136 results about "Receptor subtype" patented technology
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The receptor subtype is also defined by the pharmacological characteristics of the site and is based on the availability of selective agonists and antagonists for the subtypes. For example, beta-adrenoceptors are subdivided into beta-1 adrenoceptors, beta-2 adrenoceptors, and beta-3 adrenoceptors.
The present invention provides active fibroblastgrowth factor variants demonstrating enhanced receptor subtype specificity. The preferred novel variants retain binding to FGF Receptor Type 3 (FGFR3) triggering intracellular downstream mechanisms leading to activation of a biological response. Methods of utilizing preferred FGF mutants in preparation of medicaments for the treatment of malignancies and skeletal disorders including osteoporosis and enhancing fracture healing and wound healing processes are provided.