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Preparation of extremely small and uniform sized, iron oxide-based paramagnetic or pseudo-paramagnetic nanoparticles and mri t1 contrast agents using the same

一种氧化铁纳米、纳米颗粒的技术，应用在MRI T1显影剂,T1显影剂领域，能够解决原材料昂贵、意义小、毒性等问题，达到简单制备过程、尺寸易于、均匀尺寸分布的效果

Inactive Publication Date: 2013-06-12
HANWHA CHEMICAL CORPORATION
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  • Claims
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Problems solved by technology

However, there are stringent requirements for the preparation of iron oxide nanoparticles with a size of 4 nm or less, which in turn is not preferred in commercial applications (Jongnam Park et al. Nature Mater., 3 (2004), 891)
[0021] Further, even if nanoparticles with a size of 4nm or smaller could be prepared, the raw materials are expensive and / or severely toxic, thus having little significance in terms of commercial application (Xiaowei Teng, J. Mater. Chem., 14( 2004), 774)
[0022] Therefore, there is still a need to synthesize and mass-produce iron oxide nanoparticles with extremely small and uniform sizes of 4 nm or less in a low-cost and highly reproducible manner, as well as T1 contrast studies using the iron oxide nanoparticles, which have not yet been reported. to report

Method used

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  • Preparation of extremely small and uniform sized, iron oxide-based paramagnetic or pseudo-paramagnetic nanoparticles and mri t1 contrast agents using the same
  • Preparation of extremely small and uniform sized, iron oxide-based paramagnetic or pseudo-paramagnetic nanoparticles and mri t1 contrast agents using the same
  • Preparation of extremely small and uniform sized, iron oxide-based paramagnetic or pseudo-paramagnetic nanoparticles and mri t1 contrast agents using the same

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[0078] The preparation method of the iron oxide nanoparticles of the present invention includes: (a) reacting iron complexes, C4-C25 fatty acids, and C4-C25 fatty alcohols or C4 to C25 fatty amines at 150-350°C to prepare iron oxide nanoparticles Iron nanoparticles, said iron complex having iron as central atom and 4-25 carbon atoms bound to said central atom in the form of a ligand ("C4-C25" carboxylate group, hereinafter as defined above same), and after the preparation step (a), further comprising (b) dispersing the precipitate in an organic solvent, wherein the precipitate is obtained by cooling and washing the above nanoparticles.

[0079] The iron precursor used in the preparation step (a) of iron oxide nanoparticles may be one of the following, that is, it has an iron atom and a C10-C22 fatty acid group bound to the iron atom in the form of a ligand, and Examples of the ligand may include: stearic acid, oleic acid, linoleic acid, palmitic acid, palmitoleic acid, myristi...

Embodiment 1

[0108] Synthesis of 3nm-sized Iron Oxide Nanoparticles

[0109] 1.8 g (2 mmol) of iron oleate, 0.57 g (2 mmol) of oleic acid and 1.61 g (6 mmol) of oleyl alcohol were mixed with 10 g of diphenyl ether and placed in a round bottom flask. Vapor was removed from the flask by evacuating at 80°C for 1 hour, then argon was introduced into the flask to make the atmosphere inert. After the reaction was carried out in the flask while raising the temperature to 250°C with 10°C / min, the reaction mass turned black during the reaction. After raising the temperature to 250 °C, the reaction was continued for 30 min, resulting in 3 nm-sized nanoparticles ( figure 1 and 2 ). After the reaction, the product was rapidly cooled and then rinsed with excess acetone. After washing, the resulting precipitate is dispersed in an organic solvent such as chloroform or hexane.

Embodiment 2

[0111] Synthesis of 2.3nm-sized Iron Oxide Nanoparticles

[0112] 2.3nm -Synthesis of sized nanoparticles.

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Abstract

Provided are a preparation method of iron oxide-based paramagnetic or pseudo-paramagnetic nanoparticles, iron oxide-based nanoparticles prepared by the same, and a T1 contrast agent including the same. More particularly, the disclosure describes a method for preparation of iron oxide nanoparticles having a extremely small and uniform size of 4nm or less based on thermal decomposition of iron oleate complex, iron oxide-based paramagnetic or pseudo-paramagnetic nanoparticles prepared by the same, and a Tl contrast agent including iron oxide-based paramagnetic or pseudo-paramagnetic nanoparticles.

Description

technical field [0001] The present invention relates to a method for preparing iron oxide-based paramagnetic or pseudo-paramagnetic nanoparticles of uniform size, iron oxide-based nanoparticles prepared by the method and an MRI T1 developer comprising the nanoparticles. More specifically, the present invention relates to a method for producing extremely small and uniformly sized iron oxide nanoparticles of 4 nm or less based on thermal decomposition of an iron oleate complex, the iron oxide nanoparticles prepared by the method and comprising T1 developer of paramagnetic or pseudo-paramagnetic nanoparticles. Background technique [0002] A large number of studies involving various nanoparticles have been actively conducted recently in the field of biomedicine, such as cell staining, cell separation, drug delivery in vivo, gene delivery, diagnosis and treatment of diseases or abnormalities, molecular imaging, and the like. [0003] To determine the essential importance of suc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/08A61K49/04A61K47/02A61K47/48A61K9/16
CPCA61K49/1836A61K49/1839A61K49/1842A61K49/1845A61K49/186Y10S977/811Y10S977/882Y10S977/93Y10T428/2982A61K49/10B82Y5/00
Inventor 玄泽焕金秉晓李鲁贤金应奎全烽植权恩苾朴炷锳明岏在
Owner HANWHA CHEMICAL CORPORATION
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