5443results about How to "Easy to fold" patented technology

The invention provides polypeptides comprising a variant heavy chain variable framework domain (VFR). In some embodiments, the amino acids defining the VFR form a loop of an antigen binding pocket. In an embodiment, the polypeptide is a variable domain of a monobody and has a variant VFR. The polypeptide may optionally comprise one or more complementary determining regions (CDRs) of antibody variable domains. In an embodiment, the polypeptide is a variable domain of a monobody and has a variant VFR and one or more variant CDRs. Libraries of polypeptides that include a plurality of different antibody variable domains generated by creating diversity in a VFR, and optionally, one or more CDRs are provided and may be used as a source for identifying novel antigen binding polypeptides that can be used therapeutically or as reagents. The invention also provides fusion polypeptides, compositions, and methods for generating and using the polypeptides and libraries.

Disclosed herein are proteins that include an immunoglobulin fold and that can be used as scaffolds. Also disclosed herein are nucleic acids encoding such proteins and the use of such proteins in diagnostic methods and in methods for evolving novel compound-binding species and their ligands.

Embodiments of an access device system useful for single or limited port procedures comprises a retractor and a gel cap removably coupled to the retractor. The gel cap comprises a gel pad that acts as an artificial body wall, through which instruments may be inserted into a body cavity, either directly or through one or more trocars. The gel pad permits flexible instrument placement, as well as translational and angular degrees of freedom for the instruments while maintaining a gas tight seal.

A balloon for use in compressing cancellous bone and marrow (also known as medullary bone or trabecular bone). The balloon comprises an inflatable balloon body for insertion into said bone. The body has a shape and size to compress at least a portion of the cancellous bone to form a cavity in the cancellous bone and / or to restore the original position of the outer cortical bone, if fractured or collapsed. The balloon desirably incorporates restraints which inhibit the balloon from applying excessive pressure to various regions of the cortical bone. The wall or walls of the balloon are such that proper inflation of the balloon body is achieved to provide for optimum compression of the bone marrow. The balloon can be inserted quickly into a bone. The balloon can be made to have a suction catheter. The balloon can be used to form and / or enlarge a cavity or passage in a bone, especially in, but not limited to, vertebral bodies. Various additional embodiments facilitate directionally biasing the inflation of the balloon.

An accommodating intraocular implant for locating in the capsular bag, the implant comprising a single piece of elastically deformable material constituting a central lens (1) and at least two haptic portions (2, 4) in the form of radial arms for bearing via their free ends against the equatorial zone of the capsular bag, the free end of each radial arm (2, 4) being fitted with a shoe (6, 7) of substantially toroidal outside surface enabling the implant to bear against the equatorial zone of the bag, the connection between each shoe (6, 7) and the corresponding arm (2, 4) being of the hinge type situated in the vicinity of the posterior edge of the shoe (6, 7) and being formed by a first thin portion (2d, 4d) of the arm, while the connection between each arm and the lens is of the hinge type implemented at the anterior surface of the lens by a second likewise thin portion (2c, 4c) of the arm, the plane (P1) containing the first thin portions being situated behind the plane (P2) containing the second thin portions.

A collapsible insulated container has a base wall and a peripheral wall with an open end defining an enclosure. The peripheral wall has at least two layers and is divided into elongate pockets between the layers, with foldable crease lines between adjacent pockets. Each pocket contains a flexible-walled, insulating gel pack which substantially fills the pocket. The crease lines may be defined by stitching securing the outer and inner layers of the container together. The gel packs may be surrounded by matting, foam or mesh material which is sewn into the lines of stitching, or may have integral peripheral rims sewn into the lines of stitching. The container is foldable between an erect, open condition and a storage condition in which it is folded along the crease lines into a substantially flattened package.

The present invention provides a foldable flexible display device. A foldable flexible display device according to the present invention includes: first and second plates having a predetermined area; a hinge member for connecting the first plate and the second plate; and a flexible display screen attached to the tops of the first plate and the second plate and the hinge member, in which the hinge member folds the first plate and the second plate and the flexible display screen while folding with smooth curvature.According to this configuration, the operation for folding or unfolding the screen of a flexible display device can be smoothly operated and damage to the display screen can be prevented, resulting in remarkable improvement in reliability of a product.

