40results about How to "With photothermal effect" patented technology

The invention provides a photosensitive liposome with encapsulated water-soluble medicament, which is composed of temperature-sensitive phospholipid, cholesterol and long circulation material and hollow gold nanoparticle, wherein, the hollow gold nanoparticle has a characteristic absorption peak at the near infrared zone with the wavelength of 700-900 nm, and the particle size distribution of the hollow gold nanoparticle is in the range of 20-100 nm. According to the invention, a brand new photosensitive liposome is composed by wrapping water-soluble medicament and hollow gold nanoparticle with temperature-sensitive liposome. Under the extraneous near infrared light, the wrapped hollow gold nanoparticle generates a photo-thermal treatment effect, simultaneously, the photo-thermal effect controls a rapid site-specific delivery of medicament in a large amount from the photosensitive liposome, thereby blood vessels in the tumour part can be damaged or the tumor cells can be killed effectively with a chemical treatment effect of the medicamen. The drug loaded liposome of the present invention realizes synchronous photo-thermal and medicament molecule treatment effect, and the treatment effect of disease such as tumour is substantially improved, and the invention has clinic applicability and real treatment meaning.

The invention provides a Janus particle with a chemotherapy / photo-thermal synergistic effect and a preparation method thereof and belongs to the technical field of biomedicines, aiming at solving thetechnical problem that combined treatment of various methods on cancers is not easy to realize by other materials. The particle is of a gold-silicon dioxide / mesoporous silicon dioxide Janus nano-structure; a gold nanoparticle is reduced on the surface of an aminated mesoporous silicon dioxide semi-sphere in situ through a Pickering emulsion method and different medicines are loaded at two ends respectively. The gold nanoparticle modified aminated mesoporous silicon dioxide Janus particle is prepared through the Pickering emulsion method. The Janus particle provided by the invention can be usedfor loading the two medicines at the same time and the ratio of the two medicines can be accurately controlled; the two medicines can respond medicine releasing through external signal stimulation including pH (Potential of Hydrogen), oxidization reduction and the like, and the technical problem that sudden releasing of the medicines is caused by an existing medicine nano-carrier is solved.

The invention discloses a method for chemical design and preparation of nano-composite hydrogel with strong photothermal effect and self-repairing capability by melanin. Specifically, polydopamine type nanoparticles are prepared, also surface initiated atom transfer free radical polymerization technology is utilized, firstly an atom transfer free radical polymerization initiator (PDA@Br) is grafted on the surfaces of polydopamine type nanoparticles, then polydimethylaminoethyl methacrylate (PDMAEMA) is grafted on the surface of the polydopamine type nanoparticles, thereby achieving functionalmodification on the surfaces of the polydopamine type nanoparticles. The prepared polydopamine type nano-composite material (PDA@PDMAEMA) is implanted into a hydrogel to obtain the nano-composite hydrogel with strong photothermal effect and self-repairing performance.

The invention discloses a polypyrrole-graphene / polyurethane antifouling paint, a preparation method and application thereof, wherein the polypyrrole-graphene / polyurethane antifouling paint is composed of component A and component B; in parts by weight, A The components are mainly composed of the following raw materials: 500 parts of group-hydrolyzed polyurethane prepolymer, 25-50 parts of bentonite, 25-50 parts of titanium dioxide, 60-120 parts of zinc oxide, 15-30 parts of talc, polypyrrole-graphene 15-30 parts of nanofillers; by weight, component B is mainly composed of the following raw materials: 5-7 parts of leveling agent, 5-7 parts of defoamer, 6-15 parts of chain extender, 10 parts of silane coupling agent ‑25 parts, 1-2 parts of catalyst. The present invention is a two-component polyurethane coating, which has good adhesion, anti-collision and crack resistance, and can also improve antifouling performance and antifouling durability.

