The invention relates to two halogen-phenol compounds, namely 2, 4', 5'-trihydroxy-5, 2'-dibromo benzophenone and 2',5-dibromo-2-(2-phenyl imidazole-1-group) methyl-4',5'-dihydroxy benaophenonel, and novel pharmacological application of medicine compositions of the two compounds in the effect of promoting angiogenesis. According to the application of the two halogen-phenol compounds, the angiogenesis promotion effect of the two halogen-phenol compounds is defined, and the compounds have the specific effects that the length of a damaged internode blood vessel of a zebra fish can be remarkably increased, and the zebra fish suffering from vascular injury can be protected. The compounds can be used independently or in combination with other pharmaceutic adjuvant ingredients acceptable to pharmacy for preparing medicine having the angiogenesis promotion function, and potential application prospects in prevention and treatment of ischemic heart disease, apoplexy, muscle atrophy, far-end limb necrosis and the like are achieved.