A sport or active shoe that can be stored in a compact configuration can be folded generally in half and secured closed with a closure connected to the heel and toe. The shoe includes a single layer upper to facilitate folding. The shoe can be folded into a very compact configuration and stored conveniently in a pocket, pack, purse, etc., allowing a user to keep a pair of the shoes handy for wearing before or after sports activities or specialized activities requiring specialized or bulky footwear.

A blister pack (20) folded wallet has a mounting card (12), with a [hinged] spine segment (15), and an adhesive edge strip (16). Overlaid by a pre-formed blister pack (11), for mutual (edge) entrainment; a dedicated assembly machine entrains mounting cards and blister packs stored in respective magazines. Child resistance is available through cover latching and / or paper reinforced foil laminate (161), with through apertures (166) and perforations (163, 165) for selective localised paper patch (169) removal, over individual blister pockets (168).

This invention demonstrates the utility of a yeast expression system for the expression of functional heterologous multi-domain proteins in yeast. The yeast expression system allows for the inclusion of a plurality of (up to three) modular expression cassettes which may encode multiple polypeptide chains of a heterologous multi-domain protein on a single plasmid (Twin Cassette). Because multiple polypeptide chains may be encoded for by the expression cassettes of the present invention in a single vector, the system can produce equivalent amounts of the multiple polypeptide chains, thereby enhancing the yield of a functional heterologous multi-domain protein. For example, functional monoclonal antibodies (MAbs) comprising a heavy chain and a light chain of an immunoglobulin (IgG), and functional immunotoxins comprising an antibody domain and an oxidase toxin may be produced using the Yeast expression system of the present invention. In addition, functional single chain antibodies, antibody fragments and chimeric antibodies may also be produced.

An accommodating intraocular implant for locating in the capsular bag, the implant comprising a single piece of elastically deformable material constituting a central lens (1) and at least two haptic portions (2, 4) in the form of radial arms for bearing via their free ends against the equatorial zone of the capsular bag, the free end of each radial arm (2, 4) being fitted with a shoe (6, 7) of substantially toroidal outside surface enabling the implant to bear against the equatorial zone of the bag, the connection between each shoe (6, 7) and the corresponding arm (2, 4) being of the hinge type situated in the vicinity of the posterior edge of the shoe (6, 7) and being formed by a first thin portion (2d, 4d) of the arm, while the connection between each arm and the lens is of the hinge type implemented at the anterior surface of the lens by a second likewise thin portion (2c, 4c) of the arm, the plane (P1) containing the first thin portions being situated behind the plane (P2) containing the second thin portions.

An ultrasound measurement system including a handheld display and processing means, an ultrasound transducer, a processing means of a substantially similar weight to the handheld display and processing means, and a transmission cable interconnecting the handheld display and processing means with the ultrasound transducer and processing means, the cable being of sufficient length to provide a means to mechanically locate the system around the neck of a user.

Rotatable hand supports for performing pushups on a floor or ground surface. The handle of the supports has a grip portion adapted to be grasped by a user. The rotatable base is base has a bottom portion adapted to contact the floor, a top portion rotatably connected to the bottom portion, and a bearing assembly supporting the top portion on said bottom portion. A support connects the handle to the top portion of the base and supports the handle at an elevated position relative to the base and above the floor.

Embodiments of a surgical access system useful for single or limited port procedures comprise a trocar comprising a fixation cannula, a retractor, and a gel cap removably coupled to the retractor. The gel cap comprises a gel pad that acts as an artificial body wall, through which instruments may be inserted into a body cavity, either directly or through one or more trocars. The fixation cannula comprises a retainer and a bolster, which together, capture the artificial body wall therebetween, thereby fixing the trocar thereto. The gel pad permits flexible instrument placement, as well as translational and angular degrees of freedom for the instruments while maintaining a gas tight seal.

Disclosed herein are proteins that include an immunoglobulin fold and that can be used as scaffolds. Also disclosed herein are nucleic acids encoding such proteins and the use of such proteins in diagnostic methods and in methods for evolving novel compound-binding species and their ligands.

A collapsible insulated container has a base wall and a peripheral wall with an open end defining an enclosure. The peripheral wall has at least two layers and is divided into elongate pockets between the layers, with foldable crease lines between adjacent pockets. Each pocket contains a flexible-walled, insulating gel pack which substantially fills the pocket. The crease lines may be defined by stitching securing the outer and inner layers of the container together. The gel packs may be surrounded by matting, foam or mesh material which is sewn into the lines of stitching, or may have integral peripheral rims sewn into the lines of stitching. The container is foldable between an erect, open condition and a storage condition in which it is folded along the crease lines into a substantially flattened package.