The invention discloses a preparation method of a ZIF-67 / GO photocatalysis-photothermal composite film, which comprises the following steps: a) adding graphene oxide into ultrapure water, and carryingout ultrasonic treatment to obtain a uniform solution of graphene oxide, i.e., a GO aqueous solution; b) carrying out suction filtration on the GO aqueous solution on a PTFE film, and drying at normal temperature to obtain a GO film; c) pouring a Co(NO3)<2>.6H2O solution into a culture dish filled with the GO film, keeping at 35-45 DEG C for 8-24 hours, pouring out the solution, and cleaning thefilm with methanol; pouring a 2-methylimidazole solution into a culture dish filled with the GO film soaked by the Co(NO3)<2>.6H2O solution, keeping the temperature at 35-45 DEG C for 8-24 hours, pouring out the solution, and cleaning the film with methanol; and finally, drying the film in a vacuum drying oven at 60 DEG C to obtain the ZIF-67 / GO photocatalysis-photothermal composite film. The preparation method of the ZIF-67 / GO photocatalysis-photothermal composite film is simple, the cost is relatively low, and the ZIF-67 / GO photocatalysis-photothermal composite film has excellent photocatalysis-photothermal synergistic performance. The composite film can be used for photocatalytic-photothermal synergistic catalytic reduction of metal ions.

The invention discloses a method for preparing a rare-earth ytterbium-thulium-doped blue luminous pyrochlore-phase nanofiber and application of the nanofiber. The method comprises the steps of addingpolyvinylpyrrolidone into dimethyl formamide, preparing a one-dimensional nanofiber material under the acting force of liquid surface tension and an electric field, and then removing organic matter residues in the processes of heating, heat preservation and cooling to prepare the cubic pyrochlore-phase one-dimensional nanofiber with high crystallinity. The obtained one-dimensional nanofiber achieves blue up-conversion luminescence perceivable for eyes and has high dispersibility in water and a great photothermal effect under the irradiation of near-infrared light. The preparation method is simple, feasible and high in repeatability and can meet the requirement of industrial batch production. An up-conversion photothermal material matrix is an oxide which is high in chemical stability and free of toxin and is easily dispersed in water, and the demands of photo-thermal therapy can be met. The prepared one-dimensional pure pyrochlore-phase nano material is expected to play an important role in the treatment field of major diseases such as cancers and tumors.

The invention discloses a polydopamine nanometer diagnosis and treatment preparation and a preparation method thereof. The nano-therapeutic agent uses mesoporous polydopamine as a carrier, and carries rhodium nanoparticles in the pores and surfaces of mesoporous polydopamine respectively through hydrothermal synthesis reaction, and then absorbs photosensitizer chlorin (Ce6) on polydopamine and polydopamine. The polydopamine nanometer therapeutic agent with good dispersion is obtained on the composite nanoparticle of rhodium. The invention utilizes the photothermal effect of the carrier mesoporous polydopamine and the rhodium nanoparticle itself to locally heat up the tumor site. Combined with the catalytic properties of rhodium nanoparticles, it catalyzes the decomposition of hydrogen peroxide in the tumor microenvironment to generate oxygen. Under the conditions of photosensitizer Ce6 and external laser, it can realize the generation of singlet oxygen and effectively kill cancer cells. At the same time, combined with the photoacoustic imaging properties of polydopamine, the purpose of photoacoustic imaging-guided photothermal therapy and photodynamic synergistic therapy can be realized, which is expected to improve the effect of tumor treatment and has good biocompatibility, which has the potential for clinical application.

The invention relates to a layered double hydroxide nano drug-loaded complex and its preparation and application, and the complex is passed through Mn 2+ Doped layered double hydroxide MLDH nanosheets sequentially decorated with NH 2 ‑PEG‑COOH, loaded with heat shock protein inhibitor 17AAG, obtained. The reaction condition of the present invention is mild, easy to operate, and has the prospect of industrial implementation.

