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740results about "Disrupted materials" patented technology
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Ultrasound therapy for selective cell ablation
InactiveUS20020193784A1Ultrasound therapyElectrical/wave energy microorganism treatmentApoptosisGene product
The invention provides a method of sensitising target cells to ultrasound energy using a stimulus such as an electric field. This "electrosensitisation" enables target cells to be disrupted by ultrasound at frequencies and energies of ultrasound which do not cause disruption of non-sensitised (i.e., non-target) cells. As a consequence, the method increases the selectivity of ultrasound therapy, providing a way to ablate undesired cells, such as diseased cells (e.g., tumor cells) while minimising harm to neighboring cells. In another aspect, however, ultrasound can be used to sensitise cells while the electrical field is used to disrupt cells. The invention also provides an apparatus for performing the method and assays for identifying gene products and other molecules involved in apoptosis.
Owner:GENDEL
Therapeutic delivery systems
InactiveUS6443898B1Low costSuitable for useUltrasonic/sonic/infrasonic diagnosticsPowder deliveryMicrosphereLiposome
Therapeutic delivery systems comprising gaseous precursor-filled microspheres comprising a therapeutic are described. Methods for employing such microspheres in therapeutic delivery applications are also provided. Therapeutic delivery systems comprising gaseous precursor-filled liposomes having encapsulated therein a contrast agent or drug are preferred. Methods of and apparatus for preparing such liposomes and methods for employing such liposomes in therapeutic delivery applications are also disclosed.
Owner:CEREVAST MEDICAL
Device II
Applicants describe a cell ablation apparatus comprising: electric field signal generating circuitry for generating an electric field signal; an electric field delivery component connected to receive the electric field signal and operable to deliver an electric field to a treatment site; ultrasound signal generating circuitry for generating an ultrasound signal; an ultrasound delivery component connected to receive the ultrasound signal and operable to deliver ultrasound to the treatment site; and a controller operable to control the electric field signal generating circuitry and the ultrasound signal generating circuitry in order to ablate a cell at the treatment site. Various electrode configurations suitable for use in such an apparatus and independently are described.
Owner:GENDEL
Solid hydrogel coupling for ultrasound imaging and therapy
InactiveUS7070565B2Lower the volumeInhibition of polymerizationUltrasonic/sonic/infrasonic diagnosticsUltrasound therapyUltrasound imagingUltrasonic sensor
Owner:UNIV OF WASHINGTON
Method for treating subcutaneous tissues
ActiveUS20070055179A1Sufficient powerEliminate riskUltrasonic/sonic/infrasonic diagnosticsElectrotherapyAbnormal tissue growthCavitation
An apparatus and method for treating subcutaneous tissues using acoustic waves in the range of low acoustic pressure ultrasound waves is disclosed. The method includes injections of enhancing agents, wherein disruption of subcutaneous tissues and subcutaneous cavitational bioeffects are produced by ultrasound waves having a power that will not produce tissue cavitation in the absence of the enhancing agents. The apparatus and method of use is useful for treatment of subcutaneous abnormalities including cellulite, lipomas, and tumors.
Owner:ULTHERA INC
Enhanced transport using membrane disruptive agents
Owner:UNIV OF WASHINGTON +1
Targeted release of nitric oxide in the CNS circulation for modulating the BBB and treating disorders
A method for delivering molecules to a central nervous system (CNS) of a subject includes supplying the molecules to a blood circulation of the CNS; supplying, to a body of the subject, a carrier system that encapsulates a nitric oxide (NO) facilitator; and applying energy to the carrier system at an energy level sufficient to cause the carrier system to release the NO facilitator in a blood circulation of the subject in a vicinity of a blood-brain barrier (BBB) of the subject and thereby increase passage of the molecules from the blood circulation of the CNS, through the BBB, and into the CNS of the subject.
Owner:BRAINSGATE LTD
Composition for therapy of diseases with ultrasonic and pharmaceutical liquid composition containing the same
InactiveUSRE36939E1Good effectWeaken energySonopheresisUltrasonic/sonic/infrasonic diagnosticsDiseaseTreatment effect
A booster comprising a plenty of microbubbles of a gas in a liquid, e.g. about 4x107 cells / ml of microbubbles of a gas having a diameter of 0.1 to 100 mu m in a 3 to 5% human serum albumin solution, and a pharmaceutical liquid composition comprising the booster as set forth above and a medicament, which are useful for the therapy of various diseases together with exposure of ultrasonic, where the therapeutic effects of the medicament is enhanced by the application of ultrasound in the presence of the booster.