This invention provides an aerodynamic structure attached to the rear face of a truck cargo body, which rear typically contains a door assembly, with a plurality of doors that swing open on hinges, or a single, full-width door, which rolls upwardly. The various embodiments of the invention allow an aerodynamic structure to be permanently attached to the rear of the trailer in a manner that would obscure access to the door(s) in a deployed position, in which the aerodynamic structure generates reduced drag on the trailer body, yet enables ready access to the door(s) in a folded position. The folded position still allows the rear of the trailer to be fully accessible for loading and unloading, and in the case of swinging, hinged doors (among others), allows the doors to be folded through a full 270-degree arc from a closed position to a position flush along the sides of the vehicle, with a minimal sideways projection. The various embodiments also enable relatively rapid and easy transition between the folded position and the deployed position using a variety of actuators and linkages that tie the folding and deployment of various panels of the structure together. This allows an operator to selectively fold and deploy the structure without undue effort or strength.

A portable information kiosk. The kiosk has a self contained power supply for a computer, a display, a digital camera, a cellular, satellite capable telephone, an antenna, a printer and a flat bed scanner, all electrically connected to each other and capable of being stored in a small carrying case. A method of deploying the kiosk does not require any attaching of parts together and can be done quickly. The kiosk is ideal for in the field communications and data acquisition, such as in disasters, emergencies, or any in the field environmental monitoring.

A composite facer material for use with cementitious wallboards, where the composite facer is embedded in a top and bottom face thereof. The composite facer material, in a most preferred embodiment, comprises two layers. The first layer is preferably a carded polyester nonwoven mat, which is bonded to a second layer comprising preferably a tri-directional laid scrim fabric reinforcement layer made of continuous glass fibers. The two layers are preferably bonded together using an acrylic adhesive, which offers superior adhesion between the layers as well as superior adhesion between the composite facing material and the cementitious core.

An absorbent article is provided which includes a fluid permeable top sheet and a first absorbent core being separate and in fluid communication with a second absorbent core. The second absorbent core is separate and in fluid communication with a third absorbent core. The first, second and third absorbent cores are supported between the fluid permeable top sheet and a fluid impermeable back sheet. The second absorbent core defines at least two separate absorbent core sections in fluid communication. The separate absorbent core sections define a body facing surface that engages the fluid permeable top sheet. In an alternate embodiment, the absorbent article defines a longitudinal length and includes a fluid permeable top sheet and a first absorbent core disposed adjacent a side of a central second absorbent core and pivotable, along the longitudinal length, relative to the second absorbent core. A third absorbent core is disposed adjacent to an opposing side of the second absorbent core and pivotable, along the longitudinal length, relative to the second absorbent core. The second absorbent core has a mid-section and lateral sections disposed on opposing sides of the mid-section. The mid-section and lateral sections are separate, in fluid communication and define a body-facing surface that engages the fluid permeable top sheet. In another alternate embodiment, fluid flow channels are disposed between the absorbent cores and core sections for fluid management.

The invention provides polypeptides comprising a variant heavy chain variable framework domain (VFR). In some embodiments, the amino acids defining the VFR form a loop of an antigen binding pocket. In an embodiment, the polypeptide is a variable domain of a monobody and has a variant VFR. The polypeptide may optionally comprise one or more complementary determining regions (CDRs) of antibody variable domains. In an embodiment, the polypeptide is a variable domain of a monobody and has a variant VFR and one or more variant CDRs. Libraries of polypeptides that include a plurality of different antibody variable domains generated by creating diversity in a VFR, and optionally, one or more CDRs are provided and may be used as a source for identifying novel antigen binding polypeptides that can be used therapeutically or as reagents. The invention also provides fusion polypeptides, compositions, and methods for generating and using the polypeptides and libraries.

A carton is formed from a blank of cardboard or paperboard by folding the blank along preformed score lines or fold lines. The carton has front and rear walls, opposite side walls, corner walls, and top and bottom walls defining an enclosure for receiving the contents. Tabs are attached to the top and bottom walls at the corners and are folded downward over the corner walls to prevent light from entering the space between the corner walls and the top and bottom walls. Slots can be provided in the corner walls, and the ends of the tabs inserted into the slots to retain the tabs in a flush position against the corner walls.

