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A system and method for improving compliance by a patient with a medical regimen that has been prescribed to the patient wherein utilizing computer and electronic communication systems, patient data is compared to pharmaceutical data to verify prescribed drug dosage and prescribed medication duration are within acceptable limits, any abnormalities found by the comparisons are reported to the treating physician who may then alter the medical regimen before authorizing dispensing of the prescribed drugs and providing drug taking information to the patient, and upon authorization being issued, the patient is scheduled to receive reminder notifications prior to the prescribed time for the prescribed drugs to be administered, as well as automatically notifying the prescription distribution service to deliver the prescribed drugs to the patient, and notifying the payor service to pay for the prescribed drugs.

The invention provides various ionic and non-ionic photoacid generator compounds. Photoresist compositions that include the novel ionic and non-ionic photoacid generator compounds are also provided. The invention further provides methods of making and using the photoacid generator compounds and photoresist compositions disclosed herein. The compounds and compositions are useful as photoactive components in chemically amplified resist compositions for various microfabrication applications.

The present invention provides novel methods for monitoring subject adherence in taking prescribed drugs by detecting markers in exhaled breath after a subject takes the prescribed drug. In particular, the present invention provides novel methods for making additives that are combined with the drug(s). Upon biological breakdown of the drug / additive formulation in a subject's body, markers resulting directly from the biological breakdown of the additives are detected in exhaled breath using sensor technology. In certain embodiments of the invention, the drug adherence monitoring systems and methods include a reporting system capable of tracking subject compliance (either remotely or proximately) and of providing necessary alerts to the subject, caregiver, healthcare provider, and the like.

The invention relates to pharmaceutical compositions comprising propylene glycol solvates of APIs.

An automatic truck unloader for unloading / unpacking product, such as boxes or cases, from trailers and containers is disclosed. In one embodiment, a mobile base structure provides a support framework for a drive subassembly, conveyance subassembly, an industrial robot, a distance measurement subassembly, and a control subassembly. Under the operation of the control subassembly, an industrial robot having a suction cup-based gripper arm selectively removes boxes from the trailer and places the boxes on a powered transportation path. The control subassembly coordinates the selective articulated movement of the industrial robot and the activation of the drive subassembly based upon the distance measurement subassembly detecting objects, including boxes, within a detection space, and dimensions of the trailer provided to the control subassembly.

Every printing system has characteristic defects which detract from high quality printing. Xerographic printing systems show defects such as banding, mottled colors in large fill areas, trail-edge deletion and starvation where toner concentrations drop at certain color edges, misregistration, and so on. Ink jet printing systems can show ink bleeding, streaking in the direction of head movement, and so on. One approach to reducing printer defects is to refine the electro-mechanics for more precise printing. Another approach which works for predictable defects is to modify the digital data being sent to the printer to pre-compensate for the defect. The prior art does this to a limited extent for individual object types (strokes, fills, images, text, etc.) and for misregistered color edges (trapping). This invention extends the range of edge-related defects that can be both predicted and pre-compensated for. An embodiment of the invention is described which pre-compensates for defects such as trail-edge deletion, starvation, misregistration, halo, etc. by identifying runs of color which meet the criteria likely to cause the effect and applying a function f(edge-distance, object-type) to such runs to modify them appropriately. Both the prediction criteria and the functions applied are anamorphic (the scan direction and process direction are treated differently) and object-optimized (object attributes are taken into account). Further, both prediction criteria and applied correction functions allow user-settable input.

A multi-code multicarrier CDMA system and method for communicating data by transforming a stream of data into a plurality of code sequences selected from a code book by associating symbols of the data stream with the code sequences of the code book, wherein the codebook includes M code sequences and each of the code sequences has a length of N data symbols, copying each of the code sequences onto one or more of a plurality of subcarriers, transmitting the plurality of subcarriers, receiving the plurality of transmitted subcarriers, demodulating the received subcarriers to result in the code sequences, transforming the code sequences back into the stream of data based upon the associations between the code sequences of the code book and the symbols of the data stream, changing at least one of the number M and lengths N of the code sequences in the code book.

A set-top box with a technical configuration and system and method for use of the same are disclosed. In one embodiment of the set-top box, the set-top box executes an technical protocol to make the set-top box and an associated television ready for use. During the installation, maintenance, or repair, a human-readable visual label and a machine-readable optical label are generated that contain information about the status of the technical protocol. The labels are forwarded, via the television output, to the television. The set-top box dynamically updates the human-readable visual label and the machine-readable optical label as the status of the technical protocol changes.

