The invention belongs to the technical field of blood screening and specifically relates to an integrated blood nucleic acid screening platform; the tabletop of the screening platform is divided into five functional zones which are sequentially consumptive material zone, reagent zone, thermomagnetic operation zone, sampling zone and waste zone, wherein, the thermomagnetic operation zone is provided with a dedicated thermomagnetic swiveling mechanismAgowa7200 or a thermomagnetic device consisting of a discrete component deep-well multiwell plate magne, a deep-well multiwell plate bearing rack, a temperature control module and an oscillation module; the screening reagent comprises paramagnetic particle method nucleic acid extraction reagent for simultaneously extracting RNA and DNA and one-step method RT-PCRTaqMan fluorescent probe reagent for simultaneously augmenting HBV DNA, HCV RNA and HIV RNA; special functions such as sample scanning, mixed sample collection, extraction of nucleic acid, preparation of PCR reaction solution, split charging and loading and the like are controlled by programs. The screening platform features convenient operation, designed operating process, which greatly improves screening efficiency, therefore the screening platform is very suitable for daily use in blood centers at home and abroad, the detecting departments in enterprises producing blood products.