyzes the formation of TNF-alpha from membrane bound TNF-alpha precursor protein. It is expected that small molecule inhibitors of MMPs and TACE therefore have the potential for treating a variety of disease states. The present invention provides low molecular weight, non-peptide inhibitors of matrix metalloproteinases (MMPs) and TNF-alpha converting enzyme (TACE) for the treatment of arthritis, tumor metastasis, tissue ulceration, abnormal wound healing, periodontal disease, bone disease, diabetes (insulin resistance) and HIV infection having the formula wherein R2 and R3 form a heterocyclic ring and A is S, S(O), or S(O)2, and R1 and R4 are defined herein.

The present invention is directed to a crystalline compound comprising a hydrobromide acid (HBr) salt of a compound of formula (I) (1-{2-[(2,4-dimethylphenyl)sulfanyl]phenyl}piperazine, INN: vortioxetine), having an XRPD pattern with characteristic peaks (expressed in 2θ±0.2° 2θ (CuKα radiation)) at 5.5°, 14.8°, 16.7° and 20.0° and processes for obtaining the same.

The invention relates to a compound of the 5-acylsulfanyl-histidine type and the derivatives thereof, of general formula (I), wherein R1 to R3=H, alkyl, especially CH3; R4=H, alkyl, especially CH3, alkyle(C=0), substituted alkyl (C═O), aryl (C═O); β-alanyl (H2NCH2CH2 (C═O); α-amino-acyl; R5=alkyl, especially methyl, phenyl. The invention also relates to the use of said compound for producing compounds of the 5-sulfanyl-histidine type and the derivatives thereof, in addition to corresponding disulfides; and to the various methods for the production thereof.

The present invention relates to Pyridin-2-yl sulfanyl acid ester compounds having antiinflammatory properties. The present invention particularly relates to novel anti-inflammatory heterocyclic acid esters of Pyridin-2-yl sulfanyl having the structure of general formula 1 which have been screened for their antiinflammatory activity with respect to inhibition of adhesion of neutrophils, isolated from human peripheral blood, onto the surface of human umbilical vein endothelial cells (HU-VEC) as a result of inhibition of the cytokine-stimulated expression of cell adhesion molecule ICAM-1. The compound RS—Z, 3-(Pyridin-2-yl sulfanyl)-propionic acid pentyl ester (structure 1a, R1=H, R2=H, R3=CH2-COOC5H11) was found to be most effective for ICAM-1 and neutrophil adhesion inhibition and was found to effectively alleviate inflammation mediated by excessive leukocyte infiltration leading to inflammatory disorders or like conditions, such as acute lung injury and acute respiratory distress syndrome in mice.

A benzodiazaborole derivative has the structure of the following formula (1) as shown in the description, wherein R1 is selected from one of a group consisting of a hydrogen atom, a formula (2), a formula (3), and a formula (4), and R2 is selected from the group consisting of a hydrogen atom, a formula (3) and a formula (4), R1 is different from R2 and at least one of them is a hydrogen atom, R3 is a general formula (4) when R2 is a general formula (4), and R3 is a hydrogen atom or a general formula (3) When R2 is a hydrogen atom; R4 to R19 are independently selected from one group consistingof a hydrogen atom, a fluorine atom, a cyano group, an alkyl group, a cycloalkyl group, a alkoxy group, a haloalkyl group, a sulfanyl group, a silyl group, and an alkenyl group.

The invention relates to a method for producing 4-pentafluoride-sulfanyl-benzoylguanidines of formula (I) wherein groups from R1 to R4 correspond to meanings given in claims. The compounds of the formula (I) constitute NHE1 inhibitors and can be used for curing cardiovascular diseases.

The invention belongs to the technical field of organic optoelectronic materials, and in particular relates to a D(A-Ar) at the end of a class of alkyl / sulfanyl nitrogen heteroaromatic rings 2 Type conjugated compound and preparation method and application thereof. Taking 3,3'-difluoro-2,2'-bisthiophene donor unit as the central nucleus, through alkylation reaction, electrophilic substitution on bromine reaction and stille coupling reaction, D(A-Ar) was obtained 2 Conjugated Organic Small Molecule Photovoltaic Donor Materials with Type Structure. D(A-Ar) according to the present invention 2 The type conjugated compounds have good solubility and stability, wide spectral absorption range, strong light absorption ability and suitable electrochemical energy level, and are expected to be used as donor materials for organic solar cells. with fullerene PC 71 The maximum energy conversion efficiency and short-circuit current of single-layer device bulk heterojunction solar cells with BM as acceptor are as high as 8.91% and 16.75 mA cm, respectively ‑2 .

The invention discloses a dual-slurry ammonization granulation compound fertilizer production technology, which is characterized by high nitrogen content and adjustable available nutrients. The technology comprises the following steps: 1, carrying out secondary dechlorination at low temperature; 2, dissolving phosphorus and mixing slurries; 3, cooling and absorbing; 4, melting and dissolving urea; 5, aminating and granulating; 6, drying and cooling; 7, screening and smashing; and 8, packaging. By using the invention, nitrogen content of sulfanyl compound fertilizers rises to 25% from 13%, recycle ratio reduces to 20-30% from 40-50%, yield of single-pass granulation in a granulator is greatly improved, dechlorination time is shortened to 1h from over 2h by adopting the secondary dechlorination technology, the dechlorination is thorough, and the production efficiency is greatly improved.