A system and related methods for the management and evaluation of real estate appraisals comprising, a method of determining a standardized score representative of the accuracy and quality of a real estate appraisal. Data from the appraisal is extracted and evaluated according to a plurality of compliance and risk based rules applicable to the type of appraisal. Each rule is given a particular weight, and an appraisal score may be calculating by summing each instance of a rule triggered multiplied by the weight assigned to that rule. Weights may be set by experts, or determined by statistical analysis.

Methods and devices for ophthalmic tissue closure and fixation of ophthalmic prostheses are provided. In accordance with some embodiments, devices for both grasping and clipping a plurality of ocular tissue and ocular prostheses are provided. Various device embodiments are provided for both malleable clips and delivery of normally closed clips (i.e. shape memory). The device may accommodate a plurality of clips which include, but are not limited to: malleable metals, absorbable, shape memory, drug-eluting, and adhesive dispensing. The clips may be pigmented to match the colors of associated tissue (cornea, iris, conjunctiva, sclera, retina) to serve to camouflage fixation clips for healing duration or permanently. According to one aspect, shallow angle access to anatomy may be provided by specialized angulation of device shaft and closure jaws that are intended to access the eye through a small self-healing cornea incision and / or any ocular tissue.

Methods and systems are provided for reducing pre-ignition incidence in a variable displacement engine during reactivation from a VDE mode. During conditions when one or more deactivated cylinders are reactivated to elevated engine loads, the reactivated cylinder(s) may be temporarily and preemptively enriched to reduce the possibility of cylinder pre-ignition. The preemptive enrichment is learned and further adjusted in a closed loop fashion.

Disclosed is a method of transporting CO2 by ship for the purpose of storage in the ocean. The CO2 is transported at a temperature between −25° C. and +25° C., and under a pressure that is sufficiently high for the CO2 to be in a liquid or supercritical state. The choice of temperature / pressure conditions for the CO2 enables the transport of CO2 one way to be effectively combined with transport of compressed natural gas (CNG) the other way. Ships can be used that have relatively cheap tubular containment equipment similar to the type normally used for CNG but with lower pressure and not subject to cyclic thermal and mechanical effects of pressurizing and depressurizing.

A method is provided of systematically evaluating and treating dynamic autonomic dysregulation in a subject. The method includes having the subject sequentially assume a plurality of distinct postures that may include, for example, walking, standing, sitting or supine. In each posture of the subject, the subject is subjected to sensory stimulation while measuring at least one autonomic physiological response of the subject. The autonomic physiological response may include, for example, oxygen saturation, heart rate, pupillary response, blood pressure, sweat production, pseudomotor activity or respiration. The physiological responses in each of the distinct postures are evaluated to identify a posture wherein the subject exhibits a least amount of dysfunction.

A Gateway Location Register (GLR) for a Public Land Mobile Network (PLMN) stores information relating to each Mobile Subscriber (MS) roaming in the PLMN. The GLR may receive a request from an associated visitor registration entity of the PLMN relating to one MS and, in response, perform an action based on the stored information relating to a plurality of MS. Additionally or alternatively, the GLR selects at least one MS currently roaming in the PLMN and performs an action for at least one selected MS. The action may comprise sending a message to a visitor registration entity of the PLMN associated with each selected MS or be performed in response to a request received from an associated visitor registration entity of the PLMN in respect of a selected MS.

A two-material plastic sprocket for modular plastic conveyor belts and an associated method for molding such a sprocket. The sprocket is made of a first plastic material forming the exterior skin and a second plastic material forming the interior core. The sprocket is preferably molded in a co-injection molding process.

Methods and systems are provided for reducing pre-ignition incidence in a variable displacement engine during reactivation from a VDE mode. During conditions when one or more deactivated cylinders are reactivated to elevated engine loads, the reactivated cylinder(s) may be temporarily and preemptively enriched to reduce the possibility of cylinder pre-ignition. The preemptive enrichment is learned and further adjusted in a closed loop fashion.

Swimsuits are provided which include an outer shell made of a flexible stretchable fabric, a thoracic reinforced region arranged in an anterior thoracic region of a trunk portion of the swimsuit and having an anterior-downward converging shape, and an abdominal reinforced region arranged in a lower abdominal and hip region of the trunk portion and having an anterior-upward converging shape, two non-reinforced waist regions arranged in opposite lateral waist regions of the trunk portion and having both a medially converging shape, wherein the thoracic reinforced region, the abdominal reinforced region and the non-reinforced regions border in an X pattern in an anterior region of the trunk portion. Methods of making such swimsuits are also provided.

A securement for crawler cranes and system and method for use of the same are disclosed. In one embodiment of the system, a pair of structural securements are spaced at approximately a track-distance apart with respect to the crawler crane and coupled together by multiple transverse support members. When the crawler crane is driven onto the structural securements and fastened thereto, the tipping fulcrum of the crawler crane is shifted, thereby requiring a greater tipping force to tip and adding stability during high wind events.