Owner:EKOS CORP
Ultrasound Therapy Resulting in Bone Marrow Rejuvenation
A method and system for treating a patient to repair damaged tissue which includes exposing a selected area of bone marrow of a patient to ultrasound waves or ultra shock waves so that cells comprising stem cells, progenitor cells or macrophages are generated in the area of the bone marrow of the patient due to the ultrasound, converting the cells from the bone marrow of the patient and reducing the damaged tissue in the bone marrow of the patient by repairing the damaged tissue.
Owner:JOHNSON LANNY L
Ultrasound therapy for selective cell ablation
InactiveUS6821274B2Ultrasound therapyElectrical/wave energy microorganism treatmentSensitized cellApoptosis
The invention provides a method of sensitizing target cells to ultrasound energy using a stimulus such as an electric field. This "electrosensitisation" enables target cells to be disrupted by ultrasound at frequencies and energies of ultrasound which do not cause disruption of non-sensitized (i.e., non-target) cells. As a consequence, the method increases the selectivity of ultrasound therapy, providing a way to ablate undesired cells, such as diseased cells (e.g., tumor cells) while minimizing harm to neighboring cells. In another aspect, however, ultrasound can be used to sensitize cells while the electrical field is used to disrupt cells. The invention also provides an apparatus for performing the method and assays for identifying gene products and other molecules involved in apoptosis.
Owner:GENDEL
Methods and system for treating subcutaneous tissues
ActiveUS7588547B2Eliminate riskFacilitate ablationUltrasonic/sonic/infrasonic diagnosticsUltrasound therapyCavitationMedicine
An apparatus and method for treating subcutaneous tissues using acoustic waves in the range of low acoustic pressure ultrasound waves is disclosed. The method includes injections of enhancing agents, wherein disruption of subcutaneous tissues and subcutaneous cavitational bioeffects are produced by ultrasound waves having a power that will not produce tissue cavitation in the absence of the enhancing agents. The apparatus and method of use is useful for treatment of subcutaneous abnormalities including cellulite, lipomas, and tumors.
Owner:ULTHERA INC
Localized non-invasive biological modulation system
The present invention provides methods for non-invasive localized delivery of biologically active molecules, comprising packaging a molecule(s) of interest inside a thermosensitive particle, administering said particles to a subject, and inducing localized release of said molecules from said particles using a focused heat source. The thermosensitive particles may be thermosensitive polymer nanoparticles or thermosensitive liposomes. The particles may be delivered to a subject by any technique, including infusion. The molecules may be released from the particles using any method which induces localized hyperthermia, including focused ultrasound.
Owner:SAOIRSE CORP
Methods and systems for treating cell proliferation disorders using plasmonics enhanced photospectral therapy (PEPST) and exciton-plasmon enhanced phototherapy (EPEP)
Owner:DUKE UNIV +1
Therapeutic delivery systems
InactiveUS7083572B2Low costSuitable for useUltrasonic/sonic/infrasonic diagnosticsEchographic/ultrasound-imaging preparationsMedicineMicrosphere
Targeted therapeutic delivery systems comprising gas- or gaseous precursor-filled lipid microspheres comprising a therapeutic are described. Methods for employing such microspheres in therapeutic delivery applications are also provided.Targeted therapeutic delivery systems comprising gas- or gaseous precursor-filled liposomes having a drug encapsulated therein are preferred. Methods of and apparatus for preparing such liposomes and methods for employing such liposomes in therapeutic delivery applications are also disclosed.
Owner:BRISTOL MYERS SQUIBB MEDICAL IMAGING
Method and articles for remote magnetically induced treatment of cancer and other diseases, and method for operating such article
InactiveUS20070196281A1Avoid damagePowder deliveryHeart defibrillatorsAbnormal tissue growthCancer cell
This invention describes unique treatment methods and innovative articles that can be placed in a human or animal body to enable controlled destruction of diseased tissue. The methods include destruction of diseased cells and tissues by magnetically controlled motion and an externally controllable drug delivery process with a capability to start and stop the drug delivery at any time, for any duration. This invention provides two approaches to diseased cell destruction, (1) magneto-mechanical disturbance of cell structure (e.g. cancer cells) for cell lysis and (2) magnetically activated drug release at local regions (e.g. tumors) from a magnetic-particle-containing drug reservoir. The invention also provides combinations of both the above treatments for dual therapy. It further combines one or both of the treatments with magnetic hyperthermia for multifunctional cell destruction therapy. The approaches can be combined with magnetic MRI for monitoring the accuracy of placement as well as for following up the cancer destruction progress and appropriate reprogramming of the magneto-mechanical therapy and remote-controlled drug release.
