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Novel peptide agonists of GLP-1 activity useful for lowering blood glucose levels. The novel peptides comprise variants of the GLP-1 or the exendin-4 polypeptide sequence and are pharmacologically active and stable. These peptides are useful in the treatment of diseases that benefit from regulation of excess levels of blood glucose and / or regulation of gastric emptying, such as diabetes and eating disorders.

The present invention provides glucoimidazole (GIZ) and polyhydroxycyclohexenyl amine (PHCA) derivatives, methods of making them, and methods of use where the GIZ and PHCA derivatives have a short, flexible linker emanating from the corresponding position of the ring oxygen in a pyranose; and a lipophilic moiety connected to the linker and pharmaceutically acceptable salts thereof. More particularly, the present invention further provides a method for treating individuals having Gaucher disease by administering the novel GIZ or PHCA derivatives as “active-site specific chaperones” for the mutant glucocerebrosidase associated with the disease.

Disclosed embodiments describe a volar plate generally for use treating distal volar fractures. The volar plate is designed in accordance with anatomical features and is generally Y-shaped, having a wider distal head portion that tapers to a narrower proximal body portion. A plurality of holes in the distal head of the volar plate allow for fixation means to fix the position of bone fragments with respect to the volar plate. The plurality of holes in the distal head basically form two substantially non-linear rows, with the distal row generally curving inward proximally and the proximal row generally curving outward distally such that the fixation means inserted through the holes generally converge. A central cavity may be located in the proximal body of the volar plate to promote bone growth, and mounting screws may border the central cavity on either side to provide secure support. Additionally, K-wire holes may be included which are visually linked to corresponding holes in the distal head.

An ink tank comprises ink holding means capable of impregnating and retaining ink; and a housing for containing the ink holding means, with an ink supply port provided for the housing for supplying to the outside ink impregnated in the ink holding means, and an air inducing port for inducing the air outside into the housing. For this ink tank, the ink holding means further comprises a first ink holding member arranged on the inner face of the housing having the ink supply port open thereto, and a second ink holding member held closely to the first ink holding member, having smaller ink holding power than that of the first ink holding member, and the first ink holding member is essentially formed in the same shape as the shape of the inner face of the housing having the ink supply port open thereto, and substantially covers the inner face entirely, and grooves communicated with the ink supply port on the inner face of the housing having the ink supply port open thereto. With the structure thus arranged, ink can be filled in the second ink holding member almost uniformly on the entire abutting surface on the first ink holding member, thus making it possible to enhance the filling efficiency of ink when ink is filled.