A hot beverage lid having thermal protective flex-guards or flaps extending from opposite sides of a cover portion of the lid for protecting a consumer's fingers from heat emanating from the side of a cup. A first flap extends a first distance from under a drinking opening having sufficient area for a thumb. A second flap extends a second distance which is greater than the first flap from the opposite side of the lid and has sufficient area for at least two fingers. Each flap is contoured to conform to the curvature or the sidewall of the cup and each flap comprises swirled rib embossing for improved retention against fingers holding the cup. The top of the cover portion is concave with a hole in the center to allow liquid spillage to reenter the cup. Also, a channel surrounding the base of a circular plateau on top of the cover of the lid is provided for collecting fluid spillage.

A collapsible container has four panels that fold down on a base for storage. The base has slide sockets with vertical slots. Front and rear panels pivot on the base with slide hinges received in the slide sockets. The panels are able to slide up and down. A hinge pin has a narrowed waist portion to engage a latch. Left and right panels pivot with snap hinges received in snap sockets on the base. Trunnions, disposed in the snap sockets, are eccentric to increase or decrease the backlash between the snap hinge and the snap socket as the panels pivot. The left and right panels have edge pockets that receive edge fingers on the front and rear panels to hold the container open. The front and rear panels each have an access opening with access doors. Links pivot the access doors on two hinge rods. Locking members wedge the hinge rods in the hinge knuckles. The base has feet with bumper plates having flanges that prevent the container from shifting on an adjacent lower stacked container.

An array of photovoltaic panels is supported in rows and columns spaced from one another using a foldable bi-directional span of support members. The support members include a plurality of support joists and support rails braced at an incline. Each support rail is tubular and generally rectangular, having a lower wall section with a T-slot channel for acceptance of the head of a bolt for adjustable attachment with the support joist. Also, the support rail may have a C-slot channel for retaining electrical wires. Clips are used to secure each panel to upper wall portions of underlying support rails. Each clip has a generally U-shaped gasket and is retained to a corresponding support rail through a threaded hole in a top wall of the support rail that receives a bolt or similar threaded fastener.

A sunshade apparatus for shading a chair has a pair of vertical support legs, a pair of attachment elements, a pair of horizontally extending arms, and a flexible canopy element for shading the chair. Each of the attachment elements is attached to a bottom end of one of the support legs and is adapted for mounting the sunshade apparatus on the chair. Each of the pair of horizontally extending arms is attached to one of the support legs with a hinge. A locking element functions to lock the pair of horizontally extending arms in the extended configuration with respect to the pair of vertical support legs. A folding element joins the horizontally extending arms and folds between a collapsed configuration wherein the arms are adjacent, and a spread configuration wherein the arms are laterally spaced.

A bulk container and method suitable for forming an interlinked wall. In one embodiment, the bulk container may generally include sidewalls, lifting straps for transporting the container, and a closeable top. Linking loops may be provided on at least one sidewall which are each configured to be engaged by connecting members to link adjacent bulk containers together for forming an interlinked wall. In one embodiment, the connecting member is a belt which may be tensioned. Another possible embodiment includes a linking strap affixed to the sidewall panel and to which the linking loops may be attached or formed as an integral part thereof. A barrier wall system and method of forming the same from interlinked bulk containers is also provided. The barrier wall system is suitable for use in, but not limited to, shoreline erosion protection and flood control applications.

A sanitary napkin in which diffusing liquid hardly reaches a rear end edge is adapted to make a liquid absorbent layer less deformable in a rear region so that it can easily be kept in close contact with the wearer's buttocks. The sanitary napkin has an elongated main absorbent region surrounded by compressed grooves that are formed in a skin-side surface. Since a rear end of the main absorbent region is far away from a rear end edge of the napkin to provide a relatively large rear region, worries about rearward leakage may be relieved. Furthermore, since auxiliary longitudinal grooves are provided in the rear region, a liquid absorbent layer may hardly be twisted.

According to the invention it is disclosed an absorbent pad (1) comprising a liquid-impervious back sheet (2), a plurality of bodies (3) of liquid-absorbent material disposed on one surface of the back sheet (2), and a liquid-pervious cover sheet (4) covering said bodies (3) of absorbent material and secured to the back sheet (2) along channels (7) which separate said bodies (3) of absorbent material. The channels (7) progresses in a channel-pattern in which three channels (7), meeting in a joint, form respective edges (6) of said whole bodies (3) and said channels (7) being substantially free from absorbent material. A method for the manufacturing of such absorbent pad (1) is also disclosed.