Owner:RGT UNIV OF CALIFORNIA
Composition comprising gas-filled microcapsules for ultrasound mediated delivery
InactiveUS20090041833A1Efficient deliveryPowder deliveryDrug compositionsLipid formationActive agent
Composition comprising gas filled microcapsules and a bioactive agent, useful for an ultrasound-mediated delivery of said bioactive agent. The microcapsules comprise a relatively stiff shell of polymeric or lipid material and have in particular a resistance to a mechanical index of at least 0.15, while the bioactive agent is substantially unbound to the shell of the microcapsules. The composition of the invention is particularly suitable for effectively delivering a genetic material into a cell, upon exposure of the composition to a level of acoustic pressure capable of destroying a portion of the microcapsules and releasing the gas contained therein.
Owner:BRACCO RES USA
Method for ultrasound triggered drug delivery using hollow microbubbles with controlled fragility
InactiveUS6896659B2Ultrasonic/sonic/infrasonic diagnosticsChiropractic devicesMicrobubblesDiagnostic agent
Owner:UNIVERSITY OF PITTSBURGH
Ultrasonic concentration of carrier particles
InactiveUS20070071683A1Ultrasonic/sonic/infrasonic diagnosticsBiocideMembrane permeabilityMembrane permeabilization
Methods, compositions, and apparatus for localized delivery of compounds are provided. In certain embodiments, acoustic streaming force is used to direct carrier particles to a target site, mediate particle internalization, and release associate compounds. Ultrasound radiation is preferred as the source for the acoustic streaming force. Also encompassed are embodiments in which targeting and membrane permeability enhancement are combined with imaging of the treatment site.
Owner:RGT UNIV OF CALIFORNIA +1
System for treating subcutaneous tissues
ActiveUS20070055180A1Eliminate riskFacilitate ablationUltrasonic/sonic/infrasonic diagnosticsUltrasound therapyAbnormal tissue growthCavitation
An apparatus and method for treating subcutaneous tissues using acoustic waves in the range of low acoustic pressure ultrasound waves is disclosed. The method includes injections of enhancing agents, wherein disruption of subcutaneous tissues and subcutaneous cavitational bioeffects are produced by ultrasound waves having a power that will not produce tissue cavitation in the absence of the enhancing agents. The apparatus and method of use is useful for treatment of subcutaneous abnormalities including cellulite, lipomas, and tumors.
Owner:ULTHERA INC
Solid hydrogel coupling for ultrasound imaging and therapy
InactiveUS20060184074A1Easy to useAvoid cloggingUltrasonic/sonic/infrasonic diagnosticsEchographic/ultrasound-imaging preparationsUltrasound imagingUltrasonic sensor
The present invention employs hydrogels as acoustic couplings for clinical applications of ultrasound imaging and therapy, but is particularly applicable to high intensity focused ultrasound (HIFU) based therapy. While other materials can be used, it has been determined that polyacrylamide is sufficiently robust and transmissive to withstand the high temperatures encountered in HIFU therapy. One embodiment of a hydrogel coupling is configured in shape and size (length) to ensure that a focal region of an ultrasound transducer is disposed proximate the target area when the distal tip of the transducer is in contact with tissue. These couplings can be shaped to correspond to the beam focus characteristics of specific transducers. Water can be applied to hydrate the tip of the hydrogel coupling during use, and medication absorbed into the hydrogel material can be applied to the tissue in contact with the distal surface of the hydrogel.
Owner:UNIV OF WASHINGTON
Apparatus for treating subcutaneous tissues
ActiveUS20070055181A1Sufficient powerEliminate riskUltrasound therapyElectrotherapyAbnormal tissue growthCavitation
An apparatus and method for treating subcutaneous tissues using acoustic waves in the range of low acoustic pressure ultrasound waves is disclosed. The method includes injections of enhancing agents, wherein disruption of subcutaneous tissues and subcutaneous cavitational bioeffects are produced by ultrasound waves having a power that will not produce tissue cavitation in the absence of the enhancing agents. The apparatus and method of use is useful for treatment of subcutaneous abnormalities including cellulite, lipomas, and tumors.
Owner:ULTHERA INC
Ultrasound imaging and treatment
InactiveUS7078015B2Low costSuitable for useUltrasonic/sonic/infrasonic diagnosticsCosmetic preparationsSound energyUltrasonic imaging
Methods of and apparatus for preparing temperature activated gaseous precursor-filled liposomes are described. Gaseous precursor-filled liposomes prepared by these methods are particularly usefull for example, in ultrasonic imaging applications and in therapeutic drug delivery systems.Gas, gaseous precursors and perfluorocarbons are presented as novel potentiators for ultrasonic hyper-thermia. The gas, gaseous precursors and perfluorocarbons which may be administered into the vasculature, interstitially or into any body cavity are designed to accumulate in cancerous and diseased tissues. When therapeutic ultrasonic energy is applied to the diseased region heating is increased because of the greater effectiveness of sound energy absorption caused by these agents.
