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Hyaluronic acid and polydopamine-modified drug-loaded mesoporous titanium dioxide nanoparticles

A technology of mesoporous titanium dioxide and polydopamine, applied in the field of medical drugs, can solve the problems of poor selectivity and high toxicity, and achieve the effects of high stability, good biocompatibility and increased therapeutic function.

Active Publication Date: 2019-09-06
CHONGQING MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] The purpose of the present invention is to realize the combined application of multifunctional therapy, and improve the disadvantages of monotherapy such as poor selectivity and high toxicity.

Method used

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  • Hyaluronic acid and polydopamine-modified drug-loaded mesoporous titanium dioxide nanoparticles
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  • Hyaluronic acid and polydopamine-modified drug-loaded mesoporous titanium dioxide nanoparticles

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Experimental program
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Effect test

Embodiment 1

[0026] 1. Preparation of mesoporous titania nanoparticles

[0027] Slowly add 1ml of tetrabutyl titanate dropwise to 15ml of glacial acetic acid under stirring at room temperature, then add 0.5mL of distilled water to initiate the hydrolysis reaction of tetrabutyl titanate, then appropriately increase the stirring speed, and keep stirring the mixture at room temperature After reacting for 10 min, it was transferred to a hydrothermal reactor and reacted at 150° C. for 12 h. The precipitate was collected by centrifugation, washed three times with water and then dried to obtain mesoporous titanium dioxide (MTN).

[0028] 2. Preparation of drug-loaded mesoporous titania nanoparticles modified by hyaluronic acid and polydopamine

[0029] Weigh 10 mg of MTN and 20 mg of docetaxel, dissolve them in 1 ml of dichloromethane, sonicate in a water bath for 10 min, and then quickly remove the dichloromethane by evaporation under reduced pressure. Add 5ml tris hydrochloride buffer solutio...

Embodiment 2

[0032] 1. In vitro photothermal effects of drug-loaded mesoporous titania nanoparticles coated with hyaluronic acid and polydopamine

[0033] With a power density of 2.5W / cm 2 The drug-loaded mesoporous titanium dioxide nanoparticle suspension (1mL) wrapped by hyaluronic acid and polydopamine wrapped in a quartz cell with a concentration of 1000ug / ml placed in a quartz cell by 808nm laser irradiation, measured the temperature of the suspension every 30 seconds, and measured The time is 10 minutes. The result is as Figure 4 , the temperature of drug-loaded mesoporous titania nanoparticles wrapped by hyaluronic acid and polydopamine gradually increased with the prolongation of laser irradiation time, indicating that the drug-loaded mesoporous titania nanoparticles wrapped by hyaluronic acid and polydopamine have good photothermal conversion performance.

[0034] 2. Detection of reactive oxygen species generated in vitro by hyaluronic acid and polydopamine-modified drug-loade...

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Abstract

The invention discloses hyaluronic acid and polydopamine-modified drug-loaded mesoporous titanium dioxide nanoparticles. On the one hand, the nanoparticles can be aggregated at tumor sites through active targeting of hyaluronic acid, the selectivity of the preparation is increased, and thus the toxic and side effects of the preparation are reduced. On the other hand, mesoporous titanium dioxide can generate singlet oxygen under the ultrasonic condition, meanwhile, polydopamine can convert light energy into heat energy under the irradiation of near-infrared laser, and the combined application of sonodynamic therapy, photothermal therapy and chemotherapy can be realized along with the release of drugs.

Description

technical field [0001] The invention relates to the field of medical medicine, in particular to drug-loaded mesoporous titanium dioxide nanoparticles modified by hyaluronic acid and polydopamine. Background technique [0002] Currently, the clinical methods used to treat cancer mainly include surgery, chemotherapy, radiotherapy, and targeted drug therapy. Therefore, the development of specific killing and safe and efficient cancer treatment methods is a scientific problem and development direction of cancer treatment at present. With the development and improvement of nanotechnology and materials, multifunctional nanocomposite materials have brought new hope for precise tumor localization, early diagnosis and combined treatment. [0003] The application of nanomedicine has developed from carrying traditional drugs for chemotherapy to photothermal therapy, photodynamic therapy, sonodynamic therapy, magnetothermal therapy, gene therapy and immunotherapy. The application of n...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K9/51A61K47/02A61K47/59A61K47/61A61P35/00A61K31/337
CPCA61K9/5115A61K9/5146A61K9/5161A61K31/337A61K41/0033A61K41/0052A61P35/00A61K2300/00
Inventor 张良珂彭林娜
Owner CHONGQING MEDICAL UNIVERSITY
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