An account and product based sales professional workbench for handling sales activity information are described, with a sales activity interface comprising a grouped plurality of fields that are grouped with respect to a customer account associated with a sales representative, the grouped plurality of fields including an account name field configured to identify the customer account; and a product indication field configured to provide one or more products associated with the customer account.

Improved tissue fasteners are disclosed that can be inserted into (and optionally through) tissue structures underlying a tissue surface, for affixing overlapping tissues and tissue planes together, and the like. In some embodiments, an elongate anvil body may protrude distally and / or laterally from a fastener support disposed along the base. The anvil body may have a sharpened end and be configured to penetrate into the tissue, with the elongate anvil body optionally having a bend from a more distal orientation adjacent the clip support to a more lateral orientation adjacent the sharpened end during at least a portion of the deployment. The first leg can be driven through a desired location on the surface of the first tissue and against a receptacle of the anvil body so as to deform the fastener and affix it to the first tissue.

A method of operating a gas-filled collision cell in a mass spectrometer is provided. The collision cell has a longitudinal axis. Ions are caused to enter the collision cell. A trapping field is generated within the collision cell so as to trap the ions within a trapping volume of the collision cell, the trapping volume being defined by the trapping field and extending along the longitudinal axis. Trapped ions are processed in the collision cell and a DC potential gradient is provided, using an electrode arrangement, resulting in a non-zero electric field at all points along the axial length of the trapping volume so as to cause processed ions to exit the collision cell. The electric field along the axial length of the trapping volume has a standard deviation that is no greater than its mean value.

Methods and devices for ophthalmic tissue closure and fixation of ophthalmic prostheses are provided. In accordance with some embodiments, devices for both grasping and clipping a plurality of ocular tissue and ocular prostheses are provided. Various device embodiments are provided for both malleable clips and delivery of normally closed clips (i.e. shape memory). The device may accommodate a plurality of clips which include, but are not limited to: malleable metals, absorbable, shape memory, drug-eluting, and adhesive dispensing. The clips may be pigmented to match the colors of associated tissue (cornea, iris, conjunctiva, sclera, retina) to serve to camouflage fixation clips for healing duration or permanently. According to one aspect, shallow angle access to anatomy may be provided by specialized angulation of device shaft and closure jaws that are intended to access the eye through a small self-healing cornea incision and / or any ocular tissue.

A geolocationing system and method for providing awareness in a multi-space environment, such as a hospitality environment or educational environment, are presented. In one embodiment of the geolocationing system, a vertical and horizontal array of gateway devices is provided. Each gateway device includes a gateway device identification providing an accurately-known fixed location within the multi-space environment. Each gateway device includes a wireless transceiver that receives a beacon signal from a proximate wireless-enabled personal locator device. The gateway devices, in turn, send gateway signals to a server, which determines estimated location of the wireless-enabled personal locator device with transmitted signal strength modeling.

A controller-based apparatus for diagnosis and treatment of a subject with acquired brain injury and dysfunction. Various embodiments of the invention described herein recognize that different body postures affect the autonomic nervous system differently, and therefore various external stimuli may have different therapeutic efficacies when a patient or subject is in each body posture. Postures, such as walking, sitting, standing, prone and supine, have different effects on the autonomic nervous system, and therefore some stimuli have different physiological efficacies while a patient or subject is in a given body posture. Disclosed embodiments of the present invention leverage this relationship to provide a controller-based apparatus that determines a combination of posture and stimulus that has optimal therapeutic effect, while minimizing health practitioner involvement. The controller based apparatus provides a treatment that stimulates the nervous system through a combination of noninvasive therapies that stimulate brain cells to increase their efficiency—this promotes the formation of pathways that help transfer information throughout the brain in such a way that in the end, the affected area of the brain and overall brain function are improved without medication or surgery.

Method and kit based on real-time PCR with specific primers and probes that allow to achieve a high degree of subtyping of the complete HLA-B locus. The main advantages are the greater speed (65 minutes, including the interpretation); the ease of automation, since only eighteen tubes are necessary to obtain a good level of resolution (typing of 300 groups); reduction of the total cost per test thanks to the ease of automation and the simplicity; a surprisingly high degree of allele definition is achieved; and the risk of sample contamination is reduced because the amplified products always remain in the tubes and no post-PCR steps are necessary.

An oxygen therapy monitoring device includes an oscillation chamber with in a gas flow path adapted to pass a gas flow from a source to a breathing interface for a person. The oscillation chamber induces an oscillation in the gas flow that varies as a function of a flow rate of the gas flow. A measurement arrangement measures the oscillation induced in the gas flow and determines the flow rate on the basis of the oscillation that is measured.