57results about How to "More stable" patented technology

The present invention provides active fibroblast growth factor variants demonstrating enhanced receptor subtype specificity. The preferred novel variants retain binding to FGF Receptor Type 3 (FGFR3) triggering intracellular downstream mechanisms leading to activation of a biological response. Methods of utilizing preferred FGF mutants in preparation of medicaments for the treatment of malignancies and skeletal disorders including osteoporosis and enhancing fracture healing and wound healing processes are provided.

The invention relates to pharmaceutical compositions comprising propylene glycol solvates of APIs.

Carrier for the rack mounting of two or more data storage devices into a chassis. The carrier includes support members along the length of the carrier, to receive and retain the two or more data storage devices. The carrier further includes a single electrical communication connector to provide an electrical communication interface for all of the data storage devices in the carrier, to and from a mating connector on a board of the chassis. The carrier further includes an interposer to adapt electrical signals from the single electrical communication connector into a form that is usable by the data storage devices.

Carrier for the rack mounting of two or more data storage devices into a chassis. The carrier includes support members along the length of the carrier, to receive and retain the two or more data storage devices. The carrier further includes a single electrical communication connector to provide an electrical communication interface for all of the data storage devices in the carrier, to and from a mating connector on a board of the chassis. The carrier further includes an interposer to adapt electrical signals from the single electrical communication connector into a form that is usable by the data storage devices.

A pruning shears is revealed. The pruning shears include a first brake arm, a second brake arm, a blade, and at least one connection piece. The first brake arm is disposed with a first toothed part while the second brake arm is arranged with a second toothed part. The first toothed part and the second toothed part are engaged with each other. The connection piece is pivotally connected to the blade, the first brake arm, and the second brake arm. During a cutting process (pruning process), a force applied is reduced due to the connection piece pivotally connected to the first brake arm and the second brake arm. While the first and the second toothed parts are engaged with each other, the connection piece becomes a wall of the first and the second toothed parts for stabilizing the engagement of the first and the second toothed parts.

The invention is directed to binary oligonucleotide probes for nucleic analysis, which probes can be made of DNA or RNA that recognize nucleic acid analytes (both DNA and RNA) with unprecedented high selectivity under mild conditions and are highly sensitive to single nucleotide mismatches (SNP single nucleotide polymorphisms) without PCR amplification. In one group, the binary probes indicate that they have hybridized to a particular nucleic analyte by binding to a molecular beacon that gives off a fluorescent signal. A second group of binary probes bind to a dye such as malachite green, where upon hybridization to analyte the fluorescence of the dye increases dramatically and is easily detected and measured. The new binary probes require only about five minutes at room temperature to generate a detectable signal.

A hydroxysafflor yellow A sodium compound as shown in a formula (I) and preparation as well as medicinal application thereof are provided. According to the present invention, the safflower is utilized as a raw material. A monomer pharmaceutical compound, the hydroxysafflor yellow A sodium, is obtained by sufficient processes, and a purity thereof is surely above 98.5%. Therefore, the hydroxysafflor yellow A sodium is a monomer compound, which is safer, more effective, more stable and more controllable than hydroxysafflor yellow A, for treating blood circulation disorders such as platelet aggregation, coronary heart disease, angina pectoris and acute cerebral ischemia. Furthermore, the hydroxysafflor yellow A sodium has sufficient solubility and human tolerance.

A dump trailer comprising a U-shaped trailer body having a bottom wall and opposing side walls. The trailer includes a curved front wall and a pivotable tailgate. The front wall is U-shaped when viewed from the top and angles upwardly and forwardly from the bottom wall. A support structure provided adjacent the front wall operatively engages hitch and lift assemblies. The support structure includes spaced-apart supports secured to the front wall; and spaced-apart horizontal beams secured to the supports. The beams extend through apertures in the front wall and into the compartment. This enables the trailer body to be lowered relative to the ground, thus lowering the center of gravity of the trailer. A wheel assembly mounts to the rear end of the trailer via a mounting plate curved complementary to the bottom wall. Cut-outs in the plate reduce the overall weight of the trailer.

The present invention relates to a kind of supercharging device, which comprises: One frame body, which is being formed into a shape of cylindrical tube, has one primary end and one secondary end respectively, wherein the port of said primary end is being formed into the serrated shape along with a plurality of serration structures, however, the port of said secondary end has a smooth plane instead; one axial structure is being formed into the said frame body; there is also a plurality of blades, in which, each blade being formed into a trapezoidal-shaped blade has a upper plate and a lower plate respectively, therein the said upper plate is shorter than the said lower plate; in addition, the said plurality of blades and the said plurality of serration structures have been formed into the same number, and the upper plate of each blade is being connected to each of the said axial structure, the lower plate is being connected to internal surface within the said frame body, and it is extended from the secondary end to the peak portion of said serration structure of the said primary end, and each of blade is corresponding to each of serration structure; wherein, the said supercharging device will be able to supercharge intake air and hence to improve the said engine's horsepower by enlarging air inflow of the engine.

The invention is directed to binary oligonucleotide probes for nucleic analysis, which probes can be made of DNA or RNA that recognize nucleic acid analytes (both DNA and RNA) with unprecedented high selectivity under mild conditions and are highly sensitive to single nucleotide mismatches (SNP single nucleotide polymorphisms) without PCR amplification. In one group, the binary probes indicate that they have hybridized to a particular nucleic analyte by binding to a molecular beacon that gives off a fluorescent signal. A second group of binary probes bind to a dye such as malachite green, where upon hybridization to analyte the fluorescence of the dye increases dramatically and is easily detected and measured. The new binary probes require only about five minutes at room temperature to generate a detectable signal.