The invention relates to a coating material, in particular to an integrated coating material with anti-ice and wave absorbing functions, and a preparation method and application thereof. The present invention first provides a photocurable fluorinated epoxy resin, which can greatly reduce the surface free energy and improve the hydrophobicity of the material by introducing organic fluorine segments. The present invention also provides an integrated coating material system with anti-ice and wave absorbing functions, which comprises light-cured fluorinated epoxy resin, fluorinated Fe 3 O 4 Nanoparticles, photocuring initiators and organic solvents, this coating material system can realize the functional coupling of anti-icing and wave absorption, and has broad application prospects.

The invention provides a multifunctional nano-drug combination and a preparation method thereof. The combination comprises a carrier and active ingredients loaded on the carrier, wherein the carrier is a polymer formed by mPEG-PLGA and / or PEG-PLGA and a porphyrin compound through covalent-bond connection, and the active ingredients include hydrophobic and hydrophilic drugs. Preferentially, the carrier and the active ingredients loaded on the carrier form particles with the nano size of 50-1000 nm. The multifunctional nano-drug combination has photo-thermal effect so that the treatment efficiency can be improved based on traditional chemotherapy in combination with photo-thermal therapy, and the multifunctional nano-drug combination can be applied to cancer therapy drugs.

The invention provides a polymer drug carrier and a method for preparing the same. The polymer drug carrier is provided with a core-shell structure, a core comprises polyethylene glycol-distearoyl phosphoethanolamine nano-micelle, and a shell comprises poly-dopamine. The method includes forming the nano-micelle from polyethylene glycol-distearoyl phosphoethanolamine; forming the poly-dopamine shell on the outside of the nano-micelle to obtain the polymer drug carrier. The polymer drug carrier and the method have the advantages that the core and the shell of the polymer drug carrier comprise biodegradable polymers, accordingly, the polymer drug carrier is good in biocompatibility, and few toxic and side effects can be realized; the particle size of the polymer drug carrier is smaller than 50nm, tumor gathering effects and photo-thermal therapy effects can be realized, and tumor cell killing effects can be realized after near-infrared light irradiates on the polymer drug carrier; drugs can be encapsulated by the nano-micelle of the polymer drug carrier, diversified drugs can be loaded under chemical modification effects of the poly-dopamine, and accordingly the polymer drug carrier has an excellent application prospect in the field of medicine and pharmacology.

A Janus particle with chemotherapy / photothermal synergy and its preparation method, belonging to the field of biomedicine technology, can solve the technical problem that other materials are not easy to achieve multiple methods of combined treatment of cancer. The particle is gold-silica / mesoporous Silica Janus nanostructure, gold nanoparticles are in situ reduced on the surface of aminated mesoporous silica hemisphere by Pickering emulsion method, and different drugs are loaded on both ends. Aminated mesoporous silica Janus particles modified by gold nanoparticles are prepared by the Pickering emulsion method. The Janus particles of the present invention can simultaneously load two kinds of drugs, and can precisely control the ratio of the two kinds of drugs. The two kinds of drugs can pass pH, oxidation Reduction and other external signal stimuli respond to drug release, which solves the technical problem of drug burst release caused by existing drug nanocarriers.

The invention discloses a method for preparing rare earth ytterbium holmium double-doped pyrochlore phase nanofibers and its application. Using dimethylformamide as a solvent and adding polyvinylpyrrolidone, the droplets form Taylor cones under an electrostatic field, and on the surface of the liquid One-dimensional nanomaterials are prepared by electrospinning under the force of tension and electric field, and then the organic matter is removed through the process of heating, heat preservation and cooling, and cubic pyrochlore phase one-dimensional nanomaterials are prepared. One-dimensional nanofibers have good dispersibility in water, and have good upconversion performance and photothermal effect under near-infrared light irradiation. The preparation method is simple and easy, has good repeatability, and can meet the requirements of mass production. The matrix of the up-conversion photothermal material involved is an oxide, which has good chemical stability, is non-toxic, is cheap and is easily dispersed in water, and can meet the requirements of photothermal treatment and industrial production. It is expected to play an important role in the treatment of major diseases such as cancer and tumors.