Owner:IMARX THERAPEUTICS
Implantable products comprising nanoparticles
The present disclosure relates to nanoparticle-containing implantable and preferably biodegradable medical products and their use for the thermotherapeutic after-treatment after surgical removal of tumors and cancerous ulcers.
Owner:MAGFORCE AG
Gene or drug delivery system
The present invention includes compositions and methods for delivering one or more active agents in vivo by contacting a target organ or tissue with a microbubble encapsulated active agent comprising a neutrally charged lipid microbubble loaded with cationic liposomes comprising one or more active agents and selectively releasing the active agents at the target by exposing the microbubble at the target with ultrasound, wherein the active agents remain protected in the microbubble until selectively release at the target.
Owner:BAYLOR RES INST +1
NIR-sensitive nanoparticle
InactiveUS20060099146A1Ultrasonic/sonic/infrasonic diagnosticsBiocideNanoparticle ComplexOrganic chemistry
It is provided a Near Infrared Sensitive (NIR-sensitive) nanoparticle complex comprising a NIR-sensitive nanoparticle and surfactant(s) adsorbed on the nanoparticle, wherein the surfactant is at least one surfactant selected from: wherein X=1-9; Y=0-9; n=0-9; Z=1-9; W=0-9; m=0-9; each of R1, R2, R3 and R4, if present, is H, substituted or unsubstituted C1-C6 alkyl, substituted or unsubstituted C1-C6 aryl, HS, COOH, NH2 or OH; R5 is COOH, NH2 or OH; with the proviso that n+m is <10; (b) an amino acid having the structure in (a), wherein X=1; Y=2; Z=1; W=1; R1, R2 and R4 are not present; R3 is NH2; and R5 is COOH; or (c) a peptide, wherein the peptide comprise at least one amino acid (b). Further, it is provided a NIR-sensitive nanoparticle complex(es) having biomolecule(s), for example drug(s), loaded on the surfactant(s).
Owner:NAT UNIV OF SINGAPORE +1
Nanoshells for drug delivery
Owner:ABBOTT CARDIOVASCULAR
Lipid bilayer carrier for drugs or imaging agents
InactiveUS20130108551A1Better addressMaximize MR contrast enhancementOrganic active ingredientsDispersion deliveryChain lengthImaging agent
Disclosed are carriers for drugs and / or MR imaging agents having a lipid bilayer shell comprising a phospholipid having two terminal alkyl chains, one being a short chain having a chain length of at most seven carbon atoms, the other being a long chain having a chain length of at least fifteen carbon atoms. The mixed long / short chain phospholipids serve to tune the release properties of the carrier. Preferred phospholipids are phosphatidylcholines.
Owner:KONINKLIJKE PHILIPS ELECTRONICS NV
Booster for therapy of disease with ultrasound and pharmaceutical liquid composition containing the same
A booster comprising a plurality of microbubbles of a gas in a liquid, e.g. about 4x107 cells / ml of microbubbles of a gas having a diameter of 0.1. to 100 mum in a 3 to 5% human serum albumin solution, and a pharmaceutical liquid composition comprising the booster as set forth above and a medicament, which are useful for the therapy of various diseases together with exposure of ultrasonic, where the therapeutic effects of the medicament is enhanced by the application of ultrasound in the presence of the booster.
Owner:EKOS CORP
Method and apparatus for delivery of agents across the blood brain barrier
InactiveUS20100143241A1Enhance brain imagingQuick managementUltrasonic/sonic/infrasonic diagnosticsEchographic/ultrasound-imaging preparationsNon destructiveSide effect
We describe a method for opening the blood-brain barrier (BBB) using ultrasound and preformed microbubbles. With this method, diagnostic or therapeutic agents may be administered to the brain. This method can open a focal region of the BBB and administer agents in a targeted fashion or the method can open large regions (or the entirety) of the brain for more global administration of agents. In one embodiment, the method can be used to administer contrast agents (e.g., agents that increase or decrease the magnetic resonance imaging signal) to the brain and thereby improve the quality or information content of imaging data. In another embodiment, a standard clinical diagnostic ultrasound scanner can be used to open specific regions of the BBB and administer diagnostic or therapeutic agents. Importantly, this invention can open the BBB in a non-destructive / non-invasive fashion, allowing the subject to be awake and suffer no detectable side effects.
Owner:DUKE UNIV
Sonogenic Stimulation of Cells
ActiveUS20160220672A1Reduce enzyme activityAvoid delayUltrasonic/sonic/infrasonic diagnosticsUltrasound therapyCell typeBiological activation
The invention provides compositions featuring TRP-4 polypeptides and polynucleotides, methods for expressing such polypeptides and polynucleotides in a cell type of interest, and methods for inducing the activation of the TRP-4 polypeptide in neurons and other cell types using ultrasound.
Owner:SALK INST FOR BIOLOGICAL STUDIES
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